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Affective bipolar disorder

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https://www.readbyqxmd.com/read/29353899/assessing-caregiver-burden-in-caregivers-of-patients-with-schizophrenia-and-bipolar-affective-disorder-in-kathmandu-medical-college
#1
Rachana Sharma, Subhash Chandra Sharma, Sudarshan Narsingh Pradhan
BACKGROUND: Schizophrenia and bipolar affective disorder are chronic psychiatric illness that requires long term care. This study tends to measure psychological burden and factors associated with it among caregivers of these two illnesses. METHODS: This is a cross- sectional study that included participants by purposive sampling method. Self designed performa was used to collect the socio-demographic details of the caregivers. Modified caregiver strain index was used to assess the overall stress...
January 1, 2018: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/29352661/mechanistic-insights-into-the-genetics-of-affective-psychosis-from-prader-willi-syndrome
#2
REVIEW
Lucie C S Aman, Katherine E Manning, Joyce E Whittington, Anthony J Holland
Schizophrenia and bipolar disorder are common, severe, and disabling psychotic disorders, which are difficult to research. We argue that the genetically determined neurodevelopmental disorder Prader-Willi syndrome (PWS), which is associated with a high risk of affective psychotic illness, can provide a window into genetic mechanisms and associated neural pathways. People with PWS can all show non-psychotic psychopathology and problem behaviours, but the prevalence of psychotic illness differs markedly by genetic subtype; people with PWS due to chromosome 15 maternal uniparental disomy have higher prevalence of psychotic illness compared with patients with PWS due to 15q11-13 deletions of paternal origin...
January 15, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29352532/the-impact-of-severe-mental-disorders-and-psychotropic-medications-on-sexual-health-and-its-implications-for-clinical-management
#3
Angel L Montejo, Laura Montejo, David S Baldwin
Sexual dysfunction often accompanies severe psychiatric illness and can be due to both the mental disorder itself and the use of psychotropic treatments. Many sexual symptoms resolve as the mental state improves, but treatment-related sexual adverse events tend to persist over time, and are unfortunately under-recognized by clinicians and scarcely investigated in clinical trials. Treatment-emergent sexual dysfunction adversely affects quality of life and may contribute to reduce treatment adherence. There are important differences between the various compounds in the incidence of adverse sexual effects, associated with differences in mechanisms of action...
February 2018: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/29344532/functional-ability-of-clients-with-bipolar-disorders-in-tertiary-hospital-puducherry
#4
Rajendran Rangasamy Kavitha, Sethuramachandran Kamalam, Ravi Philip Rajkumar
Background: Bipolar Disorder (BD) is a common long standing mental illness which is episodic in nature, affecting approximately1-2% of the world adult population. BD frequently affects the patient's life. Few studies have examined the functional impairment in patients with affective illness. The main objective of the current study was to assess specific domains of functioning as well as the overall functioning of the clients with BD. Methods: This cross-sectional study aimed to assess the level of function among the clients with BD in JIPMER Hospital, Puducherry during 2015-2016 and to identify the socio- demographic and clinical factors associated with the level of functioning...
January 2018: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/29343935/effectiveness-of-mindfulness-based-cognitive-therapy-in-patients-with-bipolar-affective-disorder-a-case-series
#5
Suvarna Shirish Joshi, Mahendra Prakash Sharma, Shivarama Varambally
The present investigation was undertaken to examine the effects of mindfulness-based cognitive therapy (MBCT) on interepisodic symptoms, emotional regulation, and quality of life in patients with bipolar affective disorder (BPAD) in remission. The sample for the study comprised a total of five patients with the diagnosis of BPAD in partial or complete remission. Each patient was screened to fit the inclusion and exclusion criteria and later assessed on the Beck Depressive Inventory I, Beck Anxiety Inventory, Difficulties in Emotion Regulation Scale, Acceptance and Action Questionnaire-II, and The World Health Organization Quality of Life Assessment-BREF...
