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multinodular goitre

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https://www.readbyqxmd.com/read/29897006/indel-in-phospholipase-c-b-1-is-linked-with-euthyroid-multinodular-goitre
#1
Ameen Bakhsh, Ioannis Ladas, Marian Hamshere, Martyn Bullock, George Kirov, Lei Zhang, Peter Taylor, John Welbourn Gregory, David Michael Scott-Coombes, Henry Völzke, Alexander Teumer, Kiran Mantripragada, Dillwyn Williams, Roderick J Clifton-Bligh, Nigel Williams, Marian Ludgate
Euthyroid multinodular goiter (MNG) is common but little is known about the genetic variation conferring predisposition. Previously we reported a family with MNG of adolescent onset in which some family members developed papillary thyroid carcinomas (PTC). We conducted a genome-wide linkage analysis and next generation sequencing to identify genetic variants that may confer disease predisposition. A multipoint nonparametric LOD score of 3.01 was obtained covering 19 cM on chromosome 20p. Haplotype analysis reduced the region of interest to 10 cM; analysis of copy number variation identified an intronic InDel (~1000 bp) in the PLCB1 gene in all 8 affected family members and carriers (an unaffected person who has inherited the genetic trait) but ~1% of 'healthy' Caucasians...
June 13, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29887888/nontoxic-multinodular-goitre-and-incidental-thyroid-cancer-what-is-the-best-surgical-strategy-a-retrospective-study-of-2032-patients
#2
Krzysztof Kaliszewski, Beata Wojtczak, Jędrzej Grzegrzółka, Jacob Bronowicki, Sawsan Saeid, Bartłomiej Knychalski, Zdzisław Forkasiewicz
Objectives: A discussion with regard to the most optimal surgical procedure in nontoxic multinodular goitre (NTMNG). We assessed and compared three main types of operations in 2032 patients with NTMNG. Methods: This is a retrospective study of 2032 patients operated on in one center due to NTMNG. The observation period was 48 to 120 months (mean and SD: 87 ± 20). Results: The early complications included uni- and bilateral recurrent laryngeal nerve paralysis (URLNP, BRLNP), overt tetany (OT), and postoperative bleeding (POB)...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29886838/new-perspectives-regarding-anaplastic-thyroid-carcinoma-approach-improvement
#3
Ana Sofia Figueiredo, Patricia Andrea-Ferreira
BACKGROUND AND OBJECTIVE: Anaplastic thyroid carcinoma is rare, but represents the deadliest type of thyroid cancer that is characterised by a rapid course. Diagnosis is usually made at a late stage, when more than half of the patients have distant metastasis. Our main purpose is to review the current information on anaplastic thyroid aetiology and risk factors that might contribute to an earlier diagnosis as well as to give new perspectives regarding the most recent treatment options and future directions...
June 10, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29851122/thyrotoxicosis-after-iodine-fortification-a-21-year-danish-population-based-study
#4
Mads Petersen, Nils Knudsen, Allan Carlé, Stig Andersen, Torben Jørgensen, Hans Perrild, Lars Ovesen, Lone Banke Rasmussen, Betina Heinsbaek Thuesen, Inge Bülow Pedersen
OBJECTIVE: Monitoring the influence of cautious iodine fortification (IF) on the incidence rate of overt thyrotoxicosis in Denmark with formerly frequent multinodular toxic goitre. DESIGN: A 21 year (1997-2017) prospective population-based study identified all new cases of overt biochemical thyrotoxicosis in two open cohorts: a Western cohort with moderate iodine deficiency (ID) and an Eastern cohort with mild ID (total n=533,969 by January 1st , 1997). A diagnostic algorithm was applied to all thyroid function tests performed within the study areas...
