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"Statin adherence"

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https://www.readbyqxmd.com/read/29686133/improving-long-term-adherence-to-statin-therapy-a-qualitative-study-of-gps-experiences-in-primary-care
#1
Karen Krüger, Niklas Leppkes, Sabine Gehrke-Beck, Wolfram Herrmann, Engi A Algharably, Reinhold Kreutz, Christoph Heintze, Iris Filler
BACKGROUND: Statins substantially reduce the risk of cardiovascular disease when taken regularly. Though statins are generally well tolerated, current studies show that one-third of patients discontinue use of statins within 2 years. A qualitative approach may improve the understanding of attitudes and behaviours towards statins, the mechanisms related to discontinuation, and how they are managed in primary care. AIM: To identify factors related to statin discontinuation and approaches for long-term statin adherence...
April 23, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29619841/preventable-statin-adverse-reactions-and-therapy-discontinuation-what-can-we-learn-from-the-spontaneous-reporting-system
#2
Maurizio Sessa, Concetta Rafaniello, Cristina Scavone, Annamaria Mascolo, Gabriella di Mauro, Annamaria Fucile, Francesco Rossi, Liberata Sportiello, Annalisa Capuano
BACKGROUND: Statin treatment is often associated with poor adherence, which may be due to the onset of adverse drug reactions (ADRs). We investigated on potential risk factors related to preventable cases of statin-induced ADRs and to the discontinuation of statin therapy. METHODS: We performed a study using the database of Italian spontaneous reporting. The target population for the preventability assessment was all patients with suspected statin-induced ADRs deriving from Campania Region (a territory of Southern Italy) between 2012 and 2017...
April 5, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29577553/metformin-s-impact-on-statin-associated-muscle-symptoms-an-analysis-of-accord-study-data-and-research-materials-from-the-nhlbi-biologic-specimen-and-data-repository-information-coordinating-center
#3
Nicholas W Carris, Athanasios Tsalatsanis, Srinivas M Tipparaju, Feng Cheng, Ronald R Magness, Ambuj Kumar
Statins are widely prescribed, yet statin muscle pain limits use, leading to increased cardiovascular risk. No validated therapy for statin muscle pain exists. The goal of the study was to assess if metformin was associated with reduced muscle pain. A secondary analysis of data from the ACCORD trial was performed. An ACCORD sub-study assessed patients for muscle cramps and leg/calve pain while walking, typical non-severe statin muscle pain symptoms. We compared muscle pain between patients taking a statin (n = 445) or a statin and metformin (n = 869) at baseline...
March 25, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29552104/continuity-of-medication-management-among-adults-with-schizophrenia-and-comorbid-cardiometabolic-conditions
#4
Richard A Hansen, Natalie Hohmann, Matthew L Maciejewski, Marisa E Domino, Neepa Ray, Nirosha Mahendraratnam, Joel F Farley
Objectives: Adults with schizophrenia and cardiometabolic conditions may be good candidates for co-management by primary care prescribers and specialists. Associated risks for discontinuity in medication management have not been well-studied. This study examines whether medication adherence, inpatient admissions, and emergency department (ED) visits vary by the number and types of prescribers seen by adults with schizophrenia and cardiometabolic conditions. Methods: This study used a retrospective cohort of 4,223 adult Medicaid enrollees with schizophrenia and hypertension, hyperlipidemia, and/or diabetes from three states in 2009-2010...
March 2018: Journal of Pharmaceutical Health Services Research
https://www.readbyqxmd.com/read/29495236/-impact-of-different-intervention-models-on-adherence-to-secondary-prevention-therapies-in-patients-with-acute-coronary-syndrome
#5
J Liu, W Wang, J Liu, Y Wang, Y Qi, J Y Sun, D Zhao
Objective: To evaluate the impact of different intervention models on adherence to secondary prevention therapies in patients with acute coronary syndrome (ACS). Methods: This multi-center cross-sectional study collected data from 34 hospitals covering 22 provinces in China. Hospitals were randomly divided into four groups: control group(routine treatment and care), promotional calendar group (routine treatment and care plus giving propaganda desk calendar to patients), education group (routine treatment and care add patients education by nurses) and combined intervention group (promotional calendar and education)...
February 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29360935/a-systematic-review-and-meta-analysis-of-the-factors-associated-with-nonadherence-and-discontinuation-of-statins-among-people-aged-%C3%A2-65-years
#6
Richard Ofori-Asenso, Avtar Jakhu, Andrea J Curtis, Ella Zomer, Manoj Gambhir, Maarit Jaana Korhonen, Mark Nelson, Andrew Tonkin, Danny Liew, Sophia Zoungas
Background: Older individuals (aged ≥65 years) are commonly prescribed statins but may experience a range of barriers in adhering to therapy. The factors associated with poor statin adherence and/or discontinuation among this population have not been comprehensively reviewed. Methods: We conducted a systematic review to identify English articles published through December 12, 2016 that reported factors associated with nonadherence and/or discontinuation of statins among older persons...
