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Tonsillar hypertrophy

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https://www.readbyqxmd.com/read/29114896/a-shared-decision-making-tool-for-obstructive-sleep-apnea-without-tonsillar-hypertrophy-a-randomized-controlled-trial
#1
Mathieu Bergeron, Angela L Duggins, Aliza P Cohen, Karin Tiemeyer, Lisa Mullen, Joseph Crisalli, Angela McArthur, Stacey L Ishman
OBJECTIVES/HYPOTHESIS: Shared decision-making is a process whereby patients and clinicians jointly establish a treatment plan integrating clinical evidence and patient values and preferences. Although this approach has been successfully employed in numerous medical disciplines, often using shared decision-making tools, otolaryngologic research assessing its use is scant. Our primary objective was therefore to determine if the tools we developed reduced decisional conflict for children with obstructive sleep apnea without tonsillar hypertrophy...
November 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29110575/utility-of-neck-height-and-tonsillar-size-to-screen-for-obstructive-sleep-apnea-among-obese-youth
#2
Indra Narang, Suhail Al-Saleh, Reshma Amin, Evan J Propst, Saadoun Bin-Hasan, Paolo Campisi, Clodagh Ryan, Tetyana Kendzerska
Objectives To determine whether neck:height ratio combined with adenoid and tonsillar size is a good predictive tool for obstructive sleep apnea in obese youth. Study Design Cross-sectional study. Setting Sleep clinics at the Hospital for Sick Children, Toronto, Canada. Subjects and Methods Consented obese individuals aged 8 to 18 years were recruited between 2013 and 2015. Anthropometric measures were obtained by a trained research coordinator in a standardized manner. Otolaryngologists evaluated adenoid and tonsil sizes...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29092747/pediatric-airway-study-endoscopic-grading-system-for-quantifying-tonsillar-size-in-comparison-to-standard-adenotonsillar-grading-systems
#3
Neha A Patel, Kristen Carlin, Joseph M Bernstein
SIGNIFICANCE: Current grading systems may not allow clinicians to reliably document and communicate adenotonsillar size in the clinical setting. A validated endoscopic grading system may be useful for reporting tonsillar size in future clinical outcome studies. This is especially important as tonsillar enlargement is the cause of a substantial health care burden on children. OBJECTIVE: To propose and validate an easy-to-use flexible fiberoptic endoscopic grading system that provides physicians with a more accurate sense of the three-dimensional relationship of the tonsillar fossa to the upper-airway...
October 29, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29016983/predictors-of-sleep-disordered-breathing-in-children-the-panic-study
#4
Tiina Ikävalko, Matti Närhi, Aino-Maija Eloranta, Niina Lintu, Riitta Myllykangas, Anu Vierola, Henri Tuomilehto, Timo Lakka, Riitta Pahkala
Objective: We studied longitudinally the associations of craniofacial morphology, mouth breathing, orthodontic treatment, and body fat content with the risk of having and developing sleep disordered breathing (SDB) in childhood. We hypothesized that deviant craniofacial morphology, mouth breathing, and adiposity predict SDB among children. Materials and methods: The participants were 412 children 6-8 years of age examined at baseline and 329 children aged 9-11 years re-examined at an average 2...
July 11, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28951419/group-a-streptococcal-pharyngitis-immune-responses-involved-in-bacterial-clearance-and-gas-associated-immunopathologies
#5
REVIEW
Amelia T Soderholm, Timothy C Barnett, Matthew J Sweet, Mark J Walker
Streptococcus pyogenes, the Group A Streptococcus (GAS), is the most common cause of bacterial pharyngitis in children and adults. Innate and adaptive host immune responses are fundamental for defense against streptococcal pharyngitis and are central to the clinical manifestation of disease. Host immune responses also contribute to the severe poststreptococcal immune diseases that constitute the major disease burden for this organism. However, until recently, little was known about the host responses elicited during infection...
