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https://www.readbyqxmd.com/read/27759985/adecuaci%C3%A3-n-de-las-peticiones-de-los-niveles-de-vitamina-d-al-laboratorio
#1
Francisco Javier Valero Chávez, Luis Miguel Luengo Pérez, Javier Cubero Juánez
Introducción: ante las nuevas implicaciones atribuidas a la vitamina D y la asociación con enfermedades tales como el cáncer, diabetes, enfermedades cardiovasculares, autoinmunes y mortalidad, no es de extrañar que se haya defendido la medición de los niveles de vitamina D en la población general. Sin embargo, no existen datos experimentales que demuestren la viabilidad y rentabilidad de la estrategia de cribado en la población y tampoco se ha comprobado la existencia de beneficios para la salud, por lo que en la actualidad solo es aconsejable la medida de 25 (OH) vitamina D en los grupos de personas de alto riesgo como indican las guías clínicas internacionales...
September 20, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27445098/diabetic-kidney-disease-is-there-a-non-albuminuric-phenotype-in-type-2-diabetic-patients
#2
Ivo Laranjinha, Patrícia Matias, Sofia Mateus, Filipa Aguiar, Patrícia Pereira, Miguel Perneta Santos, Rui Costa, Ana Lourenço, José Guia, José Diogo Barata, Luís Campos
BACKGROUND: Albuminuria was widely considered as the first clinical sign of diabetic kidney disease (DKD), which is why it has traditionally been used as a screening test for DKD. However, increasing evidence has shown that a significant number of type 2 diabetes mellitus (DM) patients have a decreased glomerular filtration rate (GFR) without significant albuminuria, known as non-albuminuric DKD (NA-DKD). The aim of this study was to determine the prevalence and the demographic and clinical characteristics of patients with NA-DKD...
September 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/27137487/fasting-induced-liver-gadd45%C3%AE-restrains-hepatic-fatty-acid-uptake-and-improves-metabolic-health
#3
Jessica Fuhrmeister, Annika Zota, Tjeerd P Sijmonsma, Oksana Seibert, Şahika Cıngır, Kathrin Schmidt, Nicola Vallon, Roldan M de Guia, Katharina Niopek, Mauricio Berriel Diaz, Adriano Maida, Matthias Blüher, Jürgen G Okun, Stephan Herzig, Adam J Rose
Recent studies have demonstrated that repeated short-term nutrient withdrawal (i.e. fasting) has pleiotropic actions to promote organismal health and longevity. Despite this, the molecular physiological mechanisms by which fasting is protective against metabolic disease are largely unknown. Here, we show that, metabolic control, particularly systemic and liver lipid metabolism, is aberrantly regulated in the fasted state in mouse models of metabolic dysfunction. Liver transcript assays between lean/healthy and obese/diabetic mice in fasted and fed states uncovered "growth arrest and DNA damage-inducible" GADD45β as a dysregulated gene transcript during fasting in several models of metabolic dysfunction including ageing, obesity/pre-diabetes and type 2 diabetes, in both mice and humans...
2016: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/26534622/uso-de-recursos-y-costos-relacionados-al-tratamiento-de-complicaciones-de-la-diabetes-mellitus-tipo-2-dmt2-en-colombia-una-estimacion-basada-en-guias-de-practica-clinica-gpc
#4
M Avila
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/26215993/how-do-glucocorticoids-regulate-lipid-metabolism
#5
Roldan M de Guia, Stephan Herzig
Glucocorticoids (GCs) and their cognate, intracellular receptor, the glucocorticoid receptor (GR) have been characterized as critical checkpoints in the hormonal control of energy homeostasis in mammals. Whereas physiological levels of GCs are required for proper metabolic control, aberrant GC action has been linked to a variety of severe metabolic diseases, including type 2 diabetes and obesity. As a member of the nuclear receptor superfamily of transcription factors, the GR translocates into the cell nucleus upon GC binding where it serves as a transcriptional regulator of distinct GC-responsive target genes that are in many cases associated with lipid regulatory pathways and thereby intricately control both physiological and pathophysiological systemic lipid homeostasis...
2015: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/25759850/intestinal-microbiota-as-modulators-of-the-immune-system-and-neuroimmune-system-impact-on-the-host-health-and-homeostasis
#6
REVIEW
Carlos Magno da Costa Maranduba, Sandra Bertelli Ribeiro De Castro, Gustavo Torres de Souza, Cristiano Rossato, Francisco Carlos da Guia, Maria Anete Santana Valente, João Vitor Paes Rettore, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Antônio Márcio Resende do Carmo, Gilson Costa Macedo, Fernando de Sá Silva
Many immune-based intestinal disorders, such as ulcerative colitis and Crohn's disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and anxiety are examples of other illnesses discussed in the literature. In parallel, importance of the gut microbiota in intestinal homeostasis and immunologic conflict between tolerance towards commensal microorganisms and combat of pathogens is well known...
