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https://www.readbyqxmd.com/read/28213391/the-politics-and-policies-of-regulating-generics-in-latin-america-a-survey-of-seventeen-states
#1
Cassandra M Sweet
When patents expire, are equivalent generic alternatives available to citizens? This article contributes to current discussion on access to medicine in the aftermath of the World Trade Organization's Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS). The focus is on off-patent or "generic" medicines: their product definitions, quality standards and prescription procedures. Drawing from a survey conducted of seventeen countries across the Latin American region, this article examines the differences in definition of off-patent products and the paradox of their relatively lower consumption across multiple developing states...
February 17, 2017: Journal of Health Politics, Policy and Law
https://www.readbyqxmd.com/read/28212348/an-electromagnetic-sensor-for-the-autonomous-running-of-visually-impaired-and-blind-athletes-part-ii-the-wearable-device
#2
Marco Pieralisi, Valentina Di Mattia, Valerio Petrini, Alfredo De Leo, Giovanni Manfredi, Paola Russo, Lorenzo Scalise, Graziano Cerri
Currently, the availability of technology developed to increase the autonomy of visually impaired athletes during sports is limited. The research proposed in this paper (Part I and Part II) focuses on the realization of an electromagnetic system that can guide a blind runner along a race track without the need for a sighted guide. In general, the system is composed of a transmitting unit (widely described in Part I) and a receiving unit, whose components and main features are described in this paper. Special attention is paid to the definition of an electromagnetic model able to faithfully represent the physical mechanisms of interaction between the two units, as well as between the receiving magnetic sensor and the body of the user wearing the device...
February 16, 2017: Sensors
https://www.readbyqxmd.com/read/28212133/potential-uselessness-and-futility-of-left-atrial-appendage-occlusion-and-patent-foramen-ovale-closure-in-cardioembolic-stroke
#3
Gian L Nicolosi
International guidelines indicate that interventional closure of left atrial appendage and patent foramen ovale may be considered in selected patients for stroke prevention. These procedures appear, however, from the published literature, at high risk of uselessness and futility in the single case, if not even capable to induce harm and adverse events. In fact, all reported systematic reviews and meta-analyses have not shown in a convincing manner the superiority of these procedures in stroke prevention, taking into account the occurrence of possible complications also, as compared with alternative medical treatment...
February 16, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28211784/generic-antiretrovirals-for-the-treatment-of-hiv-a-novel-challenge-for-western-countries-%C3%A2
#4
Dario Cattaneo, Massimo Andreoni, Gianpiero Carosi, Roberto Cauda, Adriano Lazzarin, Giuliano Rizzardini
The introduction of generic antiretroviral medications in developing countries has resulted in significant CD4 cell restoration, HIV viral decline, and a noteworthy reduction in the time to initiation of therapy. Projection models have also predicted significant cost saving associated with the extensive diffusion of generic antiretrovirals in developed countries. However, some uncertainties on generics have recently been raised. These concerns mainly relate to the adequacy of the study design for bioequivalence testing, the potential for uncontrolled switching from one generic to another, and the loss of adherence if patients switched from fixed-dose coformulations to single components in order to incorporate the new generic drugs...
February 17, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28211168/the-medtronic-micro-vascular-plug%C3%A2-for-vascular-embolization-in-children-with-congenital-heart-diseases
#5
Shyam Sathanandam, Henri Justino, B Rush Waller, Srinath T Gowda, Wolfgang Radtke, Athar M Qureshi
OBJECTIVES: To describe the early multi-center, clinical experience with the Medtronic Micro Vascular Plug™ (MVP) in children with congenital heart disease (CHD) undergoing vascular embolization. BACKGROUND: The MVP is a large diameter vascular occlusion device that can be delivered through a microcatheter for embolization of abnormal blood vessels. METHODS: A retrospective review of embolization procedures using the MVP in children with CHD was performed in 3-centers...
February 16, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28210517/facetgist-collective-extraction-of-document-facets-in-large-technical-corpora
#6
Tarique Siddiqui, Xiang Ren, Aditya Parameswaran, Jiawei Han
Given the large volume of technical documents available, it is crucial to automatically organize and categorize these documents to be able to understand and extract value from them. Towards this end, we introduce a new research problem called Facet Extraction. Given a collection of technical documents, the goal of Facet Extraction is to automatically label each document with a set of concepts for the key facets (e.g., application, technique, evaluation metrics, and dataset) that people may be interested in...
