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Ana P F Santos, Bianca M Souza, Tânia F C V Silva, Rodrigo P Cavalcante, Silvio C Oliveira, Amílcar Machulek, Rui A R Boaventura, Vítor J P Vilar
The mineralization of bio-recalcitrant humic acids (HAs) by a solar photo-Fenton (SPF) process was investigated in aqueous system, in order to understand its abatement in real high-HA content matrices, such as sanitary landfill leachates. SPF reactions were performed in tubular photoreactors with CPCs at lab-scale (simulated solar light) and pilot-scale (natural sunlight). Considering the experimental conditions selected for this work, the formation of insoluble HA-Fe3+ complexes was observed. Thus, to avoid HA precipitation, oxalic acid (Ox) was added, since Fe3+ -Ox complexes present a higher stability constant...
March 15, 2018: Environmental Science and Pollution Research International
Si Liu, Baoshan Gao, Gang Wang, Weigang Wang, Xin Lian, Shan Wu, Jinyu Yu, Yaowen Fu, Honglan Zhou
Primary hyperoxaluria type 2 is a rare autosomal recessive disorder caused by glyoxylate reductase/hydroxypyruvate reductase deficiency and characterized by recurrent episodes of nephrolithiasis and nephrocalcinosis. Herein, we describe a case of primary hyperoxaluria type 2 in a 33-year-old man who failed to respond to conventional therapies; thus renal transplantation was performed. This case demonstrated that, although primary hyperoxaluria type 2 is rare, hyperoxaluria should be suspected and blood oxalate and stone component be examined in patients with recurrent episodes of nephrolithiasis, particularly in those who are unresponsive to conventional therapies...
April 2018: Experimental and Therapeutic Medicine
Maria A Morosanova, Zahar V Samodelov, Elena I Morosanova
The interaction of silica-titania xerogel with triphenylmethane dyes (pyrocatechol violet, chrome azurol S, eriochrome cyanine R) has been investigated to create a new sensor material for solid phase spectrophotometric determination of food oxalates. The complex forming reaction between xerogel incorporated titanium(IV) and triphenylmethane dyes has been studied; half-reaction periods, complex composition, equilibrium constants, and xerogel sorption capacity have been calculated for each dye. Eriochrome cyanine R (ECR) is characterized by the shortest half-reaction period, the smallest equilibrium constant, and the greatest capacity; it has been chosen for the sensor material construction because titanium(IV)-ECR complex is formed faster and can be destroyed easier than other studied complexes...
March 15, 2018: Sensors
Junjian Zheng, Zhiwei Wang, Jinxing Ma, Shaoping Xu, Zhichao Wu
Inability to remove low molecular weight anthropogenic contaminants is a critical issue in low-pressure membrane filtration processes for water treatment. In this work, a novel electrochemical ceramic membrane filtration (ECMF) system using TiO2@SnO2-Sb anode was developed for removing persistent p-chloroaniline (PCA). Results showed that the ECMF system achieved efficient removal of PCA from contaminated waters. At a charging voltage of 3 V, the PCA removal rate of TiO2@SnO2-Sb ECMF system under flow-through mode was 2...
March 15, 2018: Environmental Science & Technology
Dean G Assimos
No abstract text is available yet for this article.
May 2017: Journal of Urology
Dean G Assimos
No abstract text is available yet for this article.
May 2017: Journal of Urology
Dean G Assimos
No abstract text is available yet for this article.
May 2017: Journal of Urology
Joke I Roodnat, Anneke M E de Mik-van Egmond, Wesley J Visser, Stefan P Berger, Wilbert A G van der Meijden, Felix Knauf, Madelon van Agteren, Michiel G H Betjes, Ewout J Hoorn
Background: Enteric hyperoxaluria due to malabsorption may cause chronic oxalate nephropathy and lead to end-stage renal disease. Kidney transplantation is challenging given the risk of recurrent calcium-oxalate deposition and nephrolithiasis. Methods: We established a protocol to reduce plasma oxalic acid levels peritransplantation based on reduced intake and increased removal of oxalate. The outcomes of 10 kidney transplantation patients using this protocol are reported...
