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vestibular movement disorders

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https://www.readbyqxmd.com/read/27703443/a-cross-sectional-survey-and-cross-sectional-clinical-trial-to-determine-the-prevalence-and-management-of-eye-movement-disorders-and-vestibular-dysfunction-in-post-stroke-patients-in-the-sub-acute-phase-protocol
#1
Andoret van Wyk, Carina A Eksteen, Piet J Becker, Barbara M Heinze
INTRODUCTION: Visual impairment, specifically eye movement disorders and vestibular dysfunction may have a negative influence on the functional recovery in post-stroke patients. This type of sensory dysfunction may further be associated with poor functional outcome in patients' post-stroke. METHODS: In phase 1, a cross-sectional survey (n = 100) will be conducted to determine the prevalence of eye movement disorders and vestibular dysfunction in patients who sustained a stroke...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27638066/eye-movements-in-vestibular-disorders
#2
A Kheradmand, A I Colpak, D S Zee
The differential diagnosis of patients with vestibular symptoms usually begins with the question: is the lesion central or is it peripheral? The answer commonly emerges from a careful examination of eye movements, especially when the lesion is located in otherwise clinically silent areas of the brain such as the vestibular portions of the cerebellum (flocculus, paraflocculus which is called the tonsils in humans, nodulus, and uvula) and the vestibular nuclei as well as immediately adjacent areas (the perihypoglossal nuclei and the paramedian nuclei and tracts)...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27638061/neurotransmitters-in-the-vestibular-system
#3
C D Balaban
Neuronal networks that are linked to the peripheral vestibular system contribute to gravitoinertial sensation, balance control, eye movement control, and autonomic function. Ascending connections to the limbic system and cerebral cortex are also important for motion perception and threat recognition, and play a role in comorbid balance and anxiety disorders. The vestibular system also shows remarkable plasticity, termed vestibular compensation. Activity in these networks is regulated by an interaction between: (1) intrinsic neurotransmitters of the inner ear, vestibular nerve, and vestibular nuclei; (2) neurotransmitters associated with thalamocortical and limbic pathways that receive projections originating in the vestibular nuclei; and (3) locus coeruleus and raphe (serotonergic and nonserotonergic) projections that influence the latter components...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27557808/the-role-of-visual-stimuli-on-standing-posture-in-children-with-bilateral-cerebral-palsy
#4
Cecilia Lidbeck, Åsa Bartonek, Priti Yadav, Kristina Tedroff, Per Åstrand, Kerstin Hellgren, Elena M Gutierrez-Farewik
BACKGROUND: In children with bilateral cerebral palsy (CP) maintaining a standing position can be difficult. The fundamental motor task of standing independently is achieved by an interaction between the visual, somatosensory, and vestibular systems. In CP, the motor disorders are commonly accompanied by sensory and perceptual disturbances. Our aims were to examine the influence of visual stimuli on standing posture in relation to standing ability. METHODS: Three dimensional motion analysis with surface electromyography was recorded to describe body position, body movement, and muscle activity during three standing tasks: in a self-selected position, while blindfolded, and during an attention-demanding task...
August 24, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27552387/bilateral-vestibulopathy-aggravates-balance-and-gait-disturbances-in-sensory-ataxic-neuropathy-dysarthria-and-ophthalmoparesis-a-case-report
#5
Roeland B van Leeuwen, Bart W Smits, Richard J Rodenburg, Baziel G van Engelen
In patients with a triad of sensory ataxic neuropathy, dysarthria, and ophthalmoparesis (SANDO), the presenting features are mainly ataxia or ptosis. SANDO patients often have impaired balance and gait, which is not surprising considering the combination of sensory ataxic neuropathy, and additional symptoms like cerebellar ataxia and limb girdle weakness. We describe a SANDO patient who noticed an increasingly impaired balance and gait, without any dizziness. Neurological investigation revealed an external ophthalmeplegia and a cerebellar ataxia; the head impulse test was not reliable because of eye movement disorders...
