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https://www.readbyqxmd.com/read/29656627/ossification-of-the-posterior-longitudinal-ligament-in-cervical-spine-prevalence-management-and-prognosis
#1
REVIEW
Jau-Ching Wu, Yu-Chun Chen, Wen-Cheng Huang
Ossification of the posterior longitudinal ligament (OPLL) in the cervical spine and related neurological complications are not uncommon in East Asian countries. The estimated prevalence of cervical OPLL-related hospitalization is 7.7 per 100,000 person-years in Taiwan, and higher incidence rates have been observed in elderly and male patients. Although cervical OPLL is frequently insidious, it can eventually cause myelopathy and predispose patients to spinal cord injury (SCI). There are multiple options for managing cervical OPLL, ranging from observation to many kinds of surgical procedures, including posterior laminoplasty, laminectomy with or without fusion, anterior corpectomy with or without instrumentation, and circumferential decompression and fusion...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29656622/minimally-invasive-spinal-surgery-for-adult-spinal-deformity
#2
REVIEW
Junseok Bae, Sang-Ho Lee
The purpose of this review is to present the current techniques and outcomes of adult spine deformity (ASD) surgery using the minimally invasive spine surgery (MISS) approach. We performed a systemic search of PubMed for literature published through January 2018 with the following terms: "minimally invasive spine surgery," "adult spinal deformity," and "degenerative scoliosis." Of the 138 items that were found through this search, 57 English-language articles were selected for full-text review...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29656601/culture-independent-analysis-of-hydrocarbonoclastic-bacterial-communities-in-environmental-samples-during-oil-bioremediation
#3
Narjes Dashti, Nedaa Ali, Samar Salamah, Majida Khanafer, Ghada Al-Shamy, Husain Al-Awadhi, Samir S Radwan
To analyze microbial communities in environmental samples, this study combined Denaturing Gradient Gel Electrophoresis of amplified 16S rRNA-genes in total genomic DNA extracts from those samples with gene sequencing. The environmental samples studied were oily seawater and soil samples, that had been bioaugmented with natural materials rich in hydrocarbonoclastic bacteria. This molecular approach revealed much more diverse bacterial taxa than the culture-dependent method we had used in an earlier study for the analysis of the same samples...
April 15, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29656595/pathways-of-association-from-stress-to-obesity-in-early-childhood
#4
REVIEW
Alison L Miller, Julie C Lumeng
OBJECTIVE: The objective of this study is to critically review the literature on early life stress in relation to obesity in humans, including the multiple biological and behavioral mechanisms through which early life stress exposure (birth to the age of 5 years) may associate with obesity risk during childhood. METHODS: A review of the literature was conducted to identify studies on associations between early childhood stress and risk for obesity and the mechanisms of association...
April 14, 2018: Obesity
https://www.readbyqxmd.com/read/29656561/advances-in-controlling-differentiation-of-adult-stem-cells-for-peripheral-nerve-regeneration
#5
REVIEW
Metin Uz, Suprem R Das, Shaowei Ding, Donald S Sakaguchi, Jonathan C Claussen, Surya K Mallapragada
Adult stems cells, possessing the ability to grow, migrate, proliferate, and transdifferentiate into various specific phenotypes, constitute a great asset for peripheral nerve regeneration. Adult stem cells' ability to undergo transdifferentiation is sensitive to various cell-to-cell interactions and external stimuli involving interactions with physical, mechanical, and chemical cues within their microenvironment. Various studies have employed different techniques for transdifferentiating adult stem cells from distinct sources into specific lineages (e...
