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"Statin adherence"

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https://www.readbyqxmd.com/read/28916672/effects-of-statin-intensity-and-adherence-on-the-long-term-prognosis-after-acute-ischemic-stroke
#1
Jinkwon Kim, Hye Sun Lee, Chung Mo Nam, Ji Hoe Heo
BACKGROUND AND PURPOSE: Statin is an established treatment for secondary prevention after ischemic stroke. However, the effects of statin intensity and adherence on the long-term prognosis after acute stroke are not well known. METHODS: This retrospective cohort study using a nationwide health insurance claim data in South Korea included patients admitted with acute ischemic stroke between 2002 and 2012. Statin adherence and intensity were determined from the prescription data for a period of 1 year after the index stroke...
September 15, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28854076/estimation-of-missed-statin-prescription-use-in-an-administrative-claims-dataset
#2
Rolin L Wade, Jeetvan G Patel, Jerrold W Hill, Ajita P De, David J Harrison
BACKGROUND: Nonadherence to statin medications is associated with increased risk of cardiovascular disease and poses a challenge to lipid management in patients who are at risk for atherosclerotic cardiovascular disease. Numerous studies have examined statin adherence based on administrative claims data; however, these data may underestimate statin use in patients who participate in generic drug discount programs or who have alternative coverage. OBJECTIVE: To estimate the proportion of patients with missing statin claims in a claims database and determine how missing claims affect commonly used utilization metrics...
September 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28779966/to-persist-or-not-to-persist-learning-from-precision-medicine-to-optimize-statin-adherence
#3
Siqin Ye, Ian M Kronish
No abstract text is available yet for this article.
August 2, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28752555/relationships-between-medication-adherence-and-cardiovascular-disease-risk-factor-control-in-elderly-patients-with-diabetes
#4
Marsha A Raebel, Wendy Dyer, Gregory A Nichols, Glenn K Goodrich, Julie A Schmittdiel
BACKGROUND: The Centers for Medicare and Medicaid Services (CMS) Medicare Star program provides incentives to health plans when their patients with diabetes meet adherence targets to angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB) and statins. While a link between adherence and cardiovascular risk factor control is established, most studies included young patients with few comorbidities. Whether the Star adherence target is associated with reduced blood pressure or low-density lipoprotein cholesterol (LDL-C) in complex older patients is not well understood...
July 28, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28689954/surgical-intervention-for-peripheral-artery-disease-does-not-improve-patient-compliance-with-recommended-medical-therapy
#5
Tyler R Halle, Jaime Benarroch-Gampel, Victoria J Teodorescu, Ravi R Rajani
INTRODUCTION AND OBJECTIVES: Non-adherence to smoking abstinence, antiplatelet and statin therapies in patients with peripheral artery disease (PAD) is associated with worse long-term outcomes. We hypothesized that patients who underwent invasive revascularization procedures would be more likely to adhere to these therapies than patients who were managed medically. METHODS: Prospective survey-based interviews pertaining to medication and behavioral compliance of patients with symptomatic PAD were performed...
July 6, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28660496/role-of-cost-on-failure-to-access-prescribed-pharmaceuticals-the-case-of-statins
#6
Ian McRae, Kees van Gool, Jane Hall, Laurann Yen
BACKGROUND: In Australia, as in many other Western countries, patient surveys suggest the costs of medicines lead to deferring or avoiding filling of prescriptions. The Australian Pharmaceutical Benefits Scheme provides approved prescription medicines at subsidised prices with relatively low patient co-payments. The Pharmaceutical Benefits Scheme defines patient co-payment levels per script depending on whether patients are "concessional" (holding prescribed pension or other government concession cards) or "general", and whether they have reached a safety net defined by total out-of-pocket costs for Pharmaceutical Benefits Scheme-approved medicines...
June 28, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28606496/emotional-distress-as-a-predictor-of-statin-non-adherence-among-swedish-first-time-myocardial-infarction-patients-2006-2013
#7
C T Lissåker, J Wallert, C Held, E Olsson
BACKGROUND: Emotional distress (depression and anxiety) has been known to affect mortality after a myocardial infarction (MI). One possible mechanism is through medication non-adherence. Few studies have investigated the link between statin adherence and emotional distress, and results are not consistent. We aimed to explore whether emotional distress affects adherence among first-time MI patients younger than 75years old receiving a prescription for the first time. METHODS: We identified first-MI individuals younger than 75years from the SWEDEHEART national quality registers discharged with a statin prescription...
