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Serology in dengue

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https://www.readbyqxmd.com/read/29772885/geographical-distribution-and-spatio-temporal-patterns-of-hospitalization-due-to-dengue-infection-at-a-leading-specialist-hospital-in-malaysia
#1
Gary K K Low, Panayoti Papapreponis, Ridzuan M Isa, Seng Chiew Gan, Hui Yee Chee, Kian Keong Te, Nadia M Hatta
Increasing numbers of dengue infection worldwide have led to a rise in deaths due to complications caused by this disease. We present here a cross-sectional study of dengue patients who attended the Emergency and Trauma Department of Ampang Hospital, one of Malaysia's leading specialist hospitals. The objective was to search for potential clustering of severe dengue, in space and/or time, among the annual admissions with the secondary objective to describe the spatio-temporal pattern of all dengue cases admitted to this hospital...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29751200/biosensor-based-selective-detection-of-zika-virus-specific-antibodies-in-infected-individuals
#2
Gustavo Cabral-Miranda, Ana R Cardoso, Luis C S Ferreira, M Goreti F Sales, Martin F Bachmann
Zika virus (ZIKV) recently emerged as a global threat subsequent to its global spread because it induces microencephaly and other brain damages in infants born to infected mothers. Epidemiological monitoring of infection has been hampered by the absence of reliable serological tests capable to distinguish between ZIKV and other Flavivirus infections, in particular Dengue virus (DENV). As both viruses are transmitted by the same mosquito-species, their distributions largely overlap and reliable serological distinction between the viruses is essential...
May 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29746378/acute-encephalitis-syndrome-in-gorakhpur-uttar-pradesh-2016-clinical-and-laboratory-findings
#3
Mahima Mittal, Vijay Bondre, Manoj Murhekar, Hirawati Deval, Winsley Rose, Valsan Philip Verghese, Mahim Mittal, Gajanan Patil, R Sabarinathan, Jeromie Wesley Vivian Thangaraj, K Kanagasabai, John Antony Jude Prakash, Nivedita Gupta, Manish Gupte, Mohan D Gupte
BACKGROUND: Seasonal outbreaks of acute encephalitis syndrome (AES) with high fatality have been occurring in Gorakhpur, Uttar Pradesh, India for several years. We conducted investigations during the 2016 outbreak, to identify the etiology. METHODS: We included 407 hospitalized AES patients with CSF pleocytosis (>5 cells/cmm) in our study. These patients were clinically examined; their blood and CSF samples were collected and investigated for scrub typhus (ST), Japanese encephalitis virus (JEV), dengue virus and spotted fever group of rickettsia (SFGR) by serology and/or PCR...
May 9, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29724267/demographic-clinical-and-laboratory-features-of-leptospirosis-and-dengue-co-infection-in-malaysia
#4
Munirah Hishamshah, Norazah Ahmad, Hishamshah Mohd Ibrahim, Nurul Atiqah Nur Halim, Salbiah Nawi, Fairuz Amran
PURPOSE: In this study, we aim to describe and compare the demographical, clinical and laboratory features of leptospirosis and dengue co-infections (LDCI) against single leptospirosis infections in Malaysia. METHODOLOGY: Data of patients admitted to various hospitals in Malaysia from 2011 to 2015 diagnosed with leptospirosis in our laboratory were obtained from their admission records. Co-infection with dengue was determined by collecting dengue serology results...
May 4, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29720583/ce-blast-makes-it-possible-to-compute-antigenic-similarity-for-newly-emerging-pathogens
#5
Tianyi Qiu, Yiyan Yang, Jingxuan Qiu, Yang Huang, Tianlei Xu, Han Xiao, Dingfeng Wu, Qingchen Zhang, Chen Zhou, Xiaoyan Zhang, Kailin Tang, Jianqing Xu, Zhiwei Cao
Major challenges in vaccine development include rapidly selecting or designing immunogens for raising cross-protective immunity against different intra- or inter-subtypic pathogens, especially for the newly emerging varieties. Here we propose a computational method, Conformational Epitope (CE)-BLAST, for calculating the antigenic similarity among different pathogens with stable and high performance, which is independent of the prior binding-assay information, unlike the currently available models that heavily rely on the historical experimental data...
May 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29683399/seroprevalence-of-dengue-virus-west-nile-virus-chikungunya-virus-and-zika-virus-in-international-travelers-attending-a-travel-and-migration-center-in-2015-2017-southern-italy
#6
Daniela Loconsole, Angela Metallo, Anna Lisa De Robertis, Anna Morea, Michele Quarto, Maria Chironna
International travelers to areas endemic for vector-borne diseases (VBDs) may be at risk of contracting and spreading these diseases. The aim of this study was to evaluate the prevalence of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies that are specific for Dengue Virus (DV), West Nile Virus (WNV), Chikungunya Virus (CHIKV), or Zika Virus (ZV) in a cohort of international travelers. The study enrolled travelers who attended the Travel Medicine and Migration outpatient service of Local Health Unit of Bari, Italy, in March 2015-June 2017 for counseling and vaccine prophylaxis before travel...