October 2016: Proceedings of the ... ACM International Conference on Information & Knowledge Management
https://www.readbyqxmd.com/read/28208970/isolated-hypoplasia-of-left-pulmonary-artery-with-agenesis-of-left-lobe-of-thyroid-a-case-report
#7
Mohammed Abdul Khadir, Ganesh Narayana, Ganavi Ramagopal, Pradeep G Nayar
Isolated Unilateral hypoplasia or agenesis of a branch of pulmonary artery is very rare. It is usually seen associated with congenital heart diseases such as tetralogy of Fallot, atrial septal defect, coarctation of the aorta, right aortic arch, truncus arteriosus, patent ductus arteriosus and pulmonary atresia. It occurs as a result of lack of embryological development of either the left or right sixth aortic arch and has been found to present itself with various clinical manifestations as during childhood it presents as contralateral pulmonary hypertension and in adults as haemoptysis...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208574/complexation-of-phytochemicals-with-cyclodextrin-derivatives-an-insight
#8
REVIEW
Vasanti Suvarna, Parul Gujar, Manikanta Murahari
Natural compounds have been attracting huge attention because of their broad therapeutic properties with specificity in their action in human health care as functional foods, pharmaceuticals and nutraceuticals. However poor bioavailability and reduced bioactivity attributed to poor solubility and instability is the major drawback hindering the incorporation of these therapeutically potential molecules in novel drug delivery systems. Based on the findings of reported research investigations; complexation of poorly water soluble phytochemicals with cyclodextrins has emerged to be a promising approach to improve their aqueous solubility, stability, rate of dissolution and bioavailability...
February 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28207765/a-rapid-efficient-and-economic-device-and-method-for-the-isolation-and-purification-of-mouse-islet-cells
#9
Yin Zongyi, Zou Funian, Li Hao, Cheng Ying, Zhang Jialin, Li Baifeng
Rapid, efficient, and economic method for the isolation and purification of islets has been pursued by numerous islet-related researchers. In this study, we compared the advantages and disadvantages of our developed patented method with those of commonly used conventional methods (Ficoll-400, 1077, and handpicking methods). Cell viability was assayed using Trypan blue, cell purity and yield were assayed using diphenylthiocarbazone, and islet function was assayed using acridine orange/ethidium bromide staining and enzyme-linked immunosorbent assay-glucose stimulation testing 4 days after cultivation...
2017: PloS One
https://www.readbyqxmd.com/read/28207197/changing-the-surgical-dogma-in-frontal-sinus-trauma-transnasal-endoscopic-repair
#10
Jessica W Grayson, Hari Jeyarajan, Elisa A Illing, Do-Yeon Cho, Kristen O Riley, Bradford A Woodworth
BACKGROUND: Management of frontal sinus trauma includes coronal or direct open approaches through skin incisions to either ablate or obliterate the frontal sinus for posterior table fractures and openly reduce/internally fixate fractured anterior tables. The objective of this prospective case-series study was to evaluate outcomes of frontal sinus anterior and posterior table trauma using endoscopic techniques. METHODS: Prospective evaluation of patients undergoing surgery for frontal sinus fractures was performed...
February 16, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28206995/patent-ductus-arteriosus-in-premature-infants-to-treat-or-not-to-treat
#11
M A Mohamed, M El-Dib, S Alqahtani, K Alyami, A N Ibrahim, H Aly
OBJECTIVE: Closing patent ductus arteriosus (PDA) is a widely accepted approach in the management of very low birth weight (VLBW) infants. Our objective is to test the hypothesis that conservative management (no treatment) of PDA will not affect survival without chronic lung diseases (CLD). STUDY DESIGN: This retrospective study utilizes a prospectively collected database to compare two cohorts of VLBW infants. Infants in the first group (2001 to 2009) had their PDA treated with pharmacological and if necessary with surgical ligation...
February 16, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28203337/comparison-of-the-efficacy-of-three-natural-surfactants-curosurf-survanta-and-alveofact-in-the-treatment-of-respiratory-distress-syndrome-among-neonates-a-randomized-controlled-trial
#12
Mirhadi Mussavi, Keyvan Mirnia, Khairollah Asadollahi
BACKGROUND: Although several different types of natural surfactants are available, including Alveofact, Curosurf, and Survanta, the preferred type and the magnitude of their effects are unknown. OBJECTIVES: This study was designed to compare the effects of these three surfactants on the gas exchange and clinical outcomes of neonates with respiratory distress syndrome (RDS). METHODS: This triple-blind randomized clinical trial studied all preterm neonates ≤ 37 weeks with RDS who were admitted to the neonatal intensive care unit (NICU) of Taleghani hospital (Tabriz, Iran) between 2012 and 2013...
October 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/28202256/transseptal-puncture-review-of-anatomy-techniques-complications-and-challenges
#13
REVIEW
Barry O'Brien, Haroon Zafar, Simon De Freitas, Faisal Sharif
In recent years, the transseptal puncture approach has enabled passage of increasingly large and complex devices into the left atrium. Traditional tools remain effective in creating and dilating the initial puncture, with an acceptable safety profile. Even for skilled operators, the procedure is technically demanding and requires sound understanding of atrial anatomy. Intracardiac echocardiography is useful in cases of previous septal repair, poorly defined fossa ovalis anatomy or when considering patent foramen ovale portal crossing...
