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Elenild de Góes Costa, Soraya Oliveira Dos Santos, Mayira Sojo-Milano, Ednei C C Amador, Erica Tatto, Dilma S M Souza, Francisco de A Costa, Rui M S Póvoa
No abstract text is available yet for this article.
May 15, 2017: International Journal of Cardiology
Sakine Işik, Sule Caglayan-Sözmen, Özden Anal, Özkan Karaman, Nevin Uzuner
Allergic contact reactions to hair dyes arise mostly due to sensitization to para-phenylenediamine (PPD). Para-phenylenediamine, a derivative of p-nitroanaline, is widely used as an oxydizable hair dye and is also found in black henna tattoo. Subsequent exposure to PPD may lead to delayed type IV hypersensitivity reaction manifesting as acute contact dermatitis. Here, a 15-year-old girl is presented, who developed a hypersensitivity reaction after first exposure to hair dye. She was found to have been sensitized to PPD before, through application of black henna tatto...
October 4, 2016: Pediatric Emergency Care
Minoska Valli, Nadine E Tatto, Armin Peymann, Clemens Gruber, Nils Landes, Heinz Ekker, Gerhard G Thallinger, Diethard Mattanovich, Brigitte Gasser, Alexandra B Graf
As manually curated and non-automated BLAST analysis of the published Pichia pastoris genome sequences revealed many differences between the gene annotations of the strains GS115 and CBS7435, RNA-Seq analysis, supported by proteomics, was performed to improve the genome annotation. Detailed analysis of sequence alignment and protein domain predictions were made to extend the functional genome annotation to all P. pastoris sequences. This allowed the identification of 492 new ORFs, 4916 hypothetical UTRs and the correction of 341 incorrect ORF predictions, which were mainly due to the presence of upstream ATG or erroneous intron predictions...
September 2016: FEMS Yeast Research
N Falco, T Fontana, R Tutino, C Raspanti, A Mascolino, I Melfa, G Scerrino, G Salamone, G Gulotta
AIM: Laparoscopy is considered a good approach in treatment of colorectal neoplastic diseases; the endoscopic tattooing is then recommended (Evidence Level III and grade of recommendation A) to mark a lesion or a polypectomy site for intraoperative identification. We describe the case of perforation after tattoing treated conservatively. CASE REPORT: 63 years old woman, underwent colonoscopy for lipoma tattooing with India ink SPOT® solution kit and saline test...
March 2016: Il Giornale di Chirurgia
S Wen, M Dooner, Y Cheng, E Papa, M Del Tatto, M Pereira, Y Deng, L Goldberg, J Aliotta, D Chatterjee, C Stewart, A Carpanetto, F Collino, S Bruno, G Camussi, P Quesenberry
Mesenchymal stromal cells (MSCs) have been shown to reverse radiation damage to marrow stem cells. We have evaluated the capacity of MSC-derived extracellular vesicles (MSC-EVs) to mitigate radiation injury to marrow stem cells at 4 h to 7 days after irradiation. Significant restoration of marrow stem cell engraftment at 4, 24 and 168 h post irradiation by exposure to MSC-EVs was observed at 3 weeks to 9 months after transplant and further confirmed by secondary engraftment. Intravenous injection of MSC-EVs to 500cGy exposed mice led to partial recovery of peripheral blood counts and restoration of the engraftment of marrow...
November 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Jason M Aliotta, Mandy Pereira, Sicheng Wen, Mark S Dooner, Michael Del Tatto, Elaine Papa, Laura R Goldberg, Grayson L Baird, Corey E Ventetuolo, Peter J Quesenberry, James R Klinger
AIMS: Extracellular vesicles (EVs) from mice with monocrotaline (MCT)-induced pulmonary hypertension (PH) induce PH in healthy mice, and the exosomes (EXO) fraction of EVs from mesenchymal stem cells (MSCs) can blunt the development of hypoxic PH. We sought to determine whether the EXO fraction of EVs is responsible for modulating pulmonary vascular responses and whether differences in EXO-miR content explains the differential effects of EXOs from MSCs and mice with MCT-PH. METHODS AND RESULTS: Plasma, lung EVs from MCT-PH, and control mice were divided into EXO (exosome), microvesicle (MV) fractions and injected into healthy mice...
June 1, 2016: Cardiovascular Research
Hillary E Mulvey, Audrey Chang, Jason Adler, Michael Del Tatto, Kimberly Perez, Peter J Quesenberry, Devasis Chatterjee
BACKGROUND: Extracellular vesicles (EVs) are secreted from many cells, carrying cargoes including proteins and nucleic acids. Research has shown that EVs play a role in a variety of biological processes including immunity, bone formation and recently they have been implicated in promotion of a metastatic phenotype. METHODS: EVs were isolated from HCT116 colon cancer cells, 1459 non-malignant colon fibroblast cells, and tumor and normal colon tissue from a patient sample...
