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https://www.readbyqxmd.com/read/28918610/the-role-of-tnf-%C3%AE-in-aflatoxin-b-1-induced-hepatic-toxicity-in-isolated-perfused-rat-liver-model
#1
Kazem Koohi Mohammad, Mahmoud Ghazi-Khansari, Farzad Hayati, Hamid Staji, Morteza Keywanloo, Ebrahim Shahroozian
Aflatoxin B-1 (AFB1) is one of the major mycotoxins causing food contamination. Previous studies have shown that AFB1 can induce carcinogenicity and toxic effects in the isolated perfused rat liver and these effects are associated with its metabolites and peroxidation activity. Here we surveyed whether these pathogenic effects of AFB1 are associated with TNF-α as an inflammatory cytokine in general liver damages. In this study, we used twenty male Wistar rats (250-300 g). Rats were divided into four groups...
July 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28918598/triacsin-c-reduces-lipid-droplet-formation-and-induces-mitochondrial-biogenesis-in-primary-rat-hepatocytes
#2
Carlos R P Dechandt, Felippe H Zuccolotto-Dos-Reis, Bruno G Teodoro, Anna Maria A P Fernandes, Marcos N Eberlin, Isis C Kettelhut, Carlos Curti, Luciane C Alberici
Intracellular long-chain acyl-CoA synthetases (ACSL) activate fatty acids to produce acyl-CoA, which undergoes β-oxidation and participates in the synthesis of esterified lipids such as triacylglycerol (TAG). Imbalances in these metabolic routes are closely associated with the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Triacsin C is one of the few compounds that inhibit TAG accumulation into lipid droplets (LD) by suppressing ACSL activity. Here we report that treatment of primary rat hepatocytes with triacsin C at concentrations lower than the IC50 (4...
September 16, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28918582/removal-of-endrin-and-dieldrin-isomeric-pesticides-through-stereoselective-adsorption-behavior-on-the-graphene-oxide-magnetic-nanoparticles
#3
Kamlesh Shrivas, Archana Ghosale, Nidhi Nirmalkar, Arti Srivastava, Sunil Kumar Singh, Sandip S Shinde
A novel stereoselective removal behavior of isomeric endrin and dieldrin pesticides from sample solution is demonstrated using nanocomposite of graphene oxide (GO) and iron oxide (Fe3O4) magnetic nanoparticles (MNPs). The removal efficiency of endrin and dieldrin was found higher when GO-MNPs was used as a separating probe than the individual use of GO and MNPs. The removal efficiency of both the pesticides was found to be more favorable when the dosage amount of GO-MNPs was 30 mg for 30-min contact time with pH 4...
September 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28918575/optimum-spacing-between-electrodes-in-an-air-cathode-single-chamber-microbial-fuel-cell-with-a-low-cost-polypropylene-separator
#4
Sanath Kondaveeti, Jung Mi Moon, Booki Min
The performance of a single chamber microbial fuel cell (MFC) with a low-cost polypropylene separator was investigated at various electrode interspaces in a separator electrode assembly (SEA). The lag period was shortened (3.74-0.17 days) and voltage generation was enhanced (0.2-0.5 V) as electrode spacing was increased from 0 to 9 mm. Power density was increased from 220 to 370 mW/m(2) with increased spacing. The highest power density of 488 mW/m(2) was obtained in polarization analysis with 6 mm. The oxygen mass transfer coefficients with 0 mm (K o = 3...
September 16, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28918471/extracorporeal-membrane-oxygenation-versus-cardiopulmonary-bypass-during-lung-transplantation-a-meta-analysis
#5
Dimitrios E Magouliotis, Vasiliki S Tasiopoulou, Alexis A Svokos, Konstantina A Svokos, Dimitris Zacharoulis
BACKGROUND: We reviewed the available literature on patients undergoing lung transplantation supported by cardiopulmonary bypass (CPB) or extracorporeal membrane oxygenation (ECMO). METHODS: A systematic literature search was performed in three databases, in accordance with the PRISMA guidelines. Meta-analyses were used to compare the outcomes of ECMO and CPB procedures. RESULTS: Seven observational studies met the inclusion criteria incorporating 785 patients...
