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https://www.readbyqxmd.com/read/29156688/frequency-of-expression-and-generation-of-t-cell-responses-against-antigens-on-multiple-myeloma-cells-in-patients-included-in-the-gmmg-mm5-trial
#1
Michael Schmitt, Angela G Hückelhoven, Michael Hundemer, Anita Schmitt, Susanne Lipp, Martina Emde, Hans Salwender, Mathias Hänel, Katja Weisel, Uta Bertsch, Jan Dürig, Anthony D Ho, Igor Wolfgang Blau, Hartmut Goldschmidt, Anja Seckinger, Dirk Hose
Background: Raising T-cell response against antigens either expressed on normal and malignant plasma cells (e.g. HM1.24) or aberrantly on myeloma cells only (e.g. cancer testis antigens, CTA) by vaccination is a potential treatment approach for multiple myeloma. Results: Expression by GEP is found for HM1.24 in all, HMMR in 318/458 (69.4%), MAGE-A3 in 209/458 (45.6%), NY-ESO-1/2 in 40/458 (8.7%), and WT-1 in 4/458 (0.8%) of samples with the pattern being confirmed by RNA-sequencing...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156491/long-term-calcineurin-inhibitor-therapy-and-brain-function-in-patients-after-liver-transplantation
#2
Henning Pflugrad, Anna-Kristina Schrader, Anita Blanka Tryc, Xiaoqi Ding, Heinrich Lanfermann, Elmar Jäckel, Harald Schrem, Jan Beneke, Hannelore Barg-Hock, Jürgen Klempnauer, Karin Weissenborn
BACKGROUND AND AIMS: Calcineurin inhibitors (CNI) frequently induce neurological complications early after orthotopic liver transplantation (OLT). We hypothesize that long-term CNI therapy after OLT causes dose-dependent cognitive dysfunction and alteration of brain structure. METHODS: Eighty-five OLT patients (20 with CNI free, 35 with CNI low dose and 30 with standard dose CNI immunosuppression) underwent psychometric testing and cerebral magnetic resonance tomography about 10 years after OLT to assess brain function and structural brain alterations...
November 20, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29156348/development-of-photoprotective-antiphototoxic-and-antiphotogenotoxic-formulations-of-ocular-drugs-with-fluoroquinolones
#3
Anna Zgadzaj, Joanna Kornacka, Anita Jastrzębska, Andrzej Parzonko, Sylwester Sommer, Grzegorz Nałęcz-Jawecki
The development of innovative solutions in photosafety of photolabile pharmaceutical products may help to reduce the adverse effects of these products, caused by light exposure. Providing new data in this area of study is particularly important in case of drugs applied topically on sensitive organs such as eyes. The main goal of this research is to investigate whether two potential excipients, namely: p-coumaric acid and benzophenone-4, affect the photodegradation, phototoxicity and photogenotoxicity of water solutions of four fluoroquinolones: ciprofloxacin, lomefloxacin, fleroxacin and clinafloxacin...
November 9, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29156113/using-leadership-competencies-as-a-framework-for-career-readiness
#4
Anita R Howard, Suzanne L Healy, Richard E Boyatzis
This chapter provides an overview of how a leadership competency approach grounded in emotional and social intelligence can help educators promote career readiness for students. Strategies and approaches for building leadership competencies will be reviewed.
December 2017: New Directions for Student Leadership
https://www.readbyqxmd.com/read/29155080/a-comprehensive-analysis-of-resting-state-fmri-measures-to-classify-individual-patients-with-alzheimer-s-disease
#5
Frank de Vos, Marisa Koini, Tijn M Schouten, Stephan Seiler, Jeroen van der Grond, Anita Lechner, Reinhold Schmidt, Mark de Rooij, Serge A R B Rombouts
Alzheimer's disease (AD) patients show altered patterns of functional connectivity (FC) on resting state functional magnetic resonance imaging (RSfMRI) scans. It is yet unclear which RSfMRI measures are most informative for the individual classification of AD patients. We investigated this using RSfMRI scans from 77 AD patients (MMSE = 20.4 ± 4.5) and 173 controls (MMSE = 27.5 ± 1.8). We calculated i) FC matrices between resting state components as obtained with independent component analysis (ICA), ii) the dynamics of these FC matrices using a sliding window approach, iii) the graph properties (e...
