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https://www.readbyqxmd.com/read/28634856/estrogen-receptor-%C3%AE-gene-polymorphism-and-vascular-complications-in-girls-with-type-1-diabetes-mellitus
#1
Bartosz Słomiński, Jolanta Myśliwska, Monika Ryba-Stanisławowska, Maria Skrzypkowska, Małgorzata Myśliwiec
The effect of estrogens is mediated by activation of estrogen receptors (ERs). Because ER-α gene polymorphisms may exert different effects in childhood, we analyzed the associations between the IVS1 -397T>C (PvuII) polymorphism and systemic inflammatory state, proangiogenic factors, frequency of monocyte subsets, lipid profile, blood pressure, and vascular complications in girls with type 1 diabetes mellitus (DM1). We examined 180 young girls with DM1 and 120 healthy age-matched controls. The analysis concerned PvuII polymorphism of the ER-α gene as well as the levels of serum inflammatory markers (CRP, IL-6, TNF-α), proangiogenic factors (VEGF, angiogenin), 17β-estradiol, values of monocyte subsets (CD14(++)CD16(-) and CD14(+)CD16(+)), lipid profile, and blood pressure...
June 20, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28627612/targeted-inhibition-of-endoplasmic-reticulum-stress-new-hope-for-renal-fibrosis-review
#2
Ben Ke, Na Zhu, Fuli Luo, Yang Xu, Xiangdong Fang
Chronic kidney disease (CKD) has a very high mortality rate and remains a global health challenge. Inhibiting renal fibrosis is one of the most promising therapeutic strategies for CKD. Recent studies have indicated that endoplasmic reticulum stress (ERS) serves an active role in the development of acute and chronic kidney disease, especially with regards to renal fibrosis. In the current review, the authors summarize the latest understanding of the role of ERS during the onset of renal fibrosis. ERS promotes renal fibrosis through multiple signaling pathways, such as transforming growth factor‑β, epithelial‑mesenchymal transition and oxidative stress...
June 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28625882/analysis-of-sarcoidosis-in-the-oporto-region-portugal
#3
A V Cardoso, P C Mota, N Melo, S Guimarães, C Souto Moura, J M Jesus, R Cunha, A Morais
BACKGROUND: Sarcoidosis is a systemic granulomatous disease of unknown etiology. Epidemiological studies of different populations are essential because clinical presentation, organ involvement, disease severity, and prognosis vary significantly according to region and population. The aim of this study was to assess epidemiological and clinical characteristics, staging factors, and clinical course in patients with sarcoidosis from a tertiary hospital in Oporto, Portugal. METHODS: A retrospective analysis of patients with sarcoidosis and at least 2 years of follow-up evaluated at the Centro Hospitalar de São João between 2000 and 2014...
June 15, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28625634/imaging-features-of-tsct-predict-the-classification-of-pulmonary-preinvasive-lesion-minimally-and-invasive-adenocarcinoma-presented-as-ground-glass-nodules
#4
Yinan Liu, Hui Sun, Fei Zhou, Chunxia Su, Guanghui Gao, Shengxiang Ren, Caicun Zhou, Zhemin Zhang, Jingyun Shi
OBJECTIVES: To comprehensively investigate the role of thin section computed tomography(TSCT) features to distinguish invasive adenocarcinoma(IA) from preinvasive or minimally invasive adenocarcinoma(MIA) appearing as pure or mixed ground glass nodules (pGGNs, mGGNs), and to distinguish adenocarcinoma in situ (AIS) from atypical adenomatous hyperplasia (AAH) in pGGNs. MATERIALS AND METHODS: Three hundred thirteen patients with 334 pathologically diagnosed GGNs according to the 2011 IASLC/ATS/ERS classification were included into this study...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28622568/per-protocol-investigation-of-a-best-practice-exercise-referral-scheme
#5
L Stewart, E Dolan, P Carver, P A Swinton
OBJECTIVES: To investigate the effects of an exercise referral scheme (ERS) aligned to the UK best practice guidelines on a range of outcomes including those associated with key health concerns of the Scottish population. STUDY DESIGN: A longitudinal design with data collection at three time points (baseline, midway and post) during a 12-week ERS intervention was employed. METHODS: Health-related physical fitness was assessed through measurement of resting heart rate, blood pressure, FEV1:FEV6 (ratio of forced expiratory volume over one [FEV1] and six [FEV6] seconds), body mass and peak oxygen uptake (VO2 peak), whilst functional capacity was assessed through the five times sit to stand test...
