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https://www.readbyqxmd.com/read/29768736/change-of-signs-symptoms-and-voice-quality-evaluations-throughout-a-3-to-6-months-empirical-treatment-for-laryngopharyngeal-reflux-disease
#1
Jérôme R Lechien, Camille Finck, Mohamad Khalife, Kathy Huet, Véronique Delvaux, Myriam Picalugga, Bernard Harmegnies, Sven Saussez
OBJECTIVE: To assess the usefulness of voice quality measurements as a treatment outcome in patients with laryngopharyngeal reflux (LPR)-related symptoms. DESIGN: Prospective uncontrolled multi-center study. MATERIAL AND METHODS: A total of 80 clinically diagnosed LPR patients with a reflux finding score (RFS)>7 and a reflux symptom index (RSI)>13 were treated with pantoprazole and diet recommendations during 3 or 6 months according to their evolution...
May 16, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29767814/inborn-errors-of-coenzyme-a-metabolism-and-neurodegeneration
#2
Ivano Di Meo, Miryam Carecchio, Valeria Tiranti
Two inborn errors of coenzyme A (CoA) metabolism are responsible for distinct forms of neurodegeneration with brain iron accumulation (NBIA), a heterogeneous group of neurodegenerative diseases having as a common denominator iron accumulation mainly in the inner portion of globus pallidus. Pantothenate kinase-associated neurodegeneration (PKAN), an autosomal recessive disorder with progressive impairment of movement, vision and cognition, is the most common form of NBIA and is caused by mutations in the pantothenate kinase 2 gene (PANK2), coding for a mitochondrial enzyme, which phosphorylates vitamin B5 in the first reaction of the CoA biosynthetic pathway...
May 16, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29765892/botulinum-toxin-a-injection-in-the-treatment-of-spasticity-in-a-infantile-onset-neurodegeneration-with-brain-iron-accumulation-a-case-report
#3
Hwan Kwon Do, Geun Yeol Jo, Jun Koo Kwon, Woo Jin Kim
Pantothenate kinase-associated neurodegeneration (PKAN) is a neurodegenerative disorder characterized by iron accumulation in the globus pallidus (GP) of the brain (neurodegeneration with brain iron accumulation [NBIA]), which is characterized by dystonia and spasticity resulting in postural difficulties. A 33-month-old boy was admitted with a pronounced gait disturbance. Marked hypertonicity in the patient's both calf muscles was noted, resulting in waddling with repeated slip-falls. NBIA was suspected by high T2 intensity in the GP on brain MRI, then it was confirmed by detecting PANK2 mutation...
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29762102/dynamic-encoding-of-effort-and-reward-throughout-the-execution-of-action-by-external-globus-pallidus-neurons-in-monkeys
#4
Simon Nougaret, Sabrina Ravel
Humans and animals must evaluate the costs and expected benefits of their actions to make adaptive choices. Prior studies have demonstrated the involvement of the BG in this evaluation. However, little is known about the role of the external part of the globus pallidus (GPe), which is well positioned to integrate motor and reward-related information, in this process. To investigate this role, the activity of 126 neurons was recorded in the associative and limbic parts of the GPe of two monkeys performing a behavioral task in which different levels of force were required to obtain different amounts of liquid reward...
May 15, 2018: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29758392/effects-of-mindfulness-and-psychoeducation-on-working-memory-in-adult-adhd-a-randomised-controlled-fmri-study
#5
Katharina Bachmann, Alexandra P Lam, Peter Sörös, Manuela Kanat, Eliza Hoxhaj, Swantje Matthies, Bernd Feige, Helge Müller, Jale Özyurt, Christiane M Thiel, Alexandra Philipsen
Adult attention-deficit/hyperactivity disorder (ADHD) is a serious mental disorder associated with impaired neurocognitive performance related to working memory function. Recent clinical trials have suggested that mindfulness is a promising intervention in adults with ADHD. We performed a randomised controlled clinical trial to investigate working memory (WM) with an n-back task in adults with ADHD during fMRI before and after an 8-week mindfulness intervention (MAP) compared with psychoeducation (PE). ADHD symptoms were assessed using the self- and observer-rated Conners Adult ADHD Rating Scales (CAARS)...
