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https://www.readbyqxmd.com/read/29353231/the-preterm-heart-in-childhood-left-ventricular-structure-geometry-and-function-assessed-by-echocardiography-in-6-year-old-survivors-of-periviable-births
#1
Lilly-Ann Mohlkert, Jenny Hallberg, Olof Broberg, Annika Rydberg, Cecilia Pegelow Halvorsen, Petru Liuba, Vineta Fellman, Magnus Domellöf, Gunnar Sjöberg, Mikael Norman
BACKGROUND: Preterm birth has been associated with increased risk of cardiovascular morbidity in adult life. We evaluated whether preterm birth is associated with deviating cardiac structure and function before school start. METHODS AND RESULTS: In total, 176 children aged 6 years and born extremely preterm (EXPT; gestational age of 22-26 weeks) and 134 children born at term (control [CTRL]) were studied. We used echocardiography to assess left heart dimensions, geometry, and functions...
January 20, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29352434/author-correction-to-gene-patents-in-canada-is-there-a-new-legal-landscape
#2
Katherine J Bonter, Carmela De Luca, Christi J Guerrini
An error was subsequently identified in the article, and the following correction should be noted.
January 19, 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/29352349/factors-affecting-n-terminal-pro-b-type-natriuretic-peptide-levels-in-preterm-infants-and-use-in-determination-of-haemodynamic-significance-of-patent-ductus-arteriosus
#3
Sarah Louise Harris, Kiran More, Bronwyn Dixon, Richard Troughton, Chris Pemberton, John Horwood, Nicola Ellis, Nicola Austin
This study aimed to investigate factors affecting N-terminal pro-B-type natriuretic peptide (NTproBNP) in preterm infants and the ability of NTproBNP to predict haemodynamically significant patent ductus arteriosus (HsPDA). Prospective cohort study of 51 infants < 30 weeks gestation. Blood NTproBNP and heart ultrasound were performed on day of life 3, 10, 28 and 36 weeks corrected age. NTproBNP levels analysed for prediction of HsPDA. The effect of gestational age, ventilation, hypoxia, bronchopulmonary dysplasia (BPD), creatinine and haemoglobin levels on NTproBNP levels were investigated...
January 19, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29351934/continuous-subcutaneous-levetiracetam-in-end-of-life-care
#4
Inês Furtado, Fernando Gonçalves, João Gonçalves, João Neves
Seizures constitute a determining aspect in quality of life and are frequently challenging in palliative care-a field where treatment has yet to be standardised. Levetiracetam-a new generation anticonvulsant-has proved efficacy both through oral, as well as intravenous administration in the general population. This case reports on the use of continuous subcutaneous levetiracetam to effectively control seizures in a terminally ill patient without patent oral route.
January 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29350389/three-dimensional-visualization-of-coronary-sinus-ostium-from-the-inside-right-atrium-perspective
#5
Rafał Młynarski, Agnieszka Młynarska, Krzysztof S Gołba, Maciej Sosnowski
BACKGROUND: There is no in vivo method of coronary sinus visualization from the right atrium perspective. The objective of the study was to create a cardiac computed tomography angiography (CT) - based method of visualizing the coronary sinus ostium and the Thebesian valve from the inside right atrium perspective. METHODS: In 78 consecutive patients, a cardiac CT angiography (Aquilion 64, Toshiba) with retrospective gating (slice 0.5mm) was performed. Raw data were reconstructed on Vitrea 2 workstations (Vital Images)...
January 19, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29350388/chronic-statin-treatment-is-a-predictor-of-pre-interventional-infarct-related-artery-patency-in-patients-with-st-elevation-myocardial-infarction-treated-with-percutaneous-coronary-intervention
#6
Süleyman Özbiçer, Mustafa Gür, Gülhan Kalkan, Betül Özaltun, Murat Çaylı
BACKGROUND: Beyond lipid-lowering effects, early statin treatment has beneficial effects on prognosis after acute coronary syndrome. Infarct related artery patency before percutaneous coronary intervention is known to be a strong predictor of improved clinical outcome. AIM: We aimed to investigate the effects of chronic statin treatment before admission on the infarct related artery patency after infarction. METHODS: In this study, 938 ST elevation myocardial infarction patients admitted to the hospital within the first 12 hours of symptom onset were prospectively enrolled (682 male, 256 female; mean age 58...
