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https://www.readbyqxmd.com/read/29231497/-effect-and-postoperative-reactions-of-acupoint-catgut-embedding-for-prediabetes
#1
Ning Xue, Jianbin Zhang, Zhaoxin Xia, Nili Da
OBJECTIVE: To observe the effect and safety of acupoint catgut embedding for prediabetes. METHODS: Eighty-six patients with prediabetes were randomly assigned into an observation group and a control group, 43 cases in each one. Diabetes health education was applied in the two groups. Catgut embedding was used at bilateral Pishu (BL 20), Weiwanxiashu (EX-B 3), Ganshu (BL 18), Shenshu (BL 23), and Zusanli (ST 36) in the observation group, once every 15 days for 6 times...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29229552/caspase-6-is-a-dispensable-enabler-of-adult-mammalian-axonal-degeneration
#2
V Woo, C Cheng, A Duraikannu, A Chandrasekhar, K Purdy, J A Martinez, D W Zochodne
The progress of axonal degeneration (AxD) following injury or insult impacts both recovery from axonal transection and protection of axons from diverse insults, or axonopathy. Here we provide evidence that increases in capase-6 (Casp6) expression and action contribute to the progression of AxD. The expression of Casp6 protein and mRNA in distal branches of sensory axons undergoing AxD was confirmed. We developed and utilized a new model of axonopathy in live mice by serially visualizing the viability of cutaneous axons in the ear pinna that expressed an axonal YFP transgene, in response to capasaicin-induced AxD...
December 8, 2017: Neuroscience
https://www.readbyqxmd.com/read/29226729/formulation-of-sitagliptin-loaded-oral-polymeric-nano-scaffold-process-parameters-evaluation-and-enhanced-anti-diabetic-performance
#3
Mohammed Asadullah Jahangir, Ruqaiyah Khan, Syed Sarim Imam
PURPOSE: The aim of the study to formulate and statistically optimize sitagliptin-loaded eudragit nanoparticles (SIT-NPs) and evaluate the in-vitro pharmaceutical quality and in-vivo anti-diabetic assessment. METHOD: SIT-NPs were prepared by using combination method of solvent evaporation and nano-precipitation techniques. The influence of different independent variables as eudragit RL100 concentration (%), tween 80 concentration (%) and sonication time (min) were evaluated on dependent variables like particle size (nm), drug loading (%) and in-vitro drug release (%)...
December 9, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29225319/effects-of-aerobic-exercise-combined-with-panaxatriol-derived-from-ginseng-on-insulin-resistance-and-skeletal-muscle-mass-in-type-2-diabetic-mice
#4
Yusuke Takamura, Mitsuru Nomura, Akira Uchiyama, Satoshi Fujita
Insulin resistance reduces insulin-induced muscle protein synthesis and accelerates muscle protein degradation. Ginseng ingestion has been reported to improve insulin resistance through the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. We hypothesized that panaxatriol (PT) derived from ginseng in combination with aerobic exercise (EX) may further promote protein synthesis and suppress protein degradation, and subsequently maintain muscle mass through the amelioration of insulin resistance. KKAy insulin-resistant mice were divided into control, panaxatriol only (PT), exercise only (EX), and EX+PT groups...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29215791/protective-effects-of-carbonyl-iron-against-multiple-low-dose-streptozotocin-induced-diabetes-in-rodents
#5
Milica Vujicic, Tamara Saksida, Marija Mostarica Stojkovic, Neda Djedovic, Ivana Stojanovic, Stanislava Stosic-Grujicic
Particulate adjuvants have shown increasing promise as effective, safe and durable agents for the stimulation of immunity, or alternatively, the suppression of autoimmunity. Here we examined the potential of the adjuvant carbonyl iron (CI) for the modulation of organ-specific autoimmune disease - type 1 diabetes (T1D). T1D was induced by multiple low doses of streptozotocin (MLDS) that initiates beta cell death and triggers immune cell infiltration into the pancreatic islets. The results of this study indicate that the single in vivo application of CI to MLDS-treated DA rats, CBA/H mice, or C57BL/6 mice successfully counteracted the development of insulitis and hyperglycemia...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29206239/type-1-diabetes-alters-lipid-handling-and-metabolism-in-human-fibroblasts-and-peripheral-blood-mononuclear-cells
#6
Albert R Jones Iv, Emily L Coleman, Nicholas R Husni, Jude T Deeney, Forum Raval, Devin Steenkamp, Hans Dooms, Barbara S Nikolajczyk, Barbara E Corkey
Triggers of the autoimmune response that leads to type 1 diabetes (T1D) remain poorly understood. A possibility is that parallel changes in both T cells and target cells provoke autoimmune attack. We previously documented greater Ca2+ transients in fibroblasts from T1D subjects than non-T1D after exposure to fatty acids (FA) and tumor necrosis factor α (TNFα). These data indicate that metabolic and signal transduction defects present in T1D can be elicited ex vivo in isolated cells. Changes that precede T1D, including inflammation, may activate atypical responses in people that are genetically predisposed to T1D...
