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multinodular goitre

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https://www.readbyqxmd.com/read/29474644/dicer1-mutations-are-frequent-in-adolescent-onset-papillary-thyroid-carcinoma
#1
Jonathan D Wasserman, Nelly Sabbaghian, Somayyeh Fahiminiya, Rose Chami, Ozgur Mete, Meryl Acker, Mona K Wu, Adam Shlien, Leanne de Kock, William D Foulkes
Context: Papillary thyroid carcinoma (PTC) is a common malignancy in adolescence and is molecularly and clinically distinct from adult PTC. Mutations in the DICER1 gene are associated with thyroid abnormalities including multinodular goitre and differentiated thyroid carcinoma. Objective: In this study, we sought to characterize the prevalence of DICER1 variants in paediatric PTC, specifically in tumours without conventional PTC oncogenic alterations. Patients: Patients (n = 40) who underwent partial or total thyroidectomy and who were <18 years of age at the time of surgery were selected...
February 21, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29444549/body-weight-change-is-unpredictable-after-total-thyroidectomy
#2
Ron Glick, Paula Chang, Peter Michail, Jonathan W Serpell, Simon Grodski, James C Lee
BACKGROUND: There is a common perception that total thyroidectomy causes weight gain beyond expected age-related changes, even when thyroid replacement therapy induces a euthyroid state. The aim of this study was to determine whether patients who underwent total thyroidectomy for a wide spectrum of conditions experienced weight gain following surgery. METHODS: We retrospectively studied 107 consecutive total thyroidectomy patients treated between January 2013 and June 2014...
February 14, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29374396/thyroid-adenolipoma-a-case-report
#3
Monica Pennisi, Alessandro Conti, Renato Farina, Pietro Valerio Foti, Giuseppe Cocuzza, Andrea Boncoraglio, Valeria Costanzo, Giuliana Costanzo
Generally, small quantities of adipose tissue is present in the thyroid gland. The adenolipoma of the thyroid gland is considered a rare finding. It consists in a benign, encapsulated neoplasm composed of mature adipose tissue and glandular elements. We report a case of a 71 year-old female patient presenting with swelling of the anterior neck and history of airway obstruction. Ultrasound (US) examination showed a bulky multinodular goiter which caused dislocation and compression of the trachea. The scans performed at the level of the isthmic region showed the presence of a hyperechoic oval formation with a homogeneous echostructure and regular contours; these characteristics suggested the lipomatous nature of the nodule...
November 30, 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/29353393/131i-induced-graves-disease-in-patients-treated-for-toxic-multinodular-goitre-systematic-review-and-descriptive-analysis
#4
REVIEW
C Roque, C A Vasconcelos
BACKGROUND: Graves' disease (GD) arising after the treatment of toxic multinodular goitre (TMNG) with radioiodine has long been described but it remained unclear whether GD was in fact iodine induced, its incidence, risk factors, natural history and treatment outcomes. METHODS: A systematic search using The Cochrane Library, Medline and PubMed Central allowed the pooling of data from 3633 patients with thyroid autonomy, 1340 patients with TMNG, to fill gaps in knowledge, regarding the clinical expression of iodine-induced GD (131I-IGD) in adults...
January 20, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29346358/rates-of-unsuspected-thyroid-cancer-in-multinodular-thyroid-disease
#5
Miriam Karalus, Jade Au Tamatea, Helen M Conaglen, Goswin Y Meyer-Rochow, John V Conaglen, Marianne S Elston
BACKGROUND: Previously the risk of concomitant thyroid cancer in multinodular goitre (MNG) has been reported as approximately 4%. Cancer risk in toxic MNG was often considered lower than for non-toxic MNG, due to a possible protective effect of TSH suppression. However, recent American data suggest an approximately 18% risk of occult malignancy in both toxic and non-toxic MNG. AIMS: To assess malignancy risk in a New Zealand population undergoing thyroidectomy for MNG...
January 19, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29239041/hereditary-and-familial-thyroid-tumours
#6
REVIEW
Julie Guilmette, Vania Nosé
The worldwide incidence of thyroid malignancies has been increasing rapidly. Sensitive imaging modalities and early detection of thyroid lesions have made thyroid cancers the most rapidly increasing cancers in the USA in 2017 (SEER Cancer Facts, 2017). Clinical awareness of potential risk factors, such as inherited thyroid cancers, has allowed earlier recognition of more vulnerable population clusters. Hereditary thyroid neoplasms arising from calcitonin-producing C cells are known as familial medullary thyroid carcinomas (FMTCs), and include well-documented syndromes such as multiple endocrine neoplasia IIA or IIB, and pure familial medullary thyroid carcinoma syndrome...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29169383/predictors-of-a-follicular-nodule-thy3-outcome-of-thyroid-fine-needle-aspiration-cytology-among-saudi-patients
#7
Imad R Musa, Mukhtar El Khatim Ahmad, Fayez Salim Al Raddady, Wesal Rabih Al Rabih, Elsayed M Elsayed, Gussay Badawi Mohamed, Gasim I Gasim
OBJECTIVE: A retrospective study was performed to evaluate predictors of thyroid fine needle aspiration cytology (FNAC) outcomes among Saudis with a thyroid nodule. Socio-demographic data, thyroid function status, thyroid parameters, ultrasound and cytology results were collected from 269 files of patients with thyroid nodules. RESULT: The patients' age was 40 ± 1.4 years (mean ± SD), and the mean body mass index (BMI) was 30.3 ± 1.2 kg/m(2). The thyroid statuses were euthyroid (85...
