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https://www.readbyqxmd.com/read/28732433/the-effect-of-salt-space-on-clinical-findings-and-peak-expiratory-flow-in-children-with-mild-to-moderate-asthma-a-randomized-crossover-trial
#1
Saeideh Mazloomzadeh, Niousha Bakhshi, Akefeh Ahmadiafshar, Mehdi Gholami
The asthma treatment and control might be associated with significant burden on family and community' thus exploring other therapeutic plans could be desirable. The aim of this study was to investigate the effect of salt space on clinical findings and peak expiratory flow rate among children with asthma. In this randomized crossover trial, 34 patients aged 6-14 years old with mild to moderate asthma were selected and randomly divided into two groups. The first group went through a period of salt therapy by staying in the salt room for one hour, three times a week for 3 consecutive weeks and then was under observation for three weeks...
June 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28732397/combined-sewer-overflow-events-and-childhood-emergency-department-visits-a-case-crossover-study
#2
Cole Brokamp, Andrew F Beck, Louis Muglia, Patrick Ryan
In localities with combined sewer systems, combined sewer overflow (CSO) events frequently occur following high precipitation and can result in the release of untreated sewage and industrial wastewater into surface waters. We hypothesized that either direct contact with or proximity to aerosolized CSO effluent would increase the risk for childhood emergency department (ED) visits for asthma, gastrointestinal (GI) illnesses, and skin and soft tissue infections (SSTIs) in Cincinnati, OH, USA. ED visits for 2010-2014 due to GI diseases, asthma, and SSTIs were extracted from the Cincinnati Children's Hospital Medical Center electronic health records...
July 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28732336/using-machine-learning-to-identify-air-pollution-exposure-profiles-associated-with-early-cognitive-skills-among-u-s-children
#3
Jeanette A Stingone, Om P Pandey, Luz Claudio, Gaurav Pandey
Data-driven machine learning methods present an opportunity to simultaneously assess the impact of multiple air pollutants on health outcomes. The goal of this study was to apply a two-stage, data-driven approach to identify associations between air pollutant exposure profiles and children's cognitive skills. Data from 6900 children enrolled in the Early Childhood Longitudinal Study, Birth Cohort, a national study of children born in 2001 and followed through kindergarten, were linked to estimated concentrations of 104 ambient air toxics in the 2002 National Air Toxics Assessment using ZIP code of residence at age 9 months...
July 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28732303/do-analog-number-representations-underlie-the-meanings-of-young-children-s-verbal-numerals
#4
Susan Carey, Anna Shusterman, Paul Haward, Rebecca Distefano
Children learn to count, and even learn the cardinal meanings of the first three or four verbal numerals ("one" through "three" or "four"), before they master the numerical significance of counting. If so, it follows that the cardinal meanings of those first few numerals cannot be derived, initially, from their place in the count list and the counting routine. What non-verbal representations, then, support the cardinal meanings of verbal numerals before children have mastered how counting does so? Four experiments addressed the commonly adopted assumption that in the earliest period of learning the meanings of number words, children map verbal numerals to regions of the analog number system (ANS), a system of representation with numerical content that is widely attested in animals and in human infants...
July 18, 2017: Cognition
https://www.readbyqxmd.com/read/28732282/proficient-use-of-low-spatial-frequencies-facilitates-face-memory-but-shows-protracted-maturation-throughout-adolescence
#5
Judith C Peters, Chantal Kemner
Face perception is characterized by configural processing, which depends on visual information in the low spatial frequency (LSF) ranges. However, it is unclear whether LSF content is equally important for face memory. The present study investigated how face information in the low and high SF range plays a role in the configural encoding of faces for short-term and long-term recall. Moreover, we examined how SF-dependent face memorization develops in female adolescence, by comparing children (9-10-year-olds), adolescents (12-13-year-olds and 15-16-year-olds), and young adults (21-32-year-olds)...
