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https://www.readbyqxmd.com/read/28239345/improvements-in-orientation-and-balancing-abilities-in-response-to-one-month-of-intensive-slackline-training-a-randomized-controlled-feasibility-study
#1
Milos Dordevic, Anita Hökelmann, Patrick Müller, Kathrin Rehfeld, Notger G Müller
Background: Slackline-training has been shown to improve mainly task-specific balancing skills. Non-task specific effects were assessed for tandem stance and preferred one-leg stance on stable and perturbed force platforms with open eyes. It is unclear whether transfer effects exist for other balancing conditions and which component of the balancing ability is affected. Also, it is not known whether slackline-training can improve non-visual-dependent spatial orientation abilities, a function mainly supported by the hippocampus...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28239008/health-ministry-and-activities-in-african-american-faith-based-organizations-a-qualitative-examination-of-facilitators-barriers-and-use-of-technology
#2
Cheryl L Holt, Anita L Graham-Phillips, C Daniel Mullins, Jimmie L Slade, Alma Savoy, Roxanne Carter
African American faith-based organizations (FBOs) play an important role in addressing health disparities. Increasingly, churches offer health fairs, screenings, or education through health ministries. However, little is known about linking these organizations with evidence-based interventions (EBIs) developed by research. This study explored 1) factors that facilitate or impede health ministry activities, including the adoption of EBIs, and 2) opportunities to use technology to support/enhance the capacity of FBOs to sustain health-related activities...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28238995/assessment-of-barriers-to-essential-surgical-care-in-two-communities-in-the-upper-west-region-ghana
#3
Adam Gyedu, Godfred Boakye, Charles K Dally, Anita Eseenam Agbeko, Francis A Abantanga, Adam L Kushner, Barclay T Stewart
Systematic assessments of individual-and community-level barriers to surgical care (BSC) in low-and middle-income countries that might inform potential interventions are lacking. We used a novel tool to assess BSC systematically during a surgical outreach in two communities in Upper West region, Ghana. Results were scored in three dimensions of barriers to care (acceptability, affordability, and accessibility); higher dimension scores signified less salient barriers. A total index out of 10 was derived. In total, 169 individuals participated in Nadowli (68, 40%) and in Nandom (101, 60%)...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28238601/safety-immunogenicity-and-preliminary-clinical-efficacy-of-a-vaccine-against-extraintestinal-pathogenic-escherichia-coli-in-women-with-a-history-of-recurrent-urinary-tract-infection-a-randomised-single-blind-placebo-controlled-phase-1b-trial
#4
Angela Huttner, Christoph Hatz, Germie van den Dobbelsteen, Darren Abbanat, Alena Hornacek, Rahel Frölich, Anita M Dreyer, Patricia Martin, Todd Davies, Kellen Fae, Ingrid van den Nieuwenhof, Stefan Thoelen, Serge de Vallière, Anette Kuhn, Enos Bernasconi, Volker Viereck, Tilemachos Kavvadias, Kerstin Kling, Gloria Ryu, Tanja Hülder, Sabine Gröger, David Scheiner, Cristina Alaimo, Stephan Harbarth, Jan Poolman, Veronica Gambillara Fonck
BACKGROUND: Escherichia coli infections are increasing worldwide in community and hospital settings. The E coli O-antigen is a promising vaccine target. We aimed to assess the safety and immunogenicity of a bioconjugate vaccine containing the O-antigens of four E coli serotypes (ExPEC4V). METHODS: In this multicentre phase 1b, first-in-human, single-blind, placebo-controlled trial, we randomly assigned (1:1) healthy adult women with a history of recurrent urinary tract infection (UTI) to receive a single injection of either intramuscular ExPEC4V or placebo...
February 23, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28238512/design-and-synthesis-of-novel-potent-and-selective-hypoxanthine-analogs-as-adenosine-a1-receptor-antagonists-and-their-biological-evaluation
#5
Summon Koul, Vidya Ramdas, Dinesh A Barawkar, Yogesh B Waman, Neela Prasad, Santosh Kumar Madadi, Yogesh D Shejul, Rajesh Bonagiri, Sujay Basu, Suraj Menon, Srinivasa B Reddy, Sandhya Chaturvedi, Srinivas Rao Chennamaneni, Gaurav Bedse, Rhishikesh Thakare, Jayasagar Gundu, Sumit Chaudhary, Siddhartha De, Ashwinkumar V Meru, Venkata Palle, Anita Chugh, Kasim A Mookhtiar
Multipronged approach was used to synthesize a library of diverse C-8 cyclopentyl hypoxanthine analogs from a common intermediate III. Several potent and selective compounds were identified and evaluated for pharmacokinetic (PK) properties in Wistar rats. One of the compounds 14 with acceptable PK parameters was selected for testing in in vivo primary acute diuresis model. The compound demonstrated significant diuretic activity in this model.