2017: PloS One
https://www.readbyqxmd.com/read/29203232/thioredoxin-interacting-protein-deficiency-ameliorates-diabetic-retinal-angiogenesis
#7
Jialiang Duan, Chunyang Du, Yonghong Shi, Danyan Liu, Jingxue Ma
Diabetic retinopathy is the leading cause of blindness among working-aged adults around the world. Hyperglycemia and intraocular vascular endothelial growth factor (VEGF) over-accumulation are essential for the progression of diabetic retinopathy, which eventually results in proliferative diabetic retinopathy, characterized by pathologic angiogenesis and impaired vision. Thioredoxin-interacting protein (TXNIP) was highly induced in retinal endothelial cells under diabetic conditions. However, the role of TXNIP in diabetes-associated retinal angiogenesis remains elusive...
December 1, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29192873/incidence-of-first-stroke-and-ethnic-differences-in-stroke-pattern-in-bradford-uk-bradford-stroke-study
#8
Hawraman Ramadan, Chris Patterson, Stuart Maguire, Ian Melvin, Kirti Kain, Elizabeth Teale, Anne Forster
Background Information on ethnic disparities in stroke between White and Pakistani population in Europe is scarce. Bradford District has the largest proportion of Pakistani people in England; this provides a unique opportunity to study the difference in stroke between the two major ethnic groups. Aim To determine the first-ever-stroke incidence and examine the disparities in stroke patterns between Whites and Pakistanis in Bradford. Methods Prospective 12 months study consisting of 273,327 adults (≥18 years) residents...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29186390/direct-activation-of-the-angiotensin-ii-type-2-receptors-enhances-muscle-microvascular-perfusion-oxygenation-and-insulin-delivery-in-male-rats
#9
Fei Yan, Zhaoshun Yuan, Nasui Wang, Robert M Carey, Kevin W Aylor, Li Chen, Xinmin Zhou, Zhenqi Liu
Angiotensin II receptors regulate muscle microvascular recruitment and the delivery of nutrients, oxygen and insulin to muscle. While the angiotensin type-1 receptor antagonism increases muscle microvascular perfusion and insulin action, angiotensin type-2 receptor blockade markedly restricts muscle microvascular blood volume and decreases muscle delivery of insulin. To examine the effects of direct type-2 receptor stimulation using Compound 21 (C21) on microvascular perfusion, insulin delivery and action, and tissue oxygenation in muscle, overnight fasted adult male rats were infused with C21 systemically...
November 24, 2017: Endocrinology
https://www.readbyqxmd.com/read/29185012/systems-biology-of-the-imidia-biobank-from-organ-donors-and-pancreatectomised-patients-defines-a-novel-transcriptomic-signature-of-islets-from-individuals-with-type-2-diabetes
#10
Michele Solimena, Anke M Schulte, Lorella Marselli, Florian Ehehalt, Daniela Richter, Manuela Kleeberg, Hassan Mziaut, Klaus-Peter Knoch, Julia Parnis, Marco Bugliani, Afshan Siddiq, Anne Jörns, Frédéric Burdet, Robin Liechti, Mara Suleiman, Daniel Margerie, Farooq Syed, Marius Distler, Robert Grützmann, Enrico Petretto, Aida Moreno-Moral, Carolin Wegbrod, Anke Sönmez, Katja Pfriem, Anne Friedrich, Jörn Meinel, Claes B Wollheim, Gustavo B Baretton, Raphael Scharfmann, Everson Nogoceke, Ezio Bonifacio, Dorothée Sturm, Birgit Meyer-Puttlitz, Ugo Boggi, Hans-Detlev Saeger, Franco Filipponi, Mathias Lesche, Paolo Meda, Andreas Dahl, Leonore Wigger, Ioannis Xenarios, Mario Falchi, Bernard Thorens, Jürgen Weitz, Krister Bokvist, Sigurd Lenzen, Guy A Rutter, Philippe Froguel, Manon von Bülow, Mark Ibberson, Piero Marchetti
AIMS/HYPOTHESIS: Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for Diabetes: Improving beta-cell function and identification of diagnostic biomarkers for treatment monitoring in Diabetes (IMIDIA) consortium ( www.imidia.org ) established a comprehensive, unique multicentre biobank of human islets and pancreas tissues from organ donors and metabolically phenotyped pancreatectomised patients (PPP)...