November 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/29154884/double-up-examining-the-effects-of-adding-inhibition-training-to-food-cue-exposure-in-chocolate-loving-female-students
#6
Peggy Bongers, Katrijn Houben, Anita Jansen
In the present we study investigated whether addition of a Go/No Go training enhanced the effects of food cue exposure. We assessed desire to eat, salivation, CS-US expectancies, and eating in the absence of hunger (EAH) during and after cue exposure. Participants (N = 71) were chocolate-loving female students who tried to eat less chocolate in daily life. They received two sessions of either cue exposure with Go/No Go training (EXP + GNG), cue exposure with a sham training (EXP + shamGNG), or a control procedure with sham training (CON + shamGNG)...
November 14, 2017: Appetite
https://www.readbyqxmd.com/read/29154536/caged-naloxone-synthesis-characterization-and-stability-of-3-o-4-5-dimethoxy-2-nitrophenyl-carboxymethyl-naloxone-cnv-nlx
#7
Anita H Lewin, Scott E Fix, Desong Zhong, Louise D Mayer, Jason P Burgess, Samuel Wayne Mascarella, P Anantha Reddy, Herbert H Seltzman, F Ivy Carroll
The photo-labile analog of the broad-spectrum opioid antagonist naloxone, 3-O-(4,5-dimethoxy-2-nitrophenyl)carboxymethyl naloxone (also referred to as "caged naloxone", 3-O-(α-carboxy-6-nitroveratryl)naloxone, CNV-NLX), has been found to be a valuable biochemical probe. While the synthesis of CNV-NLX is simple, its characterization is complicated by the fact that it is produced as a mixture of αR,5R 9R,13S,14S and αS,5R,9R,13S,14S diastereomers. Using long range and heteronuclear NMR correlations, the 1H and 13CNMR resonances of both diastereomers have been fully assigned, confirming the structures...
November 20, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29154156/delta-beta-correlation-as-a-candidate-endophenotype-of-social-anxiety-a-two-generation-family-study
#8
Anita Harrewijn, Melle J W van der Molen, Irene M van Vliet, Jeanine J Houwing-Duistermaat, P Michiel Westenberg
BACKGROUND: Social anxiety disorder (SAD) is characterized by an extreme and intense fear and avoidance of social situations. In this two-generation family study we examined delta-beta correlation during a social performance task as candidate endophenotype of SAD. METHODS: Nine families with a target participant (diagnosed with SAD), their spouse and children, as well as target's siblings with spouse and children performed a social performance task in which they gave a speech in front of a camera...
November 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29153505/structural-basis-for-the-inhibitory-effects-of-ubistatins-in-the-ubiquitin-proteasome-pathway
#9
Mark A Nakasone, Timothy A Lewis, Olivier Walker, Anita Thakur, Wissam Mansour, Carlos A Castañeda, Jennifer L Goeckeler-Fried, Frank Parlati, Tsui-Fen Chou, Ortal Hayat, Daoning Zhang, Christina M Camara, Steven M Bonn, Urszula K Nowicka, Susan Krueger, Michael H Glickman, Jeffrey L Brodsky, Raymond J Deshaies, David Fushman
The discovery of ubistatins, small molecules that impair proteasomal degradation of proteins by directly binding to polyubiquitin, makes ubiquitin itself a potential therapeutic target. Although ubistatins have the potential for drug development and clinical applications, the lack of structural details of ubiquitin-ubistatin interactions has impeded their development. Here, we characterized a panel of new ubistatin derivatives using functional and binding assays. The structures of ubiquitin complexes with ubistatin B and hemi-ubistatin revealed direct interactions with ubiquitin's hydrophobic surface patch and the basic/polar residues surrounding it...
November 15, 2017: Structure
https://www.readbyqxmd.com/read/29153366/papillary-glioneuronal-tumors-a-radiopathologic-correlation
#10
Nishtha Yadav, Shilpa Rao, Jitender Saini, Chandrajit Prasad, Anita Mahadevan, Nishanth Sadashiva
OBJECTIVE: Papillary glioneuronal tumors (PGNT) are a rare and recently recognized tumor entity. The neuroimaging findings were reviewed to determine if any specific findings emerge to assist a preoperative diagnosis of PGNT. MATERIALS AND METHODS: Seven histologically confirmed cases of PGNT were evaluated from 2004 to 2014. Clinical, neuroimaging and histological findings were reviewed and tabulated. RESULTS: Headache and seizures were observed in 4 patients (57...