February 16, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28238340/payers-experiences-with-confidential-pharmaceutical-price-discounts-a-survey-of-public-and-statutory-health-systems-in-north-america-europe-and-australasia
#6
Steven G Morgan, Sabine Vogler, Anita K Wagner
Institutional payers for pharmaceuticals worldwide appear to be increasingly negotiating confidential discounts off of the official list price of pharmaceuticals purchased in the community setting. We conducted an anonymous survey about experiences with and attitudes toward confidential discounts on patented pharmaceuticals in a sample of high-income countries. Confidential price discounts are now common among the ten health systems that participated in our study, though some had only recently begun to use these pricing arrangements on a routine basis...
February 16, 2017: Health Policy
https://www.readbyqxmd.com/read/28237465/human-and-soil-exposure-during-mechanical-chlorpyrifos-myclobutanil-and-copper-oxychloride-application-in-a-peach-orchard-in-argentina
#7
Giselle Berenstein, Soledad Nasello, Érica Beiguel, Pedro Flores, Johanna Di Schiena, Silvana Basack, Enrique A Hughes, Anita Zalts, Javier M Montserrat
The objective of this study was to measure the impact of the mechanized chlorpyrifos, copper oxychloride and myclobutanil application in a small peach orchard, on humans (operators, bystanders and residents) and on the productive soil. The mean Potential Dermal Exposure (PDE) of the workers (tractor drivers) was 30.8mL·h(-1)±16.4mL·h(-1), with no specific pesticide distribution on the laborers body. Although the Margin of Safety (MOS) factor for the application stage were above 1 (safe condition) for myclobutanil and cooper oxycloride it was below 1 for chlorpyrifos...
February 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28237183/sheep-model-for-osteoporosis-the-effects-of-peripheral-hormone-therapy-on-centrally-induced-systemic-bone-loss-in-an-osteoporotic-sheep-model
#8
Ralf Oheim, Maciej J K Simon, Malte Steiner, Eik Vettorazzi, Florian Barvencik, Anita Ignatius, Michael Amling, Iain J Clarke, Pia Pogoda, F Timo Beil
Hypothalamic-pituitary disconnection (HPD) leads to low bone turnover followed by bone loss and reduced biomechanical properties in sheep. To investigate the role of peripheral hormones in this centrally induced systemic bone loss model, we planned a hormone replacement experiment. Therefore, estrogen (OHE), thyroxin (OHT) or a combination of both (OHTE) was substituted in ovariectomized HPD sheep, as both hormones are decreased in HPD sheep and are known to have a significant but yet not fully understood impact on bone metabolism...
February 20, 2017: Injury
https://www.readbyqxmd.com/read/28236077/intervention-mediators-in-a-randomized-controlled-trial-to-increase-colonoscopy-uptake-among-individuals-at-increased-risk-of-familial-colorectal-cancer
#9
Barbara H Brumbach, Wendy C Birmingham, Watcharaporn Boonyasiriwat, Scott Walters, Anita Y Kinney
BACKGROUND: Understanding the pathways by which interventions achieve behavioral change is important for optimizing intervention strategies. PURPOSE: We examined mediators of behavior change in a tailored-risk communication intervention that increased guideline-based colorectal cancer screening among individuals at increased familial risk. METHODS: Participants at increased familial risk for colorectal cancer (N = 481) were randomized to one of two arms: (1) a remote, tailored-risk communication intervention (Tele-Cancer Risk Assessment and Evaluation (TeleCARE)) or (2) a mailed educational brochure intervention...
