Christine Nguyen, Matthew Kudek, Ryan Zander, Hongshen Niu, Jian Shen, Ashley Bauer, Donia Alson, Achia Khatun, Yao Chen, Jie Sun, William Drobyski, Brian T Edelson, Weiguo Cui
In response to acute infection, naive CD4+ T cells primarily differentiate into T helper 1 (Th1) or T follicular helper (Tfh) cells that play critical roles in orchestrating cellular or humoral arms of immunity, respectively. However, despite the well established role of T-bet and BCL-6 in driving Th1 and Tfh cell lineage commitment, respectively, whether additional transcriptional circuits also underlie the fate bifurcation of Th1 and Tfh cell subsets is not fully understood. In this article, we study how the transcriptional regulator Bhlhe40 dictates the Th1/Tfh differentiation axis in mice...
April 15, 2024: Journal of Immunology