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https://www.readbyqxmd.com/read/29688551/making-a-move-in-exercise-referral-co-development-of-a-physical-activity-referral-scheme
#1
B J R Buckley, D H J Thijssen, R C Murphy, L E F Graves, G Whyte, F B Gillison, D Crone, P M Wilson, P M Watson
Background: Translational research is required to ensure exercise referral schemes (ERSs) are evidence-based and reflect local needs. This article reports process data from the co-development phase of an ERS, providing an insight into (i) factors that must be considered when translating evidence to practice in an ERS setting, and (ii) challenges and facilitators of conducting participatory research involving multiple stakeholders. Methods: An ERS was iteratively co-developed by a multidisciplinary stakeholder group (commissioners, managers, practitioners, patients and academics) via five participatory meetings and an online survey...
April 24, 2018: Journal of Public Health
https://www.readbyqxmd.com/read/29687876/the-intervention-of-enalapril-maleate-and-folic-acid-tablet-on-the-expressions-of-the-grp78-and-chop-and-vascular-remodeling-in-the-vascular-smooth-muscle-cells-of-h-hypertensive-rats-with-homocysteine
#2
F Lu, L-Y Zhao, Z-M Zhang, Q Zou, X-L Yu, C-Y Wei
OBJECTIVE: GRP78 and CHOP play essential roles in endoplasmic reticulum stress (ERS) of the vascular smooth muscle cells. We aim to investigate the effect of enalapril maleate and folic acid tablet on the expressions of GRP78 and CHOP and vascular remodeling in a homocysteine (HCY)-treated hypertensive rat model. MATERIALS AND METHODS: The hypertensive rat model was established with the technique of coarctation in the abdominal aorta, and the blood pressure of the rat was measured with the non-destructive tail-cuff method two weeks after operation...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29682154/-ginkgo-biloba-leaf-extract-protects-against-myocardial-injury-via-attenuation-of-endoplasmic-reticulum-stress-in-streptozotocin-induced-diabetic-apoe-mice
#3
Jinfan Tian, Yanfei Liu, Yue Liu, Keji Chen, Shuzheng Lyu
Diabetes was induced in high-fat diet-fed ApoE-/- mice via administration of low-dose streptozotocin (STZ) for five days. Mice were then treated with GBE (200 or 400 mg/kg) by gastric gavage daily for 12 weeks. Mice in the untreated diabetic group received saline instead, and nondiabetic C57BL/6J mice served as controls. Collagen І and ІІІ mRNA expression was measured by real-time PCR. TNF- α , IL-1 β mRNA levels, and NF- κ B expression were determined to analyze intramyocardial inflammation. Hallmarks of endoplasmic reticulum stress- (ERS-) related apoptosis pathways, including phosphorylated c-Jun N-terminal kinase (p-JNK), C/EBP homologous protein (CHOP), caspase-12, and cleaved caspase-3, were analyzed by Western blotting...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29681759/impacts-of-a-large-boreal-wildfire-on-ground-level-atmospheric-concentrations-of-pahs-vocs-and-ozone
#4
Gregory R Wentworth, Yayne-Abeba Aklilu, Matthew S Landis, Yu-Mei Hsu
During May 2016 a very large boreal wildfire burned throughout the Athabasca Oil Sands Region (AOSR) in central Canada, and in close proximity to an extensive air quality monitoring network. This study examines speciated 24-h integrated polycyclic aromatic hydrocarbon (PAH) and volatile organic compound (VOC) measurements collected every sixth day at four and seven sites, respectively, from May to August 2016. The sum of PAHs (ΣPAH) was on average 17 times higher in fire-influenced samples (852 ng m-3 , n = 8), relative to non-fire influenced samples (50 ng m-3 , n = 64)...
April 2018: Atmospheric Environment
https://www.readbyqxmd.com/read/29679599/mortality-in-pulmonary-arterial-hypertension-patients-treated-with-continuous-prostanoids
#5
S D Bartolome, N Sood, T S Shah, K Styrvoky, F T Torres, K M Chin
INTRODUCTION: Parenteral prostanoids are considered the treatment of choice for patients with severe pulmonary arterial hypertension (PAH). Prognostic studies for patients treated in the modern era are limited. METHODS: In this retrospective cohort study, patients initiating IV epoprostenol or IV or SC treprostinil therapy for PAH from 2007-2016 at UT Southwestern, Dallas, TX and Ohio State University, Columbus, OH were included. Transplant-free survival was assessed from the time of IV/SC initiation and from the time of first follow-up...
