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https://www.readbyqxmd.com/read/27914187/enhanced-nutrition-improves-growth-and-increases-blood-adiponectin-concentrations-in-very-low-birth-weight-infants
#1
Elin W Blakstad, Sissel J Moltu, Britt Nakstad, Marit B Veierød, Kenneth Strømmen, Pétur B Júlíusson, Astrid N Almaas, Arild E Rønnestad, Kristin Brække, Christian A Drevon, Per O Iversen
BACKGROUND: Adequate nutrient supply is essential for optimal postnatal growth in very low birth weight (VLBW, birth weight<1,500 g) infants. Early growth may influence the risk of metabolic syndrome later in life. OBJECTIVE: To evaluate growth and blood metabolic markers (adiponectin, leptin, and insulin-like growth factor-1 (IGF-1)) in VLBW infants participating in a randomized nutritional intervention study. DESIGN: Fifty VLBW infants were randomized to an enhanced nutrient supply or a standard nutrient supply...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27913934/neuroprotective-effect-of-antioxidants-and-moderate-hypoxia-as-combined-preconditioning-in-cerebral-ischemia
#2
O S Levchenkova, V E Novikov, E A Parfenov, K N Kulagin
We studied combined effect of moderate hypoxia and compounds pQ-4, pQ-915, pQ-1032, and pQ-1104 on neurological deficit and survival of rats after bilateral ligation of common carotid arteries. Preconditioning including moderate hypoxia and treatment with compound pQ-4 produced a neuroprotective effect and increased animal survival during the early (by 51%) and late (by 33.5%) periods of modeled ischemia and reduced neurological deficit (by 50% and 41%, respectively). Moreover, this combination of preconditioning factors prevented postischemic excessive activation of free radical oxidation in brain hemispheres and blood serum...
December 2, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27908689/pcsk9-genetic-variants-and-risk-of-type-2-diabetes-a-mendelian-randomisation-study
#3
Amand F Schmidt, Daniel I Swerdlow, Michael V Holmes, Riyaz S Patel, Zammy Fairhurst-Hunter, Donald M Lyall, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hyppönen, Christine Power, Max Moldovan, Erik van Iperen, G Kees Hovingh, Ilja Demuth, Kristina Norman, Elisabeth Steinhagen-Thiessen, Juri Demuth, Lars Bertram, Tian Liu, Stefan Coassin, Johann Willeit, Stefan Kiechl, Karin Willeit, Dan Mason, John Wright, Richard Morris, Goya Wanamethee, Peter Whincup, Yoav Ben-Shlomo, Stela McLachlan, Jackie F Price, Mika Kivimaki, Catherine Welch, Adelaida Sanchez-Galvez, Pedro Marques-Vidal, Andrew Nicolaides, Andrie G Panayiotou, N Charlotte Onland-Moret, Yvonne T van der Schouw, Giuseppe Matullo, Giovanni Fiorito, Simonetta Guarrera, Carlotta Sacerdote, Nicholas J Wareham, Claudia Langenberg, Robert Scott, Jian'an Luan, Martin Bobak, Sofia Malyutina, Andrzej Pająk, Ruzena Kubinova, Abdonas Tamosiunas, Hynek Pikhart, Lise Lotte Nystrup Husemoen, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Kenneth Starup Simonsen, Jackie Cooper, Steve E Humphries, Murray Brilliant, Terrie Kitchner, Hakon Hakonarson, David S Carrell, Catherine A McCarty, H Lester Kirchner, Eric B Larson, David R Crosslin, Mariza de Andrade, Dan M Roden, Joshua C Denny, Cara Carty, Stephen Hancock, John Attia, Elizabeth Holliday, Martin O' Donnell, Salim Yusuf, Michael Chong, Guillaume Pare, Pim van der Harst, M Abdullah Said, Ruben N Eppinga, Niek Verweij, Harold Snieder, Tim Christen, Dennis O Mook-Kanamori, Stefan Gustafsson, Lars Lind, Erik Ingelsson, Raha Pazoki, Oscar Franco, Albert Hofman, Andre Uitterlinden, Abbas Dehghan, Alexander Teumer, Sebastian Baumeister, Marcus Dörr, Markus M Lerch, Uwe Völker, Henry Völzke, Joey Ward, Jill P Pell, Daniel J Smith, Tom Meade, Anke H Maitland-van der Zee, Ekaterina V Baranova, Robin Young, Ian Ford, Archie Campbell, Sandosh Padmanabhan, Michiel L Bots, Diederick E Grobbee, Philippe Froguel, Dorothée Thuillier, Beverley Balkau, Amélie Bonnefond, Bertrand Cariou, Melissa Smart, Yanchun Bao, Meena Kumari, Anubha Mahajan, Paul M Ridker, Daniel I Chasman, Alex P Reiner, Leslie A Lange, Marylyn D Ritchie, Folkert W Asselbergs, Juan-Pablo Casas, Brendan J Keating, David Preiss, Aroon D Hingorani, Naveed Sattar
BACKGROUND: Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk...