December 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29152120/hierarchical-clustering-analysis-identifies-metastatic-colorectal-cancers-patients-with-more-aggressive-phenotype
#11
Giuseppina Opinto, Nicola Silvestris, Matteo Centonze, Giusi Graziano, Rosamaria Pinto, Livia Fucci, Giovanni Simone, Anita Mangia
A large percentage of metastatic colorectal cancer (mCRC) patients presents metastasis at the time of diagnosis. In the last years, great efforts have been made in the treatment of these patients with the identification of different phenotypes playing a key role in the definition of new systemic therapies. Unsupervised hierarchical clustering analysis (HCA) was performed considering the clinicopathological characteristics of 51 mCRCs. Using immunohistochemistry on tissue microarrays, we assessed the expression of β-catenin, NHERF1, RASSF1A, TWIST1, HIF-1α proteins in tumors and paired liver metastases...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151030/occurrence-and-features-of-childhood-myocarditis-a-nationwide-study-in-finland
#12
Anita Arola, Essi Pikkarainen, Jussi Ot Sipilä, Jouni Pykäri, Päivi Rautava, Ville Kytö
BACKGROUND: Epidemiology of myocarditis in childhood is largely unknown. Men are known to have a higher incidence of myocarditis than women in adults aged <50 years, but whether this is true by sex in pediatric age groups is unknown. We set out to study the occurrence and potential sex differences of myocarditis in a general pediatric population. METHODS AND RESULTS: Data of all hospital admissions with myocarditis in Finland occurring in patients aged ≤15 years from 2004 to 2014 were collected from a mandatory nationwide registry...
November 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29150468/prevalence-and-recognition-of-obesity-and-its-associated-comorbidities-cross-sectional-analysis-of-electronic-health-record-data-from-a-large-us-integrated-health-system
#13
Kevin M Pantalone, Todd M Hobbs, Kevin M Chagin, Sheldon X Kong, Brian J Wells, Michael W Kattan, Jonathan Bouchard, Brian Sakurada, Alex Milinovich, Wayne Weng, Janine Bauman, Anita D Misra-Hebert, Robert S Zimmerman, Bartolome Burguera
OBJECTIVE: To determine the prevalence of obesity and its related comorbidities among patients being actively managed at a US academic medical centre, and to examine the frequency of a formal diagnosis of obesity, via International Classification of Diseases, Ninth Revision (ICD-9) documentation among patients with body mass index (BMI) ≥30 kg/m(2). DESIGN: The electronic health record system at Cleveland Clinic was used to create a cross-sectional summary of actively managed patients meeting minimum primary care physician visit frequency requirements...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29149873/health-care-workers-knowledge-attitudes-and-practices-on-tuberculosis-infection-control-nepal
#14
Anita Shrestha, Dipesh Bhattarai, Barsha Thapa, Prem Basel, Rajendra Raj Wagle
BACKGROUND: Infection control remains a key challenge for Tuberculosis (TB) control program with an increased risk of TB transmission among health care workers (HCWs), especially in settings with inadequate TB infection control measures. Poor knowledge among HCWs and inadequate infection control practices may lead to the increased risk of nosocomial TB transmission. METHODS: An institution-based cross-sectional survey was conducted in 28 health facilities providing TB services in the Kathmandu Valley, Nepal...
November 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29149464/novel-intra-operative-management-in-the-meld-na-era-continuous-veno-venous-hemofiltration-for-severe-hyponatremia-in-liver-transplantation
#15
Shunji Nagai, Dilip Moonka, Anita Patel
No abstract text is available yet for this article.
November 17, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29149432/ebola-in-the-netherlands-2014-2015-costs-of-preparedness-and-response
#16
Anita W M Suijkerbuijk, Corien M Swaan, Marie-Josee J Mangen, Johan J Polder, Aura Timen, Wilhelmina L M Ruijs
The recent epidemic of Ebola virus disease (EVD) resulted in countries worldwide to prepare for the possibility of having an EVD patient. In this study, we estimate the costs of Ebola preparedness and response borne by the Dutch health system. An activity-based costing method was used, in which the cost of staff time spent in preparedness and response activities was calculated based on a time-recording system and interviews with key professionals at the healthcare organizations involved. In addition, the organizations provided cost information on patient days of hospitalization, laboratory tests, personal protective equipment (PPE), as well as the additional cleaning and disinfection required...