September 16, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28918452/pro-oxidant-status-and-nrf2-levels-in-psoriasis-vulgaris-skin-tissues-and-dimethyl-fumarate-treated-hacat-cells
#6
Yoon Jin Lee, Jin Ho Bae, Sang-Gue Kang, Sung Woo Cho, Dong-Il Chun, Seung Min Nam, Chul Han Kim, Hae Seon Nam, Seon Hwa Lee, Sang Han Lee, Moon Kyun Cho
Reactive oxygen species (ROS) contribute to pathogenesis of many inflammatory skin diseases, including psoriasis. The aim of this study is to compare antioxidant protein expression in psoriasis vulgaris (PV) skin tissues with that in normal skin tissues in vivo and to evaluate the effects of dimethyl fumarate (DMF), used for the treatment of psoriasis, on ROS generation and apoptosis in a human keratinocyte cell line HaCaT. Compared with normal skin tissues, PV skin tissues showed increased protein oxidation as well as down-regulation of Nrf2 and its regulatory proteins such as HO-1 and AKR1C3...
September 16, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28918427/safety-of-monitored-anesthesia-care-using-propofol-based-sedation-for-pleuroscopy
#7
Erik Vakil, Mona Sarkiss, David Ost, Macarena R Vial, Roberto F Casal, Georgie A Eapen, Horiana B Grosu
BACKGROUND: The optimal approach to sedation for pleuroscopy remains undefined. Propofol is the favored sedative-hypnotic for many proceduralists but has a narrow therapeutic window and the risk for oversedation is high. Propofol-based sedation administered by anesthesiologists and the routine use of end-tidal capnography and bispectral index (BIS) monitoring may attenuate risks of complications. OBJECTIVES: The purpose of our study was to evaluate the safety and efficacy of monitored anesthesia care for pleuroscopy...
September 16, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28918395/non-invasive-high-frequency-oscillatory-ventilation-in-preterm-infants-a-randomised-controlled-cross-over-trial
#8
Daniel Klotz, Hendryk Schneider, Stefan Schumann, Benjamin Mayer, Hans Fuchs
OBJECTIVE: Non-invasive high-frequency oscillatory ventilation (nHFOV) has recently been described as a novel mode of respiratory support for premature infants. This study was designed to determine whether nHFOV decreases CO2 partial pressure (pCO2) in premature infants more effectively than non-invasive continuous positive airway pressure (nCPAP). DESIGN: Non-blinded prospective randomised controlled cross-over study. SETTING: University Medical Center tertiary neonatal intensive care unit...
September 16, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28918376/effect-of-precursors-on-the-structure-and-activity-of-cuo-coox-%C3%AE-al2o3-catalysts-for-no-reduction-by-co
#9
Lingling Zhang, Xiaojiang Yao, Yiyang Lu, Chuanzhi Sun, Changjin Tang, Fei Gao, Lin Dong
Catalytic reduction of NO by CO was studied over a series of CuO-CoOx/γ-Al2O3 catalysts prepared by co-impregnation with different copper and cobalt precursors (acetate and nitrate) to evaluate the structure-activity relationship. The obtained samples were characterized in detail by means of XRD, LRS, XPS, H2-TPR and in situ FT-IR technologies. Results indicate that copper oxide is agglomerated while cobalt oxide is dispersed on γ-Al2O3 for the catalyst prepared from copper acetate and cobalt acetate precursors (CuACoA); CuxCo3-xO4 spinel is formed and agglomerated on the catalyst prepared from copper nitrate and cobalt nitrate precursors (CuNCoN); while both copper oxide and cobalt oxide could be homogeneously dispersed for the catalyst prepared from copper nitrate and cobalt acetate precursors (CuNCoA), which exhibits the best activity for NO reduction by CO...
September 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28918372/enhanced-visible-light-photocatalytic-nitrogen-fixation-over-semicrystalline-graphitic-carbon-nitride-oxygen-and-sulfur-co-doping-for-crystal-and-electronic-structure-modulation
#10
Xiangwen Feng, Huan Chen, Fang Jiang, Xin Wang
Oxygen and sulfur co-doped semicrystalline graphitic carbon nitride (HGCNOS) was synthesized by a one-pot hydrothermal method and applied in visible-light photocatalytic nitrogen fixation. Remarkably, HGCNOS exhibited a higher photocatalytic activity than pristine graphitic carbon nitride (GCN). Oxygen doping caused semicrystalline structure, making exciton dissociated at the order-disorder interfaces of HGCNOS and releasing more electrons and holes. Furthermore, the conduction band position of HGCNOS was elevated by sulfur doping, promoting the reduction ability of HGCNOS...