July 18, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28732280/evaluation-of-a-novel-median-power-spectrogram-for-seizure-detection-by-non-neurophysiologists
#6
Peter Yan, Tamar Melman, Sherry Yan, Munkhzul Otgonsuren, Zachary Grinspan
PURPOSE: (1) To evaluate how well resident physicians use a novel EEG spectral analysis tool (the median power spectrogram; MPS) to detect seizures. (2) To assess the capability of the MPS to identify different seizure types. METHODS: 120 EEG records from children with intractable seizures were converted to MPS by taking the median power across leads and using multi-taper spectral estimation. Twelve blinded neurology residents were trained to interpret the spectrogram with a five-minute video tutorial and post-test...
June 15, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28732257/epileptiform-discharges-in-eeg-and-seizure-risk-in-adolescent-children-of-women-with-epilepsy
#7
Joseph Samuel, Manna Jose, V S Nandini, Sanjeev V Thomas
We aimed to study the epileptiform discharges (ED) and seizure risk in EEG of 12-18-year-old children of women with epilepsy (WWE). Children of WWE who were prospectively followed up in the Kerala registry of epilepsy and pregnancy (KREP), aged 12-16years (n=92; males 48, females 44) underwent clinical evaluation and a 30-min digital 18-channel EEG. The EEG showed epileptiform discharges in 13 children (5 males and 8 females). The EDs were generalized in 9 and focal in 4 (occipital 2, frontal 1, and centroparietal 1)...
July 17, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28732244/thyroglossal-duct-cysts-in-children-sonographic-features-every-radiologist-should-know-and-their-histopathological-correlation
#8
REVIEW
Emilio Inarejos Clemente, Modupe Oyewumi, Evan Probst, Bo-Yee Ngan, Mary-Louise Greer
Distinguishing between thyroglossal duct cysts (TGDC) and dermoid cysts (DC) sonographically can be challenging. We illustrate the three sonographic features in neck masses in children recently identified as being most suggestive of TGDC (septa, irregular wall and solid elements) and their corresponding histopathology. These three variables form a proposed predictive model for TGDC as a guide to surgical intervention. Pediatric radiologists should be familiar with these key imaging features, as compared with other imaging features described in TGDC also illustrated here, which are less discriminating...
July 12, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28732193/what-should-a-website-dedicated-to-the-postnatal-period-contain-a-delphi-survey-among-parents-and-professionals
#9
J Slomian, P Emonts, M Erpicum, L Vigneron, J Y Reginster, O Bruyère
OBJECTIVES: Mothers have a great need for information during the postnatal period. Trying to meet this need, mothers are increasingly turning to the Internet. Nevertheless, many women have stated that they often or always found that the information that they found on the Internet was incomplete or wrong. Many women therefore believe that health professionals should suggest reliable Internet websites for new mothers. The aim of this study was therefore to find a consensus on the content of a reliable and centralized website dedicated to mothers from the end of pregnancy to 1 year after childbirth...
July 6, 2017: Midwifery
https://www.readbyqxmd.com/read/28732176/a-comprehensive-craniofacial-study-of-22q11-2-deletion-syndrome
#10
A Lewyllie, J Roosenboom, K Indencleef, P Claes, A Swillen, K Devriendt, C Carels, M Cadenas De Llano-Pérula, G Willems, G Hens, A Verdonck
The 22q11.2 deletion syndrome (22q11.2DS) is one of the most frequent microdeletion syndromes and presents with a highly variable phenotype. In most affected individuals, specific but subtle facial features can be seen. In this observational study, we aim to investigate the craniofacial and dental features of 20 children with a confirmed diagnosis of 22q11.2DS by analyzing 3-dimensional (3D) facial surface scans, 2-dimensional (2D) clinical photographs, panoramic and cephalometric radiographs, and dental casts...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28732142/network-meta-analysis-including-treatment-by-covariate-interactions-consistency-can-vary-across-covariate-values
#11
Sarah Donegan, Nicky J Welton, Catrin Tudur Smith, Umberto D'Alessandro, Sofia Dias
BACKGROUND: Many reviews aim to compare numerous treatments and report results stratified by subgroups (e.g. by disease severity). In such cases, a network meta-analysis model including treatment by covariate interactions can estimate the relative effects of all treatment pairings for each subgroup of patients. Two key assumptions underlie such models, consistency of treatment effects and consistency of the regression coefficients for the interactions. Consistency may differ depending on the covariate value at which consistency is assessed...