May 7, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29755237/the-expandable-transforaminal-lumbar-interbody-fusion-two-years-follow-up
#6
Joseph Gamal Boktor, Rhys D Pockett, Navin Verghese
Study Design: This was a retrospective, observational study. Objectives: We hypothesize that the expandable transforaminal lumbar interbody fusion (TLIF) cage achieves satisfactory clinical outcomes while allowing for safe placement, improvement, and maintenance of foraminal and disc dimensions at 24 months postsurgery with low risk of cage migration, subsidence, and nerve injury. Methods: TLIF with expandable cages was performed in 54 patients (62 levels) over a 24-month-period using open midline or minimally invasive surgery techniques with placement of Globus Caliber, Rise, or Altera expandable cages...
January 2018: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29754307/effects-of-cocaine-self-administration-and-its-extinction-on-the-rat-brain-cannabinoid-cb1-and-cb2-receptors
#7
Beata Bystrowska, Małgorzata Frankowska, Irena Smaga, Lucyna Pomierny-Chamioło, Małgorzata Filip
The aim of this study was to evaluate changes in the expression of cannabinoid type 1 (CB1) and 2 (CB2) receptor proteins in several brain regions in rats undergoing cocaine self-administration and extinction training. We used a triad-yoked procedure to distinguish between the motivational and pharmacological effects of cocaine. Using immunohistochemistry, we observed a significant decrease in CB1 receptor expression in the prefrontal cortex, dorsal striatum, and the basolateral and basomedial amygdala following cocaine (0...
May 12, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29754288/the-impact-of-hypoglycaemia-awareness-status-on-regional-brain-responses-to-acute-hypoglycaemia-in-men-with-type-1-diabetes
#8
Joel T Dunn, Pratik Choudhary, Ming Ming Teh, Ian Macdonald, Katharine F Hunt, Paul K Marsden, Stephanie A Amiel
AIMS/HYPOTHESIS: Impaired awareness of hypoglycaemia (IAH) in type 1 diabetes increases the risk of severe hypoglycaemia sixfold and can be resistant to intervention. We explored the impact of IAH on central responses to hypoglycaemia to investigate the mechanisms underlying barriers to therapeutic intervention. METHODS: We conducted [15 O]water positron emission tomography studies of regional brain perfusion during euglycaemia (target 5 mmol/l), hypoglycaemia (achieved level, 2...
May 12, 2018: Diabetologia
https://www.readbyqxmd.com/read/29742425/gat-3-dysfunction-generates-tonic-inhibition-in-external-globus-pallidus-neurons-in-parkinsonian-rodents
#9
Marine Chazalon, Elena Paredes-Rodriguez, Stéphanie Morin, Audrey Martinez, Sofia Cristóvão-Ferreira, Sandra Vaz, Ana Sebastiao, Aude Panatier, Eric Boué-Grabot, Cristina Miguelez, Jérôme Baufreton
The external globus pallidus (GP) is a key GABAergic hub in the basal ganglia (BG) circuitry, a neuronal network involved in motor control. In Parkinson's disease (PD), the rate and pattern of activity of GP neurons are profoundly altered and contribute to the motor symptoms of the disease. In rodent models of PD, the striato-pallidal pathway is hyperactive, and extracellular GABA concentrations are abnormally elevated in the GP, supporting the hypothesis of an alteration of neuronal and/or glial clearance of GABA...
May 8, 2018: Cell Reports
https://www.readbyqxmd.com/read/29737578/neuronal-connections-of-direct-and-indirect-pathways-for-stable-value-memory-in-caudal-basal-ganglia
#10
Hidetoshi Amita, Hyoung F Kim, Mitchell Smith, Atul Gopal, Okihide Hikosaka
Direct and indirect pathways in the basal ganglia work together for controlling behavior. However, it is still a controversial topic whether these pathways are segregated or merged with each other. To address this issue, we studied the connections of these two pathways in the caudal parts of the basal ganglia of rhesus monkeys using anatomical tracers. Our previous studies showed that the caudal basal ganglia control saccades by conveying long-term values (stable values) of many visual objects toward the superior colliculus...
