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Serology in dengue

Marie Louise Landry, Kirsten St George
CONTEXT: -The rapid and accurate diagnosis of Zika virus infection is an international priority. OBJECTIVE: -To review current recommendations, methods, limitations, and priorities for Zika virus testing. DATA SOURCES: -Sources include published literature, public health recommendations, laboratory procedures, and testing experience. CONCLUSIONS: -Until recently, the laboratory diagnosis of Zika infection was confined to public health or research laboratories that prepared their own reagents, and test capacity has been limited...
October 20, 2016: Archives of Pathology & Laboratory Medicine
B Mishra, B Behera
Until now, known as the demure cousin of dengue virus (DENV) inhabiting Africa, Zika virus (ZIKV) has reinvented itself to cause explosive epidemics captivating the Western hemisphere. The outbreak causing potential for ZIKV was realized when it made its way from Africa to Yap Island Micronesia in 2007, and in French Polynesia in 2013. From there, it moved on to Brazil in 2015. Now ZIKV has infected people in more than 33 countries in Central and South America and the Caribbean. Moreover the epidemiological and subsequent virological association with microcephaly cases in Brazil has prompted the World Health Organization to declare a public health emergency of International Concern...
October 2016: Journal of Postgraduate Medicine
Jasmine Porwal, Ajay Chauhan
Dengue infection accompanied by unusual complications and manifestations has been described before. Here we report a case of dengue encephalitis who was IgM positive for dengue serology and had presented to us with only motor weakness after an acute febrile episode. Dengue presenting as encephalitis is in itself a very rare feature and that too, pure motor weakness has hardly ever been reported before.
August 2016: Journal of the Association of Physicians of India
D B Kadam, Sonali Salvi, Ajay Chandanwale
The World Health Organization (WHO) has coined the term expanded dengue to describe cases which do not fall into either dengue shock syndrome or dengue hemorrhagic fever. This has incorporated several atypical findings of dengue. Dengue virus has not been enlisted as a common etiological agent in several conditions like encephalitis, Guillain Barre syndrome. Moreover it is a great mimic of co-existing epidemics like Malaria, Chikungunya and Zika virus disease, which are also mosquito-borne diseases. The atypical manifestations noted in dengue can be mutisystemic and multifacetal...
July 2016: Journal of the Association of Physicians of India
S Sheetal, Elizabeth Jacob
OBJECTIVE: This study was done to study the prevalence of cardiac manifestations of dengue fever in patients presenting to our hospital and to find out the correlation of cardiac manifestations to warning signs of dengue and severe dengue. METHODS: The study was conducted at Sree Gokulam Medical College and Research Foundation, which is a tertiary care hospital, in the Department of Medicine in the month of July 2013. One hundred consecutive patients aged 13 years or more with positive dengue serology were interviewed and examined...
May 2016: Journal of the Association of Physicians of India
Rohit Morlawar, V A Kothiwale, Veena Munnavali
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
P Padmapriya, V Senthil Kumar, R Senthil Raja, A Khaleefathullah Sheriff, T S Uma, S Mohana, Kavita Arunagiri, A Anupama, N Saran, R Kiruba, K Saravana Murali, B V Suresh Babu, N Nivas Chakravarthy, K Saraswathi, K Kaveri, P Gunasekaran
Dengue is a public health problem with an increasing global incidence and geographic distribution in almost all tropical and subtropical countries, with a transition from epidemic to endemic occurrence. In this study, we report a six-year analysis (2009-2014) performed at the Department of Virology, King Institute of Preventive Medicine, Chennai, Tamil Nadu, India. Our data confirm earlier findings that dengue is highly endemic in Chennai. In the present study, 10,099 serum samples from suspected dengue cases were tested for IgM ELISA (NIV Capture) and IgG Panbio ELISA (Australia)...
September 30, 2016: Archives of Virology
Anna Likos, Isabel Griffin, Andrea M Bingham, Danielle Stanek, Marc Fischer, Stephen White, Janet Hamilton, Leah Eisenstein, David Atrubin, Prakash Mulay, Blake Scott, Patrick Jenkins, Danielle Fernandez, Edhelene Rico, Leah Gillis, Reynald Jean, Marshall Cone, Carina Blackmore, Janet McAllister, Chalmers Vasquez, Lillian Rivera, Celeste Philip
During the first 6 months of 2016, large outbreaks of Zika virus disease caused by local mosquito-borne transmission occurred in Puerto Rico and other U.S. territories, but local mosquito-borne transmission was not identified in the continental United States (1,2). As of July 22, 2016, the Florida Department of Health had identified 321 Zika virus disease cases among Florida residents and visitors, all occurring in either travelers from other countries or territories with ongoing Zika virus transmission or sexual contacts of recent travelers...
