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"Statin adherence"

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https://www.readbyqxmd.com/read/28427340/does-the-association-between-adherence-to-statin-medications-and-mortality-depend-on-measurement-approach-a-retrospective-cohort-study
#1
Mhd Wasem Alsabbagh, Dean Eurich, Lisa M Lix, Thomas W Wilson, David F Blackburn
BACKGROUND: The aim of this study was to examine the relationship between mortality and statin adherence using two different approaches to adherence measurement (summary versus repeated-measures). METHODS: A retrospective cohort study was conducted using administrative data from Saskatchewan, Canada between 1994 and 2008. Eligible individuals received a prescription for a statin following hospitalization for acute coronary syndrome (ACS). Adherence was measured using proportion of days covered (PDC) expressed either as: 1) a fixed summary measure, or 2) as a repeatedly measured covariate...
April 20, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28404800/racial-differences-in-statin-adherence-following-hospital-discharge-for-ischemic-stroke
#2
Karen C Albright, Hong Zhao, Justin Blackburn, Nita A Limdi, T Mark Beasley, George Howard, Vera Bittner, Virginia J Howard, Paul Muntner
OBJECTIVE: To compare nonadherence to statins in older black and white adults following an ischemic stroke. METHODS: We studied black and white adults ≥66 years of age with Medicare fee-for-service insurance coverage hospitalized for ischemic stroke from 2007 to 2012 who filled a statin prescription within 30 days following discharge. Nonadherence was defined as a proportion of days covered <80% in the 365 days following hospital discharge. In addition, we evaluated factors associated with nonadherence for white and black participants separately...
April 12, 2017: Neurology
https://www.readbyqxmd.com/read/28388626/statin-adherence-and-the-risk-of-parkinson-s-disease-a-population-based-cohort-study
#3
Violetta Rozani, Nir Giladi, Baruch El-Ad, Tanya Gurevich, Judith Tsamir, Beatriz Hemo, Chava Peretz
BACKGROUND: While experimental data provided some compelling evidence on the benefits of statins on dopaminergic neurons, observational studies reported conflicting results regarding the potential of statins to effect the risk of Parkinson's disease (PD). OBJECTIVES: To evaluate the association between changes in statin adherence over time and PD risk. METHODS: A population-based cohort of new statin users (ages 40-79, years 1999-2012) was derived from a large Israeli healthcare services organization...
2017: PloS One
https://www.readbyqxmd.com/read/28345442/predicting-1-year-statin-adherence-among-prevalent-users-a-retrospective-cohort-study
#4
Alexis A Krumme, Jessica M Franklin, Danielle L Isaman, Olga S Matlin, Angela Y Tong, Claire M Spettell, Troyen A Brennan, William H Shrank, Niteesh K Choudhry
BACKGROUND: Attempts to predict who is at risk of future nonadherence have largely focused on predictions at the time of therapy initiation; however, these users are only a small proportion of all patients on therapy at any point in time. Methods to predict nonadherence for established medication users, which have not been previously described in the literature, would be helpful to guide efforts to enhance the use of evidence-based therapies. OBJECTIVE: To test approaches for adherence prediction among prevalent statin users, namely the use of short-term filling behavior, investigator-specified predictors from medical and pharmacy administrative claims, and the empirical selection of potential predictors using the high-dimensional propensity score variable selection algorithm...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28328244/-adherence-to-statins-in-patients-with-myocardial-infarction-in-hungary
#5
János Tomcsányi
INTRODUCTION: Statin therapy has proven to be one cornerstone for prevention and treatment of cardiovascular disease, but the clinical application is suboptimal. Adherence to statin therapy in Hungary in primary prevention is very low, but not known in patients with myocardial infarction. AIM: This study was designed to determine the statin and ezetimib adherence after myocardial infarction in respect of total mortality. METHOD: A retrospective study was carried out based on the National Health Insurance database between 2013-2015...
