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Benjamin Del Tatto, Anne Lejay, Vincent Meteyer, Mathieu Roussin, Yannick Georg, Fabien Thaveau, Bernard Geny, Nabil Chakfe
OBJECTIVE: The purpose of this study was to report mid-term outcomes of open repair (OR) or endovascular repair (ER) of popliteal artery aneurysms (PAA) and assess if outcomes of patients have changed in the endovascular era. METHODS: This monocentric and retrospective study included all consecutive patients treated for PAA between January 2004 and December 2016. Before 2010 all patients underwent OR, but ER was available since 2010 and the choice between OR or ER was made on the basis of clinical presentation and preoperative morphological assessment...
March 1, 2018: Annals of Vascular Surgery
A Bussmann, F Heim, C Delay, E Girsowicz, B Del Tatto, D Dion, J Papillon, A Lejay, J Chakfé, F Thaveau, Y Georg, N Chakfé
OBJECTIVE/BACKGROUND: The goal of the present study was to assess the aging phenomena on second-generation textile endoprostheses (EPs) through explant analysis and to establish a preliminary classification of observed defects and material damages. METHODS: From January 2011 to June 2016 110 second- and recent-generation EPs were collected as a part of a European collaborative retrieval program. The analysis focused on the first 41 consecutive commercial EPs collected between 2011 and 2014 and made from polyethylene terephthalate...
September 2017: European Journal of Vascular and Endovascular Surgery
Jason M Aliotta, Mandy Pereira, Sicheng Wen, Mark S Dooner, Michael Del Tatto, Elaine Papa, Yan Cheng, Laura Goldberg, Corey E Ventetuolo, Olin Liang, James R Klinger, Peter J Quesenberry
The role of bone marrow (BM) cells in modulating pulmonary hypertensive responses is not well understood. Determine if BM-derived endothelial progenitor cells (EPCs) induce pulmonary hypertension (PH) and if this is attenuated by mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs). Three BM populations were studied: (a) BM from vehicle and monocrotaline (MCT)-treated mice (PH induction), (b) BM from vehicle-, MCT-treated mice that received MSC-EV infusion after vehicle, MCT treatment (PH reversal, in vivo), (c) BM from vehicle-, MCT-treated mice cultured with MSC-EVs (PH reversal, in vitro)...
July 2017: Stem Cells Translational Medicine
Hongyun Wang, Guodong Sun, Zhigang Zhang, Yang Ou
Delivery of chemotherapeutic drugs using nanocarriers is emerging as a promising approach for the treatment of cancer. The aim of this research was to develop a dual targeted d-α-tocopheryl succinate (TOS) functionalized nanostructured lipid carriers (NLCs), using etoposide (ETP) as a model drug to prove their in vitro and in vivo anti-tumor effects. Novel ETP loaded NLCs were constructed (ETP-NLCs). Hyaluronic acid (HA) and cell-penetrating peptide transcription activator (TAT) was applied for the surface decoration of ETP NLCs (HATOS/TATTOS-ETP-NLCs)...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Elenild de Góes Costa, Soraya Oliveira Dos Santos, Mayira Sojo-Milano, Ednei C C Amador, Erica Tatto, Dilma S M Souza, Francisco de A Costa, Rui M S Póvoa
No abstract text is available yet for this article.
May 15, 2017: International Journal of Cardiology
Sakine Işik, Sule Caglayan-Sözmen, Özden Anal, Özkan Karaman, Nevin Uzuner
Allergic contact reactions to hair dyes arise mostly due to sensitization to para-phenylenediamine (PPD). Para-phenylenediamine, a derivative of p-nitroanaline, is widely used as an oxydizable hair dye and is also found in black henna tattoo. Subsequent exposure to PPD may lead to delayed type IV hypersensitivity reaction manifesting as acute contact dermatitis. Here, a 15-year-old girl is presented, who developed a hypersensitivity reaction after first exposure to hair dye. She was found to have been sensitized to PPD before, through application of black henna tatto...
June 2017: Pediatric Emergency Care
Minoska Valli, Nadine E Tatto, Armin Peymann, Clemens Gruber, Nils Landes, Heinz Ekker, Gerhard G Thallinger, Diethard Mattanovich, Brigitte Gasser, Alexandra B Graf
As manually curated and non-automated BLAST analysis of the published Pichia pastoris genome sequences revealed many differences between the gene annotations of the strains GS115 and CBS7435, RNA-Seq analysis, supported by proteomics, was performed to improve the genome annotation. Detailed analysis of sequence alignment and protein domain predictions were made to extend the functional genome annotation to all P. pastoris sequences. This allowed the identification of 492 new ORFs, 4916 hypothetical UTRs and the correction of 341 incorrect ORF predictions, which were mainly due to the presence of upstream ATG or erroneous intron predictions...