November 28, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27908671/effect-of-gnrh-and-hcg-on-progesterone-concentration-and-ovarian-and-luteal-blood-flow-in-diestrous-mares
#4
L F C Brito, J M Baldrighi, C A Wolf, O J Ginther
The objective of the present study was to investigate the effect of reproductive hormones (GnRH, hCG, LH and progesterone) on the regulation of corpus luteum (CL) and ovarian blood flow. Diestrous mares received a single treatment of saline, 100μg gonadorelin (GnRH), or 1500IU hCG 10days after ovulation. Plasma LH and progesterone concentrations, resistance index (RI) for ovarian artery blood-flow, and percentage of corpus luteum (CL) with color-Doppler signals of blood flow were determined immediately before treatment (hour 0) and at hours 0...
November 23, 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27908303/dna-damage-increase-in-peripheral-neutrophils-from-patients-with-rheumatoid-arthritis-is-associated-with-the-disease-activity-and-the-presence-of-shared-epitope
#5
Gustavo Martelli-Palomino, Adriana B Paoliello-Paschoalato, Janaina C O Crispim, Diane M Rassi, Rene D Oliveira, Paulo Louzada, Yara Maria Lucisano-Valim, Eduardo A Donadi
OBJECTIVES: Neutrophils play a major role in rheumatoid arthritis (RA) pathogenesis. We aimed to evaluate if neutrophil DNA damage in RA patients is associated with the disease activity, autoantibodies status, carriage of the RA shared epitope (SE) and treatment. METHODS: DNA damage was assessed by alkaline comet assay in peripheral blood (77 patients and 55 healthy controls) and in 10 RA synovial fluid neutrophils. Evaluation of the respiratory burst of 30 patients with RA and 30 healthy controls was done...
November 14, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27908227/improved-infant-hemoglobin-hb-and-blood-glucose-concentrations-the-beneficial-effect-of-maternal-vitamin-a-supplementation-of-malaria-infected-mothers-in-ebonyi-state-nigeria
#6
Michael O Elom, Joseph E Eyo, Fabian C Okafor, Amos Nworie, Victor U Usanga, Gerald N Attamah, Chibueze C Igwe
One hundred and fifty-two malaria-infected pregnant women whose pregnancies had advanced to the 6th month were randomised into two study groups - supplemented and placebo groups, after obtaining their approved consents. Ten thousand international units of vitamin A soft gels were administered to the supplemented group three times per week. Vitamin A soft gels devoid of their active ingredients were administered thrice weekly to the placebo group. Two hundred thousand international units of vitamin A was administered to the supplemented groups within 8 weeks postpartum...
