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Affective bipolar disorder

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https://www.readbyqxmd.com/read/28809398/precision-medicine-for-suicidality-from-universality-to-subtypes-and-personalization
#1
A B Niculescu, H Le-Niculescu, D F Levey, P L Phalen, H L Dainton, K Roseberry, E M Niculescu, J O Niezer, A Williams, D L Graham, T J Jones, V Venugopal, A Ballew, M Yard, T Gelbart, S M Kurian, A Shekhar, N J Schork, G E Sandusky, D R Salomon
Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders. Objective and precise identification of individuals at risk, ways of monitoring response to treatments and novel preventive therapeutics need to be discovered, employed and widely deployed. We sought to investigate whether blood gene expression biomarkers for suicide (that is, a 'liquid biopsy' approach) can be identified that are more universal in nature, working across psychiatric diagnoses and genders, using larger cohorts than in previous studies...
August 15, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28803680/corrigendum-to-analysis-of-association-between-common-snps-in-erbb4-and-bipolar-affective-disorder-major-depressive-disorder-and-schizophrenia-in-the-han-chinese-population-prog-neuro-psychopharmacol-biol-psychiatry-36-2012-17-21
#2
P Chen, J Chen, K Huang, W Ji, T Wang, T Li, Y Wang, H Wang, L He, G Feng, Y Shi
No abstract text is available yet for this article.
August 10, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28802190/alcohol-use-and-bipolar-disorders-risk-factors-associated-with-their-co-occurrence-and-sequence-of-onsets
#3
Jean-Michel Azorin, Léa C Perret, Eric Fakra, Sébastien Tassy, Nicolas Simon, Marc Adida, Raoul Belzeaux
BACKGROUND: Little is known about the sequence of onsets in patients affected by comorbid alcohol use and bipolar disorder. This study examines the risk factors associated with their co-occurrence and order of onset. METHOD: The demographic, clinical, and temperament characteristics as well as the course of illness were analyzed within our sample of 1090 DSM-IV bipolar I manic patients. Our sample was categorized according to the presence of comorbid alcohol use disorder and the sequence of onsets of bipolar and alcohol use disorders i...
August 3, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28793231/association-of-mitochondrial-dna-10398-a-g-polymorphism-with-attention-deficit-and-hyperactivity-disorder-in-korean-children
#4
In Wook Hwang, Jun Ho Hong, Bit Na Kwon, Hyung Jun Kim, Nu Ri Lee, Myung Ho Lim, Ho Jang Kwon, Han Jun Jin
Mitochondria are subcellular organelles that contribute to aerobic ATP generation by oxidative phosphorylation (OXPHOS). Previous studies reported that mitochondrial dysfunction and deficiency caused by mitochondrial DNA polymorphisms is associated with various diseases. Especially, mitochondrial DNA 10398 A/G polymorphism is known to affect the regulation of mitochondrial calcium levels related to energy production, and its association with psychiatric disorders such as schizophrenia and bipolar disorder has been reported...
August 6, 2017: Gene
https://www.readbyqxmd.com/read/28792954/variants-in-calcium-voltage-gated-channel-subunit-alpha1-c-gene-cacna1c-are-associated-with-sleep-latency-in-infants
#5
Katri Kantojärvi, Johanna Liuhanen, Outi Saarenpää-Heikkilä, Anna-Liisa Satomaa, Anneli Kylliäinen, Pirjo Pölkki, Julia Jaatela, Auli Toivola, Lili Milani, Sari-Leena Himanen, Tarja Porkka-Heiskanen, Juulia Paavonen, Tiina Paunio
Genetic variants in CACNA1C (calcium voltage-gated channel subunit alpha1 C) are associated with bipolar disorder and schizophrenia where sleep disturbances are common. In an experimental model, Cacna1c has been found to modulate the electrophysiological architecture of sleep. There are strong genetic influences for consolidation of sleep in infancy, but only a few studies have thus far researched the genetic factors underlying the process. We hypothesized that genetic variants in CACNA1C affect the regulation of sleep in early development...
2017: PloS One
https://www.readbyqxmd.com/read/28790543/haemorrhage-rates-after-two-commonly-used-tonsillectomy-methods-a-multicenter-study
#6
Faris Brkic, Majda Mujic, Sekib Umihanic, Nermin Hrncic, Amna Goga, Ermin Goretic
INTRODUCTION: Tonsillectomy is a frequently used, low-risk surgical procedure. The post-tonsillectomy haemorrhage occurs rarely, but is a life-threatening complication. Some studies show that the surgical technique affects the haemorrhage rate. AIMS: To analyse the post-tonsillectomy haemorrhage rate, and to determine whether the effect of the surgical technique on the haemorrhage rate exists. METHODS: We retrospectively reviewed data of all patients who underwent a tonsillectomy in three regional ENT departments in Bosnia and Herzegovina (Tuzla, Zenica and Bihac) between January 1(st) 2015 and October 31(st) 2016...
