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https://www.readbyqxmd.com/read/29342213/circulating-neutrophil-transcriptome-may-reveal-intracranial-aneurysm-signature
#1
Vincent M Tutino, Kerry E Poppenberg, Kaiyu Jiang, James N Jarvis, Yijun Sun, Ashish Sonig, Adnan H Siddiqui, Kenneth V Snyder, Elad I Levy, John Kolega, Hui Meng
BACKGROUND: Unruptured intracranial aneurysms (IAs) are typically asymptomatic and undetected except for incidental discovery on imaging. Blood-based diagnostic biomarkers could lead to improvements in IA management. This exploratory study examined circulating neutrophils to determine whether they carry RNA expression signatures of IAs. METHODS: Blood samples were collected from patients receiving cerebral angiography. Eleven samples were collected from patients with IAs and 11 from patients without IAs as controls...
2018: PloS One
https://www.readbyqxmd.com/read/29328235/non-diffracting-beams-for-label-free-imaging-through-turbid-media
#2
Harel Nagar, Elad Dekel, Dror Kasimov, Yael Roichman
We propose a new method to image through dynamically changing turbid media based on the scanning of non-diffractive laser beams. We use computer-generated holograms to create Airy beams and compare quantitatively the characteristics of their propagation in clear and turbid media. Imaging contrast is achieved by relative reflection of the scanned beams from the imaged surface. We implement our method to demonstrate experimentally our ability to image a chromium surface on a glass slide through 270 μm of highly scattering milk/water mixtures with a resolution of several microns...
January 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29317701/a-genome-wide-association-study-identifies-only-two-ancestry-specific-variants-associated-with-spontaneous-preterm-birth
#3
Nadav Rappoport, Jonathan Toung, Dexter Hadley, Ronald J Wong, Kazumichi Fujioka, Jason Reuter, Charles W Abbott, Sam Oh, Donglei Hu, Celeste Eng, Scott Huntsman, Dale L Bodian, John E Niederhuber, Xiumei Hong, Ge Zhang, Weronika Sikora-Wohfeld, Christopher R Gignoux, Hui Wang, John Oehlert, Laura L Jelliffe-Pawlowski, Jeffrey B Gould, Gary L Darmstadt, Xiaobin Wang, Carlos D Bustamante, Michael P Snyder, Elad Ziv, Nikolaos A Patsopoulos, Louis J Muglia, Esteban Burchard, Gary M Shaw, Hugh M O'Brodovich, David K Stevenson, Atul J Butte, Marina Sirota
Preterm birth (PTB), or the delivery prior to 37 weeks of gestation, is a significant cause of infant morbidity and mortality. Although twin studies estimate that maternal genetic contributions account for approximately 30% of the incidence of PTB, and other studies reported fetal gene polymorphism association, to date no consistent associations have been identified. In this study, we performed the largest reported genome-wide association study analysis on 1,349 cases of PTB and 12,595 ancestry-matched controls from the focusing on genomic fetal signals...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29305340/evidence-from-web-based-dietary-search-patterns-to-the-role-of-b12-deficiency-in-non-specific-chronic-pain-a-large-scale-observational-study
#4
Eitan Giat, Elad Yom-Tov
BACKGROUND: Profound vitamin B12 deficiency is a known cause of disease, but the role of low or intermediate levels of B12 in the development of neuropathy and other neuropsychiatric symptoms, as well as the relationship between eating meat and B12 levels, is unclear. OBJECTIVE: The objective of our study was to investigate the role of low or intermediate levels of B12 in the development of neuropathy and other neuropsychiatric symptoms. METHODS: We used food-related Internet search patterns from a sample of 8...
January 5, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29302839/in-vitro-exposure-of-nasal-epithelial-cells-to-atmospheric-dust
#5
David Elad, Uri Zaretsky, Sharon Avraham, Ruthie Gotlieb, Michael Wolf, Itzhak Katra, Shlomo Sarig, Eli Zaady
Dust storms are common phenomena in many parts of the world, and significantly increase the level of atmospheric particulate matter (PM). The soil-derived dust is a mixture of organic and inorganic particles and even remnants of pesticides from agricultural areas nearby. The risk of human exposure to atmospheric dust is well documented, but very little is known on the impact of inhaled PM on the biological lining of the nasal cavity, which is the natural filter between the external environment and the respiratory tract...