March 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28302290/statin-intolerance-and-risk-of-coronary-heart-events-and-all-cause-mortality-following-myocardial-infarction
#6
Maria-Corina Serban, Lisandro D Colantonio, Angelika D Manthripragada, Keri L Monda, Vera A Bittner, Maciej Banach, Ligong Chen, Lei Huang, Ricardo Dent, Shia T Kent, Paul Muntner, Robert S Rosenson
BACKGROUND: Many patients report adverse reactions to, and may not tolerate, statin therapy. These patients may be at increased risk for coronary heart disease (CHD) events and mortality. OBJECTIVES: This study evaluated the risk for recurrent myocardial infarction (MI), CHD events, and all-cause mortality in Medicare beneficiaries with statin intolerance and in those with high adherence to statin therapy. METHODS: We studied 105,329 Medicare beneficiaries who began a moderate- or high-intensity statin dosage after hospitalization for MI between 2007 and 2013...
March 21, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28290082/statin-adherence-and-the-risk-of-stroke-a-dose-response-meta-analysis
#7
REVIEW
Tao Xu, Xinyuan Yu, Shu Ou, Xi Liu, Jinxian Yuan, Yangmei Chen
BACKGROUND: Statins are one of the most common medications for stroke prevention. Increasing evidence indicates that the effect of statins against stroke may depend on the optimal adherence of the patients to the long-term therapies. However, the magnitude of the association between statin adherence and the risk of stroke has not been determined. OBJECTIVE: We conducted a dose-response meta-analysis to investigate the association between statin adherence and the risk of stroke...
March 13, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28270383/patterns-and-predictors-of-adherence-to-statin-therapy-among-older-patients-protocol-for-a-systematic-review
#8
Richard Ofori-Asenso, Ella Zomer, Andrea Curtis, Andrew Tonkin, Mark Nelson, Manoj Gambhir, Danny Liew, Sophia Zoungas
BACKGROUND: The benefits of statin therapy are significantly compromised by noncompliance. Although elderly patients may have particular challenges with medication adherence and persistence, previous reviews on statin adherence have not focused on this population. Additionally, comparisons of adherence and persistence specific to statin indication (primary or secondary prevention) have not been thoroughly explored. OBJECTIVE: We aim to assess the extent of, and factors associated with, adherence and persistence to statin therapy among older populations (aged ≥65 years)...
March 7, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28196429/medical-and-psychosocial-factors-and-unfavourable-low-density-lipoprotein-cholesterol-control-in-coronary-patients
#9
John Munkhaugen, Elise Sverre, Jan E Otterstad, Kari Peersen, Erik Gjertsen, Joep Perk, Lars Gullestad, Torbjørn Moum, Toril Dammen, Einar Husebye
Objective Understanding the determinants of low-density lipoprotein cholesterol (LDL-C) control constitutes the basis of modelling interventions for optimal lipid control and prognosis. We aim to identify medical and psychosocial (study) factors associated with unfavourable LDL-C control in coronary patients. Methods A cross-sectional explorative study used logistic and linear regression analysis to investigate the association between study factors and LDL-C in 1095 patients, hospitalized with myocardial infarction and/or a coronary revascularization procedure...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28195516/young-adulthood-cognitive-ability-predicts-statin-adherence-in-middle-aged-men-after-first-myocardial-infarction-a-swedish-national-registry-study
#10
John Wallert, Claudia Lissåker, Guy Madison, Claes Held, Erik Olsson
Background Cognitive ability (CA) is positively related to later health, health literacy, health behaviours and longevity. Accordingly, a lower CA is expected to be associated with poorer adherence to medication. We investigated the long-term role of CA in adherence to prescribed statins in male patients after a first myocardial infarction (MI). Methods CA was estimated at 18-20 years of age from Military Conscript Register data for first MI male patients (≤60 years) and was related to the one- and two-year post-MI statin adherence on average 30 years later...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28076703/a-systematic-review-to-assess-adherence-and-persistence-with-statins
#11
Sohan Deshpande, Ruben G W Quek, Carol A Forbes, Shelley de Kock, Jos Kleijnen, Shravanthi R Gandra, Ross J Simpson
OBJECTIVE: To identify and assess studies published over a 10 year period up to February 2016 which measure adherence or persistence with statins, to summarize their methods, strengths and weaknesses and to summarize evidence linking statin adherence/persistence with risk of cardiovascular events. METHODS: Electronic databases and abstracts from four major cardiovascular disease conferences were searched from January 2005 to February 2016. The study selection process was performed by two reviewers working independently...