June 12, 2017: Public Health
https://www.readbyqxmd.com/read/28620427/ers-noninvasive-ventilation-course-basic-concepts
#6
EDITORIAL
Bernd Schönhofer, Nicholas Hart, Raffaele Scala, Ries van den Biggelaar, Farah Idrees
Faculty and delegates of the @ERStalk course on basic concepts in NIV describe their experiences http://ow.ly/zUPn30b7jLb.
June 2017: Breathe
https://www.readbyqxmd.com/read/28616286/severe-and-uncontrolled-asthma-in-china-a-cross-sectional-survey-from-the-australasian-severe-asthma-network
#7
Gang Wang, Fang Wang, Peter G Gibson, Michael Guo, Wei-Jie Zhang, Peng Gao, Hong-Ping Zhang, Erin S Harvey, Hui Li, Jie Zhang
BACKGROUND: Severe asthma is largely unexplored in the Chinese population. Patients with asthma underwent systematic evaluation, by investigating the characteristics of uncontrolled asthma and of asthma treated with three different controller therapies. METHODS: This multi-centre, real-world study was conducted from March 2014 to September 2015. Adults with stable asthma underwent assessment of medication use, asthma control, quality of life, psychological symptoms, work productivity and activity impairment, bronchodilator response and sputum induction...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28616268/tumor-invasiveness-defined-by-iaslc-ats-ers-classification-of-ground-glass-nodules-can-be-predicted-by-quantitative-ct-parameters
#8
Qian-Jun Zhou, Zhi-Chun Zheng, Yong-Qiao Zhu, Pei-Ji Lu, Jia Huang, Jian-Ding Ye, Jie Zhang, Shun Lu, Qing-Quan Luo
BACKGROUND: To investigate the potential value of CT parameters to differentiate ground-glass nodules between noninvasive adenocarcinoma and invasive pulmonary adenocarcinoma (IPA) as defined by IASLC/ATS/ERS classification. METHODS: We retrospectively reviewed 211 patients with pathologically proved stage 0-IA lung adenocarcinoma which appeared as subsolid nodules, from January 2012 to January 2013 including 137 pure ground glass nodules (pGGNs) and 74 part-solid nodules (PSNs)...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28616142/alkene-hydrogenation-activity-of-enoate-reductases-for-an-environmentally-benign-biosynthesis-of-adipic-acid
#9
Jeong Chan Joo, Anna N Khusnutdinova, Robert Flick, Taeho Kim, Uwe T Bornscheuer, Alexander F Yakunin, Radhakrishnan Mahadevan
Adipic acid, a precursor for Nylon-6,6 polymer, is one of the most important commodity chemicals, which is currently produced from petroleum. The biosynthesis of adipic acid from glucose still remains challenging due to the absence of biocatalysts required for the hydrogenation of unsaturated six-carbon dicarboxylic acids to adipic acid. Here, we demonstrate the first enzymatic hydrogenation of 2-hexenedioic acid and muconic acid to adipic acid using enoate reductases (ERs). ERs can hydrogenate 2-hexenedioic acid and muconic acid producing adipic acid with a high conversion rate and yield in vivo and in vitro...