September 2016: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/27533944/the-role-of-trimetazidine-in-cardiovascular-disease-beyond-an-anti-anginal-agent
#6
REVIEW
Cian P McCarthy, Kieran V Mullins, David M Kerins
With evidence for efficacy in such diverse clinical settings such as stable coronary artery disease, reperfusion injury, and contrast-induced nephropathy, trimetazidine (TMZ) is novel among cardiovascular agents. In spite of this and almost half a century of clinical experience with the drug, it remains licensed only as an adjunct in the management of angina pectoris in patients who are inadequately controlled by or intolerant to first-line therapies. Although no single pharmacological mechanism has been hitherto universally accepted, TMZ is known to target deranged cellular energetics particularly in ischaemic myocardial tissue...
October 2016: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/27392833/the-development-of-the-icf-vestibular-environmental-scale
#7
Susan L Whitney, Ahmad Alghadir, Alia Alghwiri, Kefah M Alshebber, Mohammed Alshehri, Joseph M Furman, Martin Mueller, Eva Grill
UNLABELLED: People with vestibular disorders report changes in symptoms based on their environment with many situations increasing their symptoms. The purpose of this paper was to utilize the International Classification of Functioning Disability and Health (ICF) from the World Health Organization (WHO) to describe common environmental triggers for dizziness in persons living with balance and vestibular disorders. A multi-centre cross-sectional study was conducted with four different centres on three different continents, including patients from the United States (Pittsburgh), Germany (Munich), Jordan (Amman) and Saudi Arabia (Riyadh)...
July 2, 2016: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/27385797/contribution-of-intravestibular-sensory-conflict-to-motion-sickness-and-dizziness-in-migraine-disorders
#8
Joanne Wang, Richard F Lewis
Migraine is associated with enhanced motion sickness susceptibility and can cause episodic vertigo [vestibular migraine (VM)], but the mechanisms relating migraine to these vestibular symptoms remain uncertain. We tested the hypothesis that the central integration of rotational cues (from the semicircular canals) and gravitational cues (from the otolith organs) is abnormal in migraine patients. A postrotational tilt paradigm generated a conflict between canal cues (which indicate the head is rotating) and otolith cues (which indicate the head is tilted and stationary), and eye movements were measured to quantify two behaviors that are thought to minimize this conflict: suppression and reorientation of the central angular velocity signal, evidenced by attenuation ("dumping") of the vestibuloocular reflex and shifting of the rotational axis of the vestibuloocular reflex toward the earth vertical...
October 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27385658/vestibular-migraine-screening-in-a-migraine-diagnosed-patient-population-and-assessment-of-vestibulocochlear-function
#9
U Yollu, D U Uluduz, M Yilmaz, H M Yener, F Akil, B Kuzu, E Kara, D Hayir, D Ceylan, N Korkut
OBJECTIVE: The primary aim of this study is to do a vestibular migraine scan in a population of patients with migraine diagnosis using the most recent standardized diagnosis criterion which is International Classification of Headache Disorders (ICHD) 3 Beta and to identify the epidemiological data. The second part of the study involves performing several vestibulocochlear tests on patients who received vestibular migraine (VM) diagnosis to collect data that may be important for diagnostic purposes by comparing the patients with normal population when necessary...
July 6, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27358321/vestibular-and-oculomotor-influences-on-visual-dependency
#10
R Edward Roberts, Mariane Da Silva Melo, Aazim A Siddiqui, Qadeer Arshad, Mitesh Patel
The degree to which a person relies on visual stimuli for spatial orientation is termed visual dependency (VD). VD is considered a perceptual trait or cognitive style influenced by psychological factors and mediated by central reweighting of the sensory inputs involved in spatial orientation. VD is often measured with the rod-and-disk test, in which participants align a central rod to the subjective visual vertical (SVV) in the presence of a background that is either stationary or rotating around the line of sight-dynamic SVV...