April 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29656558/deep-ultraviolet-nonlinear-optical-crystal-cs%C3%A2-al%C3%A2-b%C3%A2-o%C3%A2-%C3%A2-o-a-benign-member-of-sr%C3%A2-be%C3%A2-bo%C3%A2-%C3%A2-o-family-with-al%C3%A2-b%C3%A2-o%C3%A2-%C3%A2-o-%C3%A2-double-layers
#6
Zhi Fang, Xingxing Jiang, Meihong Duan, Zhanyu Hou, Changcheng Tang, Mingjun Xia, Lijuan Liu, Zheshuai Lin, Feidi Fan, Lei Bai, Chuangtian Chen
For the explorations on deep ultraviolet (DUV) nonlinear optical (NLO) borates, a type of important optoelectronic materials, (BO3)3- group is long-termly regarded as the sole microscopic optical-active unit and the toxic Be-containing raw materials are frequently-adopted. Herein, a new DUV NLO crystal Cs2Al2(B3O6)2O (CABO) was designed and synthesized by simultaneously replacing the (BO3)3- groups and Be2+ cations in Sr2Be2(BO3)2O that possesses a favorable structure for large NLO response by (B3O6)3- units and Al3+ cations through cosubstitution approach...
April 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29656556/melt-electrowriting-of-thermoplastic-elastomers
#7
Gernot Hochleitner, Eva Fürsattel, Reiner Giesa, Jürgen Groll, Hans-Werner Schmidt, Paul D Dalton
Melt electrowriting (MEW), an additive manufacturing process, is established using polycaprolactone as the benchmark material. In this study, a thermoplastic elastomer, namely, poly(urea-siloxane), is synthesized and characterized to identify how different classes of polymers are compatible with MEW. This polyaddition polymer has reversible hydrogen bonding from the melt upon heating/cooling and highly resolved structures are achieved by MEW. The influence of applied voltage, temperature, and feeding pressure on printing outcomes behavior is optimized...
April 14, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29656548/effects-of-geranylgeranylacetone-upon-cardiovascular-diseases
#8
Shengqiang Zeng, Hong Wang, Zaihua Chen, Qianqiang Cao, Lin Hu, Yanqing Wu
Heat shock proteins (HSPs) are an important family of protective proteins. They are involved actively in an array of cellular processes, including protective effects on the cardiovascular system in response to various stimuli. Increasing evidence shows that pharmacologic interventions that induce expression of HSPs may be a novel approach for the treatment of cardiovascular diseases. However, agents that induce expression of HSPs used previously are toxic or have harmful side effects, which limit their clinical application...
April 14, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29656545/a-framework-for-treating-dsm-5-alternative-model-for-personality-disorder-features
#9
Christopher J Hopwood
Despite its demonstrated empirical superiority over the DSM-5 Section 2 categorical model of personality disorders for organizing the features of personality pathology, limitations remain with regard to the translation of the DSM-5 Section 3 alternative model of personality disorders (AMPD) to clinical practice. The goal of this paper is to outline a general and preliminary framework for approaching treatment from the perspective of the AMPD. Specific techniques are discussed for the assessment and treatment of both Criterion A personality dysfunction and Criterion B maladaptive traits...
April 15, 2018: Personality and Mental Health
https://www.readbyqxmd.com/read/29656533/a-weed-resistance-management-game-a-teaching-tool
#10
George B Frisvold
BACKGROUND: This article provides instructions and materials to moderate an interactive resistance management game. The game is designed to generate discussion about the challenges and possibilities of coordinating resistance management activities among groups of farmers. The game has been successfully applied in classroom settings, extension workshops, and at professional weed science meetings. Research has found farmers often perceive the success of their own resistance management may be thwarted if their neighbors are not adequately managing resistance as well...
April 15, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29656522/hybrid-t-2-and-t-1-weighted-radial-acquisition-for-free-breathing-abdominal-examination
#11
Thomas Benkert, John P Mugler, David S Rigie, Daniel K Sodickson, Hersh Chandarana, Kai Tobias Block
PURPOSE: Most clinical MR examinations require acquisition of different image contrasts. For abdominal exams, the scans are conventionally performed as separate acquisitions using respiratory gating or repeated breath holding, which can be time-inefficient and challenging for patients. Here, a hybrid imaging approach is described that creates T2 - and T1 -weighted images from a single scan and allows for free-breathing acquisition. THEORY AND METHODS: T2 -weighted data is collected using 3D fast spin-echo (FSE) acquisition with motion-robust radial stack-of-stars sampling...