January 2018: International Journal of Yoga
https://www.readbyqxmd.com/read/29334847/patient-and-family-psychoeducation-service-development-and-implementation-in-a-center-in-iran
#6
Zahra Mirsepassi, Maryam Tabatabaee, Vandad Sharifi, Yasaman Mottaghipour
BACKGROUND: Family and patient psychoeducation have demonstrated significant improvement in clinical and social outcomes for patients suffering from severe mental disorders and their families. However, these evidence-based practices are not widely implemented at service delivery level and into routine clinical practice, especially in less developed countries. AIM: The aim of this article is to report the processes of development and implementation of a psychoeducational service for patients with severe mental illnesses and their families in Iran...
February 2018: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/29331693/disease-management-apps-and-technical-assistance-systems-for-bipolar-disorder-investigating-the-patients%C3%A2-point-of-view
#7
Henning Daus, Natalia Kislicyn, Stephan Heuer, Matthias Backenstrass
BACKGROUND: Smartphone-based disease management has become increasingly interesting for research in the field of bipolar disorders. This article investigates the attitudes of persons affected by this disorder towards the appropriation of mobile apps or assistance systems for the management of their disease. METHODS: We conducted two separate studies. Study 1 was an online survey with 88 participants. In study 2 we consulted 15 participants during a semi-structured interview...
January 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29329066/association-of-suicidal-risk-with-ratings-of-affective-temperaments
#8
Leonardo Tondo, Gustavo H Vázquez, Gabriele Sani, Marco Pinna, Ross J Baldessarini
BACKGROUND: Ratings of particular temperament-types with the TEMPS-A autoquestionnaire have been associated with suicidal risk, and combinations of such ratings may enhance the association. However, the predictive value of scores for individual temperaments and combinations remains to be quantified. METHOD: We evaluated associations of TEMPS-A ratings for anxious (anx), cyclothymic (cyc), dysthymic (dys), hyperthymic (hyp) and irritable (irr) temperaments, with a history of suicidal acts or reported suicidal ideation in 882 patients with bipolar (BD; n = 509), major depressive (MDD; n = 268) or anxiety (ANX; n = 105) disorders...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29320540/discerning-suicide-in-drug-intoxication-deaths-paucity-and-primacy-of-suicide-notes-and-psychiatric-history
#9
Ian R H Rockett, Eric D Caine, Hilary S Connery, Gail D'Onofrio, David J Gunnell, Ted R Miller, Kurt B Nolte, Mark S Kaplan, Nestor D Kapusta, Christa L Lilly, Lewis S Nelson, Sandra L Putnam, Steven Stack, Peeter Värnik, Lynn R Webster, Haomiao Jia
OBJECTIVE: A paucity of corroborative psychological and psychiatric evidence may be inhibiting detection of drug intoxication suicides in the United States. We evaluated the relative importance of suicide notes and psychiatric history in the classification of suicide by drug intoxication versus firearm (gunshot wound) plus hanging/suffocation-the other two major, but overtly violent methods. METHODS: This observational multilevel (individual/county), multivariable study employed a generalized linear mixed model (GLMM) to analyze pooled suicides and undetermined intent deaths, as possible suicides, among the population aged 15 years and older in the 17 states participating in the National Violent Death Reporting System throughout 2011-2013...
2018: PloS One
https://www.readbyqxmd.com/read/29320386/examining-the-feasibility-and-acceptability-of-an-online-yoga-class-for-mood-disorders-a-moodnetwork-study
#10
Lisa Uebelacker, Steven C Dufour, Jacob G Dinerman, Samantha L Walsh, Casey Hearing, Lee T Gillette, Thilo Deckersbach, Andrew A Nierenberg, Lauren Weinstock, Louisa G Sylvia
BACKGROUND: Despite ongoing advances in the treatment of mood disorders, a substantial proportion of people diagnosed with major depression or bipolar disorder remain symptomatic over time. Yoga, which has been shown to reduce stress and depressive symptoms, as well as to improve overall quality of life, shows promise as an adjunctive treatment. However, dissemination of yoga for clinical populations remains challenging. The purpose of this pilot study was to test the feasibility and acceptability of an online yoga intervention for individuals with mood disorders...