April 23, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29673030/dengue-fever-and-aedes-aegypti-in-indigenous-brazilians-seroprevalence-risk-factors-knowledge-and-practices
#7
Luciano Pamplona de Góes Cavalcanti, Rafael Henrique Machado Sacramento, Fernanda Montenegro de Carvalho Araújo, Danielle Malta Lima, Carlos Carlos Henrique Alencar, Victor Emanuel Pessoa Martins, Lucas Venâncio Araújo, Tais Castelo de Oliveira
OBJECTIVE: Dengue remains an important public health problem in Brazil. We estimated the associated factors of dengue seroprevalence among native Indians of the Tremembé ethnic and their knowledge about the aspects related to the presence of mosquitoes of the genus Aedes. METHODS: An analytical cross-sectional study and a prospective environmental study to monitor the trapping of mosquito eggs monthly were performed. The serological portion of the study involved indigenous people living in the village of Tapera in northeastern Brazil...
April 19, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29665374/spectrum-of-activity-testing-for-therapeutics-against-all-four-dengue-virus-serotypes-in-ag129-mouse-models-proof-of-concept-studies-with-the-adenosine-nucleoside-inhibitor-nitd-008
#8
Gregg N Milligan, Mellodee White, Diana Zavala, Richard B Pyles, Vanessa V Sarathy, Alan D T Barrett, Nigel Bourne
Dengue is a mosquito-borne disease of global public health importance caused by four genetically and serologically related viruses (DENV-1 to DENV-4). Efforts to develop effective vaccines and therapeutics for dengue have been slowed by the paucity of preclinical models that mimic human disease. DENV-2 models in interferon receptor deficient AG129 mice were an important advance but only allowed testing against a single DENV serotype. We have developed complementary AG129 mouse models of severe disseminated dengue infection using strains of the other three DENV serotypes...
April 14, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29661824/development-of-dengue-virus-serotype-specific-ns1-capture-assays-for-the-rapid-and-highly-sensitive-identification-of-the-infecting-serotype-in-human-sera
#9
Katharina Röltgen, Natalie Rose, Alessia Ruggieri, Louisa Warryn, Nicole Scherr, Carlos Augusto Pinho-Nascimento, Marco Tamborrini, Thomas Jaenisch, Gerd Pluschke
Dengue fever can be caused by one of four distinct dengue virus (DENV) serotypes that cocirculate in many parts of the world. Point of care serotype-specific nonstructural protein-1 (NS1) capture assays for the rapid serotyping of DENV in human sera would greatly support epidemiological surveillance and potentially also prognosis in individual patients. To ensure both serotype specificity and broad coverage of variants within serotypes, we have applied an innovative approach for the generation and selection of serotype-specific anti-NS1 mAbs...
April 16, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29623138/clinical-serological-and-molecular-observations-from-a-case-series-study-during-the-asian-lineage-zika-virus-outbreak-in-grenada-during-2016
#10
Marco Brenciaglia, Trevor P Noël, Paul J Fields, Satesh Bidaisee, Todd E Myers, William M Nelson, Neeraja Venkateswaran, Kodumudi Venkateswaran, Nishanth Parameswaran, Avi Bahadoor, Katherine Yearwood, Veronica Mapp-Alexander, George Mitchell, A Desiree LaBeaud, Calum N L Macpherson
This paper describes the spatial and temporal distribution of cases, demographic characteristics of patients, and clinical manifestations of Zika virus (ZIKV) during the 2016 outbreak in Grenada. The first reported case was recorded in St. Andrew Parish in April, and the last reported case was seen in November, with peak transmission occurring in the last week of June, based on test results. Data were collected from a total of 514 patients, of whom 207 (40%) tested positive for ZIKV. No evidence was found that testing positive for ZIKV infection was related to age, gender, or pregnancy status...
