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https://www.readbyqxmd.com/read/28340026/high-rate-of-subcutaneous-implantable-cardioverter-defibrillator-sensing-screening-failure-in-patients-with-brugada-syndrome-a-comparison-with-other-inherited-primary-arrhythmia-syndromes
#1
Giulio Conte, Mihoko Kawabata, Carlo de Asmundis, Erika Taravelli, Francesco Petracca, Diego Ruggiero, Maria Luce Caputo, François Regoli, Gian-Battista Chierchia, Alessandra Chiodini, Alessandro Del Bufalo, Tiziano Moccetti, Masahiko Goya, Kenzo Hirao, Alessandro Vicentini, Gaetano M De Ferrari, Pedro Brugada, Angelo Auricchio
Aims: Subcutaneous implantable cardioverter-defibrillator (S-ICD) can avoid important complications associated with transvenous leads in patients with inherited primary arrhythmia syndromes, who do not need pacing therapy. Few data are available on the percentage of patients with inherited arrhythmia syndromes eligible for S-ICD implantation. Aim of this study was to analyse the eligibility for S-ICD in a series of patients with Brugada syndrome (BrS), and to compare it with patients with other channelopathies...
March 7, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339992/rheumatoid-arthritis-specific-cardiovascular-risk-scores-are-not-superior-to-general-risk-scores-a-validation-analysis-of-patients-from-seven-countries
#2
Cynthia S Crowson, Sherine E Gabriel, Anne Grete Semb, Piet L C M van Riel, George Karpouzas, Patrick H Dessein, Carol Hitchon, Virginia Pascual-Ramos, George D Kitas
Objectives.: Cardiovascular disease (CVD) risk calculators developed for the general population do not accurately predict CVD events in patients with RA. We sought to externally validate risk calculators recommended for use in patients with RA including the EULAR 1.5 multiplier, the Expanded Cardiovascular Risk Prediction Score for RA (ERS-RA) and QRISK2. Methods.: Seven RA cohorts from UK, Norway, Netherlands, USA, South Africa, Canada and Mexico were combined...
March 8, 2017: Rheumatology
https://www.readbyqxmd.com/read/28339989/pain-management-strategies-and-health-care-use-in-community-dwelling-individuals-living-with-chronic-pain
#3
Elizabeth G Mann, Ana Johnson, Ian Gilron, Elizabeth G VanDenKerkhof
Objective. : To describe factors associated with high clinic and emergency room (ER) use among individuals with chronic pain. Design. : This study is part of a larger cross-sectional survey on the epidemiology of chronic pain in Canada. The current analysis was guided by the Andersen-Newman Service Utilization Model. Methods. : Respondents (N = 702) were grouped into high (top 10%) and low (bottom 90%) users based on the number of visits made to clinics and ERs over the past year...
March 3, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339396/modulation-of-a%C3%AE-pp-and-gsk3%C3%AE-by-endoplasmic-reticulum-stress-and-involvement-in-alzheimer-s-disease
#4
Xin-Jun Liu, Jun Wei, Ying-Hui Shang, Han-Chang Huang, Feng-Xue Lao
Alzheimer's disease (AD) is a dementia disease with neuronal loss and synaptic impairment. This impairment is caused, at least partly, by the generation of two main AD hallmarks, namely the hyperphosphorylated tau protein comprising neurofibrillary tangles and senile plaques containing amyloid-β (Aβ) peptides. The amyloid-β protein precursor (AβPP) and glycogen synthase kinase-3β (GSK3β) are two main proteins associated with AD and are closely correlated with these hallmarks. Recently, both of the proteins were reported to be modulated by endoplasmic reticulum stress (ERS) and are involved in the pathogenesis of AD...
March 20, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28332606/lumican-effectively-regulates-the-estrogen-receptors-associated-functional-properties-of-breast-cancer-cells-expression-of-matrix-effectors-and-epithelial-to-mesenchymal-transition
#5
Konstantina Karamanou, Marco Franchi, Zoi Piperigkou, Corinne Perreau, Francois-Xavier Maquart, Demitrios H Vynios, Stéphane Brézillon
Lumican is a small leucine-rich proteoglycan that has been shown to contribute in several physiological processes, but also to exert anticancer activity. On the other hand, it has been recently shown that knockdown of the estrogen receptor α (ERα) in low invasive MCF-7 (ERα+) breast cancer cells and the suppression of ERβ in highly aggressive MDA-MB-231 (ERβ+) cells significantly alter the functional properties of breast cancer cells and the gene expression profile of matrix macromolecules related to cancer progression and cell morphology...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28331820/correlation-in-histological-subtypes-with-high-resolution-computed-tomography-signatures-of-early-stage-lung-adenocarcinoma
#6
Yingying Miao, Jianya Zhang, Jiawei Zou, Qingqing Zhu, Tangfeng Lv, Yong Song
BACKGROUND: Uncertainty remains on the association between image characteristics of the nodules in computed tomography (CT) scans and lung adenocarcinoma histopathologic subtypes. We aimed to estimate the correlation between preoperative high resolution computed tomography (HRCT) scan and postoperative histopathology of stage IA lung adenocarcinoma in East Asian Chinese population. METHODS: We retrospectively reviewed the clinical records and HRCT images of 190 patients (106 female and 84 male) with resected, preoperatively untreated stage IA adenocarcinomas...