May 31, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29850011/diagnostic-accuracy-of-preoperative-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratios-in-detecting-occult-papillary-thyroid-microcarcinomas-in-benign-multinodular-goitres
#5
Dimitrios K Manatakis, Sophia Tseleni-Balafouta, Lazaros Tzelves, Dimitrios Balalis, Adelais Tzortzopoulou, Dimitrios P Korkolis, George H Sakorafas, Emmanouil Gontikakis, Georgios Plataniotis
Objective: To investigate the diagnostic accuracy of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios in detecting occult papillary thyroid microcarcinomas in benign, multinodular goitres. Methods: 397 total thyroidectomy patients were identified from the institutional thyroid surgery database between 2007 and 2016 (94 males, 303 females, mean age 53 ± 14.5 years). NLR and PLR were calculated as the absolute neutrophil and absolute platelet counts divided by the absolute lymphocyte count, respectively, based on the preoperative complete blood cell count...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29770856/risk-factors-associated-with-intrathyroid-extension-of-thyroid-microcarcinomas
#6
Nikola Slijepcevic, Vladan Zivaljevic, Aleksandar Diklic, Milan Jovanovic, Branislav Oluic, Ivan Paunovic
PURPOSE: The aims of this study were to investigate the rate of intrathyroid extension of papillary thyroid microcarcinoma (PTMC) in patients operated for benign thyroid disease and to identify independent risk factors associated with it. METHODS: A retrospective study of 301 patients operated for benign thyroid diseases (hyperthyroid diseases, multinodular goitre, Hashimoto thyroiditis and benign thyroid tumours) was performed at a high-volume endocrine surgery unit of a tertiary referral academic hospital, in a 5-year period...
May 17, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29756110/agenesis-of-the-isthmus-of-the-thyroid-gland
#7
Uğur Kesici, Sevgi Kesici
The thyroid is an endocrine gland composed of two lobes connected by the isthmus tissue. Thyroid isthmus agenesis is a rare condition, and only a few cases have been reported in the literature. Here, we discuss the case of a 56-year-old female patient in whom agenesis of the thyroid isthmus was discovered incidentally during surgery for a multinodular goitre. When agenesis of the isthmus is found, associated thyroid lobe agenesis and the presence of ectopic thyroid tissue must be considered. In addition, associated autoimmune thyroid nodule, thyroiditis, primary thyroid carcinoma, metastasis, and amyloidosis must be considered in the differential diagnosis...
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29594054/a-case-report-of-syndromic-multinodular-goitre-in-adolescence-exploring-the-phenotype-overlap-between-cowden-and-dicer1-syndromes
#8
Dorothée Bouron-Dal Soglio, Leanne de Kock, Richard Gauci, Nelly Sabbaghian, Elizabeth Thomas, Helen C Atkinson, Nicholas Pachter, Simon Ryan, John P Walsh, M Priyanthi Kumarasinghe, Karen Carpenter, Ayça Aydoğan, Colin J R Stewart, William D Foulkes, Catherine S Choong
Background: Hereditary tumour predisposition syndromes may increase the risk for development of thyroid nodules at a young age. We present the case of an adolescent female with Cowden syndrome who had some atypical phenotypic features which overlapped with the DICER1 syndrome. Material and Methods: A 17-year-old female presented with a 3-month history of progressive right neck swelling. Fine needle cytology of the thyroid revealed a follicular neoplasm with features suggestive of follicular variant of papillary thyroid carcinoma and she underwent a hemithyroidectomy...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29579336/risk-profile-analysis-and-complications-after-surgery-for-autoimmune-thyroid-disease
#9
O Thomusch, C Sekulla, F Billmann, G Seifert, H Dralle, K Lorenz
BACKGROUND: Surgical approaches to autoimmune thyroid disease are currently hampered by concerns over postoperative complications. Risk profiles and incidences of postoperative complications have not been investigated systematically, and studies with sufficient power to show valid data have not been performed. METHODS: A prospective multicentre European study was conducted between July 2010 and December 2012. Questionnaires were used to collect data prospectively on patients who had surgery for autoimmune thyroid disease and the findings were compared with those of patients undergoing surgery for multinodular goitre...