November 23, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29141453/relationship-between-metabolic-syndrome-and-nodular-thyroid-diseases
#8
Seher Kir, Yusuf Aydin, Hulya Coskun
Nodular thyroid diseases are common in Turkey. Insulin resistance (IR) is considered as the most important component of metabolic syndrome (MetS), and it is thought to directly affect thyroid diseases, together with other components of MetS. The aim of this study was to evaluate potential factors associated with thyroid nodularity. This study was part of the prospective MELEN study. In total, randomly selected 2233 subjects were evaluated. A euthyroid subgroup of participants (n = 1432) was selected and 421 of them had MetS...
November 16, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29067943/transoral-endoscopic-total-thyroidectomy-vestibular-approach-a-case-series-and-literature-review
#9
T Sivakumar, R A Amizhthu
Conventional open thyroidectomy is often associated with post-operative complications including nerve damage, voice disturbances, paraesthesias, adhesions and prominent scarring. Several endoscopic surgical techniques have been reported as alternatives to conventional thyroidectomy. Natural orifice transluminal endoscopic surgery is a promising approach which leaves no scar, produces few complications and affords faster discharge from care. Several studies have explored its utility in total thyroidectomy in patients with benign or malignant thyroid disease...
October 23, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29038858/surgical-management-of-primary-hyperparathyroidism
#10
Stephen Ryan, Danielle Courtney, Julia Moriariu, Conrad Timon
We reviewed the surgical management of primary hyperparathyroidism through a retrospective chart review of 200 parathyroidectomy procedures performed over a 12 year period. Epidemiological data and accuracy of radiological investigations used in identifying pathological parathyroid tissue location were assessed. We determined how often simultaneous removal of thyroid tissue was required during parathyroidectomy and the associated pathology. Radiology reports were screened to determine if confirmed thyroid pathology from histological specimens were referenced pre-operatively...
December 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28974848/incidence-of-hypothyreoidism-after-radioactive-iodine-i131-treatment-in-dependance-of-hyperthyreoidism-etiology-and-therapy-dose
#11
Nermina Beslic, Sabrina Licina, Amera Sadija, Renata Milardovic
INTRODUCTION: Consensus hasn't been yet achieved about optimal dose quantity that could prevent post therapy hypothyroidism, thus dosing approach varies among different centers. I131 doses can be fixed or calculated, although treatment outcomes don't differ significantly according to recent acknowledgments. AIM: Determination of the incidence of hypothyroidism after radioiodine treatment (I131) in dependence of hyperthyroidism etiology and quantity of applied doses...
August 2017: Medical Archives
https://www.readbyqxmd.com/read/28929066/surgical-treatment-of-retrosternal-goitre
#12
Kiera Welman, Richard Heyes, Paras Dalal, Sarah Hough, Marciano Bunalade, Vladimir Anikin
This study aims to evaluate surgical approaches to the management of retrosternal goitre. Between 2004 and 2014, 35 patients (eight males; mean age 67.4 ± 10.9 years) with retrosternal goitre (mainly right-sided in 9, left-sided in 14 and bilateral in 12) underwent surgery. A palpable neck mass was found in 11 (31.4%), stridor in 10 (28.6%) and thyrotoxicosis in 4 (11.4%) cases. 4 (11.4%) patients were asymptomatic. Tracheal compression was detected radiologically in 27 (77.2%) patients with deviation in 18 (51...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28928976/disseminated-tuberculosis-presenting-as-cold-abscess-of-the-thyroid-gland-a-case-report
#13
Kiran Dv, Karthik Gunasekaran, Ajay Kumar Mishra, Ramya Iyyadurai
Tubercular involvement of the thyroid gland is a rare entity. Tuberculosis of thyroid gland can present as cold abscess, multinodular goitre, acute abscess or generalized goitre. Clinically, these patients can be euthyroid, hypothyroid or hyperthyroid. Diagnosis is made by fine needle aspiration and demonstration of acid fast bacilli. Here, we report the case of a 46-year-old male who presented with disseminated extrapulmonary tuberculosis with obstructive hydrocephalus and cold abscess of the thyroid gland...
September 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28899873/toxic-multinodular-goitre-a-surprising-finding
#14
Marlene Rodrigues, Helena Ferreira, Ana Antunes, Olinda Marques
No abstract text is available yet for this article.