January 4, 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29301033/endovascular-transcirculation-management-of-iatrogenic-vertebral-artery-dissection-with-the-floss-technique-and-flow-diversion-2-dimensional-operative-video
#6
Leonardo Rangel-Castilla, Hussain Shallwani, Hakeem J Shakir, Elad I Levy, Adnan H Siddiqui
No abstract text is available yet for this article.
December 30, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29296999/safety-and-efficacy-of-a-3-dimensional-stent-retriever-with-aspiration-based-thrombectomy-vs-aspiration-based-thrombectomy-alone-in-acute-ischemic-stroke-intervention-a-randomized-clinical-trial
#7
Raul G Nogueira, Donald Frei, Jawad F Kirmani, Osama Zaidat, Demetrius Lopes, Aquilla S Turk, Donald Heck, Brian Mason, Diogo C Haussen, Elad I Levy, Siddhart Mehta, Marc Lazzaro, Michael Chen, Arnd Dörfler, Albert J Yoo, Colin P Derdeyn, Lee Schwamm, David Langer, Adnan Siddiqui
Importance: The treatment effects of individual mechanical thrombectomy devices in large-vessel acute ischemic stroke (AIS) remain unclear. Objective: To determine whether the novel 3-dimensional (3-D) stent retriever used in conjunction with an aspiration-based mechanical thrombectomy device (Penumbra System; Penumbra) is noninferior to aspiration-based thrombectomy alone in AIS. Design, Setting, and Participants: This randomized, noninferiority clinical trial enrolled patients at 25 North American centers from May 19, 2012, through November 19, 2015, with follow-up for 90 days...
January 2, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29296821/progenitor-b-1-b-cell-acute-lymphoblastic-leukemia-is-associated-with-collaborative-mutations-in-3-critical-pathways
#8
Sheryl M Gough, Liat Goldberg, Marbin Pineda, Robert L Walker, Yuelin J Zhu, Sven Bilke, Yang Jo Chung, Joseph Dufraine, Subhadip Kundu, Elad Jacoby, Terry J Fry, Susanna Fischer, Renate Panzer-Grümayer, Paul S Meltzer, Peter D Aplan
B-1 and B-2 lymphocytes are derived from distinct developmental pathways and represent layered arms of the innate and adaptive immune systems, respectively. In contrast to a majority of murine B-cell malignancies, which stain positive with the B220 antibody, we discovered a novel form of B-cell leukemia in NUP98-PHF23 (NP23) transgenic mice. The immunophenotype (Lin- B220- CD19+ AA4.1+) was identical to that of progenitor (pro) B-1 cells, and VH gene usage was skewed toward 3' V regions, similar to murine fetal liver B cells...
September 12, 2017: Blood Advances
https://www.readbyqxmd.com/read/29289949/the-use-of-intraprocedural-reinfusion-during-mitraclip-implantation-to-reduce-blood-loss-and-transfusion-requirements
#9
Claire E Raphael, Elad Maor, Sidakpal S Panaich, Guy Reeder, Charanjit S Rihal, Mackram F Eleid
BACKGROUND: MitraClip implantation has been shown to reduce mitral regurgitation and is an effective treatment option for patients at high risk for conventional surgery. Blood loss is common during the procedure. We assessed the utility of intraprocedural reinfusion of blood aspirated during MitraClip implantation. METHODS: We compared hemoglobin before and after MitraClip implantation and transfusion requirements in patients who did (n = 83) and did not receive reinfusion (n = 31) during their procedure...
