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Nayeem Ahmad, Shamsi Khalid, Syed M Ali, Asad U Khan
Carbapenem-resistance among enterobacteriaceae has become a global health concern. The objective of this study was to understand NDM producing enterobacteriaceae and their genetic basis of resistance, spreading in neonatal intensive care unit. Carbapenem resistant NDM producing enterobacteriaceae isolates were recovered from rectal swab and blood sample of infants admitted in NICU. These were determined by using Carba-NP test. All isolates were identified using BD PhoenixTM-100 and MICs were determined by broth microdilution method...
2018: Frontiers in Microbiology
Nirav Ramesh Dava, Alok Upadhyaya, Neha Agarwal, Amarjeet Mehta, Vijaypal Choudhary, Gourav Goyal
We are reporting a rare case of hemolytic disease of newborn with weak D antigen in child. A 3rd order male child of G3 P3 A0 mother was admitted at 8th h of life with jaundice. Blood group of both mother and child were A Rh D negative. Baby's direct coombs test was positive. Weak D antigen was positive in baby. Hematological parameters showed all the signs of ongoing hemolysis, and the bilirubin level was in the zone of exchange transfusion. Exchange transfusion was done. An intravenous immunoglobulin was given to child after that...
January 2018: Asian Journal of Transfusion Science
Harita Gogri, Sabita Ray, Snehal Agrawal, S Aruna, Kanjaksha Ghosh, Ajit Gorakshakar
BACKGROUND: Molecular genotyping of ABO blood group system has identified more than 60 "O" group alleles based on the single-nucleotide polymorphisms present in the ABO gene. Heterogeneity of O group alleles has been observed in various countries from South America, Europe, Middle East, and Asia. India is a vast country with more than 1300 million population which is divided into various ethnic and tribal groups. However, very little is known about the heterogeneity of O alleles in Indians...
January 2018: Asian Journal of Transfusion Science
Claire M Keene, Arjen Dondorp, Jane Crawley, Eric O Ohuma, Mavuto Mukaka
Background: Malaria burdens global health systems, and management with limited resources requires robust treatment guidelines and comprehensive planning. Expected length of stay (LOS) is useful in health-system planning, and factors influencing it can be targeted to reduce admission time and optimise service delivery. Methods: A secondary survival analysis of 1217 adult severe malaria patients from the South-East Asia Quinine Artesunate Malaria Trial, using a competing-risk approach...
March 19, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Katarzyna Bednarska, Magdalena Klink, Zofia Sułowska, Ewa Król, Ewa Głowacka, Hanna Romanowicz, Marek Nowak, Krzysztof Szyłło
Smouldering inflammation, thrombocytosis, and platelet hyper-reactivity are linked to malignancy. The relationships between preoperative diagnostic blood morphology parameters and cancer have been the focus of much interest, because some of these parameters are correlated with advanced cancer stages and poor patient survival rates. This study aimed to perform an observational, retrospective analysis of the intradiversity of blood platelet parameters in patients with different International Federation of Gynaecology and Obstetrics (FIGO) stages and different histological types of epithelial ovarian carcinomas (EOC), and also an analysis of the overall survival rate...
March 2018: Medicine (Baltimore)
Mika Ishigaki, Paralee Puangchit, Yui Yasui, Akane Ishida, Hiroki Hayashi, Yoshihiko Nakayama, Hideya Taniguchi, Ichiro Ishimaru, Yukihiro Ozaki
In the present study, we successfully obtained non-staining blood flow images of a developing fish egg embryo using optical interference caused by the Doppler shift. The spectral distribution of light reflected by moving objects such as the heart and red cells was found to be different from that of the incident light because of the Doppler effect. Interference between different frequency components was observed in an interferogram through heterodyne interaction using an imaging-type two-dimensional Fourier spectroscopic system, and information on the intensities of the spectral components was obtained by Fourier transformation...
March 21, 2018: Analytical Chemistry
V A Mariyko, D A Dorofeev, A S Petnunas, V O Tretyakov
AIM: To evaluate an effectiveness of serosomyotomy in isoperistaltic esophagogastroplasty. MATERIAL AND METHODS: Our analysis shows that serosomyotomy improves the results of isoperistaltic esophagogastroplasty. RESULTS: Esophagogastrostomy by using of proximal graft with adequate blood supply reduced the risk of anastomosis failure. The incidence of this complication was 12.2% (n=6) and 3% (n=1) in control and main groups respectively.