February 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28324026/gonadotropin-inhibitory-hormone-gnih-the-piscine-ortholog-of-lpxrfa-participates-in-17%C3%AE-estradiol-feedback-in-female-goldfish-reproduction
#7
Xin Qi, Wenyi Zhou, Qingqing Wang, Liang Guo, Danqi Lu, Haoran Lin
Gonadotropin-inhibitory hormone (GnIH) plays a critical role in regulating GnRH, GtH and steroidogenesis in teleosts. In the present study, we sought to determine whether E2 (17β-estradiol) acts directly on GnIH neurons to regulate reproduction in goldfish, a seasonal breeder, and we investigated the role of estrogen receptors in mediating this process. We found that GnIH neurons co-express three types of ERs. Ovariectomy and letrozole implantation into female goldfish at the vitellogenic stage elicited a significant decrease in the expression of GnIH mRNA, and E2 supplementation abolished this effect...
January 4, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323912/sex-hormones-and-cardiometabolic-health-role-of-estrogen-and-estrogen-receptors
#8
Deborah Clegg, Andrea L Hevener, Kerrie L Moreau, Eugenia Morselli, Alfredo Criollo, Rachael E Van Pelt, Victoria J Vieira-Potter
With increased life expectancy, women will spend over three decades of life post-menopause. The menopausal transition increases susceptibility to metabolic diseases such as obesity, diabetes, cardiovascular disease, and cancer. Thus, it is more important than ever to develop effective hormonal treatment strategies to protect aging women. Understanding the role of estrogens, and their biological actions mediated by estrogen receptors (ERs), in the regulation of cardiometabolic health is of paramount importance to discover novel targeted therapeutics...
February 17, 2017: Endocrinology
https://www.readbyqxmd.com/read/28322764/cloning-expression-and-functional-characterization-on-vitellogenesis-of-estrogen-receptors-in-scatophagus-argus
#9
Xue-Fan Cui, Yuan Zhao, Hua-Pu Chen, Si-Ping Deng, Dong-Neng Jiang, Tian-Li Wu, Chun-Hua Zhu, Guang-Li Li
Estrogen receptors (Er) play a critical role in vitellogenesis. Three ers (erα, erβ1 and erβ2) and vitellogenins (vtg-A, vtg-B and vtg-C) subtypes were isolated in various fish species, while the contribution of each Er to the regulation of vtgs expression was not analyzed in detail. Here, erα, erβ1 and erβ2 were cloned and all were found to be expressed in female liver in Scatophagus argus. During proteic vitellogenesis stage, erα was simultaneously up-regulated, while erβ1 and erβ2 were not, with three vtgs in female liver...
March 18, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28306386/perceived-discrimination-among-racial-and-ethnic-minority-drug-users-and-the-association-with-health-care-utilization
#10
Courtney McKnight, Martha Shumway, Carmen L Masson, Enrique R Pouget, Ashly E Jordan, Don C Des Jarlais, James L Sorensen, David C Perlman
People who use drugs (PWUDs) are at increased risk for several medical conditions, yet they delay seeking medical care and utilize emergency departments (EDs) as their primary source of care. Limited research regarding perceived discrimination and PWUDs' use of health care services exists. This study explores the association between interpersonal and institutional racial/ethnic and drug use discrimination in health care settings and health care utilization among respondents (N = 192) recruited from methadone maintenance treatment programs (36%), HIV primary care clinics (35%), and syringe exchange programs (29%) in New York City (n = 88) and San Francisco (n = 104)...
March 17, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/28303170/tbhq-alleviated-endoplasmic-reticulum-stress-apoptosis-and-oxidative-stress-by-perk-nrf2-crosstalk-in-methamphetamine-induced-chronic-pulmonary-toxicity
#11
Yun Wang, Yu-Han Gu, Ming Liu, Yang Bai, Li-Ye Liang, Huai-Liang Wang
Methamphetamine (MA) leads to cardiac and pulmonary toxicity expressed as increases in inflammatory responses and oxidative stress. However, some interactions may exist between oxidative stress and endoplasmic reticulum stress (ERS). The current study is designed to investigate if both oxidative stress and ERS are involved in MA-induced chronic pulmonary toxicity and if antioxidant tertiary butylhydroquinone (TBHQ) alleviated ERS-apoptosis and oxidative stress by PERK-Nrf2 crosstalk. In this study, the rats were randomly divided into control group, MA-treated group (MA), and MA plus TBHQ-treated group (MA + TBHQ)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28296042/nickel-sulfate-induced-apoptosis-via-activating-ros-dependent-mitochondria-and-endoplasmic-reticulum-stress-pathways-in-rat-leydig-cells
#12
Lingyue Zou, Li Su, Yifan Sun, Aijie Han, Xuhong Chang, An Zhu, Fangfang Liu, Jin Li, Yingbiao Sun
Nickel can induce apoptosis of testicular Leydig cells in mice, whereas the mechanisms remain unclear. In this study, we investigated the role of nickel-induced reactive oxygen species (ROS) generation in mitochondria and endoplasmic reticulum stress (ERS) mediated apoptosis pathways in rat Leydig cells. Fluorescent DCF and Annexin-V FITC/PI staining were performed to measure the production of ROS and apoptosis in Leydig cells. RT-qPCR and Western blot were conducted to analyze the key genes and proteins involved in mitochondria and ERS apoptotic pathways...
