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https://www.readbyqxmd.com/read/29245116/human-lung-epithelial-cells-a549-epithelial-mesenchymal-transition-induced-by-pva-collagen-nanofiber
#1
Xiuchun Li, Shanshan Yan, Jing Dai, Yi Lu, Yiqun Wang, Man Sun, Jinkang Gong, Yuan Yao
Epithelial-mesenchymal transition (EMT) is a process by which epithelial cells lose their cell-cell contact to become mesenchymal stem cells, which is important on development and embryogenesis, wound healing, and cancer metastasis. This research aims to investigate the effect of topological cue as modulating factor on the EMT by tuning the diameter of electrospinning nanofiber. The cell-nanofiber interaction between human lung epithelial cell A549 and electrospinning nanofibers composed of polyvinyl alcohol (PVA) and type I collagen were investigated...
December 11, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29243324/validation-of-histone-deacetylase-3-as-a-therapeutic-target-in-castration-resistant-prostate-cancer
#2
Abigail B McLeod, James P Stice, Suzanne E Wardell, Holly M Alley, Ching-Yi Chang, Donald P McDonnell
BACKGROUND: Whereas the androgen receptor (AR) signaling axis remains a therapeutic target in castration-resistant prostate cancer (CRPC), the emergence of AR mutations and splice variants as mechanisms underlying resistance to contemporary inhibitors of this pathway highlights the need for new therapeutic approaches to target this disease. Of significance in this regard is the considerable preclinical data, indicating that histone deacetylase (HDAC) inhibitors may have utility in the treatment of CRPC...
December 15, 2017: Prostate
https://www.readbyqxmd.com/read/29243075/the-effect-of-aspirin-on-circulating-tumor-cells-in-metastatic-colorectal-and-breast-cancer-patients-a-phase-ii-trial-study
#3
L Yang, Z Lv, W Xia, W Zhang, Y Xin, H Yuan, Y Chen, X Hu, Y Lv, Q Xu, X Weng, C Ni
PURPOSE: Aspirin could reduce the risk of cancer metastasis. Circulating tumor cells (CTCs) are a key factor of cancer metastasis, but no evidence has revealed how aspirin affects CTCs and its epithelial-mesenchymal transition (EMT). Here, we conducted a clinical trial to investigate how aspirin affects CTCs in metastatic colorectal cancer (MCC) and breast cancer patients (MBC). METHODS: The trial is retrospective registered at clinicaltrials.gov (NCT02602938). The eligible patients are given 100 mg aspirin q...
December 14, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29242924/teaching-low-income-spanish-speaking-caregivers-to-implement-emt-en-espa%C3%A3-ol-with-their-young-children-with-language-impairment-a-pilot-study
#4
Tatiana Nogueira Peredo, Maria Isabel Zelaya, Ann P Kaiser
Purpose: This study examined the effectiveness of teaching low-income Spanish-speaking caregivers of young children with language impairment a naturalistic language intervention, EMT en Español. Method: A single-case, multiple-baseline, across-behaviors design replicated across 3 caregiver-child dyads was used to examine the effects of teaching core EMT en Español strategies. The training program utilized the Teach-Model-Coach-Review instructional approach to teach strategies to support children's language development in Spanish...
December 14, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29242498/microrna-221-3p-a-twist2-target-promotes-cervical-cancer-metastasis-by-directly-targeting-thbs2
#5
Wen-Fei Wei, Chen-Fei Zhou, Xiang-Guang Wu, Li-Na He, Lan-Fang Wu, Xiao-Jing Chen, Rui-Ming Yan, Mei Zhong, Yan-Hong Yu, Li Liang, Wei Wang
MicroRNAs have implicated in the relapse and metastasis of cervical cancer, which is the leading cause of cervical cancer-related mortality. However, the underlying molecular mechanisms need further elucidation. Our present study revealed that miR-221-3p is transcriptionally promoted in metastatic cervical cancer tissues compared with non-metastatic cervical cancer tissues. Forced overexpression of miR-221-3p facilitated EMT and promoted cell migration and invasion in vitro and lymphatic metastasis in vivo...
December 14, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29241727/simple-classifiers-for-molecular-subtypes-of-colorectal-cancer
#6
Woo Gyeong Kim, Joo Yeon Kim, Do Youn Park
BACKGROUND AND STUDY AIM: Colorectal cancer (CRC) is a heterogeneous disease entity with a diverse biological pathogenesis. This study aims to validate the two studies published in 2013 which established a separate CRC molecular subtype classification by utilizing a rapidly accessible miniclassifier, and verify a simplified version thereof. PATIENTS AND METHODS: Participants diagnosed with CRC (n = 568) were subtyped in three classifications for characteristic, and prognostic purposes...