September 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28918355/gallium-iii-chelates-of-mixed-phosphonate-carboxylate-triazamacrocyclic-ligands-relevant-to-nuclear-medicine-structural-stability-and-in-vivo-studies
#11
Maria I M Prata, João P André, Zoltán Kovács, Anett I Takács, Gyula Tircsó, Imre Tóth, Carlos F G C Geraldes
Three triaza macrocyclic ligands, H6NOTP (1,4,7-triazacyclononane-N,N',N″-trimethylene phosphonic acid), H4NO2AP (1,4,7-triazacyclononane-N-methylenephosphonic acid-N',N″-dimethylenecarboxylic acid), and H5NOA2P (1,4,7-triazacyclononane-N,N'-bis(methylenephosphonic acid)-N″-methylene carboxylic acid), and their gallium(III) chelates were studied in view of their potential interest as scintigraphic and PET (Positron Emission Tomography) imaging agents. A (1)H, (31)P and (71)Ga multinuclear NMR study gave an insight on the structure, internal dynamics and stability of the chelates in aqueous solution...
September 1, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28918354/indium-iii-induces-isolated-mitochondrial-permeability-transition-by-inhibiting-proton-influx-and-triggering-oxidative-stress
#12
Lian Yuan, Jiaqi Zhang, Yujiao Liu, Jie Zhao, Fenglei Jiang, Yi Liu
While Indium's toxicity to organs is realized, its effects on mitochondria are still under investigation. Mitochondrial permeability transition (MPT) is widely accepted in mitochondrial dysfunction approaches and its importance in metal-induced mitochondrial degradation has been proposed. Since mitochondria are respiratory organelles, their interaction with free In(3+) is analyzed to access structural and functional changes. Spectral methods and multimode plate reader was used to detect mitochondrial swelling, membrane potential, membrane fluidity, and inner membrane permeability...
September 8, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28918334/inner-mechanism-of-protection-of-mitochondrial-electron-transfer-proteins-against-oxidative-damage-focus-on-hydrogen-peroxide-decomposition
#13
Erik Sedlak, Andrej Musatov
It is generally recognized that the mitochondria are the major source of reactive oxygen species including hydrogen peroxide (H2O2). Although the local concentration of H2O2 near the electron-transfer chain is potentially quite high, the chain's components are rarely found to be significantly damaged by H2O2. Our experimental data, as well as the data published by others, suggest that mitochondrial electron-transfer proteins, which are in the first line to be harmed by ROS, are well prepared to defend themselves...
September 13, 2017: Biochimie
https://www.readbyqxmd.com/read/28918271/the-role-of-sulfate-reducing-prokaryotes-in-the-coupling-of-element-biogeochemical-cycling
#14
REVIEW
Peng Bao, Guo-Xiang Li, Guo-Xin Sun, Yao-Yang Xu, Andrew A Meharg, Yong-Guan Zhu
Sulfate-reducing prokaryotes (SRP) represent a diverse group of heterotrophic and autotrophic microorganisms that are ubiquitous in anoxic habitats. In addition to their important role in both sulfur and carbon cycles, SRP are important biotic and abiotic regulators of a variety of sulfur-driven coupled biogeochemical cycling of elements, including: oxygen, nitrogen, chlorine, bromine, iodine and metal(loid)s. SRP gain energy form most of the coupling of element transformation. Once sulfate-reducing conditions are established, sulfide precipitation becomes the predominant abiotic mechanism of metal(loid)s transformation, followed by co-precipitation between metal(loid)s...
September 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28918248/total-nitrogen-removal-products-and-molecular-characteristics-of-14%C3%A2-n-containing-compounds-in-supercritical-water-oxidation
#15
Bowen Yang, Zhemin Shen, Zhiwen Cheng, Wenchao Ji
Supercritical water oxidation (SCWO) process of 14 N-containing compounds was investigated with residence time of 150 s, at a stable pressure of 24 MPa, temperatures of 350-500 °C and 500% excess oxygen, resulted in total nitrogen (TN) removal from 41 to 96%. The products of N-containing species were mainly N2, nitrate, ammonium, as well as hardly nitrite or NOX. The yield distributions of nitrate and ammonium were different: the main nitrate concentrations were obtained from the compounds containing nitro-group and diazonium, like nitrobenzene, 2-nitrophenol and eriochrome blue black R (EBBR); the predominant ammonium yields were achieved from amino-group and N-heterocyclic compounds, such as aniline, 5-chloro-2-methylaniline, 3,4-dichloroaniline, 1-methylimidazole, 1,10-phenanthroline, cyanuric acid, indole and 2,3-indolinedione...