July 21, 2017: Research Synthesis Methods
https://www.readbyqxmd.com/read/28732120/the-prevalence-of-molar-incisor-hypomineralization-evidence-from-70-studies
#12
Dongdong Zhao, Bao Dong, Dandan Yu, Qiongqiong Ren, Yehuan Sun
OBJECTIVE: A growing number of studies have investigated the prevalence of Molar Incisor Hypomineralization (MIH) around the world. The aim of this study was to systematically estimate the pooled prevalence of MIH. METHODS: A comprehensive literature research was completed in English and Chinese databases. Random effect models were used to calculate the pooled prevalence. To address the heterogeneity, meta-regression, and sensitivity analyzes were conducted. Publication bias was estimated by trim and fill method...
July 21, 2017: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/28732085/point-of-care-screening-for-hepatitis-b-virus-infection-in-pregnant-women-at-an-antenatal-clinic-a-south-african-experience
#13
Nafiisah Chotun, Wolfgang Preiser, Christoffel Johannes van Rensburg, Pedro Fernandez, Gerhard Barnard Theron, Dieter Glebe, Monique Ingrid Andersson
BACKGROUND & AIMS: Elimination of HIV and syphilis mother-to-child transmission (MTCT) has received much attention but little consideration has been given to the possibility of elimination of HBV MTCT. In sub-Saharan Africa, HBV vertical transmission continues to be reported and it remains an important public health problem. This study aimed to assess the feasibility of screening pregnant women for HBV using a point-of-care (POC) test and implementing interventions to prevent HBV MTCT...
2017: PloS One
https://www.readbyqxmd.com/read/28732082/osteosarcoma-enters-a-post-genomic-era-with-in-silico-opportunities-generation-of-the-high-dimensional-database-for-facilitating-sarcoma-biology-research-a-report-from-the-children-s-oncology-group-and-the-quadw-foundation
#14
Jason Glover, Tsz-Kwong Man, Donald A Barkauskas, David Hall, Tanya Tello, Mary Beth Sullivan, Richard Gorlick, Katherine Janeway, Holcombe Grier, Ching Lau, Jeffrey A Toretsky, Scott C Borinstein, Chand Khanna, Timothy M Fan
The prospective banking of osteosarcoma tissue samples to promote research endeavors has been realized through the establishment of a nationally centralized biospecimen repository, the Children's Oncology Group (COG) biospecimen bank located at the Biopathology Center (BPC)/Nationwide Children's Hospital in Columbus, Ohio. Although the physical inventory of osteosarcoma biospecimens is substantive (>15,000 sample specimens), the nature of these resources remains exhaustible. Despite judicious allocation of these high-value biospecimens for conducting sarcoma-related research, a deeper understanding of osteosarcoma biology, in particular metastases, remains unrealized...
2017: PloS One
https://www.readbyqxmd.com/read/28732070/characterization-of-human-enterovirus71-virus-like-particles-used-for-vaccine-antigens
#15
Dandan Zhao, Bo Sun, Shiyang Sun, Bin Fu, Chuntian Liu, Dawei Liu, Yanfei Chu, Youlei Ma, Lu Bai, Yongge Wu, Yan Zhou, Weiheng Su, Ali Hou, Linjun Cai, Fei Xu, Wei Kong, Chunlai Jiang
Human enterovirus 71 (EV71) is a major causative pathogen of hand, foot and mouth disease (HFMD) and has caused outbreaks with significant mortality among young children in the Asia-Pacific region in recent years. Towards developing a vaccine for this disease, we have expressed and purified EV71 virus-like particles (VLPs), which resemble the authentic virus in appearance, capsid structure and protein sequence, from insect cells (Sf9) using a multistep chromatography process. We demonstrated intracellular localization of the VLPs in host cells by in situ immunogold detection, electron microscopy and immunofluorescence...