February 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28201974/mur-ligase-inhibitors-as-anti-bacterials-a-comprehensive-review
#14
Jaiprakash N Sangshetti, Suyog S Joshi, Rajendra H Patil, Devanand B Shinde
Exploring a new target for antibacterial drug discovery has gained much attention because of the emergence of Multidrug Resistance (MDR) strains of bacteria. To overcome this problem the development of novel antibacterial was considered as highest priority task and was one of the biggest challenges since multiple factors were involved. The bacterial peptidoglycan biosynthetic pathway has been well documented in the last few years and has been found to be an imperative source for the development of novel antibacterial agents with high target specificity as they are essential for bacterial survival and have no homologs in humans...
February 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28201961/development-and-characterization-pulsatile-microspheres-of-nifedipine-for-hypertension
#15
Rahul Taneja, Ghanshyam Das Gupta
AIM AND BACKGROUND: To develop pulsatile microspheres of Nifedipine blend of polymers Carbopol 971P and Eudragit RS100 for antihypertensive to release the drug at a particular lag time. METHODS: Pulsatile nifedipine microspheres were prepared using blend of Carbopol 971P and Eudragit RS100 at different ratio in a mixture of solvents. Formulations were prepared and optimized on the basis of particle size, percentage yield and drug entrapment efficiency. Optimized formulations were further analyzed at different resolutions per minute (rpm) by optical microscopy, scanning electron microscopy (SEM), in-vitro dissolution studies and kinetics model...
February 12, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28201948/enbrel-and-etanercept-biosimilars-a-tale-of-two-patent-systems
#16
Peter Norman
No abstract text is available yet for this article.
February 16, 2017: Pharmaceutical Patent Analyst
https://www.readbyqxmd.com/read/28199409/effect-of-chinese-patent-medicine-si-mo-tang-oral-liquid-for-functional-dyspepsia-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#17
Yunxia Hu, Yu Bai, Zhiyun Hua, Jie Yang, Huahui Yang, Wenjun Chen, Junwei Xu, Zhiqiang Zhao
BACKGROUND: Si-Mo-Tang oral liquid (SMT) has been widely used to treat functional dyspepsia (FD), but the effectiveness is still controversial. A systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to assess the efficacy and adverse effects of SMT for FD. METHODS: Investigators searched for articles with publication dates to June 21, 2016, from 9 English and Chinese electronic databases. Comparisons were SMT alone or SMT in combination with western medicine as experimental intervention, and western medicine or placebo as the control...
2017: PloS One
https://www.readbyqxmd.com/read/28198573/radiation-dose-benchmarks-in-pediatric-cardiac-catheterization-a-prospective-multi-center-c3po-qi-study
#18
Priscila C Cevallos, Aimee K Armstrong, Andrew C Glatz, Bryan H Goldstein, Todd M Gudausky, Ryan A Leahy, Christopher J Petit, Shabana Shahanavaz, Sara M Trucco, Lisa J Bergersen
OBJECTIVES: This study sought to update benchmark values to use a quality measure prospectively. BACKGROUND: Congenital Cardiac Catheterization Outcomes Project - Quality Improvement (C3PO-QI), a multi-center registry, defined initial radiation dose benchmarks retrospectively across common interventional procedures. These data facilitated a dose metric endorsed by the American College of Cardiology in 2014. METHODS: Data was collected prospectively by 9 C3PO-QI institutions with complete case capture between 1/1/2014 and 6/30/2015...
February 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28198178/side-to-side-duodeno-colic-anastomosis-provides-dramatic-weight-loss-a-potentially-strong-anti-diabetic-operation-for-type-2-diabetes
#19
Michel Gagner
BACKGROUND: Incomplete bypass of the intestines provide weight loss by hypoabsorption of nutrients and hormonal changes. The aim was to evaluate the efficacy and safety of a side- to-side duodeno-colic anastomosis (DCA) in the short term. METHODS: Seven <50 Kg swine's were allocated to a DCA, and compared to a sham group. Weights were recorded for 8 weeks and duodenoscopies performed at 8 and 28 days. Complete blood count and basic biochemistry profiles were taken at baseline, day #3 and #56...
February 14, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/28197278/patent-ductus-arteriosus-with-eisenmenger-syndrome-difficult-diagnosis-made-easily-with-saline-contrast-echocardiography
#20
Prakash Kumar, Santosh Kumar Sinha, Umeshwar Pandey, Ramesh Thakur, Chandra Mohan Varma, Mohit Sachan, Amit Goel
The diagnosis of patent ductus arteriosus (PDA) with Eisenmenger syndrome is difficult. We report a case of 35-year-old male who came to our outpatient department (OPD) for evaluation of repeated hemoptysis and dyspnea on exertion. He had already completed two courses of ATT. On examination, grade 3 ejection systolic murmur was audible over precordium. Transthoracic echocardiography (TTE) showed enlargement of right atrium (RA) and right ventricular (RV) with severe tricuspid regurgitation (TR). On agitated saline contrast injection, agitated saline was seen in pulmonary artery followed by filling of abdominal aorta without filling of ascending aorta, thus confirming the diagnosis of right to left shunt with PDA...
June 2016: Cardiology Research
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