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Ros, nos, no, lung disease

Jae-Won Lee, Ji-Won Park, Na-Rae Shin, So-Yeon Park, Ok-Kyoung Kwon, Hyun Ah Park, Yourim Lim, Hyung Won Ryu, Heung Joo Yuk, Jung Hee Kim, Sei-Ryang Oh, Kyung-Seop Ahn
Picrasma quassiodes (D.Don) Benn. (PQ) is a medicinal herb belonging to the family Simaroubaceae and is used as a traditional herbal remedy for various diseases. In this study, we evaluated the effects of PQ on airway inflammation using a mouse model of lipopolysaccharide (LPS)-induced acute lung injury (ALI) and LPS-stimulated raw 264.7 cells. ALI was induced in C57BL/6 mice by the intranasal administration of LPS, and PQ was administered orally 3 days prior to exposure to LPS. Treatment with PQ significantly attenuated the infiltration of inflammatory cells in the bronchoalveolar lavage fluid (BALF)...
September 2016: International Journal of Molecular Medicine
Yuefei Jin, Weidong Wu, Weiguo Zhang, Yang Zhao, Yongjun Wu, Guoyin Ge, Yue Ba, Qiang Guo, Tianyu Gao, Xuejing Chi, Huiyun Hao, Jing Wang, Feifei Feng
Epidemiological studies have shown that exposure to ambient fine particulate matter (PM2.5 ) is associated with respiratory diseases. Lung inflammation is a central feature of many pulmonary diseases, which can be induced by PM2.5 exposure. However, the mechanisms underlying PM2.5 -induced lung inflammation remain unclear. To characterize the role of epidermal growth factor receptor (EGFR) and inflammasome in PM2.5 -induced lung inflammation in mice, 30 BALB/c mice were intrabroncheally instilled with saline and PM2...
July 5, 2016: Environmental Toxicology
Flavia Maria Mauren, Yanti, Bibiana Widiati Lay
BACKGROUND: Hypercholesterolemia is one of the most important risk factors for atherosclerosis and subsequent cardiovascular diseases. OBJECTIVE: The present work was aimed to study the efficacy of curcuminoid fraction from Curcuma xanthorrhiza and its curcuminoid cider in reducing blood cholesterol level and four genes related to oxidative stress, including cluster of differentiation 44 (CD44), intercellular adhesion molecule 1 (ICAM-1), inducible nitric oxide synthase (iNOS), and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in high-cholesterol fed rats in vivo...
July 2016: Pharmacognosy Research
Mirjana Jerkic, Michelle Letarte
Oxidative stress causes endothelial dysfunction and is implicated in the pathogenesis of cardiovascular diseases. Our studies suggested that reactive oxygen species (ROS) play a crucial role in hereditary hemorrhagic telangiectasia (HHT) disease, a vascular dysplasia affecting 1 in 5,000-8,000 people. Mutations in endoglin (ENG) and activin receptor-like kinase 1 (ACVRL1) genes are responsible for HHT1 and HHT2 and are associated with arteriovenous malformations. ENG and ACVRL1 interact with endothelial nitric oxide synthase (eNOS) and regulate its activation...
2015: Frontiers in Genetics
Emmanuelle Charrin, Emeline Aufradet, Aymeric Douillard, Aymen Romdhani, Genevieve De Souza, Amine Bessaad, Camille Faes, Erica N Chirico, Vincent Pialoux, Cyril Martin
Oxidative stress plays a crucial role in sickle cell disease (SCD) physiopathology. Given that chronic physical activity is known to decrease reactive oxygen species (ROS) and increase nitric oxide (NO) bioavailability in healthy subjects and in patients with cardiovascular or inflammatory pathologies, modulating these factors involved in the severity of the pathology could also be beneficial in SCD. This study aimed to determine if 8 weeks of increased physical activity (PA) by voluntary wheel running affects the hypoxia/reoxygenation (H/R) responses by reducing oxidative stress and increasing NO synthesis in sickle SAD mice...
March 2015: British Journal of Haematology
Airi R A Puhakka, Terttu H Harju, Paavo K Pääkkö, Ylermi M Soini, Vuokko L Kinnula
Recent studies suggest that reactive oxygen (ROS) and nitrogen species (RNS) are highly associated with the pathogenesis of cigarette smoke related lung diseases but their role in the malignant conversion of bronchial epithelium is unclear. The immunohistochemical expression of inducible, endothelial and neuronal nitric oxide synthases (iNOS, eNOS and nNOS) and nitrotyrosine as a biomarker of oxidative/nitrosative stress was evaluated in 79 cases including 13 non-smokers, 20 smokers without chronic obstructive pulmonary disease (COPD), 22 with COPD and 24 with metaplasia-dysplasia-sequence of the bronchial epithelium...
March 2006: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
J F Engelhardt
Cellular redox state has been increasingly recognized as a critical component of stress-induced cellular responses and disease. Inherent in these responses are reactive oxygen species (ROS), which inflict direct cellular damage in addition to acting as intracellular second messengers modulating signal transduction pathways. These intracellular highways of communication are critical in determining cell fates and whole-organ responses following environmental injury. Although gene therapy for inherited and acquired disorders has exploded in the last decade, the application of gene therapeutic approaches for transient pathologic conditions resulting from environmental stress is just beginning to be recognized...
1999: Antioxidants & Redox Signaling
T Saetre, E A Höiby, T Aspelin, G Lermark, T Egeland, T Lyberg
OBJECTIVE: To test the effect of a continuous infusion of the nitric oxide (NO) synthase (S) inhibitor aminoethyl-isothiourea (AE-ITU) on survival time, hemodynamics, and oxygen transport in a porcine model of live group A streptococcal (GAS) sepsis. Furthermore, to examine the role of endothelin-1, histamine, and reactive oxygen species (ROS) in streptococcal shock. DESIGN: Prospective, randomized trial. SETTING: Laboratory at a university hospital...
August 2000: Critical Care Medicine
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