Donatella Canistro, Alessandra A Affatato, Antonio Soleti, Vincenzo Mollace, Carolina Muscoli, Francesca Sculco, Iolanda Sacco, Valeria Visalli, Barbara Bonamassa, Manuela Martano, Michelangelo Iannone, Andrea Sapone, Moreno Paolini
The removal of pathologically generated free radicals produced during ischemia, reperfusion and intracranical hemorrhage seems to be a viable approach to neuroprotection. However, at present, no neuroprotective agent has proven effective in focal ischemic stroke phase III trials, despite the encouraging data in animal models. This study aimed to explore the effect of the brain penetrant low molecular weight radical scavenger bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)-decandioate (IAC) in neurological damage subsequent to ischemia-reperfusion injury in Mongolian gerbils...
March 15, 2010: Journal of the Neurological Sciences