Changlei Bao, Qian He, Hui Wang, Yanan Sun, Yahang Xu, Yan Pan, Yadan Hu, Shichuang Zheng, Shuxin Liang, Ang Luo, Tanzilan Nahar, Jiwang Chen, Haiyang Tang, Ying Han
Background: Pulmonary arterial hypertension (PAH) is a complex pulmonary vasculature disease characterized by progressive obliteration of small pulmonary arteries and persistent increase in pulmonary vascular resistance, resulting in right heart failure and death if left untreated. Artemisinin (ARS) and its derivatives, which are common antimalarial drugs, have been found to possess a broad range of biological effects. Here, we sought to determine the therapeutic benefit and mechanism of ARS and its derivatives treatment in experimental pulmonary hypertension (PH) models...
2022: Oxidative Medicine and Cellular Longevity