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https://www.readbyqxmd.com/read/28520641/five-year-follow-up-after-epiretinal-membrane-surgery-a-single-center-experience
#1
Efrat Fleissig, Dinah Zur, Elad Moisseiev, Shay Keren, Oded Ohana, Adiel Barak
PURPOSE: To evaluate the rate of epiretinal membrane (ERM) recurrence in eyes that underwent ERM peeling surgery at least 5 years earlier. METHODS: Retrospective interventional case series study of 37 patients (15 women and 22 men; mean age, 70 ± 7.6 years) operated on for ERM removal with a follow-up of at least 5 years. The patients underwent testing for visual acuity, an ophthalmic examination, and optical coherence tomography imaging, all of which were assessed preoperatively, postoperatively, and at the 5-year follow-up...
May 16, 2017: Retina
https://www.readbyqxmd.com/read/28518194/detection-of-antibiotic-resistant-escherichia-coli-bacteria-using-infrared-microscopy-and-advanced-multivariate-analysis
#2
Ahmad Salman, Uraib Sharaha, Eladio Rodriguez-Diaz, Elad Shufan, Klaris Riesenberg, Irving J Bigio, Mahmoud Huleihel
Bacterial resistance to antibiotics is becoming a global health-care problem. Bacteria are involved in many diseases, and antibiotics have been the most effective treatment for them. It is essential to treat an infection with an antibiotic to which the infecting bacteria is sensitive; otherwise, the treatment is not effective and may lead to life-threatening progression of disease. Classical microbiology methods that are used for determination of bacterial susceptibility to antibiotics are time consuming, accounting for problematic delays in the administration of appropriate drugs...
May 18, 2017: Analyst
https://www.readbyqxmd.com/read/28507154/information-socialtaxis-and-efficient-collective-behavior-emerging-in-groups-of-information-seeking-agents
#3
Ehud D Karpas, Adi Shklarsh, Elad Schneidman
Individual behavior, in biology, economics, and computer science, is often described in terms of balancing exploration and exploitation. Foraging has been a canonical setting for studying reward seeking and information gathering, from bacteria to humans, mostly focusing on individual behavior. Inspired by the gradient-climbing nature of chemotaxis, the infotaxis algorithm showed that locally maximizing the expected information gain leads to efficient and ethological individual foraging. In nature, as well as in theoretical settings, conspecifics can be a valuable source of information about the environment...
May 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28501852/clinically-significant-sub-clonality-for-common-drivers-can-be-detected-in-26-of-kras-egfr-mutated-lung-adenocarcinomas
#4
Einav Simon, Tova Bick, Shada Sarji, Talia Shentzer, Elad Prinz, Liza Yehiam, Edmond Sabo, Ofer Ben-Izhak, Dov Hershkovitz
Genetic sub-clonality has been described in multiple malignancies, however the presence of sub-clonality for major drivers in lung adenocarcinoma and its clinical significance is a subject under debate. Using molecular and morphometric approach, 347 lung adenocarcinoma samples were analyzed for KRAS and EGFR sub-clonality, which was further correlated with clinical and pathological variables.KRAS and EGFR mutations were identified in 100 (29%) and 82 (23%) cases, respectively. One hundred and forty four KRAS or EGFR positive cases were also available for morphometric analysis, among which 37 (26%) were defined as sub-clonal...
April 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28498625/biomechanics-of-the-human-uterus
#5
REVIEW
Kristin M Myers, David Elad
The appropriate biomechanical function of the uterus is required for the execution of human reproduction. These functions range from aiding the transport of the embryo to the implantation site, to remodeling its tissue walls to host the placenta, to protecting the fetus during gestation, to contracting forcefully for a safe parturition and postpartum, to remodeling back to its nonpregnant condition to renew the cycle of menstruation. To serve these remarkably diverse functions, the uterus is optimally geared with evolving and contractile muscle and tissue layers that are cued by chemical, hormonal, electrical, and mechanical signals...