2018: Khirurgiia
A V Sakharov, A S Ozornin, S E Golygina, A O Vinogradova, M S Shvets
AIM: To study microcirculation in patients with paranoid schizophrenia by laser Doppler flowmetry. MATERIAL AND METHODS: Fifty-three patients at the age from 18 to 38 years with a diagnosis of 'paranoid schizophrenia' (F20.0) were examined in the acute psychotic state and after 3 weeks of therapy. The control group consisted of 20 healthy volunteers. To assess microcirculation, the noninvasive technique of laser Doppler flowmetry using a laser blood flow analyzer was used...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Santanu Mandal, Prabuddha Mukhopadhyay, Chiranjit Ghosh, Mithun Pal, Gourab Dutta Banik, Tanmoy Chatterjee, Shibendu Ghosh, Manik Pradhan
The underlying mechanisms towards the progression of end-stage renal disease (ESRD) in chronic kidney disease (CKD) are poorly understood and it still remains a major clinical stumbling block for early detection of CKD. Most patients with CKD pass through ESRD with the necessity of frequent hemodialysis (HD) treatment. At present, plasma urea and creatinine levels are examined in most of the CKD patients to monitor the patients' health status after dialysis. But it is really impossible to get immediate feedback of the patients' health as the conventional tests are involved with the collection of blood samples, laboratory processing for prolong time and finally analysis of those samples...
March 21, 2018: Journal of Breath Research
Ya-Ni Tang, Cheng-Fu Tan, Wei-Wei Liu, Jie Yan, Chao Wang, Mi Liu, Dong-Hai Lin, Cai-Hua Huang, Lin Du, Mei-Lin Chen, Jiao-Lan Li, Ding-Ming Zhu
OBJECTIVE: We have repeatedly demonstrated that electroacupuncture (EA) of "Neiguan"(PC 6) can improve myocardial ischemia in rats. The present study was designed to investigate the metabolomic profile of peripheral blood se-rum and myocardium involving EA-induced improvement of myocardial ischemia-reperfusion injury (MIRI) in rats by using nuclear magnetic resonance spectroscopy. METHODS: Thirty male SD rats were equally randomized into blank control, model and EA groups...
March 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
A O Jenkins, E Gormley, N Gcebe, G T Fosgate, A Conan, C Aagaard, A L Michel, V P M G Rutten
Accurate diagnosis of tuberculosis in cattle may be compromised in areas where there are high rates of exposure to environmental/non-tuberculous mycobacteria (NTM). This cross reaction of immune responses to Mycobacterium bovis antigens shared with NTMs can result in reduced specificity of commonly used diagnostic tests including tuberculin skin tests and the interferon gamma assay (IFN-ɣ). In this study we assessed the cross-reactive immune responses of M. bovis (infected) and NTM exposed animals to M. bovis and M...
April 1, 2018: Preventive Veterinary Medicine
Dominique Silva Silveira, Luis Filipe Gomes Barbosa Ferreira Lemos, Rafael Miranda Tassitano, Maria Teresa Cattuzzo, Anderson Henry Pereira Feitoza, Luisa Maria Seara Moreira Carneiro Aires, Jorge Augusto Pinto Silva Mota, Clarice Maria de Lucena Martins
This study evaluated the effect of a multi-component intervention on motor performance (MP) and metabolic risk markers (MRM) in overweight/obese youth. A secondary aim was to examine whether changes in MP are associated to changes in MRM. A 3-month multi-component intervention was performed, consisting of physical exercise sessions (twice/week;1h), nutritional education sessions (once/month), and parental support (twice/week). The sample included 35 volunteers (7-13 y.o), allocated to intervention (INT, n = 17) and control (CONT, n = 18) group...
March 20, 2018: Journal of Sports Sciences
Marcele F Bastos, Ana Carolina A V Kayano, João Luiz Silva-Filho, João Conrado K Dos-Santos, Carla Judice, Yara C Blanco, Nathaniel Shryock, Michelle K Sercundes, Luana S Ortolan, Carolina Francelin, Juliana A Leite, Rafaella Oliveira, Rosa M Elias, Niels O S Câmara, Stefanie C P Lopes, Letusa Albrecht, Alessandro S Farias, Cristina P Vicente, Claudio C Werneck, Selma Giorgio, Liana Verinaud, Sabrina Epiphanio, Claudio R F Marinho, Pritesh Lalwani, Rogerio Amino, Julio Aliberti, Fabio T M Costa
Cerebral malaria (CM) is a multifactorial syndrome involving an exacerbated proinflammatory status, endothelial cell activation, coagulopathy, hypoxia, and accumulation of leukocytes and parasites in the brain microvasculature. Despite significant improvements in malaria control, 15% of mortality is still observed in CM cases, and 25% of survivors develop neurologic sequelae for life-even after appropriate antimalarial therapy. A treatment that ameliorates CM clinical signs, resulting in complete healing, is urgently needed...