February 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28615710/an-alternative-conformation-of-er%C3%AE-bound-to-estradiol-reveals-h12-in-a-stable-antagonist-position
#10
Paulo C T Souza, Larissa C Textor, Denise C Melo, Alessandro S Nascimento, Munir S Skaf, Igor Polikarpov
The natural ligand 17β-estradiol (E2) is so far believed to induce a unique agonist-bound active conformation in the ligand binding domain (LBD) of the estrogen receptors (ERs). Both subtypes, ERα and ERβ, are transcriptionally activated in the presence of E2 with ERβ being somewhat less active than ERα under similar conditions. The molecular bases for this intriguing behavior are mainly attributed to subtype differences in the amino-terminal domain of these receptors. However, structural details that confer differences in the molecular response of ER LBDs to E2 still remain elusive...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28615037/high-sensitivity-and-negative-predictive-value-of-the%C3%A2-detect-algorithm-for-an-early-diagnosis-of-pulmonary-arterial-hypertension-in-systemic-sclerosis-application-in-a-single-center
#11
Alfredo Guillén-Del Castillo, Eduardo L Callejas-Moraga, Gabriela García, José F Rodríguez-Palomares, Antonio Román, Cristina Berastegui, Manuel López-Meseguer, Enric Domingo, Vicente Fonollosa-Plá, Carmen Pilar Simeón-Aznar
BACKGROUND: Pulmonary arterial hypertension (PAH) is one of the most relevant causes of death in systemic sclerosis. The aims of this study were to analyse the recently published DETECT algorithm comparing it with European Society of Cardiology/European Respiratory Society (ESC/ERS) 2009 guidelines: as screening of PAH; (2) identifying median pulmonary arterial pressure (mPAP) ≥21 mmHg; and (3) determining any group of pulmonary hypertension (PH). METHODS: Eighty-three patients fulfilling LeRoy's systemic sclerosis diagnostic criteria with at least right heart catheterization were studied retrospectively...
June 14, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28612709/potential-phytoestrogen-alternatives-exert-cardio-protective-mechanisms-via-estrogen-receptors
#12
Marthandam Asokan Shibu, Wei-Wen Kuo, Chia-Hua Kuo, Cecilia-Hsuan Day, Chia-Yao Shen, Li-Chin Chung, Chao-Hung Lai, Lung-Fa Pan, V Vijaya Padma, Chih-Yang Huang
The 17 beta-estradiol (E2) is a sex hormone that is most abundant and most active estrogen in premenopausal women. The importance of E2 in providing cardioprotection and reducing the occurrence of heart disease in women of reproductive age has been well recognized. There are three subtype of estrogen receptors (ERs), including ERα, ERβ and GPR30 have been identified and accumulating evidence reveal their roles on E2-mediated genomic and nongenomic pathway in cardiomyocytes against various cardiac insults...
June 2017: BioMedicine
https://www.readbyqxmd.com/read/28603066/differential-gene-expression-profiles-according-to-the-iaslc-ats-ers-histopathological-classification-in-lung-adenocarcinoma-subtypes
#13
Camilo Molina-Romero, Claudia Rangel-Escareño, Alette Ortega-Gómez, Gerardo J Alanis-Funes, Alejandro Aviles-Salas, Federico Avila-Moreno, Gabriela E Mercado, Andres F Cardona, Alfredo Hidalgo-Miranda, Oscar Arrieta
The current lung cancer classification from the Association for the Study of Lung Cancer (IASLC) / the American Thoracic Society (ATS)/ the European Respiratory Society (ERS) has considerably changed the pathologic diagnosis of lung invasive adenocarcinoma, identifying disease subtypes with substantial implications for medical practice, such as clinical, radiological, molecular and prognostic differences. We analyzed the differences in the genetic expression of adenocarcinoma subtypes according to the new classification...
June 8, 2017: Human Pathology
https://www.readbyqxmd.com/read/28601489/is-the-subscapularis-normal-after-the-open-latarjet-procedure-an-isokinetic-and-magnetic-resonance-imaging-evaluation
#14
Alexandre Caubère, Damien Lami, Pascal Boileau, Sébastien Parratte, Matthieu Ollivier, Jean-Noël Argenson
BACKGROUND: The Latarjet procedure is considered to be a violation of the subscapularis muscle. This study evaluated the postoperative status of the subscapularis through isokinetic and magnetic resonance imaging analysis after splitting. We hypothesized that compared with a healthy contralateral shoulder, there would be satisfactory recovery of subscapularis strength at the cost of some fatigability and some mild fatty infiltration. MATERIALS AND METHODS: This was a case-control retrospective study of patients who underwent a Latarjet procedure between January 2013 and January 2015...
June 7, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28597596/new-roles-for-neuronal-estrogen-receptors
#15
REVIEW
C-L Lu, C Herndon
Estrogens encompass steroid hormones which display physiological roles not only in the female reproductive system but also in other organ systems of non-reproductive controls, including the peripheral and central nervous systems. Traditionally, estrogen signals in neurons through a "genomic pathway": binding to estrogen receptors (ERs) which then interact with nuclear estrogen response elements to initiate transcription. This effect is usually delayed at onset (within several hours to days) and prolonged in duration...