2018: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29618505/incorporation-of-igg-depletion-in-a-neutralization-assay-facilitates-differential-diagnosis-of-zika-and-dengue-in-secondary-flavivirus-infection-cases
#11
Amanda E Calvert, Karen L Boroughs, Janeen Laven, Janae L Stovall, Betty E Luy, Olga I Kosoy, Claire Y-H Huang
Zika virus (ZIKV) has emerged as a major global public health concern due to its link as a causative agent of human birth defects. Serological laboratory diagnosis of suspected ZIKV specimens collected a week or more after symptom onset primarily relies on detection of anti-ZIKV specific IgM antibodies by ELISA coupled with detection of ZIKV-specific neutralizing antibody by neutralization tests. A definitive diagnosis based on serology assays is possible during primary ZIKV infections; however, due to cross-reactivity of antibodies elicited during flaviviral infections a definitive diagnosis is not always possible, especially among individuals who have been previously exposed to closely related flaviviruses such as dengue virus (DENV)...
April 4, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29618091/longitudinal-analysis-of-antibody-cross-neutralization-following-zika-and-dengue-virus-infection-in-asia-and-the-americas
#12
Magelda Montoya, Matthew Collins, Wanwisa Dejnirattisai, Leah C Katzelnick, Henry Puerta-Guardo, Ramesh Jadi, Samuel Schildhauer, Piyada Supasa, Sirijitt Vasanawathana, Prida Malasit, Juthathip Mongkolsapaya, Aruna D de Silva, Hasitha Tissera, Angel Balmaseda, Gavin Screaton, Aravinda M de Silva, Eva Harris
Background: The four dengue virus serotypes (DENV1-4) and Zika virus (ZIKV) are related mosquito-borne flaviviruses of major importance globally. While monoclonal antibodies and plasma from DENV-immune donors can neutralize or enhance ZIKV in vitro and in small animal models, and vice versa, the extent, duration, and significance of cross-reactivity remains unknown, particularly in flavivirus-endemic regions. Methods: We studied neutralizing antibodies to ZIKV and DENV1-4 in longitudinal serologic specimens through 3 years post-infection from people in Latin America and Asia with laboratory-confirmed DENV infections...
April 2, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29614385/consequences-of-a-recent-past-dengue-infection-for-acute-and-long-term-chikungunya-outcome-a-retrospective-cohort-study-in-cura%C3%A3-ao
#13
Jelte Elsinga, Yaskara Halabi, Izzy Gerstenbluth, Adriana Tami, Martin P Grobusch
BACKGROUND: Dengue and chikungunya co-infections are an emerging threat to public health in tropical and sub-tropical areas. This study investigates acute and long-term clinical presentation patterns of chikungunya against a backdrop of preceding dengue infection and determines predicting factors for long-term chikungunya sequelae. METHODS: A retrospective cohort study was performed in 2015, including 299 previously confirmed chikungunya cases, of which 162 subjects were assessed for dengue serology at disease onset...
March 31, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29609659/dengue-virus-like-particles-mimic-the-antigenic-properties-of-the-infectious-dengue-virus-envelope
#14
Stefan W Metz, Ashlie Thomas, Laura White, Mark Stoops, Markus Corten, Holger Hannemann, Aravinda M de Silva
BACKGROUND: The 4 dengue serotypes (DENV) are mosquito-borne pathogens that are associated with severe hemorrhagic disease. DENV particles have a lipid bilayer envelope that anchors two membrane glycoproteins prM and E. Two E-protein monomers form head-to-tail homodimers and three E-dimers align to form "rafts" that cover the viral surface. Some human antibodies that strongly neutralize DENV bind to quaternary structure epitopes displayed on E protein dimers or higher order structures forming the infectious virus...
April 2, 2018: Virology Journal
https://www.readbyqxmd.com/read/29609533/prolonged-persistence-of-igm-against-dengue-virus-detected-by-commonly-used-commercial-assays
#15
Yu-Wen Chien, Zi-Hu Liu, Fan-Chen Tseng, Tzu-Chuan Ho, How-Ran Guo, Nai-Ying Ko, Wen-Chien Ko, Guey Chuen Perng
BACKGROUND: Initial symptoms of dengue fever are non-specific, and thus definite diagnosis requires laboratory confirmation. Detection of IgM against dengue virus (DENV) has become widely used for dengue diagnosis. Understanding the persistence of anti-DENV IgM in subjects after acute infection is essential in order to interpret test results correctly. Although the longevity of anti-DENV IgM has been vehemently investigated in symptomatic children, anti-DENV IgM persistence in adults and in asymptomatically infected people have seldom been reported...
April 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29607357/simultaneous-detection-and-serotyping-of-dengue-infection-using-single-tube-multiplex-cdc-dengue-real-time-rt-pcr-from-india
#16
Shashi Sharma, Kundan Tandel, Surabhi Danwe, Puneet Bhatt, P K Dash, Praveer Ranjan, K R Rathi, Rajiv Mohan Gupta, M M Parida
Four antigenically different dengue virus serotypes (DENV-1, DENV-2, DENV-3 and DENV-4) are known to cause infections in humans. Some of these are known to cause more severe disease than the others. Chances for developing Dengue hemorrhagic fever-dengue shock syndrome (DHF-DSS) increases significantly with history of previous infection with one of the four serotypes. Therefore, early diagnosis, serotyping and providing early warning of dengue fever epidemics to concerned authorities becomes very important for better patient outcome and to curb the rapid spread in the community...