May 12, 2017: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/28465460/efficacy-of-stent-retriever-thrombectomy-in-magnetic-resonance-imaging-versus-computed-tomographic-perfusion-selected-patients-in-swift-prime-trial-solitaire-fr-with-the-intention-for-thrombectomy-as-primary-endovascular-treatment-for-acute-ischemic-stroke
#6
Nicolas Menjot de Champfleur, Jeffrey L Saver, Mayank Goyal, Reza Jahan, Hans-Christoph Diener, Alain Bonafe, Elad I Levy, Vitor M Pereira, Christophe Cognard, Dileep R Yavagal, Gregory W Albers
BACKGROUND AND PURPOSE: The majority of patients enrolled in SWIFT PRIME trial (Solitaire FR With the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke) had computed tomographic perfusion (CTP) imaging before randomization; 34 patients were randomized after magnetic resonance imaging (MRI). METHODS: Patients with middle cerebral artery and distal carotid occlusions were randomized to treatment with tPA (tissue-type plasminogen activator) alone or tPA+stentriever thrombectomy...
May 2, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28457231/disease-management-in-the-treatment-of-patients-with-chronic-heart-failure-who-have-universal-access-to-health-care-a-randomized-controlled-trial
#7
Ofra Kalter-Leibovici, Dov Freimark, Laurence S Freedman, Galit Kaufman, Arnona Ziv, Havi Murad, Michal Benderly, Barbara G Silverman, Nurit Friedman, Tali Cukierman-Yaffe, Elad Asher, Avishay Grupper, Dorit Goldman, Miriam Amitai, Shlomi Matetzky, Mordechai Shani, Haim Silber
BACKGROUND: The efficacy of disease management programs in improving the outcome of heart failure patients remains uncertain and may vary across health systems. This study explores whether a countrywide disease management program is superior to usual care in reducing adverse health outcomes and improving well-being among community-dwelling adult patients with moderate-to-severe chronic heart failure who have universal access to advanced health-care services and technologies. METHODS: In this multicenter open-label trial, 1,360 patients recruited after hospitalization for heart failure exacerbation (38%) or from the community (62%) were randomly assigned to either disease management or usual care...
May 1, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28455271/evaluation-of-ablation-catheter-technology-comparison-between-thigh-preparation-model-and-an-in%C3%A2-vivo-beating-heart
#8
Eran Leshem, Cory M Tschabrunn, Fernando M Contreras-Valdes, Israel Zilberman, Elad Anter
BACKGROUND: An in vivo animal thigh model is the standard technique for evaluation of ablation catheter technologies, including efficacy and safety of ablation. However, the biophysics of ablation in a thigh model may not be similar to a beating heart. OBJECTIVE: The purpose of this study was to compare efficacy and safety of ablation between a thigh preparation model and a beating heart. METHODS: In 7 swine, radiofrequency ablation using a 3...
April 26, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28449126/results-of-the-answer-trial-using-the-pulserider-for-the-treatment-of-broad-necked-bifurcation-aneurysms
#9
Alejandro M Spiotta, Colin P Derdeyn, Satoshi Tateshima, Jay Mocco, R Webster Crowley, Kenneth C Liu, Lee Jensen, Koji Ebersole, Alan Reeves, Demetrius K Lopes, Ricardo A Hanel, Eric Sauvageau, Gary Duckwiler, Adnan Siddiqui, Elad Levy, Ajit Puri, Lee Pride, Roberta Novakovic, M Imran Chaudry, Raymond D Turner, Aquilla S Turk
BACKGROUND: The safety and probable benefit of the PulseRider (Pulsar Vascular, Los Gatos, California) for the treatment of broad-necked, bifurcation aneurysms was studied in the context of the prospective, nonrandomized, single arm clinical trial-the Adjunctive Neurovascular Support of Wide-neck aneurysm Embolization and Reconstruction (ANSWER) Trial. OBJECTIVE: To present the results of the United States cases employing the PulseRider device as part of the ANSWER clinical trial...