January 19, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29350323/william-e-vidaver-1921-2017-an-innovator-enthusiastic-scientist-inspiring-teacher-and-a-wonderful-friend
#7
A H Jay Burr, Aaron Vidaver, Ulrich Schreiber, Doug Bruce, Danielle J Donnelly
William (Bill) E. Vidaver (February 2, 1921-August 31, 2017), who did his Ph.D. with Laurence (Larry) R. Blinks at Stanford (1964) and a postdoc with C. Stacy French (1965), taught and did research at Simon Fraser University (SFU) for almost 30 years. Here he published over 80 papers in photosynthesis-related areas co-authored by his graduate students, postdocs, visiting professors and SFU colleagues. He developed a unique high-pressure cuvette for the study of oxygen exchange and studied high-pressure effects in photosynthesis...
January 19, 2018: Photosynthesis Research
https://www.readbyqxmd.com/read/29350102/preoperative-clinical-and-sonographic-predictors-for-lateral-cervical-lymph-node-metastases-in-sporadic-medullary-thyroid-carcinoma
#8
Hye-Seon Oh, Hyemi Kwon, Eyun Song, MinJi Jeon, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee, Suck Joon Hong, Won Bae Kim, YoungKee Shong, Jung Hwan Baek, Won Gu Kim
<b><i>Background</i></b> Total thyroidectomy and cervical lymph node (LN) dissection is generally recommended in patients with medullary thyroid carcinoma (MTC). However, there is no clear evidence for whom to perform prophylactic lateral neck dissection in MTC patients without evident lateral cervical lymph node (LCLN) metastasis in preoperative images. This study evaluated the preoperative features for predicting the LCLN metastasis of MTC. <b><i>Methods</i></b> We included 26 MTC patients with LCLN metastasis at initial surgery (N1b group) and 47 MTC patients without any LN metastasis or recurrence of disease (N0-NED group)...
January 19, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29349838/patent-foramen-ovale-repair-at-the-time-of-double-lung-transplantation-necessary-or-not
#9
Nicholas R Hess, Stephen A Esper, Marie Tuft, Matthew Morrell, Jonathan D'Cunha
INTRODUCTION: Patient foramen ovale (PFO) is a common and often incidental intraoperative finding during lung transplantation (LTx). We sought to characterize the potential outcomes related to the decision-making of whether the PFO was repaired or left unrepaired. METHODS: We retrospectively evaluated bilateral LTx recipients between 2005 and 2015 from our prospective database. Incidence of postoperative stoke, 90-day mortality, and overall survival was compared between the PFO-positive and PFO-negative groups, and secondly compared between repaired PFO (rPFO) and non-repaired PFO (nrPFO) groups...
January 19, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29349409/salvage-of-bilateral-renal-artery-occlusion-after-endovascular-aneurysm-repair-with-open-splenorenal-bypass
#10
Samuel Jessula, Christine R Herman, Min Lee, Christopher B Lightfoot, Patrick Casey
We report renal salvage maneuvers after accidental bilateral renal artery coverage during endovascular aneurysm repair of an infrarenal abdominal aortic aneurysm. A 79-year-old man with an infrarenal abdominal aortic aneurysm was treated with endovascular aneurysm repair. Completion angiography demonstrated coverage of the renal arteries. Several revascularization techniques were attempted, including endograft repositioning and endovascular stenting through the femoral and brachial approach. The patient eventually underwent open splenorenal bypass with a Y Gore-Tex graft (W...