September 26, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28939080/prevalence-of-high-risk-human-papillomavirus-infection-and-cancer-gene-mutations-in-nonmalignant-tonsils
#6
Taru Ilmarinen, Pauliina Munne, Jaana Hagström, Caj Haglund, Eeva Auvinen, Elina I Virtanen, Annick Haesevoets, Ernst J M Speel, Leena-Maija Aaltonen
OBJECTIVES: To analyze the prevalence of high-risk HPV (human papillomavirus) and genetic alterations in nonmalignant tonsils. METHODS: We collected benign fresh tonsillar tissue specimens from 477 patients undergoing tonsillectomy because of chronic tonsillitis or tonsillar hypertrophy in 2012 (Group A, n=237) and in 2015 (Group B, n=240). Luminex xMAP technique served to detect E6/E7 DNA from 16 different high-risk HPV types. Tonsillar DNA and peripheral blood leukocyte DNA from the infected individuals were analyzed using Nimblegen SeqCap EZ Comprehensive Cancer Design panel...
October 2017: Oral Oncology
https://www.readbyqxmd.com/read/28894116/characterization-of-tonsillar-il10-secreting-b-cells-and-their-role-in-the-pathophysiology-of-tonsillar-hypertrophy
#7
Lindybeth Sarmiento Varon, Javier De Rosa, Andrés Machicote, Luis Ariel Billordo, Plácida Baz, Pablo Mariano Fernández, Isabel Kaimen Maciel, Andrés Blanco, Eloísa I Arana
The comprehension of unconventional immune functions of tonsillar B cells, their role in tolerance induction and protective immune responses, is crucial to unveil the dynamic interactions of the upper aero digestive tract with polymicrobial commensal flora and pathogens, in health and disease. Here, we describe the kinetics of IL10 intracellular expression and compare it with that of cytokines known to be produced by tonsillar B cells. Additionally, we detected a relevant proportion of IL17-expressing tonsillar B cells, which has not previously been reported...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28828761/coblation-versus-other-surgical-techniques-for-tonsillectomy
#8
REVIEW
Melissa Pynnonen, Jennifer V Brinkmeier, Marc C Thorne, Lee Yee Chong, Martin J Burton
BACKGROUND: Tonsillectomy is a very common operation and is performed using various surgical methods. Coblation is a popular method because it purportedly causes less pain than other surgical methods. However, the superiority of coblation is unproven. OBJECTIVES: To compare the effects of coblation tonsillectomy for chronic tonsillitis or tonsillar hypertrophy with other surgical techniques, both hot and cold, on intraoperative morbidity, postoperative morbidity and procedural cost...
August 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28807075/relationship-between-chronic-otitis-media-with-effusion-and-overweight-or-obesity-in-children
#9
S Kaya, E Selimoğlu, S Cureoğlu, M A Selimoğlu
OBJECTIVES: Otitis media with effusion and obesity are both common in childhood and might share some immunological alterations. This study aimed to investigate the relationship between chronic otitis media with effusion and childhood overweight or obesity, including the potential effects of adenoid or tonsillar hypertrophy on that relationship. METHODS: This study included 60 children with chronic otitis media with effusion and 86 healthy children aged from 2 to 10 years...
October 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28669256/pediatric-coblation-total-tonsillectomy-intracapsular-or-extracapsular
#10
Ying-Xia Lu, Qing-Long Gu, Zhan Wang, Bing Zhang, Chang Liu, Jie-Qiong Liang
OBJECTIVES: To compare the results of coblation intracapsular total tonsillectomy (CITT) with those of conventional coblation extracapsular total tonsillectomy (CETT) in the treatment of tonsillar hypertrophy in children with regards to efficacy and complications. METHODS: Ninety children with adenotonsillar hyperplasia underwent tonsillectomy ± adenoidectomy (48 CITT and 42 CETT). Intraoperative situation was observed and recorded. Patients were reexamined regarding recovery condition and tonsil regrowth, and were followed for at least one year...