December 11, 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29240250/microrna-139-5p-inhibits-epithelial-mesenchymal-transition-and-fibrosis-in-post-menopausal-women-with-interstitial-cystitis-by-targeting-lpar4-via-the-pi3k-akt-signaling-pathway
#7
Chen Jiang, Zhen Tong, Wei-Lin Fang, Qi-Bo Fu, Yin-Jun Gu, Ting-Ting Lv, Dong-Ming Liu, Wei Xue, Jian-Wei Lv
The study explores whether miR-139-5p targeting LPAR4 affects epithelial-mesenchymal transition (EMT) and fibrosis in post-menopausal women with interstitial cystitis (IC) via the PI3K/Akt signaling pathway. Bladder tissues of IC and normal bladder tissues were collected. The pathology of bladder tissues was observed by HE, Masson and Picrosirius red staining. LPAR4 positive expression rate were determined by IHC. ELISA was performed to detect the levels of IL-6, IL-8, IL-10 and TNF-α. Rat IC models were randomized into seven different groups...
December 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29239819/lncrna-hoxd-as1-promotes-epithelial-ovarian-cancer-cells-proliferation-and-invasion-by-targeting-mir-133a-3p-and-activating-wnt-%C3%AE-catenin-signaling-pathway
#8
Ying Zhang, Yanbing Dun, Shumin Zhou, Xiang-Hua Huang
BACKGROUND: Long non-coding RNA (lncRNA) HOXD cluster antisense RNA 1 (HOXD-AS1) functions as a crucial regulator in the progression and development of tumors. The aim of this study is to unravel the underlying mechanisms of HOXD-AS1 on epithelial ovarian cancer (EOC). METHODS: 43 paired EOC tissues and adjacent non-tumor tissues were collected postoperatively from patients. QRT-PCR was used to explore HOXD-AS1 expression in both EOC tissues and cell lines. Cell proliferation and invasion were monitored by MTT assay and transwell invasion assay...
November 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29239144/smg-1-inhibition-by-mir-192-215-causes-epithelial-mesenchymal-transition-in-gastric-carcinogenesis-via-activation-of-wnt-signaling
#9
Xiaojing Zhang, Yin Peng, Yong Huang, Mengting Yang, Ruibin Yan, Yanqiu Zhao, Yulan Cheng, Xi Liu, Shiqi Deng, Xianling Feng, Huijuan Lin, Huimin Yu, Si Chen, Zhenfu Zhao, Shanni Li, Kuan Li, Liang Wang, Yanjie Wei, Zhendan He, Xinmin Fan, Stephen J Meltzer, Song Li, Zhe Jin
SMG-1,a member of the phosphoinositide kinase-like kinase family, functioned as a tumor suppressor gene. However, the role of SMG-1 in GC remain uncharacterized. In this study, regulation of SMG-1 by miR-192 and-215, along with the biological effects of this modulation, were studied in GC. We used gene microarrays to screening and luciferase reporter assays were to verify the potential targets of miR-192 and-215. Tissue microarrays analyses were applied to measure the levels of SMG-1 in GC tissues. Western blot assays were used to assess the signaling pathway of SMG-1 regulated by miR-192 and-215 in GC...
December 13, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29238913/phthalazinone-pyrazole-enhances-the-hepatic-functions-of-human-embryonic-stem-cell-derived-hepatocyte-like-cells-via-suppression-of-the-epithelial-mesenchymal-transition
#10
Young-Jun Choi, Hyemin Kim, Ji-Woo Kim, Chang-Woo Song, Dae-Sung Kim, Seokjoo Yoon, Han-Jin Park
During liver development, nonpolarized hepatic progenitor cells differentiate into mature hepatocytes with distinct polarity. This polarity is essential for maintaining the intrinsic properties of hepatocytes. The balance between the epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) plays a decisive role in differentiation of polarized hepatocytes. In this study, we found that phthalazinone pyrazole (PP), a selective inhibitor of Aurora-A kinase (Aurora-A), suppressed the EMT during the differentiation of hepatocyte-like cells (HLCs) from human embryonic stem cells...