September 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27272105/development-of-an-effective-therapy-and-objective-assessment-for-children-with-birth-injuries
#11
Ákos Jobbágy, Judit Schultheisz, Márk Horváth, Hanna Réfy Vraskóné
Sitting in a Huple, a patented hemisphere-like tool, permanently stimulates the vestibular system, thus improving the balancing ability of children with movement disorders. The Gézengúz Foundation for Children with Birth Injuries has been successfully applying this tool in therapy. By attaching x-Inertial Measurement Unit, a wireless three-dimensional orientation sensor, to the Huple, it can serve as an input peripheral for simple PC games. Children are thus motivated; they willingly perform balance training as well as participate in the game-like test...
June 6, 2016: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/27220548/vestibulo-ocular-reflex-function-in-children-with-high-functioning-autism-spectrum-disorders
#12
Tana B Carson, Bradley J Wilkes, Kunal Patel, Jill L Pineda, Ji H Ko, Karl M Newell, James W Bodfish, Michael C Schubert, Krestin Radonovich, Keith D White, Mark H Lewis
Sensorimotor processing alterations are a growing focus in the assessment and treatment of Autism Spectrum Disorders (ASD). The rotational vestibulo-ocular reflex (rVOR), which functions to maintain stable vision during head movements, is a sensorimotor system that may be useful in understanding such alterations and their underlying neurobiology. In this study, we assessed post-rotary nystagmus elicited by continuous whole body rotation among children with high-functioning ASD and typically developing children...
May 25, 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27185559/multiple-time-courses-of-vestibular-set-point-adaptation-revealed-by-sustained-magnetic-field-stimulation-of-the-labyrinth
#13
Prem Jareonsettasin, Jorge Otero-Millan, Bryan K Ward, Dale C Roberts, Michael C Schubert, David S Zee
A major focus in neurobiology is how the brain adapts its motor behavior to changes in its internal and external environments [1, 2]. Much is known about adaptively optimizing the amplitude and direction of eye and limb movements, for example, but little is known about another essential form of learning, "set-point" adaptation. Set-point adaptation balances tonic activity so that reciprocally acting, agonist and antagonist muscles have a stable platform from which to launch accurate movements. Here, we use the vestibulo-ocular reflex-a simple behavior that stabilizes the position of the eye while the head is moving-to investigate how tonic activity is adapted toward a new set point to prevent eye drift when the head is still [3, 4]...
May 23, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27075643/eye-movement-and-vestibular-dysfunction-in-mitochondrial-a3243g-mutation
#14
Sung-Hee Kim, Ziyoda Abdulkhaevna Akbarkhodjaeva, Ileok Jung, Ji-Soo Kim
Studying eye movements and vestibular function would provide insights into brain networks that are vulnerable in mitochondrial disorders. We sought eye movement and vestibular abnormalities in three Korean patients with a mitochondrial A3243G point mutation. The patients suffered from vertigo and imbalance during the stroke-like and seizure episodes from lesions involving the posterior cerebral cortex, which were accompanied by bilateral saccadic hypermetria and horizontal gaze-evoked nystagmus. Furthermore, two patients showed bilateral impairments of the vestibulo-ocular reflex during head impulses for the horizontal and posterior canals on both sides in the absence of caloric paresis...
July 2016: Neurological Sciences
https://www.readbyqxmd.com/read/26934788/-vestibular-function-after-repeated-space-flights
#15
I A Naumov, L N Kornilova, D O Glukhikh, A S Pavlova, E V Khabarova, G A Ekimovsky, A V Vasin
Results of the vestibular function testing of 32 cosmonauts on return from repeated 125- to 215-day space flights (SF) on the International space station are presented. The cosmonauts were tested twice before flight (baseline data collection) and on days 1-2, 4-5 and 8-9 after landing. Electro- and video-oculography were used to register simultaneously eye and head movements. It was found that deadaptation following a repeated stay in long-duration SF takes statistically much shorter time. Most often, atypical vestibular disorders and changed patterns of the otolith-semicircular canal interaction are observed in cosmonauts who have made their maiden flights to microgravity...