December 1, 2016: Pathogens and Global Health
https://www.readbyqxmd.com/read/27908215/in-vitro-effect-of-myo-inositol-on-sperm-motility-in-normal-and-oligoasthenospermia-patients-undergoing-in-vitro-fertilization
#7
P G Artini, E Casarosa, E Carletti, P Monteleone, A Di Noia, O M Di Berardino
It is a known fact that abnormal seminal liquid specimens contain abnormal amounts of oxygen free radicals and reactive oxygen species (ROS), and that the use of antioxidant molecules both in vivo and in vitro leads to improvement of semen quality in terms of motility, reduction in DNA damage, with obvious consequences on the fertilization potential. Myo-inositol has been observed to have anti-oxidant properties and be present in much greater concentrations specifically in seminal liquid than in the blood. Moreover, there seems to be a direct relationship between myo-inositol and mitochondrial membrane potential (MMP) and sperm motility...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27905676/association-between-daily-hemodialysis-access-to-renal-transplantation-and-patients-survival-in-france
#8
Adélaïde Pladys, Cécile Vigneau, Maryvonne Hourmant, Gabrielle Duneau, Cécile Couchoud, Sahar Bayat
AIM: Daily hemodialysis improves patients' quality of life and blood purification, but its effect on survival remains controversial. The aim of this study was to analyze the association between daily hemodialysis and renal transplantation and survival in France. METHODS: This was an observational cohort study based on the French REIN registry. All incident patients ≥18 y/o who started daily hemodialysis in France between 2003 and 2012 were included. Using a propensity score, 575 patients on daily hemodialysis were matched with 1696 patients receiving thrice-weekly hemodialysis...
December 1, 2016: Nephrology
https://www.readbyqxmd.com/read/27905543/rapid-functional-cardiac-imaging-after-gadolinium-injection-evaluation-of-a-highly-accelerated-sequence-with-sparse-data-sampling-and-iterative-reconstruction
#9
Johannes Budjan, Holger Haubenreisser, Thomas Henzler, Sonja Sudarski, Michaela Schmidt, Christina Doesch, Ibrahim Akin, Martin Borggrefe, Nadja M Meßner, Stefan O Schoenberg, Ulrike I Attenberger, Theano Papavassiliu
To generate a patient-friendly, time-efficient cardiac MRI examination protocol, a highly accelerated real-time CINE MR sequence (SSIR) was acquired in the idle time in between contrast injection and late gadolinium enhancement phase. 20 consecutive patients underwent a cardiac MRI examination including a multi-breath-hold sequence as gold standard (Ref) as well as SSIR sequences with (SSIR-BH) and without breath-hold (SSIR-nonBH). SSIR sequences were acquired 4 minutes after gadolinium injection. Right- (RV) and left-ventricular (LV) volumetric functional parameters were evaluated and compared between Ref and SSIR sequences...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905388/-prognostic-biochemical-markers-of-thrombolytic-therapy-in-ischemic-stroke
#10
O A Kicherova, L I Reikhert, V G Skorikova, S A Semeshko
AIM: To assess prognostic value of endothelial dysfunction, endogenous intoxication and oxidative stress in the acute period of ischemic stroke (II) at the stage of making a decision on using thrombolytic therapy (TLT) as well during the follow-up in order to personalize treatment. MATERIAL AND METHODS: The study included 57 patients stratified into control group 1 (n=29) and TLT group (n=28). Contents of C-reactive protein (Nsrb), matrixmetalloproteinase-9 (MMP-9) erythrocyte lipid peroxidation products were measured in the blood of patients...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27905384/-oxidative-stress-as-an-indicator-of-metabolic-disorders-in-the-pathogenesis-of-cerebral-stroke
#11
M A Lutsky, A M Zemskov, V V Razuvaeva, Yu P Lushnikova, O Yu Karpova
AIM: To verify the oxidative stress as an indicator of metabolic disorders in the complex pathogenesis of hemorrhagic and ischemic stroke. MATERIAL AND METHODS: The study included 50 hemorrhagic stroke patients and 50 ischemic stroke patients. A control group consisted of 20 age-matched healthy subjects. In total 12 biochemical parameters, including blood indicators, indicators of free-radical oxidation (ketodiens, diene conjugates, malonic aldehyde, bityrosin, Schiff bases) and endogenous system antioxidant defense (vitamin E, reduced glutathione, total antioxidative activity, superoxide dismutase, glutathione peroxidase, glutathione reductase, catalase) were determined...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27905383/-the-role-of-atp-dependent-potassium-channels-and-nitric-oxide-system-in-the-neuroprotective-effect-of-preconditioning