May 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29556769/sequential-high-intensity-focused-ultrasound-hifu-ablation-in-the-treatment-of-benign-multinodular-goitre-an-observational-retrospective-study
#10
Brian H H Lang, Yu-Cho Woo, Keith Wan-Hang Chiu
OBJECTIVES: Assessing the efficacy and safety of sequential high-intensity focused ultrasound (HIFU) ablation in a multinodular goitre (MNG) by comparing them with single HIFU ablation. METHODS: One hundred and four (84.6%) patients underwent single ablation of a single nodule (group I), while 19 (15.4%) underwent sequential ablation of two relatively-dominant nodules in a MNG (group II). Extent of shrinkage per nodule [by volume reduction ratio (VRR)], pain scores (by 0-10 visual analogue scale) during and after ablation, and rate of vocal cord palsy (VCP), skin burn and nausea/vomiting were compared between the two groups...
March 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29474644/dicer1-mutations-are-frequent-in-adolescent-onset-papillary-thyroid-carcinoma
#11
Jonathan D Wasserman, Nelly Sabbaghian, Somayyeh Fahiminiya, Rose Chami, Ozgur Mete, Meryl Acker, Mona K Wu, Adam Shlien, Leanne de Kock, William D Foulkes
Context: Papillary thyroid carcinoma (PTC) is a common malignancy in adolescence and is molecularly and clinically distinct from adult PTC. Mutations in the DICER1 gene are associated with thyroid abnormalities, including multinodular goiter and differentiated thyroid carcinoma. Objective: In this study, we sought to characterize the prevalence of DICER1 variants in pediatric PTC, specifically in tumors without conventional PTC oncogenic alterations. Patients: Patients (N = 40) who underwent partial or total thyroidectomy and who were <18 years of age at the time of surgery were selected...
May 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29444549/body-weight-change-is-unpredictable-after-total-thyroidectomy
#12
Ron Glick, Paula Chang, Peter Michail, Jonathan W Serpell, Simon Grodski, James C Lee
BACKGROUND: There is a common perception that total thyroidectomy causes weight gain beyond expected age-related changes, even when thyroid replacement therapy induces a euthyroid state. The aim of this study was to determine whether patients who underwent total thyroidectomy for a wide spectrum of conditions experienced weight gain following surgery. METHODS: We retrospectively studied 107 consecutive total thyroidectomy patients treated between January 2013 and June 2014...
March 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29374396/thyroid-adenolipoma-a-case-report
#13
Monica Pennisi, Alessandro Conti, Renato Farina, Pietro Valerio Foti, Giuseppe Cocuzza, Andrea Boncoraglio, Valeria Costanzo, Giuliana Costanzo
Generally, small quantities of adipose tissue is present in the thyroid gland. The adenolipoma of the thyroid gland is considered a rare finding. It consists in a benign, encapsulated neoplasm composed of mature adipose tissue and glandular elements. We report a case of a 71 year-old female patient presenting with swelling of the anterior neck and history of airway obstruction. Ultrasound (US) examination showed a bulky multinodular goiter which caused dislocation and compression of the trachea. The scans performed at the level of the isthmic region showed the presence of a hyperechoic oval formation with a homogeneous echostructure and regular contours; these characteristics suggested the lipomatous nature of the nodule...
June 2018: Journal of Ultrasound
https://www.readbyqxmd.com/read/29353393/-131-i-induced-graves-disease-in-patients-treated-for-toxic-multinodular-goitre-systematic-review-and-descriptive-analysis
#14
REVIEW
C Roque, C A Vasconcelos
BACKGROUND: Graves' disease (GD) arising after the treatment of toxic multinodular goitre (TMNG) with radioiodine has long been described but it remained unclear whether GD was in fact iodine induced, its incidence, risk factors, natural history and treatment outcomes. METHODS: A systematic search using The Cochrane Library, Medline and PubMed Central allowed the pooling of data from 3633 patients with thyroid autonomy, 1340 patients with TMNG, to fill gaps in knowledge, regarding the clinical expression of iodine-induced GD (131 I-IGD) in adults...