June 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28596457/statin-adherence-is-associated-with-reduced-recurrent-stroke-risk-in-patients-with-or-without-atrial-fibrillation
#8
COMPARATIVE STUDY
Alexander C Flint, Carol Conell, Xiushui Ren, Hooman Kamel, Sheila L Chan, Vivek A Rao, S Claiborne Johnston
BACKGROUND AND PURPOSE: Outpatient statin use reduces the risk of recurrent ischemic stroke among patients with stroke of atherothrombotic cause. It is not known whether statins have similar effects in ischemic stroke caused by atrial fibrillation (AFib). METHODS: We studied outpatient statin adherence, measured by percentage of days covered, and the risk of recurrent ischemic stroke in patients with or without AFib in a 21-hospital integrated healthcare delivery system...
July 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28594479/does-the-number-of-pharmacies-a-patient-frequents-affect-adherence-to-statins
#9
Russell Christie, Ingrid Sketris, Pantalis Andreou, Anne Holbrook, Adrian Levy, Hala Tamim
BACKGROUND: We hypothesized that medication adherence is affected by the number of pharmacies a patient frequents. OBJECTIVES: The objective was to estimate the strength of association between the number of pharmacies a patient frequents and adherence to statins. METHODS: Using administrative data from the Nova Scotia Seniors' Pharmacare program, a retrospective cohort study was conducted among subjects aged 65 years and older first dispensed statin between 1998 and 2008...
May 6, 2017: Journal of Population Therapeutics and Clinical Pharmacology
https://www.readbyqxmd.com/read/28427340/does-the-association-between-adherence-to-statin-medications-and-mortality-depend-on-measurement-approach-a-retrospective-cohort-study
#10
Mhd Wasem Alsabbagh, Dean Eurich, Lisa M Lix, Thomas W Wilson, David F Blackburn
BACKGROUND: The aim of this study was to examine the relationship between mortality and statin adherence using two different approaches to adherence measurement (summary versus repeated-measures). METHODS: A retrospective cohort study was conducted using administrative data from Saskatchewan, Canada between 1994 and 2008. Eligible individuals received a prescription for a statin following hospitalization for acute coronary syndrome (ACS). Adherence was measured using proportion of days covered (PDC) expressed either as: 1) a fixed summary measure, or 2) as a repeatedly measured covariate...
April 20, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28404800/racial-differences-in-statin-adherence-following-hospital-discharge-for-ischemic-stroke
#11
COMPARATIVE STUDY
Karen C Albright, Hong Zhao, Justin Blackburn, Nita A Limdi, T Mark Beasley, George Howard, Vera Bittner, Virginia J Howard, Paul Muntner
OBJECTIVE: To compare nonadherence to statins in older black and white adults following an ischemic stroke. METHODS: We studied black and white adults ≥66 years of age with Medicare fee-for-service insurance coverage hospitalized for ischemic stroke from 2007 to 2012 who filled a statin prescription within 30 days following discharge. Nonadherence was defined as a proportion of days covered <80% in the 365 days following hospital discharge. In addition, we evaluated factors associated with nonadherence for white and black participants separately...
May 9, 2017: Neurology
https://www.readbyqxmd.com/read/28388626/statin-adherence-and-the-risk-of-parkinson-s-disease-a-population-based-cohort-study
#12
Violetta Rozani, Nir Giladi, Baruch El-Ad, Tanya Gurevich, Judith Tsamir, Beatriz Hemo, Chava Peretz
BACKGROUND: While experimental data provided some compelling evidence on the benefits of statins on dopaminergic neurons, observational studies reported conflicting results regarding the potential of statins to effect the risk of Parkinson's disease (PD). OBJECTIVES: To evaluate the association between changes in statin adherence over time and PD risk. METHODS: A population-based cohort of new statin users (ages 40-79, years 1999-2012) was derived from a large Israeli healthcare services organization...
2017: PloS One
https://www.readbyqxmd.com/read/28345442/predicting-1-year-statin-adherence-among-prevalent-users-a-retrospective-cohort-study
#13
Alexis A Krumme, Jessica M Franklin, Danielle L Isaman, Olga S Matlin, Angela Y Tong, Claire M Spettell, Troyen A Brennan, William H Shrank, Niteesh K Choudhry
BACKGROUND: Attempts to predict who is at risk of future nonadherence have largely focused on predictions at the time of therapy initiation; however, these users are only a small proportion of all patients on therapy at any point in time. Methods to predict nonadherence for established medication users, which have not been previously described in the literature, would be helpful to guide efforts to enhance the use of evidence-based therapies. OBJECTIVE: To test approaches for adherence prediction among prevalent statin users, namely the use of short-term filling behavior, investigator-specified predictors from medical and pharmacy administrative claims, and the empirical selection of potential predictors using the high-dimensional propensity score variable selection algorithm...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28328244/-adherence-to-statins-in-patients-with-myocardial-infarction-in-hungary
#14
János Tomcsányi
INTRODUCTION: Statin therapy has proven to be one cornerstone for prevention and treatment of cardiovascular disease, but the clinical application is suboptimal. Adherence to statin therapy in Hungary in primary prevention is very low, but not known in patients with myocardial infarction. AIM: This study was designed to determine the statin and ezetimib adherence after myocardial infarction in respect of total mortality. METHOD: A retrospective study was carried out based on the National Health Insurance database between 2013-2015...