February 24, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28235614/anti-inflammatory-activity-of-the-essential-oil-obtained-from-ocimum-basilicum-complexed-with-%C3%AE-cyclodextrin-%C3%AE-cd-in-mice
#10
Lindaiane Bezerra Rodrigues, Anita Oliveira Brito Pereira Bezerra Martins, Jaime Ribeiro-Filho, Francisco Rafael Alves Santana Cesário, Fyama Ferreira E Castro, Thaís Rodrigues de Albuquerque, Maria Neyze Martins Fernandes, Bruno Anderson Fernandes da Silva, Lucindo José Quintans Júnior, Adriano Antunes de Sousa Araújo, Paula Dos Passos Menezes, Paula Santos Nunes, Isabella Gonçalves Matos, Henrique Douglas Melo Coutinho, Almir Goncalves Wanderley, Irwin Rose Alencar de Menezes
Cyclodextrins (CDs) are cyclic oligosaccharides can enhance the bioavailability of drugs. Ocimum basilicum is an aromatic plant found in Brazil used in culinary. The essential oil of this plant presents anti-edematogenic and anti-inflammatory activities in acute and chronic inflammation. The aim of this study was to investigate the anti-inflammatory effects of the essential oil obtained from O. basilicum complexed with β - cyclodextrin (OBEO/β-CD) in mice. The complexation with β-cyclodextrin (β-CD) was performed by different methods and analyzed by differential scanning calorimetry (DSC), thermogravimetry (TG) and scanning electron microscopy (SEM)...
February 21, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28235525/iatrogenic-tracheal-laceration-in-the-setting-of-chronic-steroids
#11
Punit Singh, Margaret Wojnar, Anita Malhotra
We report the case of a 71-year-old woman with end-stage chronic obstructive pulmonary disease who presented with a 10-cm tracheal laceration from a presumed traumatic intubation in the setting of respiratory distress and chronic obstructive pulmonary disease exacerbation and subsequently developed significant subcutaneous emphysema along her neck and mediastinum in addition to her peritoneum and mesentery. We were successfully able to treat this patient conservatively up until the time that tracheostomy was warranted...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28231235/near-real-time-surveillance-of-u-s-norovirus-outbreaks-by-the-norovirus-sentinel-testing-and-tracking-network-united-states-august-2009-july-2015
#12
Minesh P Shah, Mary E Wikswo, Leslie Barclay, Anita Kambhampati, Kayoko Shioda, Umesh D Parashar, Jan Vinjé, Aron J Hall
Norovirus is the leading cause of endemic and epidemic acute gastroenteritis in the United States (1). New variant strains of norovirus GII.4 emerge every 2-4 years (2-4) and are often associated with increased disease and health care visits (5-7). Since 2009, CDC has obtained epidemiologic data on norovirus outbreaks from state health departments through the National Outbreak Reporting System (NORS) (8) and laboratory data through CaliciNet (9). NORS is a web-based platform for reporting waterborne, foodborne, and enteric disease outbreaks of all etiologies, including norovirus, to CDC...
February 24, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28230491/subcellular-localization-of-m-tuberculosis-in-vivo-and-effect-of-the-adaptive-immunity
#13
Maaike van Zon, Karin de Punder, Astrid van der Sar, Roland Brosch, Rogelio Hernandez Pando, Anita Grootemaat, Wikky Tigchelaar-Gutter, Nicole van der Wel
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28229281/cell-therapeutic-approaches-to-immunosuppression-after-clinical-kidney-transplantation
#14
REVIEW
Christian Morath, Anita Schmitt, Florian Kälble, Martin Zeier, Michael Schmitt, Flavius Sandra-Petrescu, Gerhard Opelz, Peter Terness, Matthias Schaier, Christian Kleist
Refinement of immunosuppressive strategies has led to further improvement of kidney graft survival in recent years. Currently, the main limitations to long-term graft survival are life-threatening side effects of immunosuppression and chronic allograft injury, emphasizing the need for innovative immunosuppressive regimens that resolve this therapeutic dilemma. Several cell therapeutic approaches to immunosuppression and donor-specific unresponsiveness have been tested in early phase I and phase II clinical trials in kidney transplantation...