April 25, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28448801/the-placental-factor-in-spontaneous-preterm-birth-in-twin-vs-singleton-pregnancies
#10
Eran Weiner, Ann Dekalo, Ohad Feldstein, Elad Barber, Letizia Schreiber, Jacob Bar, Michal Kovo
OBJECTIVE: The association between infection and inflammatory response in singleton preterm birth (PTB) is well established, yet, less is known about PTB in twins. We aimed to compare the placental component and pregnancy outcome in pregnancies complicated with PTB of singletons vs. twin deliveries. We hypothesized that due to different underlying mechanisms, placental inflammatory lesions will be more prevalent in placentas derived from singleton pregnancies than twins. STUDY DESIGN: Labor characteristics, neonatal outcome and placental histopathology reports of spontaneous PTB at 24-33(6)/7 weeks, from 1/2008-12/2015, were reviewed...
April 22, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28434097/impact-of-a-complementary-integrative-medicine-program-on-the-need-for-supportive-cancer-care-related-medications
#11
Ilanit Shalom-Sharabi, Noah Samuels, Efraim Lev, Ofer Lavie, Lital Keinan-Boker, Elad Schiff, Eran Ben-Arye
OBJECTIVE: Despite the growing evidence supporting the use of complementary/integrative medicine (CIM) in the treatment of chemotherapy-induced toxicities, little is known on CIM impact of these therapies regarding the use of medications for supportive cancer care. In this study, we examined the impact of CIM on the need for supportive cancer care-related medications. PATIENTS AND METHODS: Patients with breast or gynecological cancer referred to and attending an integrative physician (IP) consultation for gastrointestinal (GI) concerns were designated as the treatment group; those not attending as controls...
April 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28433038/four-dimensional-coherent-electronic-raman-spectroscopy
#12
Elad Harel
The correlations between different quantum-mechanical degrees of freedom of molecular species dictate their chemical and physical properties. Generally, these correlations are reflected in the optical response of the system but in low-order or low-dimensionality measurement the signals are highly averaged. Here, we describe a novel four-dimensional coherent spectroscopic method that directly correlates within and between the manifold of electronic and vibrational states. The optical response theory is developed in terms of both resonant and non-resonant field-matter interactions...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28432038/seeking-web-based-information-about-attention-deficit-hyperactivity-disorder-where-what-and-when
#13
Sara Rosenblum, Elad Yom-Tov
BACKGROUND: Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder, prevalent among 2-10% of the population. OBJECTIVE: The objective of this study was to describe where, what, and when people search online for topics related to ADHD. METHODS: Data were collected from Microsoft's Bing search engine and from the community question and answer site, Yahoo Answers. The questions were analyzed based on keywords and using further statistical methods...
April 21, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28431590/delays-in-door-to-needle-time-for-acute-ischemic-stroke-in-the-emergency-department-a-comprehensive-stroke-center-experience
#14
Ashkan Mowla, Jordan Doyle, Navdeep S Lail, Hamidreza Rajabzadeh-Oghaz, Christopher Deline, Peyman Shirani, Marilou Ching, Annemarie Crumlish, Deborah A Steck, David Janicke, Elad I Levy, Robert N Sawyer
BACKGROUND: Current American Stroke Association guidelines recommend initiating intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) within 60min of patient arrival, given the benefits of IVT for AIS are time dependent. This study aimed to identify the delaying factors in door-to-needle time (DTN) in the emergency department of one of the largest comprehensive stroke centers in New York State. We also recommended measures to reduce the delays. METHODS: We retrospectively reviewed the medical charts of all AIS patients who received IVT in our emergency department patients between April 1, 2012 and December 31, 2015 to identify those with a DTN time of >60min...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28431023/safety-and-efficacy-of-the-sofia-6f-plus-distal-access-reperfusion-catheter-in-the-endovascular-treatment-of-acute-ischemic-stroke
#15
Hussain Shallwani, Hakeem J Shakir, Leonardo Rangel-Castilla, Jason M Davies, Ashish Sonig, Mithun G Sattur, Bernard R Bendok, Kenneth V Snyder, Adnan H Siddiqui, Elad I Levy
BACKGROUND: Neuroendovascular intervention has become a key treatment option for acute ischemic stroke. The Sofia (6F) PLUS catheter was designed for neurovascular access for diagnostic or therapeutic interventions. OBJECTIVE: To report the first series describing use of the Sofia PLUS intermediate/distal access reperfusion catheter in the treatment of acute ischemic stroke. METHODS: In this retrospective study, 41 stroke cases were identified in which the catheter was utilized for thrombolysis/thrombectomy...