May 8, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29736342/validity-and-reliability-of-the-wimu-inertial-device-for-the-assessment-of-the-vertical-jump
#11
José Pino-Ortega, Javier García-Rubio, Sergio J Ibáñez
The aim of this study was to test the validity and reliability of the inertial device WIMU (Realtrack Systems SL, Almería, Spain) for the assessment of the vertical jump, counter movement jump (CMJ) and squat jump (SJ). Fifteen soccer players were evaluated in two identical sessions separated by one week. In each session, participants performed three jumps of each type. The flight time was quantified by the inertial device WIMU and by a force platform (Twin Plates; Globus Sport and Health Technologies LLC, Codogné, Italy) at the same time...
2018: PeerJ
https://www.readbyqxmd.com/read/29736078/deep-brain-stimulation-of-anteromedial-globus-pallidus-internus-for-severe-tourette-syndrome
#12
Paresh K Doshi, Raghvendra Ramdasi, Smita Thorve
Tourette syndrome (TS) is a complex disorder characterized by tics and is associated with behavioral problems. Although its intensity decreases in adolescence and adult life, in some cases it continues to remain severe and refractory to medical treatment. Deep brain stimulation has been offered as a treatment option in such cases. We report two cases of TS treated with of anteromedial globus pallidum internus. Both the cases had good postoperative control of tics and associated obsessive-compulsive behavior...
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29735116/inherited-and-acquired-choreas
#13
Claudio M de Gusmao, Jeff L Waugh
Chorea is a symptom of a broad array of genetic, structural, and metabolic disorders. While chorea can result from systemic illness and damage to diverse brain structures, injury to the basal ganglia, especially the putamen or globus pallidus, appears to be a uniting features of these diverse neuropathologies. The timing of onset, rate of progression, and the associated neurological or systemic symptoms can often narrow the differential diagnosis to a few disorders. Recognizing the correct etiology for childhood chorea is critical, as numerous disorders in this category are potentially curable, or are remediable, with early treatment...
April 2018: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/29733071/symmetrical-and-bilateral-basal-ganglia-calcification-case-series-and-literature-review
#14
Amado Jiménez-Ruiz, Omar Cárdenas-Sáenz, José Luis Ruiz-Sandoval
Introduction: Symmetric, bilateral basal ganglia calcification is rare finding that sometimes occurs asymptomatically. Its prevalence increases with age, and the most affected site is the globus pallidus. Report of cases: A series of seven cases with clinical and imaging diagnosis of basal ganglia calcification, recorded during the 2012 to 2016 period at the Department of Internal Medicine of the Hospital Civil de Guadalajara "Fray Antonio Alcalde, is presented...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29728930/the-prevalence-of-dysphonia-and-dysphagia-in-patients-affected-by-immunomediated-diseases-and-the-role-of-psychometric-tests
#15
J Galli, M R Marchese, C De Canio, M Di Salvo, I Olivieri, L Santandrea, G Paludetti
This cross-sectional investigation examined the prevalence and severity of dysphonia, globus pharyngeus, and dysphagia in patients affected by immunomediated (IM) diseases. Seventy subjects were administered the Voice Handicap Index (VHI) (scale 0-4), Glasgow-Edinburgh Throat Scale (GETS) (scale from 0 to 7) for globus pharyngeus assessment, and modified Swallowing Outcomes After Revised Laryngectomy (SOAL) (scale 0, 1, 2) to test swallowing symptoms. VHI: the mean percentage of answers with a score greater than 1 (corresponding to a frequency of situation's occurrence "sometimes," "almost always," or "always") was 25...
May 5, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29727632/the-oscillatory-boundary-conditions-of-different-frequency-bands-in-parkinson-s-disease
#16
Bing Hu, Qianqian Shi, Yu Guo, Xiyezi Diao, Heng Guo, Jinsong Zhang, Liang Yu, Hao Dai, Luonan Chen
Parkinson's disease (PD) is a neurodegenerative disease that is common in the elderly population. The most important pathological change in PD is the degeneration and death of dopaminergic neurons in the substantia nigra of the midbrain, which results in a decrease in the dopamine (DA) content of the striatum. The exact cause of this pathological change is still unknown. Numerous studies have shown that the evolution of PD is associated with abnormal oscillatory activities in the basal ganglia, with different oscillation frequency ranges, such as the typical beta band (13-30 Hz), the alpha band (8-12 Hz), the theta band (4-7 Hz) and the delta band (1-3 Hz)...