August 1, 2015: BMC Cancer
Fabio Gosetti, Bianca Bolfi, Emilio Marengo
This article deals with the photodegradation of sulforhodamine B, a dye widely used in nonpermanent tattoos. Degradation evidence was obtained from both aqueous and sweat-simulating solutions of the dye after 9 days of Solarbox irradiation. The identification of the degradation products was achieved using a nontarget approach. For this purpose, a micro liquid chromatography method coupled with tandem high-resolution mass spectrometry was developed. In addition, the chemical structures of five degradation products and two dye impurities were elucidated...
June 2015: Analytical and Bioanalytical Chemistry
T Jaehn, A Kaiser, C Grüneis, A A Saalabian, B Reichert
Allergic reactions occurring after tattooing, especially after the use of red tattoo ink ingredients are relatively rare. We report a painful skin reaction occurring 6 months after the tattoing of the right lower extremity in a 30-year-old female patient. Pathohistological and immunchemical results confirmed a pseudolymphoma. Only the tangential excision of the affected areas led to a sufficient healing process. Split thickness skin grafts were used for defect coverage. 2 years later, the patient was still pain free and the wounds had healed completely without any irritation...
December 2014: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
Andreas Maccani, Matthias Hackl, Christian Leitner, Willibald Steinfellner, Alexandra B Graf, Nadine E Tatto, Michael Karbiener, Marcel Scheideler, Johannes Grillari, Diethard Mattanovich, Renate Kunert, Nicole Borth, Reingard Grabherr, Wolfgang Ernst
MicroRNAs are short non-coding RNAs that play an important role in the regulation of gene expression. Hence, microRNAs are considered as potential targets for engineering of Chinese hamster ovary (CHO) cells to improve recombinant protein production. Here, we analyzed and compared the microRNA expression patterns of high, low, and non-producing recombinant CHO cell lines expressing two structurally different model proteins in order to identify microRNAs that are involved in heterologous protein synthesis and secretion and thus might be promising targets for cell engineering to increase productivity...
September 2014: Applied Microbiology and Biotechnology
Hirofumi Nose, Shunji Kitamura, Tatto Nishikawa
A specific mathematical ventilation model was assumed to derive a new expression for the concentration of each gas in the alveoli with only the ventilatory parameters or with the functional residual volume, tidal volume, anatomical dead space, and end-tidal gas concentration. The inequality derived from the mean concentration equation showed that, if the I to E ratio was inversed, the end-tidal P(CO2) was higher than the mean alveolar P(CO2), which was almost equal to the sampled arterial P(CO2). In the present model, at the inverse ratio ventilation (IRV), the end-tidal P(CO2) was higher than the arterial P(CO2)...
October 2013: Masui. the Japanese Journal of Anesthesiology
Kiriaki Panagopoulos, Sam Cross-Knorr, Christen Dillard, Dionysios Pantazatos, Michael Del Tatto, David Mills, Lisa Goldstein, Joseph Renzulli, Peter Quesenberry, Devasis Chatterjee
BACKGROUND: Extracellular vesicle (EV) trafficking is a fundamental cellular process that occurs in cells and is required for different aspects of pathophysiology. EV trafficking leads to changes in cellular function including apoptosis, angiogenesis and proliferation required for increased tumor formation. RESULTS: We report several phenotypic changes mediated by EVs isolated from non-malignant and malignant prostate cells as well as patient biopsied prostate tumor samples...
October 8, 2013: Molecular Cancer
L R Goldberg, M S Dooner, K W Johnson, E F Papa, M G Pereira, M Del Tatto, D M Adler, J M Aliotta, P J Quesenberry
Prevailing wisdom holds that hematopoietic stem cells (HSCs) are predominantly quiescent. Although HSC cycle status has long been the subject of scrutiny, virtually all marrow stem cell research has been based on studies of highly purified HSCs. Here we explored the cell cycle status of marrow stem cells in un-separated whole bone marrow (WBM). We show that a large number of long-term multi-lineage engraftable stem cells within WBM are in S/G2/M phase. Using bromodeoxyuridine, we show rapid transit through the cell cycle of a previously defined relatively dormant purified stem cell, the long-term HSC (LT-HSC; Lineage(-)/c-kit(+)/Sca-1(+)/Flk-2(-))...
April 2014: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Peter J Quesenberry, Mark S Dooner, Laura R Goldberg, Jason M Aliotta, Mandy Pereira, Ashley Amaral, Michael M Del Tatto, Douglas C Hixson, Bharat Ramratnam
The hierarchical models of stem cell biology have been based on work first demonstrating pluripotental spleen-colony-forming units, then showing progenitors with many differentiation fates assayed in in vitro culture; there followed the definition and separation of "stem cells" using monoclonal antibodies to surface epitopes and fluorescent-activated cell characterization and sorting (FACS). These studies led to an elegant model of stem cell biology in which primitive dormant G0 stem cells with tremendous proliferative and differentiative potential gave rise to progressively more restricted and differentiated classes of stem/progenitor cells, and finally differentiated marrow hematopoietic cells...