December 13, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/29238068/microrna-105-is-involved-in-tnf-%C3%AE-related-tumor-microenvironment-enhanced-colorectal-cancer-progression
#11
Zetao Shen, Rui Zhou, Chen Liu, Yaofeng Wang, Wanqi Zhan, Ziyun Shao, Jian Liu, Feifei Zhang, Lijun Xu, Xinying Zhou, Lu Qi, Feng Bo, Yanqing Ding, Liang Zhao
TNF-α is a central proinflammatory cytokine contributing to malignant tumor progression in tumor microenvironment. In this study, we found the upregulation of miR-105 in colorectal cancer was associated with aggressive phenotype, and the enhanced expression of miR-105 was required for TNF-α-induced epithelial-mesenchymal transition (EMT). The expression of miR-105 was remarkably stimulated by TNF-α in a time-dependent manner using real-time qPCR analysis. Inhibition of miR-105 remarkably weakened the aggressive effects of TNF-α through preventing the activation of NF-κB signaling and the initiation of EMT...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29237530/-mechanism-of-action-of-bet-bromodomain-inhibitor-jq1-in-treating-airway-remodeling-in-asthmatic-mice
#12
Xiao-Hua Zhu, Qiu-Gen Li, Jun Wang, Guo-Zhu Hu, Zhi-Qiang Liu, Qing-Hua Hu, Gang Wu
OBJECTIVE: To investigate the molecular mechanism of action of BET bromodomain inhibitor JQ1 in treating airway remodeling in asthmatic mice. METHODS: A total of 24 mice were randomly divided into control group, ovalbumin (OVA)-induced asthma group (OVA group), and JQ1 intervention group (JQ1+OVA group), with 8 mice in each group. OVA sensitization/challenge was performed to establish a mouse model of asthma. At 1 hour before challenge, the mice in the JQ1+OVA group were given intraperitoneal injection of JQ1 solution (50 μg/g)...
December 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29237483/adipocytes-promote-cholangiocarcinoma-metastasis-through-fatty-acid-binding-protein-4
#13
Jihua Nie, Jingying Zhang, Lili Wang, Lunjie Lu, Qian Yuan, Fangmei An, Shuyu Zhang, Yang Jiao
BACKGROUND: The early occurrence regional nodal and distant metastases cholangiocarcinoma (CCA) is one of the major reasons for its poor prognosis. However, the related mechanisms are largely elusive. Recently, increasing evidences indicate that adipocytes might be involved in the proliferation, homing, migration and invasion of several malignancies. In the present study, we attempt to determine the effects and possible mechanisms of adipocytes on regulating progression of CCA. METHODS: Adipocyte-CCA cell co-culture system and CCA metastasis mice model were used to determine the effects of adipocytes on CCA metastasis...
December 13, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29237157/hypoxia-accelerates-aggressiveness-of-hepatocellular-carcinoma-cells-involving-oxidative-stress-epithelial-mesenchymal-transition-and-non-canonical-hedgehog-signaling
#14
Zhikui Liu, Kangsheng Tu, Yufeng Wang, Bowen Yao, Qing Li, Liang Wang, Changwei Dou, Qingguang Liu, Xin Zheng
BACKGROUND/AIMS: Hypoxic microenvironment, a common feature of hepatocellular carcinoma (HCC), can induce HIF-1α expression and promote the epithelial-mesenchymal transition (EMT) and invasion of cancer cells. However, the underlying molecular mechanisms have not fully elucidated. METHODS: HCC cells were cultured under controlled hypoxia conditions or normoxic conditions. Transwell assays were used to examine the migration and invasion capacity. HIF-1α siRNA, cyclopamine (a SMO antagonist) and GLI1 siRNA were used to inhibit HIF-1α transcription or Hh signaling activation...
December 11, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29237043/veratramine-modulates-ap-1-dependent-gene-transcription-by-directly-binding-to-programmable-dna
#15
Fang Bai, Kangdong Liu, Huiliang Li, Jiawei Wang, Junsheng Zhu, Pei Hao, Lili Zhu, Shoude Zhang, Lei Shan, Weiya Ma, Ann M Bode, Weidong Zhang, Honglin Li, Zigang Dong
Because the transcription factor activator protein-1 (AP-1) regulates a variety of protein-encoding genes, it is a participant in many cellular functions, including proliferation, transformation, epithelial mesenchymal transition (EMT), and apoptosis. Inhibitors targeting AP-1 have potential use in the treatment of cancer and other inflammatory diseases. Here, we identify veratramine as a potent natural modulator of AP-1, which selectively binds to a specific site (TRE 5'-TGACTCA-3') of the AP-1 target DNA sequence and regulates AP-1-dependent gene transcription without interfering with cystosolic signaling cascades that might lead to AP-1 activation...