#12
O G Deryagin, S A Gavrilova, S V Buravkov, V V Andrianov, G G Yafarova, Kh L Gainutdinov, V B Koshelev
AIM: To study a role of ATP-dependent potassium channels (K+ATP) in the neuroprotective effect of ischemic (IP) and pharmacological (PP) preconditioning and evaluate the dynamics of blood nitric oxide (NO) metabolites in cerebral ischemia. MATERIAL AND METHODS: A model of ischemic stroke induced by the electrocoagulation of a middle cerebral artery (MCA) branch was used in male rats (n=86). Glibenclamide, a selective inhibitor of ATP-sensitive K+ channels, and diazoxide, a potassium channel activator, were used...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27904760/serum-glycoprotein-derived-n-and-o-linked-glycans-as-cancer-biomarkers
#13
REVIEW
Ying Lan, Cui Hao, Xuan Zeng, Yanli He, Pengjiao Zeng, Zhihua Guo, Lijuan Zhang
Early detection of cancer is the key to improving survival. Since most clinically used serum cancer biomarkers are either glycoproteins or glycan structures that can be recognized by specific monoclonal antibodies, developing glycan structure-based biomarkers from human serum/plasma glycoproteins through mass spectrometry (MS) analysis are active research field during the past decades. Numerous studies have shown that changes in serum/plasma glycan structures occur during cancer initiation, progression, and treatment...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27904683/rapamycin-targets-interleukin-6-il-6-expression-and-suppresses-endothelial-cell-invasion-stimulated-by-tumor-cells
#14
Oleksandr Ekshyyan, Alok R Khandelwal, Xiaohua Rong, Tara Moore-Medlin, Xiaohui Ma, Jonathan Steven Alexander, Cherie-Ann O Nathan
mTOR inhibitors have potent antiangiogenic and anti-lymphangiogenic effects in addition to their growth inhibitory effects in head and neck squamous cell carcinoma (HNSCC). Lymphatogenous spread is much more predominant in HNSCC than hematogenous spread and significantly decreases survival. In this study we evaluated the effects of rapamycin on targeting tumor-stroma crosstalk in HNSCC. HNSCC tumor cells (FaDu) and human lymphatic endothelial cells (HMEC-1A) were co-cultured in various combinations using transwell cell culture inserts to study tumor-stroma crosstalk and the effects of mTOR inhibitor rapamycin...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27904601/evaluation-effects-of-nebulized-gentamicin-in-exacerbation-of-chronic-obstructive-lung-disease
#15
Forogh Soltaninejad, Soleiman Kheiri, Roya Habibian, Arshia Amra, Shahin Asgari-Savadjani
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality throughout the world. Exacerbation of COPD has negative effect on quality of life. Therapeutic effect of nebulized antibiotics in pulmonary infections has been reported previously. Hence, we evaluated the effect of nebulized gentamicin in acute exacerbation of COPD (AECOPD). MATERIALS AND METHODS: In this clinical trial study, 86 hospitalized patients with AECOPD were divided into two groups for using nebulized gentamicin twice daily (case group) and placebo (control group) for 5 days in addition to standard treatment...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903817/effects-of-orthostatic-hypotension-on-cognition-in-parkinson-disease
#16
Justin Centi, Roy Freeman, Christopher H Gibbons, Sandy Neargarder, Alexander O Canova, Alice Cronin-Golomb
OBJECTIVE: To investigate the relation between orthostatic hypotension (OH) and posture-mediated cognitive impairment in Parkinson disease (PD) using a cross-sectional and within-group design. METHODS: Individuals without dementia with idiopathic PD included 18 with OH (PDOH) and 19 without OH; 18 control participants were also included. Neuropsychological tests were conducted in supine and upright-tilted positions. Blood pressure was assessed in each posture. RESULTS: The PD groups performed similarly while supine, demonstrating executive dysfunction in sustained attention and response inhibition, and reduced semantic fluency and verbal memory (encoding and retention)...