2012: Transactions of the American Clinical and Climatological Association
Hans Marx, Alexandra Bettina Graf, Nadine Elpida Tatto, Gerhard Günther Thallinger, Diethard Mattanovich, Michael Sauer
Megasphaera elsdenii is a Gram-negative ruminal bacterium. It is being investigated as a probiotic supplement for ruminants as it may provide benefits for energy balance and animal productivity. Furthermore, it is of biotechnological interest due to its capability of producing various volatile fatty acids. Here we report the complete genome sequence of M. elsdenii DSM 20460, the type strain for the species.
October 2011: Journal of Bacteriology
Michael Del Tatto, Thomas Ng, Jason M Aliotta, Gerald A Colvin, Mark S Dooner, David Berz, Gerri J Dooner, Elaine F Papa, Douglas C Hixson, Bharat Ramratnam, Bassam I Aswad, Edmund H Sears, John Reagan, Peter J Quesenberry
Microvesicles have been shown to mediate varieties of intercellular communication. Work in murine species has shown that lung-derived microvesicles can deliver mRNA, transcription factors, and microRNA to marrow cells and alter their phenotype. The present studies evaluated the capacity of excised human lung cancer cells to change the genetic phenotype of human marrow cells. We present the first studies on microvesicle production by excised cancers from human lung and the capacity of these microvesicles to alter the genetic phenotype of normal human marrow cells...
November 2011: Experimental Hematology
H Vandenburgh, J Shansky, M Del Tatto, J Chromiak
Skeletal muscle structure is regulated by many factors, including nutrition, hormones, electrical activity, and tension. The muscle cells are subjected to both passive and active mechanical forces at all stages of development, and these forces play important but poorly understood roles in regulating muscle organogenesis and growth. For example, during embryogenesis, the rapidly growing skeleton places large passive mechanical forces on the attached muscle tissue. These forces not only help to organize the proliferating mononucleated myoblasts into the oriented, multinucleated myofibers of a functional muscle, but also tightly couple the growth rate of muscle to that of bone...
1999: Methods in Molecular Medicine
Felipe E Rodrigues, Rafael B Tatto, Larissa Vauchinski, Letícia M Leães, Mariana M Rodrigues, Vinícius B Rodrigues, Alessandra Catharino, Mariana Cainelli, Gabriela P Prates, Thais M Cerqueira, Linjie Zhang
OBJECTIVE: To evaluate the trend of pneumonia mortality in Brazilian children aged 4 years and younger from 1991 to 2007. METHODS: We conducted a retrospective study based on the database of the IT Department of the Brazilian Unified Health System (DATASUS), from which we obtained the number of deaths from pneumonia and the population aged 4 years and younger living in the five Brazilian regions and in the whole country. Mortality rate was calculated according to the number of deaths from pneumonia divided by the population, multiplied by 1,000 for the age group under 1 year old and by 10,000 in the age group from 1 to 4 years...
March 2011: Jornal de Pediatria
Joseph F Renzulli, Michael Del Tatto, Gerri Dooner, Jason Aliotta, Lisa Goldstein, Mark Dooner, Gerald Colvin, Devasis Chatterjee, Peter Quesenberry
PURPOSE: Transfer of genetic material from cancer cells to normal cells occurs via microvesicles. Cell specific phenotypes can be induced in normal cells by the transfer of material in microvesicles, leading to genetic changes. We report the identification and expression of prostate specific genes in normal human marrow cells co-cultured with human prostate cancer cells. MATERIALS AND METHODS: We harvested prostate tissue from 11 patients with prostate cancer. In 4 cases prostate tissue was co-cultured across from human marrow for 2 or 7 days but separated from it by a 0...
November 2010: Journal of Urology
Dalva M V Wanderley, Vera L C C Rodrigues, Ruth Moreira Leite, Sueli Yasumaro Diaz, Maria Esther de Carvalho, Soraya O Santos, Erica Tatto, Maria Salete Carli, Kunie I R Coelho, Paulo Ribeiro da Silva, Sandra Aparecida Túlio, Isaias Ribeiro da Silva, Maria A Shikanai-Yasuda
No vector transmitted cases of Chagas disease had been notified in the state of São Paulo since the 1970s. However, in March, 2006, the death of a six-year-old boy from the municipality of Itaporanga was notified to the Center for Epidemiological Survey of the São Paulo State Health Secretariat: an autochthonous case of acute Chagas disease. The postmortem histopathological examination performed in the Hospital das Clínicas of the Botucatu School of Medicine confirmed the diagnosis. Reference to hospital records, consultation with the health professionals involved in the case and interviews with members of the patient's family supplied the basis for this study...
May 2010: Revista do Instituto de Medicina Tropical de São Paulo
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