July 2, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28595595/multiplex-detection-in-tonsillar-tissue-of-all-known-human-polyomaviruses
#11
Mohammadreza Sadeghi, Yilin Wang, Torbjörn Ramqvist, Leena-Maija Aaltonen, Lari Pyöriä, Mari Toppinen, Maria Söderlund-Venermo, Klaus Hedman
BACKGROUND: In the past few years, eleven new human viruses have joined the two previously known members JCPyV and BKPyV of the Polyomaviridae family, by virtue of molecular methods. Serology data suggest that infections with human polyomaviruses (HPyVs) occur since childhood and the viruses are widespread in the general population. However, the viral persistence sites and transmission routes are by and large unknown. Our previous studies demonstrated that the four new HPyVs - KIPyV, WUPyV, MCPyV and TSPyV - were present in the tonsils, and suggested lymphoid tissue as a persistent site of these emerging human viruses...
June 8, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28583496/the-effect-of-perioperative-dexamethasone-dosing-on-post-tonsillectomy-hemorrhage-risk
#12
Yin Yiu, Justin B Mahida, Jennifer N Cooper, Nicole M Elsey, Katherine J Deans, Peter C Minneci, Tyler B Merrill, Joseph D Tobias, Charles A Elmaraghy
OBJECTIVES: Dexamethasone is currently recommended for routine prophylaxis against postoperative nausea and vomiting after tonsillectomy procedures. However, some studies have raised concern that dexamethasone use may lead to higher rates of post-tonsillectomy hemorrhage. Our objective was to determine whether higher doses of dexamethasone administered perioperatively during tonsillectomy procedures are associated with an increased risk of secondary post-tonsillectomy hemorrhage. METHODS: We conducted a retrospective review of 9843 patients who underwent tonsillectomy and received dexamethasone at our institution from January 2010 to October 2014...
July 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28576543/pycnodysostosis-at-otorhinolaryngology
#13
Tekin Baglam, Adem Binnetoglu, Muhammet Fatih Topuz, Nilay Baş Ikizoglu, Refika Ersu, Serap Turan, Murat Sarı
AIM: Pycnodysostosis is a rare autosomal, recessive, skeletal dysplasia caused by a mutation in the cathepsin k gene. Pycnodysostosis is characterized by short stature, characteristic facial appearance (delayed closure of fontanelles and cranial sutures, mandibular hypoplasia and angle disorder, blue sclera), and acroosteolysis of the distal phalanges. Our aim was to describe the otorhinolaryngologic findings, differential diagnoses, various treatment options, and followup in eight cases of pycnodysostosis...
April 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28576540/refractory-sleep-apnea-caused-by-tubal-tonsillar-hypertrophy
#14
Seok Chan Hong, Hyun Jin Min, Kyung Soo Kim
Snoring/sleep apnea are usual symptoms of adenotonsillar hypertrophy, and adenotonsillectomy is usually recommended. In rare cases, symptoms remain after surgery, and tubal tonsil hypertrophy could be the cause. We experienced a pediatric patient whose symptoms were refratory snoring/sleep apnea although he previously underwent three times of adenotonsillectomy. We diagnosed tubal tonsil hypertrophy which was the cause of refractory symptoms, and decided to perform volume reduction with radiofrequency ablation...
April 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28576518/refractory-sleep-disordered-breathing-due-to-unilateral-lingual-tonsillar-hypertrophy-in-a-child-with-proteus-syndrome
#15
Courtni R Salinas, Brian A Nuyen, Aria Jafari, Javan Nation
Proteus Syndrome (PS) is a rare congenital overgrowth disease affecting bones, skin, adipose and the central nervous system. The result is asymmetric, disfiguring hypertrophy which can manifest as craniofacial dysmorphia and aerodigestive tract abnormalities. We report the case of obstructive lingual tonsillar hypertrophy resulting in residual sleep disordered breathing after adenotonsillectomy in a child with PS, a previously unrecognized manifestation of the disease. Endoscopic treatment with coblation effectively and safely treated the obstructive symptoms...