November 28, 2017: Diabetologia
https://www.readbyqxmd.com/read/29182576/nut-consumption-and-cardiovascular-risk-factors-a-cross-sectional-study-in-a-mediterranean-population
#11
Ajka Relja, Ana Miljković, Andrea Gelemanović, Maria Bošković, Caroline Hayward, Ozren Polašek, Ivana Kolčić
Nuts are often considered beneficial for health, yet few studies have examined determinants of their intake and the associations between nut consumption and various cardiovascular disease risk factors. The aim of this study was to identify factors associated with nut intake in a Mediterranean population, in Croatia, and to investigate the association of nut intake and various cardiovascular risk factors. METHODS: Subjects from the Island of Vis, Island of Korčula and the City of Split were included in this cross-sectional study (n = 4416 in total; 4011 without known cardiovascular disease)...
November 28, 2017: Nutrients
https://www.readbyqxmd.com/read/29181780/3d-models-of-insulin-producing-%C3%AE-cells-from-primary-islet-cells-to-stem-cell-derived-islets
#12
REVIEW
Diana Ribeiro, Alexander J Kvist, Pernilla Wittung-Stafshede, Ryan Hicks, Anna Forslöw
There is a need for physiologically relevant assay platforms to provide functionally relevant models of diabetes, to accelerate the discovery of new treatment options and boost developments in drug discovery. In this review, we compare several 3D-strategies that have been used to increase the functional relevance of ex vivo human primary pancreatic islets and developments into the generation of stem cell derived pancreatic beta-cells (β-cells). Special attention will be given to recent approaches combining the use of extracellular matrix (ECM) scaffolds with pancreatic molecular memory, which can be used to improve yield and functionality of in vitro stem cell-derived pancreatic models...
November 27, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/29180572/the-atpase-activity-of-asna1-trc40-is-required-for-pancreatic-progenitor-cell-survival
#13
Stefan Norlin, Vishal Parekh, Helena Edlund
Asna1, also known as TRC40, is implicated in delivery of tail anchored (TA) proteins into the ER, in vesicle-mediated transport, and in chaperoning unfolded proteins during oxidative stress/ATP depletion. We recently showed that Asna1 inactivation in β-cells resulted in impaired retrograde transport, ER stress and diabetes in mice. Here we show that Asna1 inactivation in pancreatic progenitor cells leads to redistribution of the Golgi TA SNAREs Syntaxin-5 and Syntaxin-6, Golgi fragmentation, and accumulation of cytosolic p62+ puncta...
November 27, 2017: Development
https://www.readbyqxmd.com/read/29167541/effect-of-post-cessation-hyperglycemia-on-cardiovascular-disease-and-mortality-among-middle-aged-men-an-eight-year-longitudinal-study
#14
Seulggie Choi, Kyuwoong Kim, Jooyoung Chang, Sung Min Kim, Hye-Yeon Koo, Ji-Hye Jun, Mi Hee Cho, Kiheon Lee, Sang Min Park
Smoking cessation reduces the risk of cardiovascular disease (CVD), but also elevates fasting serum glucose (FSG) levels. The effect of post-cessation hyperglycemia on cardiovascular disease is unknown. The study population consisted of 127,066 men without type 2 diabetes from the Korean National Health Insurance System - Health Screening Cohort database. Change in smoking habits and FSG was determined by the difference in smoking status and FSG levels from the first (2002 and 2003) and second (2004 and 2005) health examinations...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29165724/protective-effect-and-potential-mechanism-of-simvastatin-on-myocardial-injury-induced-by-diabetes-with-hypoglycemia
#15
Haiqing Li, Qianqian Zhao, Rong Liu, Lan Yang, Huanzhen Chen, Xiangli Cui
Background Simvastatin has been reported to reduce cardiovascular related morbidity and mortality in clinical trials which was independent of its cholesterol-lowering effect. This study aims to investigate the protective effect of simvastatin on myocardial injury caused by diabetic hypoglycemia and the possible underlying mechanism. Methods We used streptozotocin (STZ) at a dose of 55 mg/kg to induce diabetes mellitus (DM) and over-dose insulin to induce hypoglycemia to establish diabetic hypoglycemia rat models...