September 12, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28874217/impact-of-pre-operative-serum-25-hydroxyvitamin-d-on-post-operative-serum-calcium-in-patients-undergoing-total-thyroidectomy-for-benign-goitre-retrospective-study-of-246-patients
#15
M Erlem, N Klopp-Dutote, A Biet-Hornstein, V Strunski, C Page
OBJECTIVE: To determine whether pre-operative serum 25-hydroxyvitamin D has an impact on post-operative parathyroid hormone and serum calcium levels in patients undergoing total thyroidectomy for benign goitre. METHODS: This single-centre, retrospective study comprised 246 unselected surgical patients who had undergone total thyroidectomy for bilateral, benign, multinodular goitre. The correlation between pre-operative serum 25-hydroxyvitamin D and post-operative serum parathyroid hormone and serum calcium was studied to determine whether low pre-operative serum 25-hydroxyvitamin D was predictive of post-operative hypocalcaemia...
October 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28737965/comparison-of-three-competitive-immunoassays-for-measurement-of-tsh-receptor-antibodies-in-patients-with-graves-disease
#16
Sara Doroudian, Inge Bülow Pedersen, Cindy Soendersoe Knudsen, Aase Handberg, Stine Linding Andersen
Thyrotropin (TSH) receptor antibodies (TRAb) mediate the hyperthyroidism of Graves' disease (GD). The aim of the study was to compare the diagnostic performance and assay agreement between three immunoassays for the measurement of TRAb in patients with newly diagnosed GD. TRAb was measured with three different assays [H-TRAb (BRAHMS Diagnostica), M22-Man (RSR Limited) and M22-Aut (Roche Diagnostics)] in 387 participants who were recruited from two Danish population-based studies and diagnosed with GD (n = 101), multinodular toxic goitre (n = 88), primary autoimmune hypothyroidism (n = 100) or included as controls (n = 98)...
July 24, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28624166/retrograde-thyroidectomy-for-preservation-of-the-external-branch-of-the-superior-laryngeal-nerve-a-case-series
#17
Vijay Naraynsingh, Shamir Cawich, Dale Hassranah, Ravi Maharaj, Shariful Islam, Yardesh Singh
BACKGROUND: The external branch of the Superior Laryngeal nerve (EBSLN) is at high risk of injury in surgery for large multinodular goitre (MNG) since the upper pole is high in the neck, well cephalad to the EBSLN. We present a technique of drawing the lobe caudally by retrograde thyroidectomy in order to minimize nerve injury. DESIGN & METHOD: All patients having surgery for benign MNG were included. Cases with previous thyroid surgery, malignant and toxic disease were excluded...
May 15, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28619420/study-of-factors-that-influence-the-outcome-of-131-i-treatment-in-hyperthyroidism-secondary-to-nodular-goitre
#18
O Tabuenca-Dopico, R Boente-Varela, J L Lamas-Ferreiro
OBJECTIVE: To assess the outcome after (131)I treatment in patients with multinodular (MNG) and nodular toxic goitre (NTG) according to the administered dose and other factors related to the patient, pathology, or previous treatments. MATERIAL AND METHODS: A retrospective study was conducted on 108 patients (67 MNG and 41 NTG) treated in our department, with a follow-up period of at least 2 years. Development of hypothyroidism and treatment failure were evaluated along with their relationship with the administered dose and other factors such as age, sex, grade of hyperthyroidism, type of goitre, presence of autoimmunity, or previous antithyroid medication...
November 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28584708/analyses-of-antioxidant-status-and-nucleotide-alterations-in-genes-encoding-antioxidant-enzymes-in-patients-with-benign-and-malignant-thyroid-disorders
#19
Nur Siti Fatimah Ramli, Sarni Mat Junit, Ng Khoon Leong, Nurhanani Razali, Jaime Jacqueline Jayapalan, Azlina Abdul Aziz
BACKGROUND: Synthesis of thyroid hormones and regulation of their metabolism involve free radicals that may affect redox balance in the body. Thyroid disorders causing variations in the levels of thyroid hormones may alter cellular oxidative stress. The aim of this study was to measure the antioxidant activities and biomarkers of oxidative stress in serum and red blood cells (RBC) of patients with benign and malignant thyroid disorders and to investigate if changes in the antioxidant activities in these patients were linked to alterations in genes encoding the antioxidant enzymes...
2017: PeerJ
https://www.readbyqxmd.com/read/28537560/analysis-of-factors-affecting-the-development-of-hypocalcaemia-after-multinodular-goitre-surgery
#20
Piotr Papaj, Sławomir Kozieł, Sławomir Mrowiec
INTRODUCTION: Thyroidectomy is a common surgery performed especially in treatment of multinodular goitre. The most common post-thyroidectomy complication is a postoperative hypocalcaemia, and the percentage of postoperative hypoparathyroidism could reach even 50%. Tested group and methods: A forward-looking, randomized testing was done on a group of 113 women being subject to multinodular goitre surgery. In this article, we wish to present an analysis of the results obtained in the control group, focusing on the predicative factors which determine the development of postoperative hypocalcaemia...
April 30, 2017: Polski Przeglad Chirurgiczny
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