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antiproteinuric value of ACE inhibitors and ARBs

Yanqin Zhang, Fang Wang, Jie Ding, Hongwen Zhang, Xiaoyu Liu, Suxia Wang, Huijie Xiao, Yong Yao, Jingcheng Liu, Xuhui Zhong, Na Guan, Baige Su, Guohong Wu, Lixia Yu
BACKGROUND: The aim of this study was to analyze the long-term efficacy and safety of angiotensin-converting enzyme inhibitor (ACEi) and ACEi + angiotensin receptor blocker (ARB) treatments in a cohort of children with Alport syndrome (AS). METHODS: This was a respective review of 79 Chinese children with AS who received ACEi alone or combined ACEi + ARB therapy. RESULTS: The mean age of the pediatric patients with AS at onset of treatment was 8...
January 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
E Morales, A Huerta, E Gutiérrez, E Gutiérrez Solís, J Segura, M Praga
BACKGROUND: Obesity increases the risk of proteinuria and chronic renal insufficiency and hastens the progression of renal diseases. Increased activity of renin-angiotensin-aldosterone system and elevated levels of aldosterone are common in obese patients. No studies have compared the efficacy of the currently available antiproteinuric strategies (ACE inhibitors -ACEI-, angiotensin receptor blockers -ARB-, aldosterone antagonists) in obese patients with proteinuric renal diseases. METHODS: Single centre, prospective, randomized study...
2009: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Yoshio Horita, Kouichi Taura, Takashi Taguchi, Akira Furusu, Shigeru Kohno
BACKGROUND: We are investigating whether aldosterone breakthrough negatively impacts on the antiproteinuric effects of angiotensin-converting enzyme (ACE) inhibitors and/or angiotensin II receptor blockers (ARB). METHODS: We examine the role of aldosterone breakthrough in 43 normotensive, proteinuric (0.7 +/- 0.3 g/day) outpatients (aged 41.5 +/- 10.9 years) with immunoglobulin A nephropathy (IgAN) accompanied by stable renal function (creatinine clearance >50 mL/min)...
October 2006: Nephrology
George L Bakris, Matthew R Weir, Michelle Secic, Brett Campbell, Annette Weis-McNulty
BACKGROUND: Numerous studies suggest that the dihydropyridine calcium antagonists (DCAs) and nondihydropyridine calcium antagonists (NDCAs) have differential antiproteinuric effects. Proteinuria reduction is a correlate of the progression of renal disease. In an earlier systematic review, calcium antagonists were shown as effective antihypertensive drugs, but there was uncertainty about their renal benefits in patients with proteinuria and renal insufficiency. METHODS: A systematic review was conducted to assess the differential effects of DCAs and NDCAs on proteinuria in hypertensive adults with proteinuria, with or without diabetes, and to determine whether these differential effects translate into altered progression of nephropathy...
June 2004: Kidney International
Juliá Segura, Manuel Praga, Carlos Campo, José L Rodicio, Luis M Ruilope
OBJECTIVE: The combination of an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin II (Ang II) receptor antagonist (ARB) could provide a higher degree of blockade of the renin-angiotensin system(RAS) than either agent alone. The primary aim of this study was to look at the effect of three therapeutic regimens (titrated ACE inhibitor (ACE-I) versus titrated ARB versus the combination of an ACE-I and an ARB) on the attainment of adequate blood pressure (BP) control and antiproteinuric effect...
March 2003: Journal of the Renin-angiotensin-aldosterone System: JRAAS
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