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"Statin persistence"

John N Booth, Lisandro D Colantonio, Ligong Chen, Robert S Rosenson, Keri L Monda, Monika M Safford, Meredith L Kilgore, Todd M Brown, Benjamin Taylor, Ricardo Dent, Paul Muntner, Emily B Levitan
BACKGROUND: Although the benefits of statins accrue over time, treatment discontinuation is common. Examining the patterns of statin discontinuation, reinitiation, and persistence after reinitiation among Medicare beneficiaries after hospital discharge for a myocardial infarction may help increase statin use in high-risk patients. METHODS AND RESULTS: Medicare beneficiaries with a statin fill claim within 30 days after hospital discharge for myocardial infarction in 2007 to 2012 (n=158 795) were followed for 182 days post-discharge to identify discontinuation, defined as 60 continuous days without statins available...
October 2017: Circulation. Cardiovascular Quality and Outcomes
Sara Malo, Isabel Aguilar-Palacio, Cristina Feja, Enrica Menditto, María Jesús Lallana, Elena Andrade, José Antonio Casasnovas, María José Rabanaque
INTRODUCTION AND OBJECTIVES: The aim of this study was to assess patterns of treatment persistence in a cohort of male Spanish workers receiving statin therapy for primary prevention of cardiovascular disease. METHODS: This descriptive study was conducted within the framework of the prospective longitudinal Aragon Workers' Health Study (N = 5400). Incident male statin users were identified based on data collected from the regional government's medication consumption information system...
January 2018: Revista Española de Cardiología
Huabing Zhang, Jorge Plutzky, Maria Shubina, Alexander Turchin
BACKGROUND: Patients with both diabetes and coronary artery disease (CAD) have exceedingly high cardiovascular risk. Nevertheless, little is known about prevalence of statin therapy in this population and reasons why some patients may not be receiving this potentially life-saving treatment. OBJECTIVE: To investigate prevalence and predictors of statin therapy in patients with combined diabetes and CAD. METHODS: We conducted a retrospective cohort study of primary care patients with diabetes and CAD followed at 2 academic medical centers between 2000 and 2011...
November 2016: Journal of Clinical Lipidology
Anna Citarella, Marie Linder, Helle Kieler, Ingegärd Anveden Berglind, Anders Sundström, Björn Wettermark, Morten Andersen
PURPOSE: Persistence to statins is low, in part due to lack of perception of cardiovascular (CV) risk. High values of low-density lipoprotein cholesterol (LDL-C) might increase the motivation for patients to be persistent. We investigated whether the baseline LDL-C value influences the discontinuation of statin treatment in patients with and without previous CV events. METHODS: A cohort study was performed using information from the Swedish national registers concerning dispensed drugs, hospital contacts, cause of death, and socioeconomic status, and linked with data from clinical laboratories...
March 2016: European Journal of Clinical Pharmacology
Sune Fallgaard Nielsen, Børge Grønne Nordestgaard
AIM: We tested the hypothesis that statin-related news stories, cardiovascular disease, diabetes, statin dose, calendar year, and socio-demographic status are associated with early statin discontinuation. We also examined frequency and consequences of early statin discontinuation. METHODS AND RESULTS: From the entire Danish population, we studied 674 900 individuals aged 40 or older who were initiated on statin therapy in 1995-2010, and followed them until 31 December 2011...
March 14, 2016: European Heart Journal
Claudia Chauvet, Celine Nicolas, Claire Lafay-Chebassier, Mohamed Jaber, Nathalie Thiriet, Marcello Solinas
Statins are drugs that have been used for decades in humans for the treatment of hypercholesterolemia. More recently, several lines of evidence demonstrate that statins, in addition to their peripheral effects, produce a wide variety of effects in the brain and may be beneficial in neurological and psychiatric conditions. In this study, we allowed rats to self-administer cocaine for several weeks and, at the end of self-administration training, we treated them with low doses of statins daily for a 21-day period of abstinence...
May 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Mary A De Vera, Vidula Bhole, Lindsay C Burns, Diane Lacaille
AIMS: While suboptimal adherence to statin medication has been quantified in real-world patient settings, a better understanding of its impact is needed, particularly with respect to distinct problems of medication taking. Our aim was to synthesize current evidence on the impacts of statin adherence, discontinuation and persistence on cardiovascular disease and mortality outcomes. METHODS: We conducted a systematic review of peer-reviewed studies using a mapped search of Medline, Embase and International Pharmaceutical Abstracts databases...
October 2014: British Journal of Clinical Pharmacology
Anna Citarella, Helle Kieler, Anders Sundström, Marie Linder, Björn Wettermark, Ingegärd Anveden Berglind, Morten Andersen
PURPOSE: Persistence to statins is low, presumably due to lack of perception of risk. Having a close relative suffering from cardiovascular disease (CVD) might increase persistence to statins. We investigated whether family history of CVD influences the discontinuation of statin treatment. METHODS: A population-based cohort study was performed. Swedish registers on dispensed drugs, hospitalization and cause of death were linked to the Multi-generation Register. Incident statin users 20-72 years of age were identified between 2006 and 2007 and followed until 30 June 2009...
June 2014: European Journal of Clinical Pharmacology
Jian-Qiang Wang, Guo-Rong Wu, Zheng Wang, Xiao-Ping Dai, Xiang-Rong Li
BACKGROUND: The effect of statin treatment on the long-term prognosis in patients with chronic heart failure (CHF) remains uncertain. This study aimed to answer the question by a meta-analysis. METHODS: The Cochrane databases, MEDLINE and EMBASE, were systematically searched. The eligibility of prospective studies that assigned CHF patients to receive statin treatment and a control (no statin treatment), had defined prognostic outcomes as primary endpoint, and had a minimal follow-up of 12 months was determined...
February 2014: Heart, Lung & Circulation
Hae Sun Suh, Joel W Hay, Kathleen A Johnson, Jason N Doctor
PURPOSE: Type 2 diabetes is associated with increased cardiovascular risk. The comparative effectiveness of statin plus fibrate combination therapy and statin monotherapy in reducing risk of cardiovascular disease in real-world settings is unknown. METHODS: A retrospective database analysis was performed using a large managed care claims database of patients identified with type 2 diabetes based on diagnosis codes from January 2002 through December 2003 and continuously enrolled for the entire study period, 5...
May 2012: Pharmacoepidemiology and Drug Safety
Kristen T Reaume, Steven R Erickson, Michael P Dorsch, Niquole L M Dunham, Susan M Hiniker, Nitya Prabhakar, Eva M Kline-Rogers, Kim A Eagle
BACKGROUND: Medication-taking behavior is influenced by many factors, as described by the Health Belief Model. Information on withdrawals of drugs from the market may be an example of negative external stimuli that might influence patients' decisions to persist with long-term drug therapy. OBJECTIVE: To evaluate the association between the withdrawal of cerivastatin from the market and persistence in taking all other statins in patients who recently experienced acute coronary syndrome (ACS)...
July 2008: Annals of Pharmacotherapy
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