April 15, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29656517/a-color-tunable-fluorescent-supramolecular-hyperbranched-polymer-constructed-by-pillar-5-arene-based-host-guest-recognition-and-metal-ion-coordination-interaction
#12
Hui Li, Wenzhuo Chen, Fenfen Xu, Xiaodong Fan, Tongxiang Liang, Xiaopeng Qi, Wei Tian
Fluorescent supramolecular polymers are an important kind of smart material. In this work, a new fluorescent supramolecular hyperbranched polymer (FSHP) is constructed by orthogonal self-assembly: pillararene-based host-guest interaction and metal ion complexation interaction. The FSHP exhibits concentration-controllable fluorescence emissions. The photoluminescence spectra and light-emitting colors of FSHP can be effectively tuned by changing metal ion types or using mixed metal ions. The fluorescence quenching of FSHP solutions or FSHP-based films would occur when removing the metal ions from the backbone of FSHP...
April 14, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29656514/microbial-diversity-and-biomarker-analysis-of-modern-freshwater-microbialites-from-laguna-bacalar-mexico
#13
D B Johnson, P A Beddows, T M Flynn, M R Osburn
Laguna Bacalar is a sulfate-rich freshwater lake on the Yucatan Peninsula that hosts large microbialites. High sulfate concentrations distinguish Laguna Bacalar from other freshwater microbialite sites such as Pavilion Lake and Alchichica, Mexico, as well as from other aqueous features on the Yucatan Peninsula. While cyanobacterial populations have been described here previously, this study offers a more complete characterization of the microbial populations and corresponding biogeochemical cycling using a three-pronged geobiological approach of microscopy, high-throughput DNA sequencing, and lipid biomarker analyses...
April 15, 2018: Geobiology
https://www.readbyqxmd.com/read/29656511/neuropathic-pain-a-patient-centred-approach-to-measuring-outcomes
#14
Steve Hwang, Floortje van Nooten, Ted Wells, Aisling Ryan, Bruce Crawford, Christopher Evans, Marci English
BACKGROUND: Neuropathic pain (NP) is a complex, chronic pain state initiated by a primary lesion or dysfunction of the nervous system and presents as a variety of symptoms across multiple disease states. OBJECTIVE: To develop a patient-centred conceptual model of symptoms and impacts in subjects with diabetic peripheral neuropathy (DPN) or post-herpetic neuralgia (PHN) that can inform the measurement strategy in clinical trials. METHOD: Thirty subjects with DPN or PHN participated in in-person interviews which were performed until saturation was achieved...
April 15, 2018: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29656510/robust-motion-correction-in-cest-imaging-exploiting-low-rank-approximation-of-the-z-spectrum
#15
Tobias Wech, Herbert Köstler
PURPOSE: To introduce and evaluate an image registration technique for robust quantification of CEST acquisitions corrupted by motion. METHODS: The proposed iterative algorithm exploits a low-rank approximation of the z-spectrum (LRAZ), to gradually separate the contrast variation due to saturation at different off-resonance frequencies and accompanying motion. This registration method was first tested in a creatine CEST analysis of a phantom with simulated rigid motion...
April 15, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29656508/the-3-rd-world-conference-on-kisspeptin-kisspeptin-2017-brain-and-beyond-unresolved-questions-challenges-and-future-directions-for-the-field
#16
REVIEW
Michael N Lehman, Lique M Coolen, Robert A Steiner, Genevieve Neal-Perry, Luhong Wang, Suzanne M Moenter, Aleisha M Moore, Robert L Goodman, Shel Hwa-Yeo, Stephanie L Padilla, Alexander S Kauffman, James Garcia, Martin J Kelly, Jenny Clarkson, Sally Radovick, Andy V Babwah, Silvia Leon, Manuel Tena-Sempere, Alex Comninos, Stephanie Seminara, Waljit S Dhillo, Jon Levine, Ei Terasawa, Ariel Negron, Allan E Herbison
The 3rd World Conference on Kisspeptin, "Kisspeptin 2017: Brain and Beyond" was held March 30-31 at the Rosen Centre Hotel in Orlando, Florida, providing an international forum for multidisciplinary scientists to meet and share cutting-edge research on kisspeptin biology and its relevance to human health and disease. The meeting built upon previous world conferences focused on the role of kisspeptin and associated peptides in the control of gonadotropin-releasing hormone (GnRH) secretion and reproduction...