August 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28918125/iodinated-chlorin-p6-copper-complex-induces-anti-proliferative-effect-in-oral-cancer-cells-through-elevation-of-intracellular-reactive-oxygen-species
#16
Paromita Sarbadhikary, Alok Dube
We investigated the anticancer chemotoxicity of previously reported iodinated chlorin p6 copper complex (ICp6-Cu), a novel chlorophyll derivative in which copper is attached to the side chain carboxylate groups via coordination. Human oral carcinoma cells NT8e, 4451 and the non-cancerous keratinocyte HaCaT cells were treated with ICp6-Cu for 48 h in dark and cell viability, proliferation and morphological alterations were examined. ICp6-Cu showed pronounced cytotoxicity in cancer cells with IC50 ∼40 μM, whereas, the viability of HaCaT cells was not affected...
September 13, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28918123/carnosic-acid-induces-apoptosis-of-hepatocellular-carcinoma-cells-via-ros-mediated-mitochondrial-pathway
#17
Xinrui Zhang, Yiling Chen, Guangsheng Cai, Xin Li, Di Wang
Carnosic acid (CA), an important bioactive phenolic diterpene mainly found in labiate plants, exerts various biological functions, including antioxidant, anti-inflammatory, antitumor, and neuroprotective activities. In the present study, we proved the deleterious effects of CA against hepatocellular carcinoma (HCC) in both in vitro and in vivo models. In vitro, CA significantly decreased cell viability, inhibited cell proliferation and migration, enhanced apoptosis, and increased caspase-3, -8, and -9 activities in HepG2 and SMMC-7721 cells...
September 13, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28918088/evaluation-of-cerebrovascular-reactivity-in-subjects-with-and-without-obstructive-sleep-apnea
#18
Clodagh M Ryan, Anne Battisti-Charbonney, Olivia Sobczyk, David J Mikulis, James Duffin, Joseph A Fisher, Lashmi Venkatraghavan
BACKGROUND: Both obstructive sleep apnea (OSA) and altered cerebrovascular reactivity (CVR) are associated with increased stroke risk. Nevertheless, the incidence of abnormal CVR in patients with OSA is uncertain due to the high variability in the way CVR is measured both within and between studies. We hypothesized that a standardized CVR with a consistent vasoactive stimulus and cerebral blood flow (CBF) measure would be reduced in patients with severe OSA compared with healthy controls...
September 13, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28918077/membrane-electro-oxidizer-a-new-hybrid-membrane-system-with-electrochemical-oxidation-for-enhanced-organics-and-fouling-control
#19
Naresh Mameda, Hyung-June Park, Kwang-Ho Choo
The synergistic combination of membrane filtration with advanced oxidation is of particular interest for next-generation wastewater treatment technologies. A membrane electro-oxidizer (MEO) hybridizing a submerged microfilter and an electrochemical cell was developed and investigated for tertiary treatment of secondary industrial (textile) wastewater effluent. Laboratory- and pilot-scale MEO systems were designed and evaluated for treatment efficiency and membrane fouling control. The MEO achieved substantial removal of color (50-90%), turbidity (>90%), and bacteria (>4 log) as well as chemical oxygen demand (13-31%) and 1,4-dioxane (∼25-53%)...
September 5, 2017: Water Research
https://www.readbyqxmd.com/read/28917889/fabrication-of-cellulose-nanocrystal-from-carex-meyeriana-kunth-and-its-application-in-the-adsorption-of-methylene-blue
#20
Xue Yang, Hui Liu, Fuyi Han, Shuai Jiang, Lifang Liu, Zhaopeng Xia
Cellulose nanocrystal (CNC) was extracted from Carex meyeriana Kunth (CMK) by a combination of TEMPO oxidation and mechanical homogenization method, and used to remove methylene blue (MB) from aqueous solution. After alkali-oxygen treatment, the aqueous biphasic system (polyethylene glycol/inorganic salt) was applied to further remove lignin from CMK. The characteriazation of CNC, and the effects of H2O2 dosage, CNC dosage, adsorption time, and initial MB concentration on the MB removal capacity of CNC were investigated...
November 1, 2017: Carbohydrate Polymers
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