2015: Aviakosmicheskaia i Ekologicheskaia Meditsina, Aerospace and Environmental Medicine
https://www.readbyqxmd.com/read/26918638/hippocampal-gray-matter-volume-in-bilateral-vestibular-failure
#16
Martin Göttlich, Nico M Jandl, Andreas Sprenger, Jann F Wojak, Thomas F Münte, Ulrike M Krämer, Christoph Helmchen
Bilateral vestibular failure (BVF) is a severe chronic disorder of the labyrinth or the eighth cranial nerve characterized by unsteadiness of gait and disabling oscillopsia during head movements. According to animal data, vestibular input to the hippocampus is proposed to contribute to spatial memory and spatial navigation. Except for one seminal study showing the association of impaired spatial navigation and hippocampal atrophy, patient data in BVF are lacking. Therefore, we performed a voxel-wise comparison of the hippocampal gray matter volume (GMV) in a clinically representative sample of 27 patients with incomplete BVF and 29 age- and gender-matched healthy controls to test the hypothesis of hippocampal atrophy in BVF...
May 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/26890428/anticompensatory-quick-eye-movements-after-head-impulses-a-peripheral-vestibular-sign-in-spontaneous-nystagmus
#17
L Luis, N Lehnen, E Muñoz, M de Carvalho, E Schneider, J Valls-Solé, J Costa
BACKGROUND: Differentiating central from peripheral origins of spontaneous nystagmus (SN) is challenging. Looking for a simple sign of peripheral disease with the video Head Impulsive Test we noticed anti-compensatory eye movements (AQEM) in patients with peripheral etiologies of spontaneous nystagmus (SN). Here we assess the diagnostic accuracy of AQEM in differentiating peripheral from central vestibular disorders. METHODS: We recorded the eye movements in response to horizontal head impulses in a group of 43 consecutive patients with acute vestibular syndrome (12 with central, 31 with peripheral disorders), 5 patients after acute vestibular neurectomy (positive controls) and 39 healthy subjects (negative controls)...
2016: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/26878121/bilateral-posterior-semi-circular-canal-obliteration-surgery-for-refractory-benign-paroxysmal-positional-vertigo-bppv-in-three-patients
#18
Sudip Das, Peter A Rea
Benign paroxysmal positional vertigo (BPPV) is a common cause of peripheral vestibular disorder(1) characterised by a short lasting rotatory vertigo triggered by movement of the head. Unilateral posterior canal plugging has become an accepted, if uncommonly used, method of treating intractable cases. However there is very limited experience of bilateral posterior canal plugging. When the current series of cases began, there were no cases reported in the literature. Two small series have since been reported from America and Australia...
February 15, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/26864309/task-specific-balance-training-improves-the-sensory-organisation-of-balance-control-in-children-with-developmental-coordination-disorder-a-randomised-controlled-trial
#19
Shirley S M Fong, X Guo, Karen P Y Liu, W Y Ki, Lobo H T Louie, Raymond C K Chung, Duncan J Macfarlane
Sensory organisation of balance control is compromised in children with developmental coordination disorder (DCD). A randomised controlled trial involving 88 children with DCD was conducted to evaluate the efficacy of a task-specific balance training (functional-movement training, FMT) programme in improving balance deficits in a DCD population. The DCD participants were randomly assigned to either a FMT group or a control group. The FMT group received two training sessions/ week for 3 months. Measurements of the participants' sensory organisation (somatosensory, vestibular and visual ratios), balance and motor proficiency (Movement Assessment Battery for Children, MABC scores) and center of pressure sway velocity (Unilateral Stance Test, UST scores) were taken at baseline, immediately after FMT and 3 months after FMT...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26755003/gaze-disorders-a-clinical-approach
#20
Pulikottil Wilson Vinny, Vivek Lal
A single clear binocular vision is made possible by the nature through the oculomotor system along with inputs from the cortical areas as well their descending pathways to the brainstem. Six systems of supranuclear control mechanisms play a crucial role in this regard. These are the saccadic system, the smooth pursuit system, the vestibular system, the optokinetic system, the fixation system, and the vergence system. In gaze disorders, lesions at different levels of the brain spare some of the eye movement systems while affecting others...
January 2016: Neurology India
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