April 18, 2018: Chest
https://www.readbyqxmd.com/read/29678945/ers-ecdc-statement-european-union-standards-for-tuberculosis-care-2017-update
#6
G B Migliori, G Sotgiu, S Rosales-Klintz, R Centis, L D'Ambrosio, I Abubakar, G Bothamley, J A Caminero, D M Cirillo, M Dara, G de Vries, S Aliberti, A T Dinh-Xuan, R Duarte, F Midulla, I Solovic, D Subotic, M Amicosante, A M Correira, A Cirule, G Gualano, H Kunst, F Palmieri, V Riekstina, S Tiberi, R Verduin, M J van der Werf
The International Standards for Tuberculosis (TB) Care define the essential level of care for managing patients who have or are presumed to have TB, or are at increased risk of developing the disease. The resources and capacity in the European Union and the European Economic Area (EU/EEA) permit higher standards of care to secure quality and timely TB diagnosis, prevention and treatment. On this basis, the European Union Standards for Tuberculosis Care (ESTC) were published in 2012 as standards specifically tailored to the EU-setting...
April 20, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29678396/time-to-peak-torque-and-acceleration-time-are-altered-in-male-patients-following-traumatic-shoulder-instability
#7
Jin Hyuck Lee, Ji Soon Park, Hyun Jung Hwang, Woong Kyo Jeong
BACKGROUND: Numerous authors have evaluated the strength of the rotator cuff muscles in patients with shoulder instability. However, only limited data are available with regard to neuromuscular control in patients with traumatic anterior shoulder instability, in particular at 90° of abduction. This study was designed to assess muscle strength and neuromuscular control ability using time to peak torque and acceleration time in nonathletic patients with traumatic anterior shoulder instability...
April 17, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29677675/nitrogen-use-efficiency-and-crop-production-patterns-of-regional-variation-in-the-united-states-1987-2012
#8
Dennis P Swaney, Robert W Howarth, Bongghi Hong
National-level summaries of crop production and nutrient use efficiency, important for international comparisons, only partially elucidate agricultural dynamics within a country. Agricultural production and associated environmental impacts in large countries vary significantly because of regional differences in crops, climate, resource use and production practices. Here, we review patterns of regional crop production, nitrogen use efficiency (NUE), and major inputs of nitrogen to US crops over 1987-2012, based on the Farm Resource Regions developed by the Economic Research Service (USDA-ERS)...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29677166/in-vitro-identification-of-new-transcriptomic-and-mirnomic-profiles-associated-with-pulmonary-fibrosis-induced-by-high-doses-everolimus-looking-for-new-pathogenetic-markers-and-therapeutic-targets
#9
Simona Granata, Gloria Santoro, Valentina Masola, Paola Tomei, Fabio Sallustio, Paola Pontrelli, Matteo Accetturo, Nadia Antonucci, Pierluigi Carratù, Antonio Lupo, Gianluigi Zaza
The administration of Everolimus (EVE), a mTOR inhibitor used in transplantation and cancer, is often associated with adverse effects including pulmonary fibrosis. Although the underlying mechanism is not fully clarified, this condition could be in part caused by epithelial to mesenchymal transition (EMT) of airway cells. To improve our knowledge, primary bronchial epithelial cells (BE63/3) were treated with EVE (5 and 100 nM) for 24 h. EMT markers (α-SMA, vimentin, fibronectin) were measured by RT-PCR. Transepithelial resistance was measured by Millicell-ERS ohmmeter...
April 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29672880/enamel-renal-syndrome-case-report
#10
Luiz Henrique Soares Torres, Sérgio Lins de-Azevedo-Vaz, Danielle Resende Camisasca Barroso, Daniela Nascimento Silva, Tânia Regina Grão Velloso, Liliana Aparecida Pimenta de Barros
AIMS: to describe a case in which dental changes were observed and investigation proceeded to consider Enamel-Renal-Syndrome (ERS), a rare disorder that associates amelogenesis imperfecta with nephrocalcinosis. CASE REPORT: an 11-year-old male patient upon intraoral examination revealed generalized gingival hyperplasia, a few teeth were absent clinically and the remaining ones were yellowish-brown in color. The enamel alterations were suggesting of amelogenesis imperfecta...