April 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27881912/assessing-the-feasibility-and-quality-of-shared-decision-making-in-china-evaluating-a-clinical-encounter-intervention-for-chinese-patients
#12
Rongchong Huang, Xiantao Song, Jian Wu, Wei Huang, Aaron L Leppin, Michael R Gionfriddo, Yongxian Liu, Kasey R Boehmer, Henry H Ting, Victor M Montori
BACKGROUND: The aim of this study was to evaluate the feasibility of using the Statin Choice decision aid to have discussions about starting a statin medication for cardiovascular risk reduction in Chinese patients with stable coronary artery diseases. METHODS: A prospective, pilot study of the Statin Choice decision aid in two teaching hospitals in Northern China was conducted. A total of seven clinicians were enrolled and underwent a 12-hour, group-based, in-person training on shared decision making (SDM) and the Statin Choice decision aid...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27756795/socioeconomic-inequalities-in-statin-adherence-under-universal-coverage-does-sex-matter
#13
Emma Aarnio, Janne Martikainen, Aaron N Winn, Risto Huupponen, Jussi Vahtera, Maarit J Korhonen
BACKGROUND: Previous research shows that low socioeconomic position (SEP; especially low income) is associated with statin nonadherence. We investigated the relationship between SEP and statin adherence in a country with universal coverage using group-based trajectory modeling in addition to the proportion of days covered. METHODS AND RESULTS: Using data from Finnish healthcare registers, we identified 116 846 individuals, aged 45 to 75 years, who initiated statin therapy for primary prevention of cardiovascular disease...
November 2016: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/27696318/statin-adherence-does-gender-matter
#14
Karen M Goldstein, Leah L Zullig, Lori A Bastian, Hayden B Bosworth
PURPOSE OF REVIEW: Cardiovascular disease (CVD) continues to be the leading cause of death for men and women in the USA. Statins have contributed significantly to noted declines in cardiovascular-related mortality in the last decade; however, the benefit of statins is inequitable across genders. Women continue to be less likely to take statins and to meet target LDL goals than men. As a possible contributing factor to this disparity, we explore the evidence for gender-based differences in provision of, and adherence to statins...
November 2016: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/27677773/patient-centered-interventions-to-improve-adherence-to-statins-a-narrative-synthesis-of-systematically-identified-studies
#15
REVIEW
Magnus Jörntén-Karlsson, Stéphane Pintat, Michael Molloy-Bland, Staffan Berg, Matti Ahlqvist
Poor adherence to statins increases cardiovascular disease risk. We systematically identified 32 controlled studies that assessed patient-centered interventions designed to improve statin adherence. The limited number of studies and variation in study characteristics precluded strict quality criteria or meta-analysis. Cognitive education or behavioural counselling delivered face-to-face multiple times consistently improved statin adherence compared with control groups (7/8 and 3/3 studies, respectively). None of four studies using medication reminders and/or adherence feedback alone reported significantly improved statin adherence...