January 2018: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/29320364/cardiometabolic-effects-of-psychotropic-medications
#11
REVIEW
Oluchi Abosi, Sneha Lopes, Samantha Schmitz, Jess G Fiedorowicz
Background Many psychiatric disorders including schizophrenia, bipolar disorder and major depression convey an excess burden of cardiovascular morbidity and mortality. The medications used to treat these conditions may further adversely affect cardiovascular risk and exacerbate health disparities for vulnerable populations. There is a clinical need to appreciate the cardiometabolic adverse effects of psychotropic medications. Methods This paper reviews the most relevant cardiometabolic effects of psychotropic medications, organized around the components of metabolic syndrome...
January 10, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29317602/genome-wide-meta-analyses-of-stratified-depression-in-generation-scotland-and-uk-biobank
#12
Lynsey S Hall, Mark J Adams, Aleix Arnau-Soler, Toni-Kim Clarke, David M Howard, Yanni Zeng, Gail Davies, Saskia P Hagenaars, Ana Maria Fernandez-Pujals, Jude Gibson, Eleanor M Wigmore, Thibaud S Boutin, Caroline Hayward, Generation Scotland, David J Porteous, Ian J Deary, Pippa A Thomson, Chris S Haley, Andrew M McIntosh
Few replicable genetic associations for Major Depressive Disorder (MDD) have been identified. Recent studies of MDD have identified common risk variants by using a broader phenotype definition in very large samples, or by reducing phenotypic and ancestral heterogeneity. We sought to ascertain whether it is more informative to maximize the sample size using data from all available cases and controls, or to use a sex or recurrent stratified subset of affected individuals. To test this, we compared heritability estimates, genetic correlation with other traits, variance explained by MDD polygenic score, and variants identified by genome-wide meta-analysis for broad and narrow MDD classifications in two large British cohorts - Generation Scotland and UK Biobank...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29310919/increased-complications-for-schizophrenia-and-bipolar-disorder-patients-undergoing-total-joint-arthroplasty
#13
Michael M Kheir, You Na P Kheir, Timothy L Tan, Colin T Ackerman, Alexander J Rondon, Antonia F Chen
BACKGROUND: Although it has been shown that anxiety and depression are associated with increased complications after total joint arthroplasty (TJA), the outcomes of TJA in patients with a history of psychosis are unknown. This study evaluated the influence of bipolar and schizophrenic disorders on complications after TJA, particularly aseptic and septic revisions. METHODS: A retrospective review of 156 TJAs (125 primaries and 31 revisions) was performed at a single institution from 2000 to 2015...
December 14, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29308715/exploring-the-relationship-between-vitamin-d-and-mania-correlations-between-serum-vitamin-d-levels-and-disease-activity
#14
Neslihan Altunsoy, Rabia Nazik Yüksel, Merve Cingi Yirun, Ayşegül Kılıçarslan, Çiğdem Aydemir
BACKGROUND: Several studies suggest an association between hypovitaminosis D and mood disorders including major depressive disorder, seasonal affective disorder and premenstrual dysphoric disorder. On the other hand, there is not enough study about acute manic episode and hypovitaminosis D. This data insufficient zone led us to study on whether vitamin D deficiency is associated with acute manic episode and has an impact on disease activity Methods: Thirty-one patients with bipolar disorder in remission, 26 patients with acute manic episode and 40 healthy controls with no major psychopathology were recruited in this study...
January 7, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29303917/clinical-and-environmental-risk-factors-for-bipolar-disorder-review-of-prospective-studies
#15
Ciro Marangoni, Gianni L Faedda, Ross J Baldessarini
After participating in this activity, learners should be better able to:• Evaluate factors that have been identified in prospective studies as predicting the onset of bipolar disorder ABSTRACT: The prodromal phase of bipolar disorder (BD) remains incompletely characterized, limiting early detection of BD and delaying interventions that might limit future morbidity and disability. Retrospective and family-risk studies have consistently found evidence of prodromal psychopathology in subjects later diagnosed with BD...