March 15, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28290612/immunohistochemical-localization-of-sex-hormone-receptors-in-two-raillietina-tapeworms
#13
L Chen, Y M Sun, L Mu, Y Zeng, H Y Li, T H Yang
Sex hormone receptors play critical roles in development and reproduction. However, it is not known whether they exist in Raillietina tapeworms, and if they do, whether they have a similar function to that in vertebrates. We examined the immunohistochemical distributions of androgen receptors (ARs), estrogen receptors (ERs), and progesterone receptors (PRs) in the tissues of two tapeworm species: Raillietina echinobothrida and Raillietina tetragona. Immunopositive ARs were found in the entire reproductive system of R...
March 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28289506/regulation-of-mitochondrial-function-and-endoplasmic-reticulum-stress-by-nitric-oxide-in-pluripotent-stem-cells
#14
REVIEW
Estefania Caballano-Infantes, José Terron-Bautista, Amparo Beltrán-Povea, Gladys M Cahuana, Bernat Soria, Hajji Nabil, Francisco J Bedoya, Juan R Tejedo
Mitochondrial dysfunction and endoplasmic reticulum stress (ERS) are global processes that are interrelated and regulated by several stress factors. Nitric oxide (NO) is a multifunctional biomolecule with many varieties of physiological and pathological functions, such as the regulation of cytochrome c inhibition and activation of the immune response, ERS and DNA damage; these actions are dose-dependent. It has been reported that in embryonic stem cells, NO has a dual role, controlling differentiation, survival and pluripotency, but the molecular mechanisms by which it modulates these functions are not yet known...
February 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/28289455/confidences-de-salon
#15
(no author information available yet)
Maria Bonsignore, Head of ERS Assembly 4, gives an insight into her life http://ow.ly/bt1W3062Qho.
March 2017: Breathe
https://www.readbyqxmd.com/read/28289454/assembly-5-airway-diseases-meet-the-assemblies
#16
Antonio Spanevello
Meet ERS Assembly 5: airway diseases http://ow.ly/M4ou306WbrQ.
March 2017: Breathe
https://www.readbyqxmd.com/read/28289446/continuing-professional-development-introducing-the-ers-international-certificate-in-respiratory-sleep-medicine
#17
EDITORIAL
Sharon Mitchell, Renata L Riha, Gernot Rohde, Anita K Simonds
Certification of specialists in respiratory sleep medicine for the purposes of continuing professional development http://ow.ly/4uX9309g3Hs.
March 2017: Breathe
https://www.readbyqxmd.com/read/28289444/comprehensive-management-of-ventilator-dependent-patients-course-report
#18
EDITORIAL
Nicolino Ambosino, Elena Fatnic
ERS hosted a postgraduate course on comprehensive management of ventilator-dependent patients in Barcelona, Spain http://ow.ly/jYzL306W0l6.
March 2017: Breathe
https://www.readbyqxmd.com/read/28289443/ers-clinical-fellowship-report
#19
EDITORIAL
Aleksandar Yankulov
An ERS clinical fellowship is an excellent opportunity to discover and develop a new field in your medical career http://ow.ly/WmiY306uzUM.
March 2017: Breathe
https://www.readbyqxmd.com/read/28286511/bhbzip60-from-resurrection-plant-boea-hygrometrica-is-an-mrna-splicing-activated-endoplasmic-reticulum-stress-regulator-involved-in-drought-tolerance
#20
Bo Wang, Hong Du, Zhennan Zhang, Wenzhong Xu, Xin Deng
Adverse environmental conditions cause endoplasmic reticulum (ER) stress in plants. To mitigate ER stress damage, ER associated transcription factors and inositol-requiring enzyme-1 (IRE1)-mediated bZIP60 mRNA splicing are activated in plants. A drought-induced gene, encoding the ortholog of AtbZIP60, was identified in the resurrection plant Boea hygrometrica, termed BhbZIP60. In response to ER stress and dehydration, BhbZIP60 mRNA can be spliced to create a frame shift in the C terminus by the excision of 23b segment in a manner of its ortholog in other plants, thus translocating to the nucleus instead of the cytoplasm...
2017: Frontiers in Plant Science
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