November 17, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29165561/evaluation-of-short-exposure-times-of-antimicrobial-wound-solutions-against-microbial-biofilms-from-in-vitro-to-in-vivo
#16
K Johani, M Malone, S O Jensen, H G Dickson, I B Gosbell, H Hu, Q Yang, G Schultz, K Vickery
Objectives: Test the performance of topical antimicrobial wound solutions against microbial biofilms using in vitro, ex vivo and in vivo model systems at clinically relevant exposure times. Methods: Topical antimicrobial wound solutions were tested under three different conditions: (in vitro) 4% w/v Melaleuca oil, polyhexamethylene biguanide, chlorhexidine, povidone iodine and hypochlorous acid were tested at short duration exposure times for 15 min against 3 day mature biofilms of Staphylococcus aureus and Pseudomonas aeruginosa; (ex vivo) hypochlorous acid was tested in a porcine skin explant model with 12 cycles of 10 min exposure, over 24 h, against 3 day mature P...
November 18, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29162916/afm-based-detection-of-glycocalyx-degradation-and-endothelial-stiffening-in-the-db-db-mouse-model-of-diabetes
#17
Marta Targosz-Korecka, Magdalena Jaglarz, Katarzyna E Malek-Zietek, Aleksandra Gregorius, Agnieszka Zakrzewska, Barbara Sitek, Zenon Rajfur, Stefan Chlopicki, Marek Szymonski
Degradation of the glycocalyx and stiffening of endothelium are important pathophysiological components of endothelial dysfunction. However, to our knowledge, these events have not been investigated in tandem in experimental diabetes. Here, the mechanical properties of the glycocalyx and endothelium in ex vivo mouse aorta were determined simultaneously in indentation experiments with an atomic force microscope (AFM) for diabetic db/db and control db/+ mice at ages of 11-19 weeks. To analyze highly heterogeneous aorta samples, we developed a tailored classification procedure of indentation data based on a bi-layer brush model supplemented with Hertz model for quantification of nanomechanics of endothelial regions with and without the glycocalyx surface...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29158265/topical-mevastatin-promotes-wound-healing-by-inhibiting-the-transcription-factor-c-myc-via-the-glucocorticoid-receptor-and-the-long-noncoding-rna-gas5
#18
Andrew P Sawaya, Irena Pastar, Olivera Stojadinovic, Sonja Lazovic, Stephen C Davis, Joel Gil, Robert S Kirsner, Marjana Tomic-Canic
Diabetic foot ulcers (DFU), a life-threatening complication of diabetes mellitus, have limited treatment options, often resulting in amputations. HMG-CoA reductase inhibitors such as statins are cholesterol-reducing agents that may provide a new therapeutic option. Statins target the cholesterol pathway and block the synthesis of the wound-healing inhibitors farnesyl pyrophosphate (FPP) and cortisol, ligands for the glucocorticoid receptor (GR). Here we demonstrate that the naturally occurring statin, mevastatin, reverses FPP's effects and promotes healing by using in vitro wound healing assays, human ex vivo and porcine in vivo wound models, and DFU tissue...
November 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29157668/iron-induced-rna-oxidation-in-the-general-population-and-in-mouse-tissue
#19
Vanja Cejvanovic, Laura Kofoed Kjær, Helle Kirstine Mørup Bergholdt, Arendse Torp-Pedersen, Trine Henriksen, Allan Weimann, Christina Ellervik, Henrik Enghusen Poulsen
Iron promotes formation of hydroxyl radicals by the Fenton reaction, subsequently leading to potential oxidatively generated damage of nucleic acids. Oxidatively generated damage to RNA, measured as 8-oxo-7,8-dihydroguanosine (8-oxoGuo) in urine, is increased in patients with genetic iron overload, which have led us to test the hypothesis that high iron status, assessed by iron biomarkers and genetic disposition, increases urinary excretion of 8-oxoGuo. In a general Danish population study we used a Mendelian randomization design with HFE genotypes as a proxy for iron status and supplemented with ex vivo experiments in mice muscle tissue exposed to iron(II) sulfate to attempt to clarify this hypothesis...
November 17, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29155454/harnessing-the-power-of-regulatory-t-cells-to-control-autoimmune-diabetes-overview-and-perspective
#20
REVIEW
Hua Yu, Ricardo Paiva, Richard A Flavell
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease resulting in islet β-cell destruction, hypoinsulinemia, and severely altered glucose homeostasis. Although the mechanisms that initiate T1D still remain elusive, a breakdown of immune tolerance between effector T cells (Teff) and regulatory T cells (Treg) is considered to be the crucial component leading to autoimmunity. As such, strategies have been developed to boost the number and/or function of Treg in the hope of specifically hampering the pathogenic Teff activity...
November 20, 2017: Immunology
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