April 19, 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29670516/the-effects-of-fluency-enhancing-conditions-on-sensorimotor-control-of-speech-in-typically-fluent-speakers-an-eeg-mu-rhythm-study
#11
Tiffani Kittilstved, Kevin J Reilly, Ashley W Harkrider, Devin Casenhiser, David Thornton, David E Jenson, Tricia Hedinger, Andrew L Bowers, Tim Saltuklaroglu
Objective : To determine whether changes in sensorimotor control resulting from speaking conditions that induce fluency in people who stutter (PWS) can be measured using electroencephalographic (EEG) mu rhythms in neurotypical speakers. Methods : Non-stuttering (NS) adults spoke in one control condition (solo speaking) and four experimental conditions (choral speech, delayed auditory feedback (DAF), prolonged speech and pseudostuttering). Independent component analysis (ICA) was used to identify sensorimotor μ components from EEG recordings...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29665822/toxoplasma-gondii-dense-granule-protein-15-induces-apoptosis-in-choriocarcinoma-jeg-3-cells-through-endoplasmic-reticulum-stress
#12
Wei Wei, Fangfang Zhang, He Chen, Yuanyuan Tang, Tian Xing, Qingli Luo, Li Yu, Jian Du, Jilong Shen, Linjie Zhang
BACKGROUND: Toxoplasma gondii, a single-celled parasite commonly found in mammals, has been shown to induce trophoblast cell apoptosis and subsequently cause fetal damage and abortion. Although dense granule protein 15 (GRA15) has been identified as a key component in innate immunity to T. gondii infection and its pathogenesis, its role in host cell apoptosis remains unclarified. METHODS: Type II GRA15 (GRA15II ) cDNA was inserted into a plasmid encoding enhanced green fluorescent protein (pEGFP)...
April 17, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29665051/hyperbaric-oxygen-treatment-sensitizes-gastric-cancer-cells-to-melatonin-induced-apoptosis-through-multiple-pathways
#13
Xiang Wei, Yinliang Qi, Ning Jia, Qing Zhou, Sumei Zhang, Yuan Wang
Although extensive efforts have been made in recent decades to treat advanced gastric cancer with comprehensive therapy based on chemotherapy, effective anti-gastric cancer therapeutics are still lacking in the clinics. Therefore, potent novel anti-gastric cancer ways are greatly needed. Here, we explored hyperbaric oxygen treatment as a novel and effective adjuvant treatment method which has anti-gastric cancer effects when used together with melatonin. When performed together with MLT, HBO effectively inhibited tumorigenicity of gastric cancer through selectively inducing a robust tumor suppressive apoptosis response...
April 17, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29665007/protective-effect-of-mir378-on-doxorubicin-induced-cardiomyocyte-injury-via-calumenin
#14
Yu Wang, Xiaoxue Cui, Yilin Wang, Yao Fu, Xin Guo, Jie Long, Chengxi Wei, Ming Zhao
Doxorubicin (Dox) is a highly effective antitumor antibiotic, however myocardial toxicity severely limits its use clinically. The pathogenesis of doxorubicin-induced cardiomyopathy is unclear. In Dox cardiomyopathy mice, there is a decline in cardiac function, a change in myocardial pathology and a reduction in miR378* expression. Expression changes in calumenin, an endoplasmic reticulum stress (ERS) chaperone protein and pathway factor, as well as apoptosis, were observed in cardiomyocytes after doxorubicin-induced injury...
April 17, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29663989/-high-mobility-group-box-1-contributes-to-the-endoplasmic-reticulum-stress-of-liver-in-rats-with-trauma
#15
Qingjie Zhang, Jianfeng Lu, Xuehao Li, Yichang Liu, Guoqing Liu, Xinhua Han, Zhenyong Gu
OBJECTIVE: To investigate the role of high mobility group box 1 (HMGB1) in hepatic endoplasmic reticulum stress (ERS) in rats with trauma. METHODS: Sixty SPF Sprague-Dawley (SD) rats were randomly divided into groups (n = 6). The rat model of liver injury following traumatic stress was established by continuous compressing the bilateral hind-limbs of rats for 3 hours and then intermittent compressing and decompressing for 30 minutes respectively three times with standard weight of 15 kg...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29662238/structural-underpinnings-of-oestrogen-receptor-mutations-in-endocrine-therapy-resistance
#16
REVIEW
John A Katzenellenbogen, Christopher G Mayne, Benita S Katzenellenbogen, Geoffrey L Greene, Sarat Chandarlapaty
Oestrogen receptor-α (ERα), a key driver of breast cancer, normally requires oestrogen for activation. Mutations that constitutively activate ERα without the need for hormone binding are frequently found in endocrine-therapy-resistant breast cancer metastases and are associated with poor patient outcomes. The location of these mutations in the ER ligand-binding domain and their impact on receptor conformation suggest that they subvert distinct mechanisms that normally maintain the low basal state of wild-type ERα in the absence of hormone...