2015: Journal of Immunology Research
https://www.readbyqxmd.com/read/25752863/-consensus-on-the-detection-and-management-of-prediabetes-consensus-and-clinical-guidelines-working-group-of-the-spanish-diabetes-society
#7
M Mata-Cases, S Artola, J Escalada, P Ezkurra-Loyola, J C Ferrer-García, J A Fornos, J Girbés, I Rica
In Spain, according to the Di@bet.es study, 13.8% of the adult population suffers from diabetes and 14.8% from some form of prediabetes (impaired glucose tolerance, impaired fasting glucose or both). Since early detection of prediabetes can facilitate the implementation of therapeutic measures to prevent its progression to diabetes, we believe that preventive strategies in primary care and specialized clinical settings should be agreed. Screening for diabetes and prediabetes using a specific questionnaire (FINDRISC) and/or the measurement of fasting plasma glucose in high risk patients leads to detecting patients at risk of developing diabetes and it is necessary to consider how they should be managed...
July 2015: Semergen
https://www.readbyqxmd.com/read/25735589/-consensus-on-the-detection-and-management-of-prediabetes-consensus-and-clinical-guidelines-working-group-of-the-spanish-diabetes-society
#8
M Mata-Cases, S Artola, J Escalada, P Ezkurra-Loyola, J C Ferrer-García, J A Fornos, J Girbés, I Rica
In Spain, according to the Di@bet.es study, 13.8% of the adult population suffers from diabetes and 14.8% from some form of prediabetes (impaired glucose tolerance, impaired fasting glucose or both). Since early detection of prediabetes can facilitate the implementation of therapeutic measures to prevent its progression to diabetes, we believe that preventive strategies in primary care and specialized clinical settings should be agreed. Screening for diabetes and prediabetes using a specific questionnaire (FINDRISC) and/or the measurement of fasting plasma glucose in high risk patients leads to detecting patients at risk of developing diabetes and it is necessary to consider how they should be managed...
August 2015: Atencion Primaria
https://www.readbyqxmd.com/read/25648701/-consensus-on-the-detection-and-management-of-prediabetes-consensus-and-clinical-guidelines-working-group-of-the-spanish-diabetes-society
#9
M Mata-Cases, S Artola, J Escalada, P Ezkurra-Loyola, J C Ferrer-García, J A Fornos, J Girbés, I Rica
In Spain, according to the Di@bet.es study, 13.8% of the adult population suffers from diabetes and 14.8% from some form of prediabetes (impaired glucose tolerance, impaired fasting glucose or both). Since early detection of prediabetes can facilitate the implementation of therapeutic measures to prevent its progression to diabetes, we believe that preventive strategies in primary care and specialized clinical settings should be agreed. Screening for diabetes and prediabetes using a specific questionnaire (FINDRISC) and/or the measurement of fasting plasma glucose in high risk patients leads to detecting patients at risk of developing diabetes and it is necessary to consider how they should be managed...
March 2015: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
https://www.readbyqxmd.com/read/25553948/consensus-on-the-detection-and-management-of-prediabetes-consensus-and-clinical-guidelines-working-group-of-the-spanish-diabetes-society
#10
M Mata-Cases, S Artola, J Escalada, P Ezkurra-Loyola, J C Ferrer-García, J A Fornos, J Girbés, I Rica
In Spain, according to the Di@bet.es study, 13.8% of the adult population suffers from diabetes and 14.8% from some form of prediabetes (impaired glucose tolerance, impaired fasting glucose or both). Since early detection of prediabetes can facilitate the implementation of therapeutic measures to prevent its progression to diabetes, we believe that preventive strategies in primary care and specialized clinical settings should be agreed. Screening for diabetes and prediabetes using a specific questionnaire (FINDRISC) and/or the measurement of fasting plasma glucose in high risk patients leads to detecting patients at risk of developing diabetes and it is necessary to consider how they should be managed...