April 14, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29656506/enantiospecific-total-syntheses-of-hapalindole-h-and-12-epi-hapalindole-u
#17
Dattatraya Hanumant Dethe, Saikat Das, Vijay Kumar B, Nisar Ahmed Mir
Enantiospecific total syntheses of (+)-hapalindole H, (-)-12-epi-hapalindole U, formal synthesis of (+)-hapalindole Q and (+)-12-epi-fischerindole U isothiocyanate have been described. Key steps of our approach feature expedient, highly regio- and diastereoselective Lewis acid catalyzed Friedel-Crafts reaction of indole with cyclic allylic alcohols and intramolecular reductive Heck reaction. Efficiency of the synthetic route also relies on an alkynyl aluminate complex driven regioselective nucleophilic epoxide opening from sterically hindered site...
April 14, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29656505/facile-n-alkylation-n-arylation-process-a-direct-approach-to-aromatic-aminoalkyl-amines
#18
Qiming Zhu, Mingwei Chen, Jinyu Hu, Luyi Yang
An intriguing C-N transformation involving a catalyst-free N-alkylation/N'-arylation process in a multicomponent reaction with secondary amines, cyclic tertiary amines and electron-deficient aryl halides has been described. In this case, the N-alkylation of secondary amines, utilizing cyclic tertiary amines as alkyl group sources, is enabled by a facile C-N cleavage. Such an operationally simple method could facilitate access to aromatic aminoalkyl amines, nitrogen-containing bioactive molecules, in good to excellent yields...
April 14, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29656492/pd-1-blockade-cellular-vesicles-for-cancer-immunotherapy
#19
Xudong Zhang, Chao Wang, Jinqiang Wang, Quanyin Hu, Benjamin Langworthy, Yanqi Ye, Wujin Sun, Jing Lin, Tianfu Wang, Jason Fine, Hao Cheng, Gianpietro Dotti, Peng Huang, Zhen Gu
Cancer cells resist to the host immune antitumor response via multiple suppressive mechanisms, including the overexpression of PD-L1 that exhausts antigen-specific CD8+ T cells through PD-1 receptors. Checkpoint blockade antibodies against PD-1 or PD-L1 have shown unprecedented clinical responses. However, limited host response rate underlines the need to develop alternative engineering approaches. Here, engineered cellular nanovesicles (NVs) presenting PD-1 receptors on their membranes, which enhance antitumor responses by disrupting the PD-1/PD-L1 immune inhibitory axis, are reported...
April 14, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29656478/transplantation-of-neural-progenitor-cells-expressing-glial-cell-line-derived-neurotrophic-factor-into-the-motor-cortex-as-a-strategy-to-treat-amyotrophic-lateral-sclerosis
#20
Gretchen M Thomsen, Pablo Avalos, Annie A Ma, Mor Alkaslasi, Noell Cho, Livia Wyss, Jean-Philippe Vit, Marlesa Godoy, Patrick Suezaki, Oksana Shelest, Krystof S Bankiewicz, Clive N Svendsen
Early dysfunction of cortical motor neurons may underlie the initiation of amyotrophic lateral sclerosis (ALS). As such, the cortex represents a critical area of ALS research and a promising therapeutic target. In the current study, human cortical-derived neural progenitor cells engineered to secrete glial cell line-derived neurotrophic factor (GDNF) were transplanted into the SOD1G93A ALS rat cortex, where they migrated, matured into astrocytes, and released GDNF. This protected motor neurons, delayed disease pathology and extended survival of the animals...
April 15, 2018: Stem Cells
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