April 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28576514/ultrasonographic-assessment-of-tonsillar-volume-in-children
#16
Panagiotis Asimakopoulos, David J L Pennell, Constantinos Mamais, Derek Veitch, Samuel Stafrace, Thomas Engelhardt
OBJECTIVES: Adenotonsillar hypertrophy in children is the most common anatomical abnormality associated with obstructive sleep apnoea. Perioperative complications associated with adenotonsillectomy are more common in children with severe obstructive sleep apnoea. An objective preoperative method to determine the size of tonsils is missing. This study assessed the validity of ultrasound as a tool for measuring tonsillar size in children. METHODS: Single-institution prospective study of twenty-six children aged 2-6 years who underwent elective bilateral tonsillectomy...
April 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28551703/bacteriology-and-antibiotic-sensitivity-of-tonsillar-diseases-in-chinese-children
#17
Qian Wang, Jingdong Du, Chen Jie, Hong Ouyang, Renzhong Luo, Wei Li
Although many bacteriology studies on tonsillar diseases have been completed, only a few studies investigated bacteriology of tonsillar diseases in recent years, especially in Asian children population. The aim of our study is to elucidate the bacterial flora and antibiotic sensitivity of tonsillar diseases in Chinese children. A three-center study was performed on 2994 children with or without tonsillar diseases. We compared and analyzed differences of bacterial pathogens among recurrent tonsillitis, tonsillar hypertrophy and controls...
August 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28542273/expression-profile-of-epstein-barr-virus-and-human-adenovirus-small-rnas-in-tonsillar-b-and-t-lymphocytes
#18
Farzaneh Assadian, Wael Kamel, Göran Laurell, Catharina Svensson, Tanel Punga, Göran Akusjärvi
We have used high-throughput small RNA sequencing to characterize viral small RNA expression in purified tonsillar B and T lymphocytes isolated from patients tested positive for Epstein-Barr virus (EBV) or human adenovirus (HAdV) infections, respectively. In the small set of patients analyzed, the expression profile of EBV and HAdV miRNAs could not distinguish between patients diagnosed with tonsillar hypertrophy or chronic/recurrent tonsillitis. The EBV miR-BART expression profile among the patients diagnosed with tonsillar diseases resembles most closely the pattern seen in EBV+ tumors (Latency II/I)...
2017: PloS One
https://www.readbyqxmd.com/read/28514363/-the-immunological-characteristics-and-enzymatic-activity-of-lymphocytes-from-the-peripheral-blood-of-the-children-presenting-with-pharyngeal-tonsillar-hypertrophy
#19
L M Kurtasova, N A Shakina, T V Lubnina, A I Nikolaeva
The objective of the present work was to study the immunological characteristics and activity of NAD(P)-dependent dehydrogenases in peripheral blood lymphocytes in the young children presenting with pharyngeal tonsil hypertrophy (PTH). A total of 57 children at the age from 1 to 3 years with PTH were available for the examination. The control group was comprised of 35 age-matched practically healthy children. The amount of CD3+, CD4+, CD8+, CD16+/56-, and CD19+ cells in the peripheral blood was determined with the use of the cytoflowmetric technique...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28390595/obstructive-sleep-apnea-in-a-5-month-old-with-tonsillar-hypertrophy-secondary-to-congenital-neutropenia-case-report-and-literature-review
#20
REVIEW
O G Ahmed, E M Lambert
Tonsillectomy and adenoidectomy (T&A) is the primary surgical treatment for obstructive sleep apnea (OSA) in children with tonsillar and adenoid hypertrophy (TAH). We present the case of a 5-month old male with congenital neutropenia who developed severe TAH during treatment with granulocyte colony-stimulating factor (G-CSF). He had severe OSA, decreased oral intake, and failure to thrive (FTT) which all improved after undergoing a successful intracapsular T&A. We describe a successful procedure to help alleviate symptoms of OSA and FTT in this young infant with congenital neutropenia who developed TAH during treatment with G-CSF...
May 2017: International Journal of Pediatric Otorhinolaryngology
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