January 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29280762/brentuximab-vedotin-with-avd-shows-safety-in-the-absence-of-strong-cyp3a4-inhibitors-in-newly-diagnosed-hiv-associated-hodgkin-lymphoma
#10
Paul G Rubinstein, Page C Moore, Michelle A Rudek, David H Henry, Juan C Ramos, Lee Ratner, Erin Reid, Elad Sharon, Ariela Noy
OBJECTIVE: Brentuximab vedotin (BV) is an FDA approved anti-CD30 antibody drug conjugate potently active in Hodgkin lymphoma (HL). Trials of BV with doxorubicin, vinblastine, and dacarbazine (AVD-BV) excluded patients with HIV. We studied the safety of (AVD-BV) in newly diagnosed HIV-associated classical Hodgkin lymphoma (HIV-cHL). DESIGN AND METHODS: Patients diagnosed with Stage II-IV HIV-cHL received AVD-BV on days 1 and 15 every 28 days for 6 cycles. Anti-HIV medications with strong CYP3A4 inhibition were excluded...
December 26, 2017: AIDS
https://www.readbyqxmd.com/read/29273272/ifpa-meeting-2017-workshop-report-clinical-placentology-3d-structure-based-modeling-of-placental-function-placental-bed-and-treating-placental-dysfunction
#11
Ganesh Acharya, John Aplin, Paul Brownbill, Judith Bulmer, Graham Burton, Larry Chamley, Igor Chernyavsky, Alys Clark, Sally Collins, Elizabeth Cottrell, Mark Dilworth, David Elad, Marcel Filoche, Natalie Hannan, Alexander E P Heazell, Oliver Jensen, Edward D Johnstone, Lopa Leach, Rohan Lewis, Terry Morgan, Jenny Myers, Gareth Nye, Michelle Oyen, Carolyn Salafia, Henning Schneider, Perrie O'Tierney-Ginn
Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2017 there were four themed workshops, all of which are summarized in this report. These workshops discussed new knowledge and technological innovations in the following areas of research: 1) placental bed; 2) 3D structural modeling; 3) clinical placentology; 4) treatment of placental dysfunction.
December 15, 2017: Placenta
https://www.readbyqxmd.com/read/29240407/membrane-determinants-affect-fibrillation-processes-of-%C3%AE-sheet-charged-peptides
#12
Elad Arad, Ravit Malishev, Hanna Rapaport, Raz Jelinek
Assembly of fibrillar peptide structures is dependent both upon their intrinsic propensities towards β-structure formation, as well as on structural modulation by external molecular factors. β-sheet structures may either be designed to form useful assemblies or be the undesired consequence of protein denaturation to toxic amyloid structures in several neurodegenerative diseases. Membrane bilayers have been implicated as primary initiators and modulators of amyloid fibrillation and the reasons for this effect are yet to be elucidated...
December 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29230321/the-management-of-retinal-detachment-techniques-and-perspectives
#13
EDITORIAL
Elad Moisseiev, Anat Loewenstein, Ala Moshiri, Glenn Yiu
No abstract text is available yet for this article.
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29220577/from-solvent-free-to-dilute-electrolytes-essential-components-for-a-continuum-theory
#14
Nir Gavish, Doron Elad, Arik Yochelis
The increasing number of experimental observations on highly concentrated electrolytes and ionic liquids show qualitative features that are distinct from dilute or moderately concentrated electrolytes, such as self-assembly, multiple-time relaxation, and under-screening, which all impact the emergence of fluid/solid interfaces, and transport in these systems. Since these phenomena are not captured by existing mean field models of electrolytes, there is a paramount need for a continuum framework for highly concentrated electrolytes and ionic liquids...
December 8, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29220033/challenges-and-recommendations-for-epigenomics-in-precision-health
#15
Ava C Carter, Howard Y Chang, George Church, Ashley Dombkowski, Joseph R Ecker, Elad Gil, Paul G Giresi, Henry Greely, William J Greenleaf, Nir Hacohen, Chuan He, David Hill, Justin Ko, Isaac Kohane, Anshul Kundaje, Megan Palmer, Michael P Snyder, Joyce Tung, Alexander Urban, Marc Vidal, Wing Wong
No abstract text is available yet for this article.