November 30, 2016: Neurology
https://www.readbyqxmd.com/read/27903614/association-between-inpatient-sleep-loss-and-hyperglycemia-of-hospitalization
#17
Regina H DePietro, Kristen L Knutson, Lisa Spampinato, Samantha L Anderson, David O Meltzer, Eve Van Cauter, Vineet M Arora
OBJECTIVE: To determine whether inpatient sleep duration and efficiency are associated with a greater risk of hyperglycemia in hospitalized patients with and without diabetes. RESEARCH DESIGN AND METHODS: In this retrospective analysis of a prospective cohort study, medical inpatients ≥50 years of age were interviewed, and their charts were reviewed to obtain demographic data and diagnosis. Using World Health Organization criteria, patients were categorized as having normal blood glucose, impaired fasting blood glucose, or hyperglycemia based on morning glucose from the electronic health record...
November 30, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27903470/preoperative-white-blood-cell-count-in-patients-with-abdominal-aortic-aneurysms-and-its-relation-to-survival-following-surgery
#18
Camilla Berge, Anne I Hagen, Hans O Myhre, Torbjørn Dahl
OBJECTIVES: The aim of the present study was to explore whether preoperative white blood cell count (WBC) may predict 30-day mortality and long-term survival following surgery for abdominal aortic aneurysm (AAA). Secondarily we wanted to assess the potential sex differences in WBC in these patients. MATERIAL AND METHODS: The study was carried out as a retrospective cohort study. Patients undergoing surgery for intact and ruptured AAA at our institution consecutively in the time-period 1994-2007 were included...
November 26, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27903362/-levels-of-dichlorodiphenyltrichloroethane-internal-exposure-levels-in-pregnant-women-of-xiamen-and-influencing-factors
#19
X S Yu, J He, J H Chen, Z B Lai, Y H Su, M M Shi, Z X Huang, Q J Cheng, X Y Ke, B H Zhao
Objective: To investigate the level of and factors influencing internal exposure to dichlorodiphenyltrichloroethane (DDT) in pregnant women. Methods: In all, 1 064 pregnant women were recruited in a hospital of Xiamen. Participants were asked to complete a questionnaire to obtain data on sociodemographic characteristics and lifestyle. Peripheral venous blood and cord blood samples were collected. Of the 1 064 pregnant women, 600 were enrolled in this study after completing the questionnaire and providing peripheral venous blood and cord blood...
November 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27903296/factors-affecting-long-term-efficacy-of-t-regulatory-cell-based-therapy-in-type-1-diabetes
#20
Natalia Marek-Trzonkowska, Małgorzata Myśliwiec, Dorota Iwaszkiewicz-Grześ, Mateusz Gliwiński, Ilona Derkowska, Magdalena Żalińska, Maciej Zieliński, Marcelina Grabowska, Hanna Zielińska, Karolina Piekarska, Anna Jaźwińska-Curyłło, Radosław Owczuk, Agnieszka Szadkowska, Krystyna Wyka, Piotr Witkowski, Wojciech Młynarski, Przemysława Jarosz-Chobot, Artur Bossowski, Janusz Siebert, Piotr Trzonkowski
BACKGROUND: Recent studies suggest that immunotherapy using T regulatory cells (Tregs) prolongs remission in type 1 diabetes (T1DM). Here, we report factors that possibly affect the efficacy of this treatment. METHODS: The metabolic and immune background of 12 children with recently diagnosed T1DM, as well as that of untreated subjects, during a 2-year follow-up is presented. Patients were treated with up to 30 × 10(6)/kg b.w. of autologous expanded CD3(+)CD4(+)CD25(high)CD127(-) Tregs...
December 1, 2016: Journal of Translational Medicine
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