April 2017: Medical Archives
https://www.readbyqxmd.com/read/28777981/childhood-trauma-dimensions-of-psychopathology-and-the-clinical-expression-of-bipolar-disorders-a-pathway-analysis
#7
B Etain, M Lajnef, C Henry, V Aubin, J M Azorin, F Bellivier, T Bougerol, P Courtet, S Gard, J P Kahn, C Passerieux, M Leboyer
BACKGROUND: This study aims at testing for paths from childhood abuse to clinical indicators of complexity in bipolar disorder (BD), through dimensions of affective dysregulation, impulsivity and hostility. METHOD: 485 euthymic patients with BD from the FACE-BD cohort were included from 2009 to 2014. We collect clinical indicators of complexity/severity: age and polarity at onset, suicide attempt, rapid cycling and substance misuse. Patients completed questionnaires to assess childhood emotional, sexual and physical abuses, affective lability, affect intensity, impulsivity, motor and attitudinal hostility...
July 29, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28776766/utility-of-functioning-measures-in-the-prediction-of-independent-living-status-in-older-adults-with-serious-mental-illness
#8
Karen L Fortuna, Matthew C Lohman, Martha L Bruce, Stephen J Bartels
OBJECTIVE: The objective of the study was to compare the predictive utility of three commonly used functioning measures for people with serious mental illness in the prediction of independent living status. METHODS: We conducted a secondary data analysis from the Helping Older People Experience Success study with adults aged 50 years and older with a diagnosis of bipolar disorder, schizoaffective disorder, schizophrenia, or major depressive disorder (N = 183)...
August 4, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28763060/bace1-inhibition-by-microdose-lithium-formulation-np03-rescues-memory-loss-and-early-stage-amyloid-neuropathology
#9
E N Wilson, S Do Carmo, M F Iulita, H Hall, A Ducatenzeiler, A R Marks, S Allard, D T Jia, J Windheim, A C Cuello
Lithium is first-line therapy for bipolar affective disorder and has recently been shown to have protective effects in populations at risk for Alzheimer's disease (AD). However, the mechanism underlying this protection is poorly understood and consequently limits its possible therapeutic application in AD. Moreover, conventional lithium formulations have a narrow therapeutic window and are associated with a severe side effect profile. Here we evaluated a novel microdose formulation of lithium, coded NP03, in a well-characterized rat model of progressive AD-like amyloid pathology...
August 1, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28755604/perceived-expressed-emotions-in-relatives-of-patients-with-severe-mental-illness-a-comparative-study
#10
Olaniyi Ayilara, Adegboyega Ogunwale, Emmanuel Babalola
There is paucity of studies on expressed emotion (EE) in families of patients with severe mental illness in sub-Saharan Africa. This study aimed to assess and compare the levels of expressed emotion (LEE) in relatives of patients with schizophrenia and bipolar affective disorder attending an out-patient clinic in Southwestern Nigeria. One hundred and forty consecutive clinic attendees with Mini-Plus diagnosis of schizophrenia and bipolar affective disorder and 140 accompanying relatives were recruited. The patients and relatives were interviewed using a socio-demographic questionnaire...
July 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28754344/the-effect-of-childhood-trauma-on-serum-bdnf-in-bipolar-depression-is-modulated-by-the-serotonin-promoter-genotype
#11
Francesco Benedetti, Oliver Ambrée, Clara Locatelli, Cristina Lorenzi, Sara Poletti, Cristina Colombo, Volker Arolt
In healthy humans, both childhood trauma and the short form of the serotonin promoter transporter genotype (5-HTTLPR) are associated with lower levels of brain-derived neurotrophic factor (BDNF). In subjects with bipolar disorder (BD), lower levels of BDNF and a higher degree of childhood trauma were observed compared with healthy controls. However, is still unknown if the functional 5-HTTLPR polymorphisms exerts an effect on both abnormalities. In 40 inpatients affected by a major depressive episode in the course of BD, we genotyped 5-HTTLPR, measured serum BDNF with ELISA, and assessed early adversities by the childhood trauma questionnaire (CTQ)...