December 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29236960/microrna-128-3p-mediated-depletion-of-drosha-promotes-lung-cancer-cell-migration
#16
Tania Frixa, Andrea Sacconi, Mario Cioce, Giuseppe Roscilli, Fabiana Fosca Ferrara, Luigi Aurisicchio, Claudio Pulito, Stefano Telera, Maria Antonia Carosi, Paola Muti, Sabrina Strano, Sara Donzelli, Giovanni Blandino
Alteration in microRNAs (miRNAs) expression is a frequent finding in human cancers. In particular, widespread miRNAs down-regulation is a hallmark of malignant transformation. In the present report, we showed that the miR-128-3p, which is up-regulated in lung cancer tissues, has Drosha and Dicer, two key enzymes of miRNAs processing, as the main modulation targets leading to the widespread down-regulation of miRNA expression. We observed that the miRNAs downregulation induced by miR-128-3p contributed to the tumorigenic properties of lung cancer cells...
December 11, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29236331/reduction-of-histone-marks-h3k9me3-and-h3k27me3-by-epidrug-induces-neuroendocrine-differentiation-in-prostate-cancer
#17
Eunsohl Lee, Jingcheng Wang, Younghun Jung, Frank C Cackowski, Russell S Taichman
Neuroendocrine prostate cancer (NE PCa) is an aggressive malignancy, often presenting with advanced metastasis. We previously reported that reduction of histone marks regulated by DNMT1 following epidrug (5-Azacitidine, 5-Aza) treatment controls induction of epithelial to mesenchymal (EMT) and a cancer stem cell (CSC) phenotype, which facilitates tumorigenesis in PCa cells. Here, we use the epidrug 5-Aza as a model for how histone marks may regulate the reprogramming of prostate adenocarcinoma into NE phenotypic cells...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236328/mirnalet-7a-mediates-prostate-cancer-pc-3-cell-invasion-migration-by-inducing-epithelial-mesenchymal-transition-through-ccr7-mapk-pathway
#18
Tang Guanlin, Du Ruoyang, Tang Zhaobing, Kuang Youlin
Prostate cancer is one of the most common malignancies in older men. Recent evidence has demonstrated microRNA (miRNA) Let-7a expression decreased in prostate cancer, while the expression of C-C chemokine receptor type 7 (CCR7) increased. In this study, we investigated whether CCR7 overexpression was associated with a decrease in the expression of miRNA let-7a in invasion and metastasis of prostate cancer cell. Methods Synthetic let-7a mimics and let-7a inhibitors were transfected into prostate cancer PC-3 cells repectively...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236310/insulin-induces-an-emt-like-process-in-mammary-epithelial-cells-mcf10a
#19
Cecilia Rodriguez-Monterrosas, Ricardo Díaz-Aragon, Elizabeth Leal-Orta, Pedro Cortes-Reynosa, Eduardo Perez Salazar
Diabetes mellitus has been related with an increased risk of breast cancer, whereas it has been suggested that links between diabetes mellitus and cancer are hyperinsulinemia, insulin resistance, hyperglycemia and chronic inflammation induced by adipose tissue. Contribution of hyperinsulinemia to carcinogenesis is mediated through resistance to endogenous insulin and by exogenous insulin used in treatment. Epithelial to mesenchymal transition (EMT) is a process by which epithelial cells are transdifferentiated to a mesenchymal state that has been implicated in cancer progression...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29234448/aristolochic-acid-induced-autophagy-promotes-epithelial-to-myofibroblast-transition-in-human-renal-proximal-tubule-epithelial-cells
#20
Yu-Lin Man, Hong-Liang Rui, Yi-Pu Chen, Guo-Qin Wang, Li-Jun Sun, Hong Cheng
Autophagy plays an essential role in cellular homeostasis in kidney. Previous studies have found that aristolochic acid (AA) can induce autophagy of renal tubular epithelial cells and epithelial-to-myofibroblast transition (EMT). However, the relationship between AA-induced autophagy and EMT is unclear. Our results showed that, after AA stimulation, the appearance of autophagy preceded EMT. Autophagy of HKC cells began to increase gradually from the 3rd hour, reached the peak at 12th hour, and then weakened gradually until 36th hour; the EMT process of HKC continued to increase from 6th hour to 36th hour after AA stimulation...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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