September 2016: FEMS Yeast Research
N Falco, T Fontana, R Tutino, C Raspanti, A Mascolino, I Melfa, G Scerrino, G Salamone, G Gulotta
AIM: Laparoscopy is considered a good approach in treatment of colorectal neoplastic diseases; the endoscopic tattooing is then recommended (Evidence Level III and grade of recommendation A) to mark a lesion or a polypectomy site for intraoperative identification. We describe the case of perforation after tattoing treated conservatively. CASE REPORT: 63 years old woman, underwent colonoscopy for lipoma tattooing with India ink SPOT® solution kit and saline test...
March 2016: Il Giornale di Chirurgia
S Wen, M Dooner, Y Cheng, E Papa, M Del Tatto, M Pereira, Y Deng, L Goldberg, J Aliotta, D Chatterjee, C Stewart, A Carpanetto, F Collino, S Bruno, G Camussi, P Quesenberry
Mesenchymal stromal cells (MSCs) have been shown to reverse radiation damage to marrow stem cells. We have evaluated the capacity of MSC-derived extracellular vesicles (MSC-EVs) to mitigate radiation injury to marrow stem cells at 4 h to 7 days after irradiation. Significant restoration of marrow stem cell engraftment at 4, 24 and 168 h post irradiation by exposure to MSC-EVs was observed at 3 weeks to 9 months after transplant and further confirmed by secondary engraftment. Intravenous injection of MSC-EVs to 500cGy exposed mice led to partial recovery of peripheral blood counts and restoration of the engraftment of marrow...
November 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Jason M Aliotta, Mandy Pereira, Sicheng Wen, Mark S Dooner, Michael Del Tatto, Elaine Papa, Laura R Goldberg, Grayson L Baird, Corey E Ventetuolo, Peter J Quesenberry, James R Klinger
AIMS: Extracellular vesicles (EVs) from mice with monocrotaline (MCT)-induced pulmonary hypertension (PH) induce PH in healthy mice, and the exosomes (EXO) fraction of EVs from mesenchymal stem cells (MSCs) can blunt the development of hypoxic PH. We sought to determine whether the EXO fraction of EVs is responsible for modulating pulmonary vascular responses and whether differences in EXO-miR content explains the differential effects of EXOs from MSCs and mice with MCT-PH. METHODS AND RESULTS: Plasma, lung EVs from MCT-PH, and control mice were divided into EXO (exosome), microvesicle (MV) fractions and injected into healthy mice...
June 1, 2016: Cardiovascular Research
Hillary E Mulvey, Audrey Chang, Jason Adler, Michael Del Tatto, Kimberly Perez, Peter J Quesenberry, Devasis Chatterjee
BACKGROUND: Extracellular vesicles (EVs) are secreted from many cells, carrying cargoes including proteins and nucleic acids. Research has shown that EVs play a role in a variety of biological processes including immunity, bone formation and recently they have been implicated in promotion of a metastatic phenotype. METHODS: EVs were isolated from HCT116 colon cancer cells, 1459 non-malignant colon fibroblast cells, and tumor and normal colon tissue from a patient sample...
August 1, 2015: BMC Cancer
Fabio Gosetti, Bianca Bolfi, Emilio Marengo
This article deals with the photodegradation of sulforhodamine B, a dye widely used in nonpermanent tattoos. Degradation evidence was obtained from both aqueous and sweat-simulating solutions of the dye after 9 days of Solarbox irradiation. The identification of the degradation products was achieved using a nontarget approach. For this purpose, a micro liquid chromatography method coupled with tandem high-resolution mass spectrometry was developed. In addition, the chemical structures of five degradation products and two dye impurities were elucidated...
June 2015: Analytical and Bioanalytical Chemistry
T Jaehn, A Kaiser, C Grüneis, A A Saalabian, B Reichert
Allergic reactions occurring after tattooing, especially after the use of red tattoo ink ingredients are relatively rare. We report a painful skin reaction occurring 6 months after the tattoing of the right lower extremity in a 30-year-old female patient. Pathohistological and immunchemical results confirmed a pseudolymphoma. Only the tangential excision of the affected areas led to a sufficient healing process. Split thickness skin grafts were used for defect coverage. 2 years later, the patient was still pain free and the wounds had healed completely without any irritation...
December 2014: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
Andreas Maccani, Matthias Hackl, Christian Leitner, Willibald Steinfellner, Alexandra B Graf, Nadine E Tatto, Michael Karbiener, Marcel Scheideler, Johannes Grillari, Diethard Mattanovich, Renate Kunert, Nicole Borth, Reingard Grabherr, Wolfgang Ernst
MicroRNAs are short non-coding RNAs that play an important role in the regulation of gene expression. Hence, microRNAs are considered as potential targets for engineering of Chinese hamster ovary (CHO) cells to improve recombinant protein production. Here, we analyzed and compared the microRNA expression patterns of high, low, and non-producing recombinant CHO cell lines expressing two structurally different model proteins in order to identify microRNAs that are involved in heterologous protein synthesis and secretion and thus might be promising targets for cell engineering to increase productivity...