July 25, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28754273/effects-of-psychopharmacological-treatment-with-antidepressants-on-the-vascular-system
#12
REVIEW
Kai G Kahl, Mechthild Westhoff-Bleck, Tillmann H C Krüger
Psychopharmacological treatment with antidepressants is an essential part of guideline-based treatment strategies in affective disorders, such as major depressive disorder, persistent depressive disorder, and bipolar disorder. Furthermore, antidepressants are frequently prescribed in patients with physical disorders, such as cardiovascular diseases, and comorbid depression. The type of association between physical diseases, particularly chronic diseases, and depression is bidirectional, meaning that affective disorders enhance the risk for the development of cardiovascular and metabolic disorders, and that cardiovascular/metabolic disorders enhance the risk for the development of depressive disorders...
July 25, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28734460/affected-anatomical-rich-club-and-structural-functional-coupling-in-young-offspring-of-schizophrenia-and-bipolar-disorder-patients
#13
Guusje Collin, Lianne H Scholtens, René S Kahn, Manon H J Hillegers, Martijn P van den Heuvel
BACKGROUND: Emerging evidence suggests disruptions in the wiring organization of the brain's network in schizophrenia (SZ) and bipolar disorder (BD). As the importance of genetic predisposition has been firmly established in these illnesses, children (offspring) of patients constitute an at-risk population. This study examines connectome organization in children at familial high risk for psychosis. METHODS: Diffusion-weighted magnetic resonance imaging scans were collected from 127 nonpsychotic offspring 8 to 18 years of age (average age = 13...
June 21, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28730183/aberrant-cerebellar-connectivity-in-bipolar-disorder-with-psychosis
#14
Ann K Shinn, Youkyung S Roh, Caitlin T Ravichandran, Justin T Baker, Dost Öngür, Bruce M Cohen
BACKGROUND: The cerebellum, which modulates affect and cognition in addition to motor functions, may contribute substantially to the pathophysiology of mood and psychotic disorders, such as bipolar disorder. A growing literature points to cerebellar abnormalities in bipolar disorder. However, no studies have investigated the topographic representations of resting state cerebellar networks in bipolar disorder, specifically their functional connectivity to cerebral cortical networks. METHODS: Using a well-defined cerebral cortical parcellation scheme as functional connectivity seeds, we compared ten cerebellar resting state networks in 49 patients with bipolar disorder and a lifetime history of psychotic features and 55 healthy control participants matched for age, sex, and image signal-to-noise ratio...
July 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28728797/-prevalence-of-hypothyroidism-in-major-psychiatric-disorders-in-hospitalised-patients-in-montserrat-hospital-during-the-period-march-to-october-2010
#15
Pedro Vargas Navarro, Edgar Antonio Ibañez Pinilla, Alejandra Galeano España, Ana María Noguera Bravo, Sandra Milena Pantoja, Ana María Suárez Acosta
INTRODUCTION: Hypothyroidism results from inadequate production of thyroid hormone. It is known that there is a relationship between the major psychiatric disorders and hypothyroidism. OBJECTIVE: To determine the prevalence of hypothyroidism in patients admitted due to major psychiatric disorders in Montserrat Hospital during the period from March to October 2010. MATERIAL AND METHODS: A descriptive cross-sectional study was conducted on 105 patients admitted to Montserrat Hospital with a primary diagnosis of major psychiatric disorder (major depression, bipolar affective disorder, generalised panic disorder, panic disorder, mixed anxiety-depressive disorder, and schizophrenia) in the aforementioned period...
July 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28728796/-lifetime-psychiatric-disorders-a-comparision-study-between-offspring-of-parents-with-bipolar-disorder-type-i-versus-the-offspring-of-community-controls-parents
#16
Juan David Palacio-Ortiz, Cristian Esteban Peña-Quintero, María Alejandra Gómez-Valero, Paula Andrea Bustamante-Gómez, Pilar Helena Arroyave-Sierra, Cristian David Vargas-Upeguí, Carlos López-Jaramillo
INTRODUCTION: Literature reports show that Bipolar Offspring (BO) present with a wide range of psychiatric disorders. Comparison between BO and Control Parent Offspring (CPO) may help to identify which psychopathological findings are specific to this high-risk group. OBJECTIVE: To compare the psychopathological characteristics between a group of BO type-I and a group of CPO, by identifying the presence of psychiatric disorders according the DSM-IV-TR. METHODS: A descriptive-correlational, cross-sectional and comparative study was conducted with 127 offspring of parents with bipolar disorder type-I from the multimodal intervention program (PRISMA) and with 150 CPO between 6 and 30 years of age...