2017: PloS One
https://www.readbyqxmd.com/read/28732068/effects-of-liver-stage-clearance-by-primaquine-on-gametocyte-carriage-of-plasmodium-vivax-and-p-falciparum
#16
Rahel Wampfler, Natalie E Hofmann, Stephan Karl, Inoni Betuela, Benson Kinboro, Lina Lorry, Mariabeth Silkey, Leanne J Robinson, Ivo Mueller, Ingrid Felger
BACKGROUND: Primaquine (PQ) is the only currently licensed antimalarial that prevents Plasmodium vivax (Pv) relapses. It also clears mature P. falciparum (Pf) gametocytes, thereby reducing post-treatment transmission. Randomized PQ treatment in a treatment-to-reinfection cohort in Papua New Guinean children permitted the study of Pv and Pf gametocyte carriage after radical cure and to investigate the contribution of Pv relapses. METHODS: Children received radical cure with Chloroquine, Artemether-Lumefantrine plus either PQ or placebo...
July 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28732066/inhibition-of-pulmonary-%C3%AE-carotene-15-15-oxygenase-expression-by-glucocorticoid-involves-ppar%C3%AE
#17
Xiaoming Gong, Raju Marisiddaiah, Lewis P Rubin
β-carotene 15,15'-oxygenase (BCO1) catalyzes the first step in the conversion of dietary provitamin A carotenoids to vitamin A. This enzyme is expressed in a variety of developing and adult tissues, suggesting that its activity may regulate local retinoid synthesis. Vitamin A and related compounds (retinoids) are critical regulators of lung epithelial development, integrity, and injury repair. A balance between the actions of retinoids and glucocorticoids (GCs) promotes normal lung development and, in particular, alveolarization...
2017: PloS One
https://www.readbyqxmd.com/read/28732058/the-role-of-a-fads1-polymorphism-in-the-association-of-fatty-acid-blood-levels-bmi-and-blood-pressure-in-young-children-analyses-based-on-path-models
#18
Maike Wolters, Carmen Dering, Alfonso Siani, Paola Russo, Jaakko Kaprio, Patrizia Risé, Luis A Moreno, Stefaan De Henauw, Kirsten Mehlig, Toomas Veidebaum, Denés Molnár, Michael Tornaritis, Licia Iacoviello, Yannis Pitsiladis, Claudio Galli, Ronja Foraita, Claudia Börnhorst
BACKGROUND: The recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood pressure (BP) is associated with (long-chain) polyunsaturated fatty acids (LC PUFA), genetic variation in desaturase enzymes being involved in the synthesis of LC PUFA may be associated with BP. This study aimed to investigate the direct effects (independent of mediating variables) and indirect effects (mediated through intermediate variables) of a common variant in the FADS1 gene, rs174546, known to affect delta-5 desaturase (D5D) activity on PUFA level, body mass index (BMI) and BP...
2017: PloS One
https://www.readbyqxmd.com/read/28732038/analysis-of-patient-data-from-laboratories-during-the-ebola-virus-disease-outbreak-in-liberia-april-2014-to-march-2015
#19
Yuki Furuse, Mosoka Fallah, Hitoshi Oshitani, Ling Kituyi, Nuha Mahmoud, Emmanuel Musa, Alex Gasasira, Tolbert Nyenswah, Bernice Dahn, Luke Bawo
An outbreak of Ebola virus disease (EVD) in Liberia began in March 2014 and ended in January 2016. Epidemiological information on the EVD cases was collected and managed nationally; however, collection and management of the data were challenging at the time because surveillance and reporting systems malfunctioned during the outbreak. EVD diagnostic laboratories, however, were able to register basic demographic and clinical information of patients more systematically. Here we present data on 16,370 laboratory samples that were tested between April 4, 2014 and March 29, 2015...
July 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28731921/loss-of-cdkn1c-in-a-recurrent-atypical-teratoid-rhabdoid-tumor
#20
Dustin Tran, Sandra Camelo-Piragua, Avneesh Gupta, Kate Gowans, Patricia L Robertson, Rajen Mody, Carl Koschmann
Atypical teratoid/rhabdoid tumor (AT/RT) is a malignant tumor that is commonly associated with biallelic alterations of SMARCB1. Recurrent or refractory AT/RT has not been molecularly characterized as well. We present the case of a child with recurrent AT/RT who underwent clinically integrated molecular profiling (germline DNA and tumor DNA/RNA sequencing). This demonstrated a somatic lesion in CDKN1C alongside hallmark loss of SMARCB1. This data allowed us to explore potential personalized therapies for this patient and expose a molecular driver that may be involved in similar cases...
July 20, 2017: Journal of Pediatric Hematology/oncology
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