January 19, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29226893/assessment-of-factors-related-to-statin-non-adherence-in-patients-with-established-coronary-artery-disease-a-single-center-observational-study
#7
Tuba Özdemir, İrfan Şahin, İlhan İlker Avcı, Barış Güngör, Eser Durmaz, Sevil Tuğrul, Mert İlker Hayıroğlu, Serdar Kahyaoğlu, Orkhan Karımov, Ertuğrul Okuyan
OBJECTIVE: Lifelong statin treatment is recommended in patients with cardiovascular diseases, but drug adherence is a significant problem. The aim of this study was to investigate factors related to statin discontinuation in high-risk patients with coronary artery disease (CAD) diagnosed by coronary angiography. METHODS: A total of 300 consecutive patients who were followed-up with a diagnosis of CAD were recruited. Patients were categorized as statin adherent or statin non-adherent (patients interrupting statin therapy >30 days)...
December 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29155848/an-electronic-health-record-based-model-predicts-statin-adherence-ldl-cholesterol-and-cardiovascular-disease-in-the-united-states-military-health-system
#8
Joseph E Lucas, Taylor C Bazemore, Celan Alo, Patrick B Monahan, Deepak Voora
HMG-CoA reductase inhibitors (or "statins") are important and commonly used medications to lower cholesterol and prevent cardiovascular disease. Nearly half of patients stop taking statin medications one year after they are prescribed leading to higher cholesterol, increased cardiovascular risk, and costs due to excess hospitalizations. Identifying which patients are at highest risk for not adhering to long-term statin therapy is an important step towards individualizing interventions to improve adherence...
2017: PloS One
https://www.readbyqxmd.com/read/29067759/who-benefits-from-fixed-dose-combinations-two-year-statin-adherence-trajectories-in-initiators-of-combined-amlodipine-atorvastatin-therapy
#9
Andrea L Schaffer, Nicholas A Buckley, Sallie-Anne Pearson
PURPOSE: We compared statin adherence in individuals initiating combined amlodipine/atorvastatin therapy as a fixed-dose (FDC) or free combination and identified subgroups benefiting most from FDCs. METHODS: We used a 10% sample of Australian Pharmaceutical Benefits Scheme dispensing data (2005-2015) to identify individuals initiating amlodipine and atorvastatin as an FDC (n = 3996) or free combination (n = 5434), with or without prior statin dispensing. We measured the proportion of days covered in each 30-day period over 24 months and classified patterns of statin adherence using group-based trajectory models...
December 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29051213/changes-in-statin-adherence-following-an-acute-myocardial-infarction-among-older-adults-patient-predictors-and-the-association-with-follow-up-with-primary-care-providers-and-or-cardiologists
#10
Ryan P Hickson, Jennifer G Robinson, Izabela E Annis, Ley A Killeya-Jones, Maarit Jaana Korhonen, Ashley L Cole, Gang Fang
BACKGROUND: Hospitalizations for acute myocardial infarctions (AMIs) are associated with changes in statin adherence. It is unclear to what extent adherence changes, which patients are likely to change, and how post-discharge follow-up is associated with statin adherence change. METHODS AND RESULTS: This retrospective study used Medicare data for all fee-for-service beneficiaries 66 years and older with an AMI hospitalization in 2008-2010 and statin use before their index AMI...
October 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28916672/effects-of-statin-intensity-and-adherence-on-the-long-term-prognosis-after-acute-ischemic-stroke
#11
Jinkwon Kim, Hye Sun Lee, Chung Mo Nam, Ji Hoe Heo
BACKGROUND AND PURPOSE: Statin is an established treatment for secondary prevention after ischemic stroke. However, the effects of statin intensity and adherence on the long-term prognosis after acute stroke are not well known. METHODS: This retrospective cohort study using a nationwide health insurance claim data in South Korea included patients admitted with acute ischemic stroke between 2002 and 2012. Statin adherence and intensity were determined from the prescription data for a period of 1 year after the index stroke...
October 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28854076/estimation-of-missed-statin-prescription-use-in-an-administrative-claims-dataset
#12
Rolin L Wade, Jeetvan G Patel, Jerrold W Hill, Ajita P De, David J Harrison
BACKGROUND: Nonadherence to statin medications is associated with increased risk of cardiovascular disease and poses a challenge to lipid management in patients who are at risk for atherosclerotic cardiovascular disease. Numerous studies have examined statin adherence based on administrative claims data; however, these data may underestimate statin use in patients who participate in generic drug discount programs or who have alternative coverage. OBJECTIVE: To estimate the proportion of patients with missing statin claims in a claims database and determine how missing claims affect commonly used utilization metrics...
September 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28779966/to-persist-or-not-to-persist-learning-from-precision-medicine-to-optimize-statin-adherence
#13
Siqin Ye, Ian M Kronish
No abstract text is available yet for this article.