September 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29349403/a-novel-hybrid-left-renal-vein-transposition-and-endovascular-stenting-technique-for-the-treatment-of-posterior-nutcracker-syndrome
#11
Kristin Stawiarski, Matthew Wosnitzer, Young Erben
Posterior nutcracker syndrome occurs when a retroaortic left renal vein becomes compressed between the abdominal aorta and the lumbar spine. Although open surgical approaches remain the treatment of choice, endovascular stenting has been used successfully. We describe a case of a 28-year-old man who presented with microscopic hematuria, left-sided flank pain, and testicular swelling. Computed tomography findings were consistent with posterior nutcracker syndrome. He underwent a novel hybrid operation that included left renal vein transposition followed by endovascular stenting...
September 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29349390/durability-of-the-viabahn-stent-graft-after-axillary-artery-pseudoaneurysm-exclusion
#12
Aaron Y Chen, Isaac Laniado, Peter H Lin
Pseudoaneurysm formation caused by iatrogenic arterial injury during a regional anesthetic block is a rare complication. We report a case of a 56-year-old male patient who developed an axillary artery pseudoaneurysm caused by brachial plexus block performed for an upper extremity dialysis access operation. Successful repair of this pseudoaneurysm was achieved with endovascular stent graft exclusion. The repaired axillary artery with the stent graft remained patent after 10 years of follow-up. The successful long-term patency of this treatment and a strategy to potentially avoid this complication are discussed...
June 2017: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29348397/placement-of-an-aortohepatic-conduit-as-an-alternative-to-standard-arterial-anastomosis-in-liver-transplantation
#13
Dong-Hwan Jung, Cheon-Soo Park, Tae-Yong Ha, Gi-Won Song, Gil-Chun Park, Yong-Pil Cho, Sung-Gyu Lee
BACKGROUND The aim of this study was to assess the impact of placement of an aortohepatic conduit on graft and patient survival after liver transplantation (LT) in selected patients with an inadequate recipient hepatic artery (HA) for a standard arterial anastomosis. MATERIAL AND METHODS Of 331 patients who underwent deceased donor LT, 25 (7.6%) who received placement of an aortohepatic conduit at the time of transplantation were included. Clinical characteristics and outcomes, including postoperative complications, conduit patency, and graft and patient survival rates, were analyzed...
January 19, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29348196/placental-findings-and-effect-of-prophylactic-hydrocortisone-in-extremely-preterm-infants
#14
Alice Héneau, Fabien Guimiot, Damir Mohamed, Aline Rideau Batista Novais, Corinne Alberti, Olivier Baud
OBJECTIVES: To investigate the relationship between histologic findings of the placenta and response to early postnatal hydrocortisone treatment used to prevent bronchopulmonary dysplasia (BPD) in extremely preterm infants. METHODS: In an exploratory analysis of the Early Low-Dose Hydrocortisone to Improve Survival Without Bronchopulmonary Dysplasia in Extremely Preterm Infants (PREMILOC) trial, detailed placental analyses were performed on the basis of standardized macroscopic and histologic examinations...
January 18, 2018: Pediatrics
https://www.readbyqxmd.com/read/29348195/morbidity-and-mortality-in-small-for-gestational-age-infants-at-22-to-29-weeks-gestation
#15
Nansi S Boghossian, Marco Geraci, Erika M Edwards, Jeffrey D Horbar
OBJECTIVES: To identify the relative risks of mortality and morbidities for small for gestational age (SGA) infants in comparison with non-SGA infants born at 22 to 29 weeks' gestation. METHODS: Data were collected (2006-2014) on 156 587 infants from 852 US centers participating in the Vermont Oxford Network. We defined SGA as sex-specific birth weight <10th centile for gestational age (GA) in days. Binomial generalized additive models with a thin plate spline term on GA by SGA were used to calculate the adjusted relative risks and 95% confidence intervals for outcomes by GA...