July 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28593420/does-the-histologic-predominance-of-pathological-stage-ia-lung-adenocarcinoma-influence-the-extent-of-resection
#16
Hiroyuki Ito, Haruhiko Nakayama, Shuji Murakami, Tomoyuki Yokose, Kayoko Katayama, Yoshihiro Miyata, Morihito Okada
OBJECTIVES: We studied whether histologic subtype according to the new IASLC/ATS/ERS adenocarcinoma classification influences the extent of resection in patients with pathological stage IA lung adenocarcinoma. METHODS: Data on 288 patients with pathological stage IA lung adenocarcinoma were analyzed retrospectively. Recurrence-free survival (RFS) rates were compared according to clinicopathological characteristics, including predominant histologic subtype and extent of resection...
June 7, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28592342/treatment-of-obsessive-compulsive-disorder-and-excessive-reassurance-seeking-in-an-older-adult-a-single-case-quasi-experimental-design
#17
Brynjar Halldorsson, Paul M Salkovskis
BACKGROUND: Cognitive behavioural interventions for excessive reassurance seeking (ERS) typically focus on encouraging individuals to refrain from seeking any reassurance and in some cases banning caregivers (e.g. family members) from providing it. However, this blanket consideration that reassurance is a bad thing that should simply be stopped may not always be appropriate or helpful. Cognitive behavioural treatment (CBT) targeting ERS by helping the sufferer to shift from seeking reassurance to seeking support may be a promising treatment intervention...
June 8, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28591870/transcriptome-profiling-reveals-bisphenol-a-alternatives-activate-estrogen-receptor-alpha-in-human-breast-cancer-cells
#18
Robin Mesnage, Alexia Phedonos, Matthew Arno, Sucharitha Balu, J Christopher Corton, Michael N Antoniou
Plasticizers with estrogenic activity, such as bisphenol A (BPA), have potential adverse health effects in humans. Due to mounting evidence of these health effects, BPA is being phased out and replaced by other bisphenol variants in "BPA-free" products. We have compared estrogenic activity of BPA to 6 bisphenol analogues (bisphenol S, BPS; bisphenol F, BPF; bisphenol AP, BPAP; bisphenol AF, BPAF; bisphenol Z, BPZ; bisphenol B, BPB) in three human breast cancer cell lines. Estrogenicity was assessed (10-11M to 10-4M) by cell growth in an estrogen receptor (ER)-mediated cell proliferation assay, and by the induction of estrogen response element-mediated transcription in a luciferase assay...
June 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28588640/compounds-from-cynomorium-songaricum-with-estrogenic-and-androgenic-activities-suppress-the-oestrogen-androgen-induced-bph-process
#19
Xueni Wang, Rui Tao, Jing Yang, Lin Miao, Yu Wang, Jose Edouard Munyangaju, Nuttapong Wichai, Hong Wang, Yan Zhu, Erwei Liu, Yanxu Chang, Xiumei Gao
OBJECTIVE: To investigate the phytoestrogenic and phytoandrogenic activities of compounds isolated from CS and uncover the role of CS in prevention of oestrogen/androgen-induced BPH. METHODS: Cells were treated with CS compounds, and immunofluorescence assay was performed to detect the nuclear translocation of ERα or AR in MCF-7 or LNCaP cells; luciferase reporter assay was performed to detect ERs or AR transcriptional activity in HeLa or AD293 cells; MTT assay was performed to detect the cell proliferation of MCF-7 or LNCaP cells...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28588554/female-reproductive-factors-and-differentiated-thyroid-cancer
#20
REVIEW
Mariacarla Moleti, Giacomo Sturniolo, Maria Di Mauro, Marco Russo, Francesco Vermiglio
Differentiated thyroid cancer (DTC) is markedly more common in women than men, the highest female-to-male ratio being recorded during the reproductive period. This evidence has led to the suggestion that female hormonal and reproductive factors may account for the observed DTC gender disparity. This review focuses on current evidence on the risk of DTC in conjunction with major female reproductive factors, including the impact of pregnancy on DTC occurrence and progression/recurrence. Overall, studies exploring the link between the risk of DTC and menstrual and menopausal factors, oral contraceptives and/or hormone replacement therapy, showed these associations, if any, to be generally weak...
2017: Frontiers in Endocrinology
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