March 2018: Virusdisease
https://www.readbyqxmd.com/read/29588874/clinical-and-laboratory-profile-of-zika-and-dengue-infected-patients-lessons-learned-from-the-co-circulation-of-dengue-zika-and-chikungunya-in-brazil
#17
Elzinandes Leal Azeredo, Flavia Barreto Dos Santos, Luciana Santos Barbosa, Thiara Manuele Alves Souza, Jessica Badolato-Corrêa, Juan Camilo Sánchez-Arcila, Priscila Conrado Guerra Nunes, Luzia Maria de-Oliveira-Pinto, Ana Maria de Filippis, Márcia Dal Fabbro, Izilyanne Hoscher Romanholi, Rivaldo Venancio da Cunha
BACKGROUND: The current triple epidemic caused by dengue, zika and chikungunya constitutes a serious health problem in Brazil. The aim of this study was to investigate acute samples (up to the 7 days of symptoms) from patients presenting acute fever syndrome suspected as arboviral infection and characterize the clinical and laboratorial profile during the co-circulation of dengue, zika and chikungunya in Campo Grande, Mato Grosso do Sul (MS), midwest region of Brazil. METHODS: All suspected cases (n=134) were tested by using serological and molecular diagnostic tests including DENV, ZIKV and CHIKV RT-PCR, Dengue nonstructural protein 1 (NS1) antigen capture ELISA, anti- DENV IgM ELISA and anti-CHIKV IgM ELISA...
February 15, 2018: PLoS Currents
https://www.readbyqxmd.com/read/29580756/case-series-of-ocular-involvement-due-to-dengue-first-reported-cases-in-guatemala
#18
M A Carrillo-Soto
OBJECTIVE: Describe the ocular findings of a case series of 8 patients with a diagnosis of dengue. MATERIALS AND METHODS: Review of clinical records and interviews with patients during outpatient visits, after informed consent was obtained and following the ethical standards of the Helsinki declaration. The patients were diagnosed with diagnosis by IgM / IgG dengue serology in whom ocular involvement was identified, between January and October 2017 in Retinal-vascular clinic of the "Dr...
March 23, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29577083/human-antibody-responses-to-emerging-mayaro-virus-and-cocirculating-alphavirus-infections-examined-by-using-structural-proteins-from-nine-new-and-old-world-lineages
#19
Jessica L Smith, Christine L Pugh, Emily D Cisney, Sarah L Keasey, Carolina Guevara, Julia S Ampuero, Guillermo Comach, Doris Gomez, Margarita Ochoa-Diaz, Robert D Hontz, Robert G Ulrich
Mayaro virus (MAYV), Venezuelan equine encephalitis virus (VEEV), and chikungunya virus (CHIKV) are vector-borne alphaviruses that cocirculate in South America. Human infections by these viruses are frequently underdiagnosed or misdiagnosed, especially in areas with high dengue virus endemicity. Disease may progress to debilitating arthralgia (MAYV, CHIKV), encephalitis (VEEV), and death. Few standardized serological assays exist for specific human alphavirus infection detection, and antigen cross-reactivity can be problematic...
March 2018: MSphere
https://www.readbyqxmd.com/read/29575672/serological-evidence-of-widespread-exposure-of-grenada-fruit-bats-to-chikungunya-virus
#20
D Stone, A C Lyons, Y-J S Huang, D L Vanlandingham, S Higgs, B J Blitvich, A A Adesiyun, S E Santana, L Leiser-Miller, S Cheetham
Antibody detection against selected potentially zoonotic vector-borne alphaviruses and flaviviruses was conducted on sera from bats from all six parishes in Grenada, West Indies. Sera were tested for (i) antibodies to flaviviruses West Nile virus, St. Louis encephalitis virus, Ilhéus virus, Bussuquara virus (BSQV), Rio Bravo virus and all four serotypes of dengue virus (DENV) by plaque reduction neutralization test (PRNT); (ii) antibodies to alphaviruses western equine encephalitis virus, Venezuelan equine encephalitis virus and eastern equine encephalitis virus by epitope-blocking enzyme-linked immunosorbent assay (ELISA); and (iii) antibodies to the alphavirus chikungunya (CHIKV) by PRNT...
March 25, 2018: Zoonoses and Public Health
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