October 2016: Drugs
https://www.readbyqxmd.com/read/27612487/patient-and-partner-feedback-reports-to-improve-statin-medication-adherence-a-randomized-control-trial
#16
Ashok Reddy, Tiffany L Huseman, Anne Canamucio, Steven C Marcus, David A Asch, Kevin Volpp, Judith A Long
BACKGROUND: Simple nudges such as reminders and feedback reports to either a patient or a partner may facilitate improved medication adherence. OBJECTIVE: To test the impact of a pill bottle used to monitor adherence, deliver a daily alarm, and generate weekly medication adherence feedback reports on statin adherence. DESIGN: Three-month, three-arm randomized clinical trial (ClinicalTrials.gov identifier: NCT02480530). PARTICIPANTS: One hundred and twenty-six veterans with known coronary artery disease and poor adherence (medication possession ratio <80 %)...
March 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27599748/statin-adherence-rates-in-patients-utilizing-a-patient-centered-medical-home-based-pharmacy
#17
Erin M Slazak, Jessica T Kozakiewicz, Natalie S Winters, Jason R Smith, Scott V Monte
BACKGROUND: Medication nonadherence contributes to approximately US$290 billion per year in avoidable health-care spending. Statins are of particular interest because of their importance to patient outcomes, costs of treatment failure, and categorization as a Medicare star measure linked to financial reimbursement. OBJECTIVE: To evaluate statin adherence as defined by the proportion of days covered (PDC) among patients who use an embedded dispensing pharmacy in a patient-centered medical home (PCMH)...
September 6, 2016: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27581815/community-pharmacists-assisting-in-total-cardiovascular-health-cpatch-a-cluster-randomized-controlled-trial-testing-a-focused-adherence-strategy-involving-community-pharmacies
#18
David F Blackburn, Charity D Evans, Dean T Eurich, Kerry D Mansell, Derek J Jorgenson, Jeff G Taylor, William M Semchuk, Yvonne M Shevchuk, Alfred J Remillard, David A Tran, Anne P Champagne
STUDY OBJECTIVE: To test a brief intervention for preventing statin nonadherence among community pharmacy patrons. DESIGN: Prospective, cluster-randomized, controlled trial (the Community Pharmacists Assisting in Total Cardiovascular Health [CPATCH] trial). SETTING: Thirty community pharmacies in Saskatchewan, Canada. PATIENTS: Participating pharmacies were randomized to 15 intervention pharmacies where a brief statin adherence intervention was delivered by pharmacists (intervention group [907 patients]) or 15 usual care pharmacies where no statin adherence intervention was delivered (usual care group [999 patients]) to new users of statins (defined as less than 1 yr of statin therapy)...
October 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27545127/-impact-of-adherence-to-statins-on-cardiovascular-adverse-events-in-patients-with-coronary-artery-disease-a-meta-analysis
#19
S T Li, J Y Xu, R C Huang
OBJECTIVE: To evaluate the impact of different adherence mode to statins on cardiovascular adverse events in patients with coronary artery disease (CAD). METHODS: Electronic searches, including PubMed, Scopus, Ovid MEDLINE, Ovid EMBASE, Ovid EBM Reviews CENTRAL, CINAHL, The Cochrane Library, Ovid PsycInfo, Wanfang data, CNKI and Science & Technology Magazine Online, were performed and all related literatures of all languages were retrieval till to March 1, 2015...
August 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27459651/antihyperlipidemic-medication-treatment-patterns-and-statin-adherence-among-patients-with-ascvd-in-a-managed-care-plan-after-release-of-the-2013-acc-aha-guideline-on-the-treatment-of-blood-cholesterol
#20
Brandon K Bellows, Cody J Olsen, Jennifer Voelker, Curtis Wander
BACKGROUND: The American College of Cardiology (ACC) and American Heart Association (AHA) released a new blood cholesterol treatment guideline in November 2013. It is unknown how the new recommendations have affected cholesterol medication use and adherence in a commercial health plan. OBJECTIVE: To evaluate the effect of the 2013 guideline release on antihyperlipidemic treatment patterns and statin adherence in patients with atherosclerotic cardiovascular disease (ASCVD) compared with a historical control group...
August 2016: Journal of Managed Care & Specialty Pharmacy
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