April 16, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29662122/shallow-deformation-of-the-san-andreas-fault-5-years-following-the-2004-parkfield-earthquake-mw6-combining-ers2-and-envisat-insar
#17
Guillaume Bacques, Marcello de Michele, Daniel Raucoules, Hideo Aochi, Frédérique Rolandone
This study focuses on the shallow deformation that occurred during the 5 years following the Parkfield earthquake (28/09/2004, Mw 6, San Andreas Fault, California). We use Synthetic Aperture Radar interferometry (InSAR) to provide precise measurements of transient deformations after the Parkfield earthquake between 2005 and 2010. We propose a method to combine both ERS2 and ENVISAT interferograms to increase the temporal data sampling. Firstly, we combine 5 years of available Synthetic Aperture Radar (SAR) acquisitions including both ERS-2 and Envisat...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29656753/extraction-of-radiomic-values-from-lung-adenocarcinoma-with-near-pure-subtypes-in-the-international-association-for-the-study-of-lung-cancer-the-american-thoracic-society-the-european-respiratory-society-iaslc-ats-ers-classification
#18
Shun-Mao Yang, Li-Wei Chen, Hao-Jen Wang, Leng-Rong Chen, Kuo-Lung Lor, Yi-Chang Chen, Mong-Wei Lin, Min-Shu Hsieh, Jin-Shing Chen, Yeun-Chung Chang, Chung-Ming Chen
INTRODUCTION: Histological subtypes of lung adenocarcinomas (ADCs) classified by the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) system have been investigated using radiomic approaches. However, the results have had limitations since <80% of invasive lung ADCs were heterogeneous, with two or more subtypes. To reduce the influence of heterogeneity during radiomic analysis, computed tomography (CT) images of lung ADCs with near-pure ADC subtypes were analyzed to extract representative radiomic features of different subtypes...
May 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29653259/bisphenol-a-and-its-derivatives-decrease-expression-of-chemerin-which-reverses-its-stimulatory-action-in-ovarian-cancer-cells
#19
Marta Hoffmann, Agnieszka Rak, Anna Ptak
Chemerin is an adipocyte-secreted protein that associates with obesity, inflammation, metabolic dysfunction, and carcinogenesis. Previous studies have shown human granulosa cells to produce bioactive chemerin and its receptor CMKLR1. In the present study, we demonstrated that the mRNA level of chemerin receptor is higher in a granulosa cell tumor cell line than in epithelial cancer cells, whereas chemerin expression and secretion were lower. Various exogenous factors, such as bisphenol A and its halogenated derivatives tetrabromobisphenol A and tetrachlorobisphenol A, can affect adipokine expression...
April 10, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29650694/lymphatic-vasculature-requires-er-estrogen-receptor-%C3%AE-signaling-to-protect-from-lymphedema
#20
Florent Morfoisse, Florence Tatin, Benoit Chapût, Nicole Therville, Charlotte Vaysse, Raphael Métivier, Julie Malloizel-Delaunay, Francoise Pujol, Anne-Claire Godet, Fabienne De Toni, Frederic Boudou, Katia Grenier, David Dubuc, Eric Lacazette, Anne-Catherine Prats, Julie Guillermet-Guibert, Francoise Lenfant, Barbara Garmy-Susini
OBJECTIVE: Estrogens exert beneficial effect on the blood vascular system. However, their role on the lymphatic system has been poorly investigated. We studied the protective effect of the 17β estradiol-the most potent endogenous estrogen-in lymphedema-a lymphatic dysfunction, which results in a massive fluid and fat accumulation in the limb. APPROACH AND RESULTS: Screening of DNA motifs able to mobilize ERs (estrogen receptors) and quantitative real-time polymerase chain reaction analysis revealed that estradiol promotes transcriptional activation of lymphangiogenesis-related gene expression including VEGF (vascular endothelial growth factor)-D, VEGFR (VEGF receptor)-3, lyve-1, and HASs (hyaluronan synthases)...
April 12, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
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