January 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28752555/relationships-between-medication-adherence-and-cardiovascular-disease-risk-factor-control-in-elderly-patients-with-diabetes
#14
Marsha A Raebel, Wendy Dyer, Gregory A Nichols, Glenn K Goodrich, Julie A Schmittdiel
BACKGROUND: The Centers for Medicare and Medicaid Services (CMS) Medicare Star program provides incentives to health plans when their patients with diabetes meet adherence targets to angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACEIs/ARBs) and statins. While a link between adherence and cardiovascular risk factor control is established, most studies included young patients with few comorbidities. Whether the Star adherence target is associated with reduced blood pressure or low-density lipoprotein cholesterol (LDL-C) in complex older patients is not well understood...
October 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28689954/surgical-intervention-for-peripheral-artery-disease-does-not-improve-patient-compliance-with-recommended-medical-therapy
#15
Tyler R Halle, Jaime Benarroch-Gampel, Victoria J Teodorescu, Ravi R Rajani
INTRODUCTION AND OBJECTIVES: Non-adherence to smoking abstinence, antiplatelet and statin therapies in patients with peripheral artery disease (PAD) is associated with worse long-term outcomes. We hypothesized that patients who underwent invasive revascularization procedures would be more likely to adhere to these therapies than patients who were managed medically. METHODS: Prospective survey-based interviews pertaining to medication and behavioral compliance of patients with symptomatic PAD were performed...
July 6, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28660496/role-of-cost-on-failure-to-access-prescribed-pharmaceuticals-the-case-of-statins
#16
Ian McRae, Kees van Gool, Jane Hall, Laurann Yen
BACKGROUND: In Australia, as in many other Western countries, patient surveys suggest the costs of medicines lead to deferring or avoiding filling of prescriptions. The Australian Pharmaceutical Benefits Scheme provides approved prescription medicines at subsidised prices with relatively low patient co-payments. The Pharmaceutical Benefits Scheme defines patient co-payment levels per script depending on whether patients are "concessional" (holding prescribed pension or other government concession cards) or "general", and whether they have reached a safety net defined by total out-of-pocket costs for Pharmaceutical Benefits Scheme-approved medicines...
October 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28606496/emotional-distress-as-a-predictor-of-statin-non-adherence-among-swedish-first-time-myocardial-infarction-patients-2006-2013
#17
C T Lissåker, J Wallert, C Held, E Olsson
BACKGROUND: Emotional distress (depression and anxiety) has been known to affect mortality after a myocardial infarction (MI). One possible mechanism is through medication non-adherence. Few studies have investigated the link between statin adherence and emotional distress, and results are not consistent. We aimed to explore whether emotional distress affects adherence among first-time MI patients younger than 75years old receiving a prescription for the first time. METHODS: We identified first-MI individuals younger than 75years from the SWEDEHEART national quality registers discharged with a statin prescription...
June 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28596457/statin-adherence-is-associated-with-reduced-recurrent-stroke-risk-in-patients-with-or-without-atrial-fibrillation
#18
COMPARATIVE STUDY
Alexander C Flint, Carol Conell, Xiushui Ren, Hooman Kamel, Sheila L Chan, Vivek A Rao, S Claiborne Johnston
BACKGROUND AND PURPOSE: Outpatient statin use reduces the risk of recurrent ischemic stroke among patients with stroke of atherothrombotic cause. It is not known whether statins have similar effects in ischemic stroke caused by atrial fibrillation (AFib). METHODS: We studied outpatient statin adherence, measured by percentage of days covered, and the risk of recurrent ischemic stroke in patients with or without AFib in a 21-hospital integrated healthcare delivery system...
July 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28594479/does-the-number-of-pharmacies-a-patient-frequents-affect-adherence-to-statins
#19
Russell Christie, Ingrid Sketris, Pantalis Andreou, Anne Holbrook, Adrian Levy, Hala Tamim
BACKGROUND: We hypothesized that medication adherence is affected by the number of pharmacies a patient frequents. OBJECTIVES: The objective was to estimate the strength of association between the number of pharmacies a patient frequents and adherence to statins. METHODS: Using administrative data from the Nova Scotia Seniors' Pharmacare program, a retrospective cohort study was conducted among subjects aged 65 years and older first dispensed statin between 1998 and 2008...
May 6, 2017: Journal of Population Therapeutics and Clinical Pharmacology
https://www.readbyqxmd.com/read/28427340/does-the-association-between-adherence-to-statin-medications-and-mortality-depend-on-measurement-approach-a-retrospective-cohort-study
#20
Mhd Wasem Alsabbagh, Dean Eurich, Lisa M Lix, Thomas W Wilson, David F Blackburn
BACKGROUND: The aim of this study was to examine the relationship between mortality and statin adherence using two different approaches to adherence measurement (summary versus repeated-measures). METHODS: A retrospective cohort study was conducted using administrative data from Saskatchewan, Canada between 1994 and 2008. Eligible individuals received a prescription for a statin following hospitalization for acute coronary syndrome (ACS). Adherence was measured using proportion of days covered (PDC) expressed either as: 1) a fixed summary measure, or 2) as a repeatedly measured covariate...
April 20, 2017: BMC Medical Research Methodology
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