November 17, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/29149179/postmenopausal-hormone-therapy-and-risk-of-stroke-a-pooled-analysis-of-data-from-population-based-cohort-studies
#17
Germán D Carrasquilla, Paolo Frumento, Anita Berglund, Christer Borgfeldt, Matteo Bottai, Chiara Chiavenna, Mats Eliasson, Gunnar Engström, Göran Hallmans, Jan-Håkan Jansson, Patrik K Magnusson, Peter M Nilsson, Nancy L Pedersen, Alicja Wolk, Karin Leander
BACKGROUND: Recent research indicates a favourable influence of postmenopausal hormone therapy (HT) if initiated early, but not late, on subclinical atherosclerosis. However, the clinical relevance of timing of HT initiation for hard end points such as stroke remains to be determined. Further, no previous research has considered the timing of initiation of HT in relation to haemorrhagic stroke risk. The importance of the route of administration, type, active ingredient, and duration of HT for stroke risk is also unclear...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29148879/a-multicenter-investigation-of-factors-influencing-women-s-participation-in-clinical-trials
#18
Samantha Myles, Cheryl Tocci, Michele Falk, Stephanie Lynch, Caroline Torres, Barbara Brown, Brandy Leopanto Firman, Marian Lake, Cynthia A Maser, Ameneh Onativia, Erin M Obermeier, Jennifer Macfarlan, Ronald Wapner, John C Smulian, Anita Kurt
OBJECTIVE: To identify factors that influence women's participation in clinical research. METHODS: We administered a survey in outpatient and inpatient populations of Obstetrics and Gynecology facilities of six institutions located in four states. The survey included questions regarding any of the participant's past experiences in clinical research and the factors that would influence their participation in clinical research. Analyses included descriptive statistics and a Principal Component Analysis...
November 17, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29148835/2017-white-paper-on-recent-issues-in-bioanalysis-aren-t-bmv-guidance-guidelines-scientific-part-1-lcms-small-molecules-peptides-and-small-molecule-biomarkers
#19
Jan Welink, Eric Yang, Nicola Hughes, Brian Rago, Eric Woolf, Jens Sydor, Laura Coppola, Brad Ackermann, Wenkui Li, Stephen C Alley, Mark Arnold, Isabella Berger, Chad Briscoe, Michael Buonarati, Mark Bustard, Mark Cancilla, Seongeun Julia Cho, Jeff Duggan, Daniela Fraier, Fabio Garofolo, Rachel Green, Sam Haidar, Lucinda Hittle, Akiko Ishii-Watabe, Rafiq Islam, Rand Jenkins, Barry Jones, John Kadavil, Sean Kassim, Olga Kavetska, Olivier Le Blaye, Anita Lee, Hanlan Liu, John Mehl, Gustavo Mendes Lima Santos, Adrien Musuku, Ragu Ramanathan, Yoshiro Saito, Natasha Savoie, Scott Summerfield, Sekhar Surapaneni, Matthew Szapacs, Nilufer Tampal, Tom Verhaeghe, Stephen Vinter, Emma Whale
The 2017 11th Workshop on Recent Issues in Bioanalysis (11th WRIB) took place in Los Angeles/Universal City, California from 3 April 2017 to 7 April 2017 with participation of close to 750 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations and regulatory agencies worldwide. WRIB was once again a 5-day, weeklong event - A Full Immersion Week of Bioanalysis, Biomarkers and Immunogenicity. As usual, it was specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small and large molecule analysis involving LCMS, hybrid LBA/LCMS and ligand-binding assay (LBA) approaches...
November 17, 2017: Bioanalysis
https://www.readbyqxmd.com/read/29148602/nurses-professional-stigma-and-attitudes-towards-postpartum-women-with-severe-mental-illness
#20
Revital Ordan, Ron Shor, Michal Liebergall-Wischnitzer, Lawrence M Noble, Anita Noble
AIMS AND OBJECTIVES: To examine professional stigma and attitudes of parenthood towards postpartum women with severe mental illness and the association between postpartum nurses' attitudes and nursing interventions that promote motherhood. BACKGROUND: Stigma and attitudes toward parenthood of women with severe mental illness may influence nurses' clinical practices. DESIGN: Cross sectional, mixed methods. METHODS: The Stigma among Health Professionals towards People with Severe Mental Illness, Attitudes towards Parenthood among People with Severe Mental Illness and Nursing Interventions that Promote Becoming a Mother Questionnaires were used in the study, as well as qualitative analysis...
November 17, 2017: Journal of Clinical Nursing
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