July 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28728036/the-relationship-between-brain-volumes-and-intelligence-in-bipolar-disorder
#17
Annabel Vreeker, Lucija Abramovic, Marco P M Boks, Sanne Verkooijen, Annet H van Bergen, Roel A Ophoff, René S Kahn, Neeltje E M van Haren
OBJECTIVES: Bipolar disorder type-I (BD-I) patients show a lower Intelligence Quotient (IQ) and smaller brain volumes as compared with healthy controls. Considering that in healthy individuals lower IQ is related to smaller total brain volume, it is of interest to investigate whether IQ deficits in BD-I patients are related to smaller brain volumes and to what extent smaller brain volumes can explain differences between premorbid IQ estimates and IQ after a diagnosis of BD-I. METHODS: Magnetic resonance imaging brain scans, IQ and premorbid IQ scores were obtained from 195 BDI patients and 160 controls...
July 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28725222/neuronal-surface-autoantibodies-in-neuropsychiatric-disorders-are-there-implications-for-depression
#18
REVIEW
Shenghua Zong, Carolin Hoffmann, Marina Mané-Damas, Peter Molenaar, Mario Losen, Pilar Martinez-Martinez
Autoimmune diseases are affecting around 7.6-9.4% of the general population. A number of central nervous system disorders, including encephalitis and severe psychiatric disorders, have been demonstrated to associate with specific neuronal surface autoantibodies (NSAbs). It has become clear that specific autoantibodies targeting neuronal surface antigens and ion channels could cause severe mental disturbances. A number of studies have focused or are currently investigating the presence of autoantibodies in specific mental conditions such as schizophrenia and bipolar disorders...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28723388/region-specific-impairments-in-parvalbumin-interneurons-in-social-isolation-reared-mice
#19
Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Motoi Okamoto, Yosuke Matsumoto, Takeshi Ishihara
Many neuropsychiatric disorders show localized dysfunction in specific cortical regions. The mechanisms underlying such region-specific vulnerabilities are unknown. Post-mortem analyses have demonstrated a selective reduction in the expression of parvalbumin (PV) in GABAergic interneurons in the frontal rather than the sensory cortex of patients with neuropsychiatric disorders such as schizophrenia, autism spectrum disorders, and bipolar disorders. PV neurons are surrounded by perineuronal nets (PNNs), and are protected from oxidative stress...
July 16, 2017: Neuroscience
https://www.readbyqxmd.com/read/28722128/solar-insolation-in-springtime-influences-age-of-onset-of-bipolar-i-disorder
#20
M Bauer, T Glenn, M Alda, M A Aleksandrovich, O A Andreassen, E Angelopoulos, R Ardau, Y Ayhan, C Baethge, S R Bharathram, R Bauer, B T Baune, C Becerra-Palars, F Bellivier, R H Belmaker, M Berk, Y Bersudsky, Ş Bicakci, H Birabwa-Oketcho, T D Bjella, L Bossini, J Cabrera, E Y W Cheung, M Del Zompo, S Dodd, M Donix, B Etain, A Fagiolini, K N Fountoulakis, M A Frye, A Gonzalez-Pinto, J F Gottlieb, P Grof, H Harima, C Henry, E T Isometsä, S Janno, F Kapczinski, M Kardell, S Khaldi, S Kliwicki, B König, T L Kot, R Krogh, M Kunz, B Lafer, M Landén, E R Larsen, U Lewitzka, R W Licht, C Lopez-Jaramillo, G MacQueen, M Manchia, W Marsh, M Martinez-Cengotitabengoa, I Melle, F Meza-Urzúa, M Yee Ming, S Monteith, G Morken, E Mosca, R Munoz, S V Mythri, F Nacef, R K Nadella, F G Nery, R E Nielsen, C O'Donovan, A Omrani, Y Osher, H Østermark Sørensen, U Ouali, Y Pica Ruiz, M Pilhatsch, M Pinna, F D R da Ponte, D Quiroz, R Ramesar, N Rasgon, M S Reddy, A Reif, P Ritter, J K Rybakowski, K Sagduyu, Â M Scippa, E Severus, C Simhandl, D J Stein, S Strejilevich, M Subramaniam, A H Sulaiman, K Suominen, H Tagata, Y Tatebayashi, L Tondo, C Torrent, A E Vaaler, J Veeh, E Vieta, B Viswanath, M Yoldi-Negrete, M Zetin, Y Zgueb, P C Whybrow
OBJECTIVE: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. METHOD: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. RESULTS: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset...
July 19, 2017: Acta Psychiatrica Scandinavica
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