March 2015: Revista Clínica Española
https://www.readbyqxmd.com/read/25390020/glucocorticoid-hormones-and-energy-homeostasis
#11
REVIEW
Roldan M de Guia, Adam J Rose, Stephan Herzig
Glucocorticoids (GC) and their cognate intracellular receptor, the glucocorticoid receptor (GR), have been characterised as critical checkpoints in the endocrine control of energy homeostasis in mammals. Indeed, aberrant GC action has been linked to a variety of severe metabolic diseases, including obesity, insulin resistance and type 2 diabetes. As a steroid-binding member of the nuclear receptor superfamily of transcription factors, the GR translocates into the cell nucleus upon GC binding where it serves as a transcriptional regulator of distinct GC-responsive target genes that are - in many cases - associated with glucose and lipid regulatory pathways and thereby intricately control both physiological and pathophysiological systemic energy homeostasis...
August 2014: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/24634828/hepatic-transforming-growth-factor-%C3%AE-1-stimulated-clone-22-d1-controls-systemic-cholesterol-metabolism
#12
Julia Jäger, Vera Greiner, Daniela Strzoda, Oksana Seibert, Katharina Niopek, Tjeerd P Sijmonsma, Michaela Schäfer, Allan Jones, Roldan De Guia, Marc Martignoni, Geesje M Dallinga-Thie, Mauricio B Diaz, Thomas G Hofmann, Stephan Herzig
Disturbances in lipid homeostasis are hallmarks of severe metabolic disorders and their long-term complications, including obesity, diabetes, and atherosclerosis. Whereas elevation of triglyceride (TG)-rich very-low-density lipoproteins (VLDL) has been identified as a risk factor for cardiovascular complications, high-density lipoprotein (HDL)-associated cholesterol confers atheroprotection under obese and/or diabetic conditions. Here we show that hepatocyte-specific deficiency of transcription factor transforming growth factor β 1-stimulated clone (TSC) 22 D1 led to a substantial reduction in HDL levels in both wild-type and obese mice, mediated through the transcriptional down-regulation of the HDL formation pathway in liver...
April 2014: Molecular Metabolism
https://www.readbyqxmd.com/read/24256689/therapeutic-potential-of-laminin-biodritin-microcapsules-for-type-1-diabetes-mellitus
#13
Ana Lucia Campanha-Rodrigues, Gisella Grazioli, Talita C Oliveira, Ana Carolina V Campos-Lisbôa, Thiago R Mares-Guia, Mari C Sogayar
Pancreatic islet microencapsulation constitutes an attractive therapy for type 1 diabetes mellitus; however, long-term β-cell function remains a major problem. Loss of extracellular matrix interactions during islet isolation dramatically affects β-cell viability. We have previously shown beneficial effects of laminin (LN) in human islet cultures. Herein, we investigated whether LN could improve the outcome of transplantation after islet microencapsulation in Biodritin, an alginate-based material. To test LN-Biodritin stability, microcapsules were subjected to different types of in vitro stress...
2015: Cell Transplantation
https://www.readbyqxmd.com/read/23884803/does-adding-antibiotics-to-cement-reduce-the-need-for-early-revision-in-total-knee-arthroplasty
#14
Eric Bohm, Naisu Zhu, Jing Gu, Nicole de Guia, Cassandra Linton, Tammy Anderson, David Paton, Michael Dunbar
BACKGROUND: There is considerable debate about whether antibiotic-loaded bone cement should be used for fixation of TKAs. While antibiotics offer the theoretical benefit of lowering early revision due to infection, they may weaken the cement and thus increase the likelihood of aseptic loosening, perhaps resulting in a higher revision rate. QUESTIONS/PURPOSES: We (1) compared the frequency of early knee revision arthroplasty in patients treated with antibiotic-loaded or non-antibiotic-loaded cement for initial fixation, (2) determined effects of age, sex, comorbidities, and surgeons' antibiotic-loaded cement usage patterns on revision rate, and (3) compared causes of revision (aseptic or septic) between groups...
January 2014: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/21496265/snp-based-pathway-enrichment-analysis-for-genome-wide-association-studies
#15
Lingjie Weng, Fabio Macciardi, Aravind Subramanian, Guia Guffanti, Steven G Potkin, Zhaoxia Yu, Xiaohui Xie
BACKGROUND: Recently we have witnessed a surge of interest in using genome-wide association studies (GWAS) to discover the genetic basis of complex diseases. Many genetic variations, mostly in the form of single nucleotide polymorphisms (SNPs), have been identified in a wide spectrum of diseases, including diabetes, cancer, and psychiatric diseases. A common theme arising from these studies is that the genetic variations discovered by GWAS can only explain a small fraction of the genetic risks associated with the complex diseases...