March 20, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Robert Galinsky, Joanne O Davidson, Justin M Dean, Colin R Green, Laura Bennet, Alistair J Gunn
Perinatal encephalopathy remains a major cause of disability, such as cerebral palsy. Therapeutic hypothermia is now well established to partially reduce risk of disability in late preterm/term infants. However, new and complementary therapeutic targets are needed to further improve outcomes. There is increasing evidence that glia play a key role in neural damage after hypoxia-ischemia and infection/inflammation. In this review, we discuss the role of astrocytic gap junction (connexin) hemichannels in the spread of neural injury after hypoxia-ischemia and/or infection/inflammation...
February 2018: Neural Regeneration Research
Lingling Shan, Xin Zhuo, Fuwu Zhang, Yunlu Dai, Guizhi Zhu, Bryant C Yung, Wenpei Fan, Kefeng Zhai, Orit Jacobson, Dale O Kiesewetter, Ying Ma, Guizhen Gao, Xiaoyuan Chen
Folate receptor (FR) has proven to be a valuable target for chemotherapy using folic acid (FA) conjugates. However, FA-conjugated chemotherapeutics still have low therapeutic efficacy accompanied with side effects, resulting from complications such as short circulation half-life, limited tumor delivery, as well as high kidney accumulation. Herein, we present a novel FA-conjugated paclitaxel (PTX) prodrug which was additionally conjugated with an Evans blue (EB) derivative for albumin binding. The resulting bifunctional prodrug prolonged blood circulation, enhanced tumor accumulation, and consequently improved tumor therapeutic efficacy...
2018: Theranostics
S O Martins, O F Folasire, A E Irabor
Introduction: Prediabetes is a condition in which individuals have blood glucose levels higher than normal but not high enough to be classified as diabetes mellitus. Inadequate moderate-intensity physical activity, amidst other risk factors, is a well-documented risk factor for prediabetes. Hospital administrative staff can be particularly vulnerable to prediabetes because of the greater number of hours spent in a sitting or sedentary position during administrative duties. The aim of this study was to find the prevalence of prediabetes and to determine its predictors among administrative staff of a tertiary health centre in southwestern Nigeria...
December 2017: Annals of Ibadan Postgraduate Medicine
A M Adeoye, O Adebayo, M Nwosu, A Adebiyi, M O Owolabi, B O Tayo, B L Salako, A Ogunniyi, R S Cooper
Background: Studies differ on which anthropometric measure of adiposity shows good correlation with cardiovascular diseases. In this study, we evaluated the effects of common epidemiological measures of adiposity as a correlate of elevated blood pressure in an African population. Methodology: The study was carried out between June 2009 and December 2011 at the medical out-patient department of a tertiary healthcare center in Nigeria. Correlation analysis was used to assess the relationship between blood pressure and body mass index (BMI), waist to height ratio (WHtR), and waist circumference (WC)...
December 2017: Annals of Ibadan Postgraduate Medicine
Carl J Lavie, Richard V Milani, Hector O Ventura
No abstract text is available yet for this article.
March 19, 2018: Heart: Official Journal of the British Cardiac Society
Jenifer K McIntyre, Jessica I Lundin, James R Cameron, Michelle I Chow, Jay W Davis, John P Incardona, Nathaniel L Scholz
Adult coho salmon (Oncorhynchus kisutch) prematurely die when they return from the ocean to spawn in urban watersheds throughout northwestern North America. The available evidence suggests the annual mortality events are caused by toxic stormwater runoff. The underlying pathophysiology of the urban spawner mortality syndrome is not known, and it is unclear whether closely related species of Pacific salmon are similarly at risk. The present study co-exposed adult coho and chum (O. keta) salmon to runoff from a high traffic volume urban arterial roadway...
March 16, 2018: Environmental Pollution
Ling Huang, Jun-Hua Peng, Qing-Hua Liang, Rui-Xing Yin, Cheng-Wu Liu, Shang-Ling Pan, Hao Huang, Hua-Yu Wu, Rui-Jing Gan, Lan-Ying Tang, Li-Na Zhu, Yan-Zhen Xu, Si-Bang Chen, Xiao-Ling Zhou
OBJECTIVES: To look at the possible effect of IGF2R rs9456497 on cardiovascular risks in a long-lived population. METHODS: IGF-2R rs9456497 was genotyped by iMLDR for 496 long-lived Zhuang Chinese (90-107 y/o) and their offspring (n = 723, 60-75 y/o) and healthy controls (n = 611, 60-75 y/o). Association analyses were then conducted among genotypes and cardiovascular risks. RESULTS: The G genotype (GA/GG) was found to represent more frequently in males of general population...
March 3, 2018: Archives of Gerontology and Geriatrics
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