December 8, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/29191905/the-image-forming-mirror-in-the-eye-of-the-scallop
#16
Benjamin A Palmer, Gavin J Taylor, Vlad Brumfeld, Dvir Gur, Michal Shemesh, Nadav Elad, Aya Osherov, Dan Oron, Steve Weiner, Lia Addadi
Scallops possess a visual system comprising up to 200 eyes, each containing a concave mirror rather than a lens to focus light. The hierarchical organization of the multilayered mirror is controlled for image formation, from the component guanine crystals at the nanoscale to the complex three-dimensional morphology at the millimeter level. The layered structure of the mirror is tuned to reflect the wavelengths of light penetrating the scallop's habitat and is tiled with a mosaic of square guanine crystals, which reduces optical aberrations...
December 1, 2017: Science
https://www.readbyqxmd.com/read/29191582/patterns-of-care-and-survival-among-patients-with-malignant-mesothelioma-in-the-united-states
#17
Lindsey Enewold, Elad Sharon, Anish Thomas
BACKGROUND: Mesothelioma is a rare malignancy that is associated with poor survival. This study aimed to describe the patterns of care and subsequent survival among malignant mesothelioma patients in the United States, while adjusting for patient demographics and comorbidities. METHODS: A random sample of patients diagnosed with histologically confirmed mesothelioma in 2011, as reported to the National Cancer Institute's Surveillance Epidemiology and End Results program, were included...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29174016/de-novo-mitral-regurgitation-as-a-cause-of-heart-failure-exacerbation-in-patients-with-hypertrophic-cardiomyopathy
#18
Rafael Kuperstein, Robert Klempfner, Efrat Ofek, Elad Maor, Dov Freimark, Leonid Sternik, Ilan Goldenberg, Ehud Raanani, Michael Arad
No abstract text is available yet for this article.
November 21, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29171941/extracorporeal-cellular-therapy-elad-in-severe-alcoholic-hepatitis-a-multinational-prospective-controlled-randomized-trial
#19
Julie Thompson, Natasha Jones, Ali Al-Khafaji, Shahid Malik, David Reich, Santiago Munoz, Ross MacNicholas, Tarek Hassanein, Lewis Teperman, Lance Stein, Andrés Duarte-Rojo, Raza Malik, Talal Adhami, Sumeet Asrani, Nikunj Shah, Paul Gaglio, Anupama Duddempudi, Brian Borg, Rajiv Jalan, Robert Brown, Heather Patton, Rohit Satoskar, Simona Rossi, Amay Parikh, Ahmed ElSharkawy, Parvez Mantry, Linda Sher, David Wolf, Marquis Hart, Charles Landis, Alan Wigg, Shahid Habib, Geoffrey McCaughan, Steven Colquhoun, Alyssa Henry, Patricia Bedard, Lee Landeen, Michael Millis, Robert Ashley, William Frank, Andrew Henry, Jan Stange, Ram Subramanian
Severe Alcoholic Hepatitis (sAH) is associated with a poor prognosis. There is no proven effective treatment for sAH, which is why early transplantation has been increasingly discussed. Hepatoblastoma-derived C3A cells express anti-inflammatory proteins and growth factors and were tested in an extracorporeal liver treatment (ELAD) study to establish their effect on survival for subjects with sAH. Adults with sAH, bilirubin ≥8 mg/dL, Maddrey's Discriminant Function (DF) ≥32 and Model for End-Stage Liver Disease (MELD) score ≤35, were randomized to receive standard of care (SOC) only or 3-5 days of continuous ELAD treatment plus SOC...
November 24, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29168873/throughput-enhancement-of-parallel-step-emulsifier-devices-by-shear-free-and-efficient-nozzle-clearance
#20
Elad Stolovicki, Roy Ziblat, David A Weitz
Step emulsification is an attractive method for production of monodisperse drops. Its main advantage is the ability to parallelize many step emulsifier nozzles to achieve high production rates. However, step emulsification is sensitive to any obstructions at the nozzle exit. At high production rates, drops can accumulate at nozzle exits, disturb the formation of subsequent drops and impair monodispersity. As a result, parallelized step emulsifier devices typically do not work at maximum productivity. Here a design is introduced that parallelizes hundreds of step emulsifier nozzles, and effectively removes drops from the nozzle exits...
November 23, 2017: Lab on a Chip
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