2011: BMC Bioinformatics
https://www.readbyqxmd.com/read/21382648/-recommendations-for-the-pharmacological-treatment-of-hyperglycemia-in-type-2-diabetes
#16
Edelmiro Menéndez Torre, Francisco Javier Lafita Tejedor, Sara Artola Menéndez, Jesús Millán Núñez-Cortés, Angeles Alonso García, Manuel Puig Domingo, José Ramón García Solans, Fernando Alvarez Guisasola, Javier García Alegría, Javier Mediavilla Bravo, Carlos Miranda Fernández-Santos, Ramón Romero González et al.
No abstract text is available yet for this article.
April 2011: Atencion Primaria
https://www.readbyqxmd.com/read/19347181/-islet-transplantation-as-a-clinical-tool-present-state-and-future-perspectives
#17
REVIEW
Freddy Goldberg Eliaschewitz, Denise Reis Franco, Thiago Rennó Mares-Guia, Irene L Noronha, Leticia Labriola, Mari Cleide Sogayar
Islet transplant is an innovative treatment for type 1 diabetic patients, which still lies between experimental and approved transplant therapy. Islet cells are seeded in a non-physiological territory where an uncertain fraction will be able to adapt and survive. Thus, the challenge lies in improving the whole procedure, employing the tools of cell biology, immunology and laboratory techniques, in order to reach the results obtained with whole organ transplant. This review describes the procedure, its progress to the present methodology and clinical results obtained...
February 2009: Arquivos Brasileiros de Endocrinologia e Metabologia
https://www.readbyqxmd.com/read/18374092/biodritin-microencapsulated-human-islets-of-langerhans-and-their-potential-for-type-1-diabetes-mellitus-therapy
#18
A C V Campos-Lisbôa, T R Mares-Guia, G Grazioli, A C Goldberg, M C Sogayar
BACKGROUND: Microencapsulation of pancreatic islets with polymeric compounds constitutes an attractive alternative therapy for type 1 diabetes mellitus. The major limiting factor is the availability of a biocompatible and mechanically stable polymer. We investigated the potential of Biodritin, a novel polymer constituted of alginate and chondroitin sulfate, for islet microencapsulation. METHODS: Biodritin microcapsules were obtained using an air jet droplet generator and gelated with barium or calcium chloride...
March 2008: Transplantation Proceedings
https://www.readbyqxmd.com/read/18327551/nucel-cell-and-molecular-therapy-center-a-multidisciplinary-center-for-translational-research-in-brazil
#19
REVIEW
C Colin, M A Demasi, T L Degaki, J C Bustos-Valenzuela, R C S Figueira, W R Montor, L O Cruz, F H Lojudice, A G Muras, T M Pereira, S M B Winnischofer, A P G Hasegawa, A C Carreira, N V Verbisck, R G Corrêa, H M Garay-Malpartida, T R Mares-Guia, M L Corrêa-Giannella, J M Granjeiro, M C Sogayar
Social and economical development is closely associated with technological innovation and a well-developed biotechnological industry. In the last few years, Brazil's scientific production has been steadily increasing; however, the number of patents is lagging behind, with technological and translational research requiring governmental incentive and reinforcement. The Cell and Molecular Therapy Center (NUCEL) was created to develop activities in the translational research field, addressing concrete problems found in biomedical and veterinary areas and actively searching for solutions by employing a genetic engineering approach to generate cell lines over-expressing recombinant proteins to be transferred to local biotech companies, aiming at furthering the development of a national competence for local production of biopharmaceuticals of widespread use and of life-saving importance...
June 2008: Molecular Biotechnology
https://www.readbyqxmd.com/read/16750642/molecular-dynamics-and-circular-dichroism-studies-of-human-and-rat-c-peptides
#20
COMPARATIVE STUDY
Thiago Rennó Mares-Guia, Bernard Maigret, Natália Florêncio Martins, Ana Luiza Turchetti Maia, Luciano Vilela, Carlos Henrique Inácio Ramos, Luiz Juliano Neto, Maria Aparecida Juliano, Marcos Luiz dos Mares-Guia, Marcelo Matos Santoro
Proinsulin C-peptide has been recently described as an endogenous peptide hormone, responsible for important physiological functions others than its role in proinsulin processing. Accumulating evidences that C-peptide exerts beneficial effects in the treatment of long term complications of patients with type 1 diabetes mellitus indicate that this molecule may be administered together with insulin in future therapies. Despite its clear pharmacological interest, the secondary and three-dimensional (3D) structures of human C-peptide are still points of controversy...
December 2006: Journal of Molecular Graphics & Modelling
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