2016: MMWR. Morbidity and Mortality Weekly Report
A Kuna, M Bykowska, N Kulawiak, B Biernat, B Szostakowska, W L Nahorski, W Pawlowski, L Chomicz
BACKGROUND & OBJECTIVES: Dengue is a mosquito-borne viral disease, incidences of which have increased rapidly in the past decade. About 400 million new infections are recorded annually worldwide, and 40% of the human population lives in the areas at risk of dengue transmission. In this study, the clinical and laboratory profile of dengue diagnosed patients returning to Poland from tropical areas has been analyzed. METHODS: This is a retrospective study of 65 patients based on clinical symptoms and serological tests conducted in the Department of Tropical Parasitology of Institute of Maritime and Tropical Medicine (IMTM) in Gdynia, Poland during 2010-15...
July 2016: Journal of Vector Borne Diseases
M R Wilson, L L Zimmermann, E D Crawford, H A Sample, P R Soni, A N Baker, L M Khan, J L DeRisi
Solid organ transplant patients are vulnerable to suffering neurologic complications from a wide array of viral infections and can be sentinels in the population who are first to get serious complications from emerging infections like the recent waves of arboviruses, including West Nile virus, Chikungunya virus, Zika virus, and Dengue virus. The diverse and rapidly changing landscape of possible causes of viral encephalitis poses great challenges for traditional candidate-based infectious disease diagnostics that already fail to identify a causative pathogen in approximately 50% of encephalitis cases...
September 20, 2016: American Journal of Transplantation
Amoolya Bhat, Vijaya Chowdappa, Smita Surendra Masamatti
INTRODUCTION: Dengue affects more than 50 million people per year and is one of the most common causes of severe thrombocytopaenia. Thrombocytopaenia is a common complication of dengue and other viral fevers apart from malaria, typhoid, leptospirosis, leukaemia and megaloblastic anaemia. A platelet count of <20,000/μl is characteristically seen in dengue haemorrhagic fever and dengue fever. It results from immune complex mediated platelet destruction or bone marrow suppression. Severe thrombocytopaenia <10,000/μl is one of the indications for prophylactic platelet transfusion therapy to prevent haemorrhage...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Fernando Rosso, Sara Vanegas, Sarita Rodríguez, Robinson Pacheco
INTRODUCTION: Little is known about the prevalence and clinical course of dengue infection in elderly patients living in endemic areas; it is presumed that there is a lower prevalence but higher severity, complications and mortality.  OBJECTIVE: To describe the prevalence and clinical course of dengue infection in elderly patients who were admitted to a referral care center for infectious diseases in an endemic region.  MATERIALS AND METHODS: We conducted an observational and descriptive study between 2011 and 2014, using a cohort of elderly patients with serological diagnosis of dengue...
2016: Biomédica: Revista del Instituto Nacional de Salud
Lorena Matta, Mario M Barbosa, Cristhian D Morales-Plaza
INTRODUCTION: Dengue virus infection is amongst the most important arboviral diseases in the country and has become a major global public health concern.  OBJECTIVE: To describe the clinical profile of patients with dengue virus infection hospitalized in a tertiary hospital in the city of Cali, Colombia. We also describe the trend analysis of the number of cases by epidemiological weeks in 2013.  MATERIALS AND METHODS: We conducted a retrospective study of admitted patients suspected to have dengue infection in the Rafael Uribe Uribe Clinic in the year 2013...
2016: Biomédica: Revista del Instituto Nacional de Salud
Sriram Pothapregada, Banupriya Kamalakannan, Mahalaskhmy Thulasingham, Srinivasan Sampath
OBJECTIVE: To study the clinical profile and outcome of dengue fever in children at a tertiary care hospital in Puducherry. MATERIALS AND METHODS: All children (0-12 years of age) diagnosed and confirmed as dengue fever from August 2012 to January 2015 were reviewed retrospectively from hospital case records as per the revised World Health Organization guidelines for dengue fever. The diagnosis was confirmed by NS1 antigen-based ELISA test or dengue serology for IgM and IgG antibodies, and the data were analyzed using SPSS 16...