January 2018: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/29286593/circadian-rhythm-sleep-wake-disorders-predict-shorter-time-to-relapse-of-mood-episodes-in-euthymic-patients-with-bipolar-disorder-a-prospective-48-week-study
#16
Yoshikazu Takaesu, Yuichi Inoue, Kotaro Ono, Akiko Murakoshi, Kunihiro Futenma, Yoko Komada, Takeshi Inoue
OBJECTIVE: Circadian rhythm dysfunction has been considered to be common in bipolar disorder (BD) and plays an important role in mood dysregulation in this disorder. However, no study has investigated whether circadian rhythm dysfunction would affect the clinical course of BD. The aim of this study was to test the hypothesis that circadian rhythm dysfunction could be a predictor of relapse in euthymic BD patients. METHODS: One hundred four euthymic outpatients with BD diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), participated in this prospective follow-up study from August 2014 to April 2015...
December 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29284814/a-rare-presentation-of-a-case-of-obsessive-compulsive-disorder-comorbid-with-bipolar-affective-disorder
#17
Nimmy Chandran, Arpit Parmar, Koushik Sinha Deb
Obsessive-compulsive disorder (OCD) is a chronic illness with waxing and waning course. OCD is not uncommonly found to be comorbid with bipolar affective disorder (BPAD). The course and prognosis of OCD have distinctive features in such cases. Only rarely symptoms of OCD emerge during mania in such individuals. We hereby report a very unusual case of OCD comorbid with BPAD in which obsession and compulsion symptoms occurred only during manic episodes with complete remission during periods between manic episodes (including during depressive episodes)...
November 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29282470/efficacy-and-safety-of-transcranial-direct-current-stimulation-as-an-add-on-treatment-for-bipolar-depression-a-randomized-clinical-trial
#18
Bernardo Sampaio-Junior, Gabriel Tortella, Lucas Borrione, Adriano H Moffa, Rodrigo Machado-Vieira, Eric Cretaz, Adriano Fernandes da Silva, Renério Fraguas, Luana V Aparício, Izio Klein, Beny Lafer, Stephan Goerigk, Isabela Martins Benseñor, Paulo Andrade Lotufo, Wagner F Gattaz, André Russowsky Brunoni
Importance: More effective, tolerable interventions for bipolar depression treatment are needed. Transcranial direct current stimulation (tDCS) is a novel therapeutic modality with few severe adverse events that showed promising results for unipolar depression. Objective: To determine the efficacy and safety of tDCS as an add-on treatment for bipolar depression. Design, Setting, and Participants: A randomized, sham-controlled, double-blind trial (the Bipolar Depression Electrical Treatment Trial [BETTER]) was conducted from July 1, 2014, to March 30, 2016, at an outpatient, single-center academic setting...
December 27, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29280686/state-dependent-alterations-of-lipid-profiles-in-patients-with-bipolar-disorder
#19
Yu-Jui Huang, Shang-Ying Tsai, Kuo-Hsuan Chung, Pao-Huan Chen, Shou-Hung Huang, Chian-Jue Kuo
Objective Serum lipid levels may be associated with the affective severity of bipolar disorder, but data on lipid profiles in Asian patients with bipolar disorder and the lipid alterations in different states of opposite polarities are scant. We investigated the lipid profiles of patients in the acute affective, partial, and full remission state in bipolar mania and depression. Methods The physically healthy patients aged between 18 and 45 years with bipolar I disorder, as well as age-matched healthy normal controls were enrolled...
January 1, 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29275842/risk-of-hospitalization-for-psychiatric-disorders-among-siblings-and-parents-of-probands-with-psychotic-or-affective-disorders-a-population-based-study
#20
Dina Popovic, Shira Goldberg, Daphna Fenchel, Or Frenkel, Abraham Reichenberg, Rinat Yoffe, Michael Davidson, Mark Weiser
Relatives of people diagnosed with psychotic and affective disorders have a higher risk of developing psychiatric disorders compared to the general population. This study examined the risk of hospitalization for psychiatric disorders among siblings and parents of patients affected with major psychiatric disorders. In this large population-based case-control study, 17,895 siblings and parents of 7671 hospitalized subjects with a diagnosis of narrowly defined schizophrenia (SZ), broadly defined SZ, schizoaffective disorder (SAD), bipolar disorder (BD) or unipolar depression (UD) were identified from the Israeli Psychiatric Hospitalization Registry and compared to 71,580 age and gender-matched controls from the Israeli Population Registry...
December 21, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
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