January 18, 2018: Pediatrics
https://www.readbyqxmd.com/read/29348012/coronary-embolus-an-underappreciated-cause-of-acute-coronary-syndromes
#16
REVIEW
Claire E Raphael, John A Heit, Guy S Reeder, Melanie C Bois, Joseph J Maleszewski, R Thomas Tilbury, David R Holmes
Coronary embolism is the underlying cause of 3% of acute coronary syndromes but is often not considered in the differential of acute coronary syndromes. It should be suspected in the case of high thrombus burden despite a relatively normal underlying vessel or recurrent coronary thrombus. Coronary embolism may be direct (from the aortic valve or left atrial appendage), paroxysmal (from the venous circulation through a patent foramen ovale), or iatrogenic (following cardiac intervention). Investigations include transesophageal echocardiography to assess the left atrial appendage and atrial septum and continuous electrocardiographic monitoring to assess for paroxysmal atrial fibrillation...
January 22, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29347998/radiation-exposure-in-transcatheter-patent-ductus-arteriosus-closure-time-to-tune
#17
Olivier Villemain, Sophie Malekzadeh-Milani, Fidelio Sitefane, Meriem Mostefa-Kara, Younes Boudjemline
OBJECTIVES: The aims of this study were to describe radiation level at our institution during transcatheter patent ductus arteriosus occlusion and to evaluate the components contributing to radiation exposure. BACKGROUND: Transcatheter occlusion relying on X-ray imaging has become the treatment of choice for patients with patent ductus arteriosus. Interventionists now work hard to minimise radiation exposure in order to reduce risk of induced cancers. METHODS: We retrospectively reviewed all consecutive children who underwent transcatheter closure of patent ductus arteriosus from January 2012 to January 2016...
January 19, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29346141/caffeine-controversies
#18
Samuel J Gentle, Colm P Travers, Waldemar A Carlo
PURPOSE OF REVIEW: Caffeine use in preterm infants has endured several paradigms: from standard of care to possible neurotoxin to one of the few medications for which there is evidence of bronchopulmonary dysplasia (BPD) risk reduction. The purpose of the review is to analyze this dynamic trajectory and discuss controversies that still remain after decades of caffeine use. RECENT FINDINGS: Following concerns for caffeine safety in preterm infants, a large randomized controlled trial demonstrated a reduction in BPD and treatment for patent ductus arteriosus...
January 17, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29345599/crystalline-ethylene-oxide-and-propylene-oxide-triblock-copolymer-solid-dispersion-enhance-solubility-stability-and-promoting-time-controllable-release-of-curcumin
#19
Thais Francine Ribeiro Alves, Franciely Lopes, Marcia Rebelo, Juliana Souza, Katiusca Pontes, Carolina Santos, Patricia Severino, Jose Junior, Daniel Komatsu, Marco Vinicius Chaud
AIMS AND BACKGROUND: The design and development of an effective medicine are however often faced with a number of challenges. One of them is the close relationship of drug's bioavailability with solubility, dissolution rate and permeability. The use of curcumin's (CUR) therapeutic potential is limited by its poor water solubility and low chemical stability. The purpose was to evaluate the effect of polymer and solid dispersion (SD) preparation techniques to enhance the aqueous solubility, dissolution rate and stability of the CUR...
January 17, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29345510/preliminary-evaluation-of-the-viability-of-peritoneal-drainage-catheters-implanted-in-rats-for-extended-durations
#20
Nathan Legband, Arielle Black, Craig Kreikemeier-Bower, Benjamin S Terry
Purpose/Aim: In developing a novel peritoneal oxygenation therapy, catheters implanted into the peritoneal cavity became obstructed with omental tissue and prevented the infusion and removal of fluid from the peritoneal cavity. The obstruction of peritoneal catheters is a significant failure in researching various peritoneal treatments as further fluid administration is no longer possible. The purpose of this preliminary study was to determine the most effective catheter design for infusion and removal of fluid into the peritoneal cavity of rats...
January 18, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
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