Merle Hönig, Daniele Altomare, Camilla Caprioglio, Lyduine Collij, Frederik Barkhof, Bart Van Berckel, Philip Scheltens, Gill Farrar, Mark R Battle, Hendrik Theis, Kathrin Giehl, Gerard N Bischof, Valentina Garibotto, José Luis L Molinuevo, Oriol Grau-Rivera, Julien Delrieu, Pierre Payoux, Jean Francois Demonet, Agneta K Nordberg, Irina Savitcheva, Zuzana Walker, Paul Edison, Andrew W Stephens, Rossella Gismondi, Frank Jessen, Christopher J Buckley, Juan Domingo Gispert, Giovanni B Frisoni, Alexander Drzezga
OBJECTIVES: Higher-educated patients with Alzheimer disease (AD) can harbor greater neuropathologic burden than those with less education despite similar symptom severity. In this study, we assessed whether this observation is also present in potential preclinical AD stages, namely in individuals with subjective cognitive decline and clinical features increasing AD likelihood (SCD+). METHODS: Amyloid-PET information ([18 F]Flutemetamol or [18 F]Florbetaben) of individuals with SCD+, mild cognitive impairment (MCI), and AD were retrieved from the AMYPAD-DPMS cohort, a multicenter randomized controlled study...
March 26, 2024: Neurology