September 2014: Applied Microbiology and Biotechnology
Hirofumi Nose, Shunji Kitamura, Tatto Nishikawa
A specific mathematical ventilation model was assumed to derive a new expression for the concentration of each gas in the alveoli with only the ventilatory parameters or with the functional residual volume, tidal volume, anatomical dead space, and end-tidal gas concentration. The inequality derived from the mean concentration equation showed that, if the I to E ratio was inversed, the end-tidal P(CO2) was higher than the mean alveolar P(CO2), which was almost equal to the sampled arterial P(CO2). In the present model, at the inverse ratio ventilation (IRV), the end-tidal P(CO2) was higher than the arterial P(CO2)...
October 2013: Masui. the Japanese Journal of Anesthesiology
Kiriaki Panagopoulos, Sam Cross-Knorr, Christen Dillard, Dionysios Pantazatos, Michael Del Tatto, David Mills, Lisa Goldstein, Joseph Renzulli, Peter Quesenberry, Devasis Chatterjee
BACKGROUND: Extracellular vesicle (EV) trafficking is a fundamental cellular process that occurs in cells and is required for different aspects of pathophysiology. EV trafficking leads to changes in cellular function including apoptosis, angiogenesis and proliferation required for increased tumor formation. RESULTS: We report several phenotypic changes mediated by EVs isolated from non-malignant and malignant prostate cells as well as patient biopsied prostate tumor samples...
October 8, 2013: Molecular Cancer
L R Goldberg, M S Dooner, K W Johnson, E F Papa, M G Pereira, M Del Tatto, D M Adler, J M Aliotta, P J Quesenberry
Prevailing wisdom holds that hematopoietic stem cells (HSCs) are predominantly quiescent. Although HSC cycle status has long been the subject of scrutiny, virtually all marrow stem cell research has been based on studies of highly purified HSCs. Here we explored the cell cycle status of marrow stem cells in un-separated whole bone marrow (WBM). We show that a large number of long-term multi-lineage engraftable stem cells within WBM are in S/G2/M phase. Using bromodeoxyuridine, we show rapid transit through the cell cycle of a previously defined relatively dormant purified stem cell, the long-term HSC (LT-HSC; Lineage(-)/c-kit(+)/Sca-1(+)/Flk-2(-))...
April 2014: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Peter J Quesenberry, Mark S Dooner, Laura R Goldberg, Jason M Aliotta, Mandy Pereira, Ashley Amaral, Michael M Del Tatto, Douglas C Hixson, Bharat Ramratnam
The hierarchical models of stem cell biology have been based on work first demonstrating pluripotental spleen-colony-forming units, then showing progenitors with many differentiation fates assayed in in vitro culture; there followed the definition and separation of "stem cells" using monoclonal antibodies to surface epitopes and fluorescent-activated cell characterization and sorting (FACS). These studies led to an elegant model of stem cell biology in which primitive dormant G0 stem cells with tremendous proliferative and differentiative potential gave rise to progressively more restricted and differentiated classes of stem/progenitor cells, and finally differentiated marrow hematopoietic cells...
2012: Transactions of the American Clinical and Climatological Association
Hans Marx, Alexandra Bettina Graf, Nadine Elpida Tatto, Gerhard Günther Thallinger, Diethard Mattanovich, Michael Sauer
Megasphaera elsdenii is a Gram-negative ruminal bacterium. It is being investigated as a probiotic supplement for ruminants as it may provide benefits for energy balance and animal productivity. Furthermore, it is of biotechnological interest due to its capability of producing various volatile fatty acids. Here we report the complete genome sequence of M. elsdenii DSM 20460, the type strain for the species.
October 2011: Journal of Bacteriology
Michael Del Tatto, Thomas Ng, Jason M Aliotta, Gerald A Colvin, Mark S Dooner, David Berz, Gerri J Dooner, Elaine F Papa, Douglas C Hixson, Bharat Ramratnam, Bassam I Aswad, Edmund H Sears, John Reagan, Peter J Quesenberry
Microvesicles have been shown to mediate varieties of intercellular communication. Work in murine species has shown that lung-derived microvesicles can deliver mRNA, transcription factors, and microRNA to marrow cells and alter their phenotype. The present studies evaluated the capacity of excised human lung cancer cells to change the genetic phenotype of human marrow cells. We present the first studies on microvesicle production by excised cancers from human lung and the capacity of these microvesicles to alter the genetic phenotype of normal human marrow cells...
November 2011: Experimental Hematology
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