July 2016: Journal of Global Infectious Diseases
Andréia Moreira Dos Santos Carmo, Rodrigo Buzinaro Suzuki, Michele Marcondes Riquena, André Eterovic, Márcia Aparecida Sperança
BACKGROUND: Dengue fever (DF) outbreaks present regionally specific epidemiological and clinical characteristics. In certain medium-sized cities (100 000-250 000 inhabitants) of São Paulo State, Brazil, and after reaching an incidence of 150 cases/100 000 inhabitants ("epidemiological threshold"), clinical diagnosis indicated dengue virus (DENV) infection. During this period, other seasonally infectious diseases with symptoms and physical signs mimicking DF can simultaneously occur, with the consequential overcrowding of health care facilities as the principal drawbacks...
2016: Infectious Diseases of Poverty
Ryan R Hemme, B Katherine Poole-Smith, Elizabeth A Hunsperger, Gilberto E Felix, Kalanthe Horiuchi, Brad J Biggerstaff, Ricardo Lopez-Ortiz, Roberto Barrera
An important step to incriminate a mosquito as a vector of a disease pathogen is finding evidence of direct contact between the mosquito and humans. Typically, this is accomplished through landing/biting catches, or host blood meal analysis in engorged mosquitoes via immunologic assays. An alternate approach is to identify the presence of specific mosquito anti-saliva protein antibodies in the blood of exposed hosts. Following the discovery of dengue infected, free roaming non-human primates in Puerto Rico, we investigated which mosquito species had bitten these primates using a serologic assay...
September 2, 2016: Acta Tropica
Colin J Carlson, Eric R Dougherty, Wayne Getz
The current outbreak of Zika virus poses a severe threat to human health. While the range of the virus has been cataloged growing slowly over the last 50 years, the recent explosive expansion in the Americas indicates that the full potential distribution of Zika remains uncertain. Moreover, many studies rely on its similarity to dengue fever, a phylogenetically closely related disease of unknown ecological comparability. Here we compile a comprehensive spatially-explicit occurrence dataset from Zika viral surveillance and serological surveys based in its native range, and construct ecological niche models to test basic hypotheses about its spread and potential establishment...
August 2016: PLoS Neglected Tropical Diseases
Steven L Moulton, Jane Mulligan, Anon Srikiatkhachorn, Siripen Kalayanarooj, Greg Z Grudic, Sharone Green, Robert V Gibbons, Gary W Muniz, Carmen Hinojosa-Laborde, Alan L Rothman, Stephen J Thomas, Victor A Convertino
BACKGROUND: Early recognition and treatment of circulatory volume loss is essential in the clinical management of dengue viral infection. We hypothesized that a novel computational algorithm, originally developed for noninvasive monitoring of blood loss in combat casualties, could: (1) indicate the central volume status of children with dengue during the early stages of "shock"; and (2) track fluid resuscitation status. METHODS: Continuous noninvasive photoplethysmographic waveforms were collected over a 5-month period from three children of Thai ethnicity with clinical suspicion of dengue...
August 24, 2016: Journal of Medical Case Reports
Jayashamani Tamibmaniam, Narwani Hussin, Wee Kooi Cheah, Kee Sing Ng, Prema Muninathan
BACKGROUND: WHO's new classification in 2009: dengue with or without warning signs and severe dengue, has necessitated large numbers of admissions to hospitals of dengue patients which in turn has been imposing a huge economical and physical burden on many hospitals around the globe, particularly South East Asia and Malaysia where the disease has seen a rapid surge in numbers in recent years. Lack of a simple tool to differentiate mild from life threatening infection has led to unnecessary hospitalization of dengue patients...
2016: PloS One
Li Ting Soh, Raynal C Squires, Li Kiang Tan, Kwoon Yong Pok, HuiTing Yang, Christina Liew, Aparna Singh Shah, John Aaskov, Sazaly Abubakar, Futoshi Hasabe, Lee Ching Ng, Frank Konings
OBJECTIVE: To conduct an external quality assessment (EQA) of dengue and chikungunya diagnostics among national-level public health laboratories in the Asia Pacific region following the first round of EQA for dengue diagnostics in 2013. METHODS: Twenty-four national-level public health laboratories performed routine diagnostic assays on a proficiency testing panel consisting of two modules. Module A contained serum samples spiked with cultured dengue virus (DENV) or chikungunya virus (CHIKV) for the detection of nucleic acid and DENV non-structural protein 1 (NS1) antigen...
April 2016: Western Pacific Surveillance and Response Journal: WPSAR
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