April 19, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28430749/neonatal-cervical-osteomyelitis-with-bilateral-upper-limb-paresis
#16
Elad Ben-Meir, Marina Rubinshtein, Itai Pessach, Galia Barkai, Nathan Keller, Chen Hoffman, Zeev Feldman, Gidi Paret
Neonatal cervical osteomyelitis is extremely rare, with only a few cases having been reported. We report a neonate with cervical osteomyelitis and extensive inflammation of the surrounded tissues that caused nerve root compression and upper limb paresis.
April 19, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28427075/diabetic-macular-edema-emerging-strategies-and-treatment-algorithms
#17
Elad Moisseiev, Anat Loewenstein
Diabetic macular edema (DME) is the most common cause of vision loss in diabetic patients, and its management is often a long process requiring frequent monitoring and therapeutic interventions. During the past several decades, numerous treatments have been developed for the treatment of DME. Although many of them have been found to be effective and safe, there is relatively little comparative data, and no established guidelines for the optimal treatment approach exist. In this chapter, the evolution of DME therapies is reviewed, and the current common practice patterns are discussed...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28424299/adult-neural-stem-cell-multipotency-and-differentiation-are-directed-by-the-methyl-cpg-binding-protein-mbd1
#18
Elad Lax, Daniel M Sapozhnikov
No abstract text is available yet for this article.
April 19, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28414527/advantages-and-limitations-of-in-vitro-and-in-vivo-methods-of-iron-and-zinc-bioavailability-evaluation-in-the-assessment-of-biofortification-program-effectiveness
#19
Desirrê Morais Dias, Neuza Maria Brunoro Costa, Marilia Regini Nutti, Elad Tako, Hércia Stampini Duarte Martino
Biofortification aims to improve the micronutrient concentration of staple food crops through the best practices of breeding and modern biotechnology. However, increased zinc and iron concentrations in food crops may not always translate into proportional increases in absorbed zinc (Zn) and iron (Fe). Therefore, assessing iron and zinc bioavailability in biofortified crops is imperative to evaluate the efficacy of breeding programs. This review aimed to investigate the advantages and limitations of in vitro and in vivo methods of iron and zinc bioavailability evaluation in the assessment of biofortification program effectiveness...
April 17, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28411263/use-of-platelet-function-testing-before-pipeline-embolization-device-placement-a-multicenter-cohort-study
#20
Nimer Adeeb, Christoph J Griessenauer, Paul M Foreman, Justin M Moore, Hussain Shallwani, Rouzbeh Motiei-Langroudi, Abdulrahman Alturki, Adnan H Siddiqui, Elad I Levy, Mark R Harrigan, Christopher S Ogilvy, Ajith J Thomas
BACKGROUND AND PURPOSE: Thromboembolic complications constitute a significant source of morbidity after neurointerventional procedures. Flow diversion using the pipeline embolization device for the treatment of intracranial aneurysms necessitates the use of dual antiplatelet therapy to reduce this risk. The use of platelet function testing before pipeline embolization device placement remains controversial. METHODS: A retrospective review of prospectively maintained databases at 3 academic institutions was performed from the years 2009 to 2016 to identify patients with intracranial aneurysms treated with pipeline embolization device placement...
April 14, 2017: Stroke; a Journal of Cerebral Circulation
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