May 1, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29727401/signal-changes-in-the-dentate-nucleus-and-globus-pallidus-on-unenhanced-t1-weighted-magnetic-resonance-images-after-intrathecal-administration-of-macrocyclic-gadolinium-contrast-agent
#17
Kerem Ozturk, Omer Fatih Nas, Esra Soylu, Bahattin Hakyemez
OBJECTIVES: The aim of this study was to evaluate signal changes in the dentate nucleus and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance (MR) images (T1 WI) in a cohort of patients who have received intrathecal macrocyclic ionic gadolinium-based contrast agent (GBCA) gadoterate meglumine. MATERIALS AND METHODS: A group of 20 patients (male/female ratio, 8:12; mean age, 39.5 ± 15.5 years) who had not received intravenous GBCA but had received an intrathecal macrocyclic ionic GBCA (plus baseline and an additional final magnetic resonance imaging [MRI] for reference) from 2012 to 2017 were retrospectively included in this institutional review board-approved study...
April 30, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29726781/microsurgical-anatomy-of-the-subthalamic-nucleus-correlating-fiber-dissection-results-with-3-t-magnetic-resonance-imaging-using-neuronavigation
#18
Abuzer Güngör, Şevki Serhat Baydın, Vanessa M Holanda, Erik H Middlebrooks, Cihan Isler, Bekir Tugcu, Kelly Foote, Necmettin Tanriover
OBJECTIVE Despite the extensive use of the subthalamic nucleus (STN) as a deep brain stimulation (DBS) target, unveiling the extensive functional connectivity of the nucleus, relating its structural connectivity to the stimulation-induced adverse effects, and thus optimizing the STN targeting still remain challenging. Mastering the 3D anatomy of the STN region should be the fundamental goal to achieve ideal surgical results, due to the deep-seated and obscure position of the nucleus, variable shape and relatively small size, oblique orientation, and extensive structural connectivity...
May 4, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29722955/increased-iron-deposition-on-brain-quantitative-susceptibility-mapping-correlates-with-decreased-cognitive-function-in-alzheimer-s-disease
#19
Lei Du, Zifang Zhao, Ailing Cui, Yijiang Zhu, Lu Zhang, Jing Liu, Sumin Shi, Chao Fu, Xiaowei Han, Wenwen Gao, Tianbin Song, Lizhi Xie, Lei Wang, Shilong Sun, Runcai Guo, Guolin Ma
The excessive accumulation of iron in deep gray structures is an important pathological characteristic in patients with Alzheimer's disease (AD). Quantitative susceptibility mapping (QSM) is more specific than other imaging-based iron measurements modalities and allows non-invasively assessment of tissue magnetic susceptibility, which has been shown to correlate well to the brain iron levels. This study aimed to investigate the correlations between the magnetic susceptibility values of deep gray matter nuclei and the cognitive functions assessed by mini-mental state examination (MMSE) and montreal cognitive assessment (MoCA) in patients with the mild and moderate AD...
May 3, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29714526/brain-intrinsic-network-connectivity-in-individuals-with-frequent-tanning-behavior
#20
Ariel Ketcherside, Francesca M Filbey, Pamela M Aubert, John P Seibyl, Julianne L Price, Bryon Adinoff
BACKGROUND: Emergent studies suggest a bidirectional relationship between brain functioning and the skin. This neurocutaneous connection may be responsible for the reward response to tanning and, thus, may contribute to excessive tanning behavior. To date, however, this association has not yet been examined. OBJECTIVES: To explore whether intrinsic brain functional connectivity within the default mode network (DMN) is related to indoor tanning behavior. METHODS: Resting state functional connectivity (rsFC) was obtained in twenty adults (16 females) with a history of indoor tanning...
May 1, 2018: American Journal of Drug and Alcohol Abuse
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