January 20, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29346358/rates-of-unsuspected-thyroid-cancer-in-multinodular-thyroid-disease
#15
Miriam Karalus, Jade Au Tamatea, Helen M Conaglen, Goswin Y Meyer-Rochow, John V Conaglen, Marianne S Elston
BACKGROUND: Previously the risk of concomitant thyroid cancer in multinodular goitre (MNG) has been reported as approximately 4%. Cancer risk in toxic MNG was often considered lower than for non-toxic MNG, due to a possible protective effect of TSH suppression. However, recent American data suggest an approximately 18% risk of occult malignancy in both toxic and non-toxic MNG. AIMS: To assess malignancy risk in a New Zealand population undergoing thyroidectomy for MNG...
January 19, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29239041/hereditary-and-familial-thyroid-tumours
#16
REVIEW
Julie Guilmette, Vania Nosé
The worldwide incidence of thyroid malignancies has been increasing rapidly. Sensitive imaging modalities and early detection of thyroid lesions have made thyroid cancers the most rapidly increasing cancers in the USA in 2017 (SEER Cancer Facts, 2017). Clinical awareness of potential risk factors, such as inherited thyroid cancers, has allowed earlier recognition of more vulnerable population clusters. Hereditary thyroid neoplasms arising from calcitonin-producing C cells are known as familial medullary thyroid carcinomas (FMTCs), and include well-documented syndromes such as multiple endocrine neoplasia IIA or IIB, and pure familial medullary thyroid carcinoma syndrome...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29169383/predictors-of-a-follicular-nodule-thy3-outcome-of-thyroid-fine-needle-aspiration-cytology-among-saudi-patients
#17
Imad R Musa, Mukhtar El Khatim Ahmad, Fayez Salim Al Raddady, Wesal Rabih Al Rabih, Elsayed M Elsayed, Gussay Badawi Mohamed, Gasim I Gasim
OBJECTIVE: A retrospective study was performed to evaluate predictors of thyroid fine needle aspiration cytology (FNAC) outcomes among Saudis with a thyroid nodule. Socio-demographic data, thyroid function status, thyroid parameters, ultrasound and cytology results were collected from 269 files of patients with thyroid nodules. RESULT: The patients' age was 40 ± 1.4 years (mean ± SD), and the mean body mass index (BMI) was 30.3 ± 1.2 kg/m2 . The thyroid statuses were euthyroid (85...
November 23, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29141453/relationship-between-metabolic-syndrome-and-nodular-thyroid-diseases
#18
Seher Kir, Yusuf Aydin, Hulya Coskun
Nodular thyroid diseases are common in Turkey. Insulin resistance (IR) is considered as the most important component of metabolic syndrome (MetS), and it is thought to directly affect thyroid diseases, together with other components of MetS. The aim of this study was to evaluate potential factors associated with thyroid nodularity. This study was part of the prospective MELEN study. In total, randomly selected 2233 subjects were evaluated. A euthyroid subgroup of participants (n = 1432) was selected and 421 of them had MetS...
February 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29067943/transoral-endoscopic-total-thyroidectomy-vestibular-approach-a-case-series-and-literature-review
#19
T Sivakumar, R A Amizhthu
Conventional open thyroidectomy is often associated with post-operative complications including nerve damage, voice disturbances, paraesthesias, adhesions and prominent scarring. Several endoscopic surgical techniques have been reported as alternatives to conventional thyroidectomy. Natural orifice transluminal endoscopic surgery is a promising approach which leaves no scar, produces few complications and affords faster discharge from care. Several studies have explored its utility in total thyroidectomy in patients with benign or malignant thyroid disease...
April 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29038858/surgical-management-of-primary-hyperparathyroidism
#20
Stephen Ryan, Danielle Courtney, Julia Moriariu, Conrad Timon
We reviewed the surgical management of primary hyperparathyroidism through a retrospective chart review of 200 parathyroidectomy procedures performed over a 12 year period. Epidemiological data and accuracy of radiological investigations used in identifying pathological parathyroid tissue location were assessed. We determined how often simultaneous removal of thyroid tissue was required during parathyroidectomy and the associated pathology. Radiology reports were screened to determine if confirmed thyroid pathology from histological specimens were referenced pre-operatively...
December 2017: European Archives of Oto-rhino-laryngology
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