March 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28302290/statin-intolerance-and-risk-of-coronary-heart-events-and-all-cause-mortality-following-myocardial-infarction
#15
Maria-Corina Serban, Lisandro D Colantonio, Angelika D Manthripragada, Keri L Monda, Vera A Bittner, Maciej Banach, Ligong Chen, Lei Huang, Ricardo Dent, Shia T Kent, Paul Muntner, Robert S Rosenson
BACKGROUND: Many patients report adverse reactions to, and may not tolerate, statin therapy. These patients may be at increased risk for coronary heart disease (CHD) events and mortality. OBJECTIVES: This study evaluated the risk for recurrent myocardial infarction (MI), CHD events, and all-cause mortality in Medicare beneficiaries with statin intolerance and in those with high adherence to statin therapy. METHODS: We studied 105,329 Medicare beneficiaries who began a moderate- or high-intensity statin dosage after hospitalization for MI between 2007 and 2013...
March 21, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28290082/statin-adherence-and-the-risk-of-stroke-a-dose-response-meta-analysis
#16
REVIEW
Tao Xu, Xinyuan Yu, Shu Ou, Xi Liu, Jinxian Yuan, Yangmei Chen
BACKGROUND: Statins are one of the most common medications for stroke prevention. Increasing evidence indicates that the effect of statins against stroke may depend on the optimal adherence of the patients to the long-term therapies. However, the magnitude of the association between statin adherence and the risk of stroke has not been determined. OBJECTIVE: We conducted a dose-response meta-analysis to investigate the association between statin adherence and the risk of stroke...
March 13, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28270383/patterns-and-predictors-of-adherence-to-statin-therapy-among-older-patients-protocol-for-a-systematic-review
#17
Richard Ofori-Asenso, Ella Zomer, Andrea Curtis, Andrew Tonkin, Mark Nelson, Manoj Gambhir, Danny Liew, Sophia Zoungas
BACKGROUND: The benefits of statin therapy are significantly compromised by noncompliance. Although elderly patients may have particular challenges with medication adherence and persistence, previous reviews on statin adherence have not focused on this population. Additionally, comparisons of adherence and persistence specific to statin indication (primary or secondary prevention) have not been thoroughly explored. OBJECTIVE: We aim to assess the extent of, and factors associated with, adherence and persistence to statin therapy among older populations (aged ≥65 years)...
March 7, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28196429/medical-and-psychosocial-factors-and-unfavourable-low-density-lipoprotein-cholesterol-control-in-coronary-patients
#18
John Munkhaugen, Elise Sverre, Jan E Otterstad, Kari Peersen, Erik Gjertsen, Joep Perk, Lars Gullestad, Torbjørn Moum, Toril Dammen, Einar Husebye
Objective Understanding the determinants of low-density lipoprotein cholesterol (LDL-C) control constitutes the basis of modelling interventions for optimal lipid control and prognosis. We aim to identify medical and psychosocial (study) factors associated with unfavourable LDL-C control in coronary patients. Methods A cross-sectional explorative study used logistic and linear regression analysis to investigate the association between study factors and LDL-C in 1095 patients, hospitalized with myocardial infarction and/or a coronary revascularization procedure...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28195516/young-adulthood-cognitive-ability-predicts-statin-adherence-in-middle-aged-men-after-first-myocardial-infarction-a-swedish-national-registry-study
#19
John Wallert, Claudia Lissåker, Guy Madison, Claes Held, Erik Olsson
Background Cognitive ability (CA) is positively related to later health, health literacy, health behaviours and longevity. Accordingly, a lower CA is expected to be associated with poorer adherence to medication. We investigated the long-term role of CA in adherence to prescribed statins in male patients after a first myocardial infarction (MI). Methods CA was estimated at 18-20 years of age from Military Conscript Register data for first MI male patients (≤60 years) and was related to the one- and two-year post-MI statin adherence on average 30 years later...
April 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28076703/a-systematic-review-to-assess-adherence-and-persistence-with-statins
#20
REVIEW
Sohan Deshpande, Ruben G W Quek, Carol A Forbes, Shelley de Kock, Jos Kleijnen, Shravanthi R Gandra, Ross J Simpson
OBJECTIVE: To identify and assess studies published over a 10 year period up to February 2016 which measure adherence or persistence with statins, to summarize their methods, strengths and weaknesses and to summarize evidence linking statin adherence/persistence with risk of cardiovascular events. METHODS: Electronic databases and abstracts from four major cardiovascular disease conferences were searched from January 2005 to February 2016. The study selection process was performed by two reviewers working independently...
April 2017: Current Medical Research and Opinion
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