February 23, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28228963/a-rare-cause-of-tonsil-mass-in-a-child-lymphoid-polyp
#15
Hongzhao Ji, Seckin O Ulualp, Anita Sengupta
OBJECTIVE: Solitary mass lesions of the palatine tonsils are rare in children. While a tonsillar mass can be concerning for a neoplasm, benign conditions may present with a mass arising from the surface of the palatine tonsils in children. We describe clinical and histopathological characteristics of a lymphoid polyp in a child with unilateral tonsillar mass. METHODS: Retrospective chart review. RESULTS: A 6-year-old girl presented for evaluation of recurrent acute tonsillitis and a mass on the left palatine tonsil...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28228604/opinion-gender-diversity-leads-to-better-science
#16
Mathias Wullum Nielsen, Sharla Alegria, Love Börjeson, Henry Etzkowitz, Holly J Falk-Krzesinski, Aparna Joshi, Erin Leahey, Laurel Smith-Doerr, Anita Williams Woolley, Londa Schiebinger
No abstract text is available yet for this article.
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28226886/complementary-sensors-for-rapid-and-sensitive-detection-of-wound-bacteria
#17
Roya Sheybani, Anita Shukla, Roya Sheybani, Anita Shukla, Anita Shukla, Roya Sheybani
Dual sensors for timely wound bacterial infection detection through the measurement of pH and bacterial cell attachment were developed. A high sensitivity of -57.98 ± 7.08 mV/pH (pH 1-13; over 14 days) and a minimum detectable bacteria concentration of 10(3) CFU/mL was achieved for the pH and cell-based sensors, respectively. Sensors were capable of successfully monitoring growth of bacteria (Staphylococcus aureus and Pseudomonas aeruginosa) over time with and without antibiotics in simulated would fluid.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225819/lipid-interactions-and-angle-of-approach-to-the-hiv-1-viral-membrane-of-broadly-neutralizing-antibody-10e8-insights-for-vaccine-and-therapeutic-design
#18
Adriana Irimia, Andreia M Serra, Anita Sarkar, Ronald Jacak, Oleksandr Kalyuzhniy, Devin Sok, Karen L Saye-Francisco, Torben Schiffner, Ryan Tingle, Michael Kubitz, Yumiko Adachi, Robyn L Stanfield, Marc C Deller, Dennis R Burton, William R Schief, Ian A Wilson
Among broadly neutralizing antibodies to HIV, 10E8 exhibits greater neutralizing breadth than most. Consequently, this antibody is the focus of prophylactic/therapeutic development. The 10E8 epitope has been identified as the conserved membrane proximal external region (MPER) of gp41 subunit of the envelope (Env) viral glycoprotein and is a major vaccine target. However, the MPER is proximal to the viral membrane and may be laterally inserted into the membrane in the Env prefusion form. Nevertheless, 10E8 has not been reported to have significant lipid-binding reactivity...
February 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28223498/attenuated-pfspz-vaccine-induces-strain-transcending-t-cells-and-durable-protection-against-heterologous-controlled-human-malaria-infection
#19
Kirsten E Lyke, Andrew S Ishizuka, Andrea A Berry, Sumana Chakravarty, Adam DeZure, Mary E Enama, Eric R James, Peter F Billingsley, Anusha Gunasekera, Anita Manoj, Minglin Li, Adam J Ruben, Tao Li, Abraham G Eappen, Richard E Stafford, Natasha Kc, Tooba Murshedkar, Floreliz H Mendoza, Ingelise J Gordon, Kathryn L Zephir, LaSonji A Holman, Sarah H Plummer, Cynthia S Hendel, Laura Novik, Pamela J M Costner, Jamie G Saunders, Nina M Berkowitz, Barbara J Flynn, Martha C Nason, Lindsay S Garver, Matthew B Laurens, Christopher V Plowe, Thomas L Richie, Barney S Graham, Mario Roederer, B Kim Lee Sim, Julie E Ledgerwood, Stephen L Hoffman, Robert A Seder
A live-attenuated malaria vaccine, Plasmodium falciparum sporozoite vaccine (PfSPZ Vaccine), confers sterile protection against controlled human malaria infection (CHMI) with Plasmodium falciparum (Pf) parasites homologous to the vaccine strain up to 14 mo after final vaccination. No injectable malaria vaccine has demonstrated long-term protection against CHMI using Pf parasites heterologous to the vaccine strain. Here, we conducted an open-label trial with PfSPZ Vaccine at a dose of 9.0 × 10(5) PfSPZ administered i...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28223113/imaging-redundancy-in-screening-for-abdominal-aortic-aneurysm-a-case-study
#20
Guangzu Gao, Anita Arora, Leslie Scoutt, Mahan Mathur
No abstract text is available yet for this article.
February 17, 2017: Journal of the American College of Radiology: JACR
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