Sebastien Brodeur, Dominic Oliver, Muhammad S Ahmed, Joaquim Radua, Jemma Venables, Yueming Gao, Vincenzo Gigante, Giulia Veneziano, Giulia Vinci, Edward Chesney, Sunil Nandha, Andrea De Micheli, Ilaria Basadonne, Valentina Floris, Gonzalo Salazar de Pablo, Paolo Fusar-Poli
The effectiveness of universal preventive approaches in reducing the incidence of affective/psychotic disorders is unclear. We therefore aimed to synthesise the available evidence from randomised controlled trials. For studies reporting change in prevalence, we simulated all possible scenarios for the proportion of individuals with the disorder at baseline and at follow-up to exclude them. We then combined these data with studies directly measuring incidence and conducted random effects meta-analysis with relative risk (RR) to estimate the incidence in the intervention group compared to the control group...
April 8, 2024: Neuroscience and Biobehavioral Reviews