December 2017: Transplantation Direct
Nilubon Singhto, Rattiyaporn Kanlaya, Angkhana Nilnumkhum, Visith Thongboonkerd
In kidney stone disease, macrophages secrete various mediators via classical secretory pathway and cause renal interstitial inflammation. However, whether their extracellular vesicles, particularly exosomes, are involved in kidney stone pathogenesis remained unknown. This study investigated alterations in exosomal proteome of U937-derived macrophages (by phorbol-12-myristate-13-acetate activation) after exposure to calcium oxalate monohydrate (COM) crystals for 16-h using 2-DE-based proteomics approach. Six significantly altered proteins in COM-treated exosomes were successfully identified by nanoscale liquid chromatography-electrospray ionization-electron transfer dissociation tandem mass spectrometry as proteins involved mainly in immune processes, including T-cell activation and homeostasis, Fcγ receptor-mediated phagocytosis, interferon-γ (IFN-γ) regulation, and cell migration/movement...
2018: Frontiers in Immunology
Qiying Zhou, Xia Jiang, Yinghui Guo, Guochen Zhang, Wenju Jiang
Mesoporous carbon is considered as the most effective adsorbent for dyes with large molecule diameter. In this study, an ultra-high surface area mesoporous carbon was derived using a kind of new template precursors (manganese salts), i.e. manganese carbonate (MC), manganese oxalate (MO) and manganese acetate (MA). The XRD results demonstrated that after the pyrolysis of the mixture of manganese salts and poly(vinyl alcohol) (PVA) over 500 °C, MnO was only the Mn species on carbon and the particle sizes of the generated MnO were in the range of 1...
March 7, 2018: Chemosphere
Taro Mukaibo, Takashi Munemasa, Alvin T George, Duy T Tran, Xin Gao, Jesse Herche, Chihiro Masaki, Gary E Shull, Manoocher Soleimani, James E Melvin
The solute carrier family 26 (SLC26) gene family encodes at least 10 different anion exchangers. SLC26 member 6 (SLC26A6 or CFEX/PAT-1) and cystic fibrosis transmembrane conductance regulator (CFTR) co-localize to the apical membrane of pancreatic duct cells where they act in concert to drive HCO3- and fluid secretion. By contrast, in the small intestine, SLC26A6 serves as the major pathway for oxalate secretion. However, little is known about the function of Slc26a6 in murine salivary glands. Here, RNA-Seq-based transcriptional profiling and Western blots revealed that Slc26a6 is highly expressed in mouse submandibular and sublingual salivary glands...
March 12, 2018: Journal of Biological Chemistry
Michelle H Fung, Kārlis Bērziņš, Raj Suryanarayanan
In an earlier investigation, coamorphous systems of ketoconazole (KTZ) prepared with each oxalic (OXA), tartaric (TAR), citric (CIT) and succinic (SUC) acid, revealed drug-acid ionic and/or hydrogen bonding interactions in the solid-state (Fung et al, Mol Pharmaceutics, 2018, 15(x), xxxx-yyyy). We showed that the drug-acid interactions in KTZ-TAR were the strongest, followed by KTZ-OXA, KTZ-CIT and KTZ-SUC. In this study, we investigated the crystallization propensity and dissolution behavior of the KTZ-acid coamorphous systems...
March 12, 2018: Molecular Pharmaceutics
B Handan Özdemir, Şebnem Ayva, Gökçe Özdemir, Alev Ok Atılgan, Eda Akçay, F Nurhan Özdemir, Mehmet Haberal
OBJECTIVES: The interaction between calcium oxalate deposition and urinary tract infection is not well established. We aimed to identify the association between these and to determine the role of calcium oxalate deposition on interstitial fibrosis development. MATERIALS AND METHODS: Renal allograft biopsies of 967 patients were reviewed to identify those with calcium oxalate deposition in the renal allograft, with 27 (2.8%) identified. Follow-up biopsies were conducted to reevaluate for calcium oxalate presence and interstitial fibrosis development...
March 2018: Experimental and Clinical Transplantation
Melda Onal, Alex H Carlson, Jeff D Thostenson, Nancy A Benkusky, Mark B Meyer, Seong M Lee, J Wesley Pike
Fibroblast growth factor 23 (FGF23) production is regulated by both calciotropic hormones and inflammation. Consistent with this, elevated FGF23 levels are associated with inflammatory markers as well as parathyroid hormone (PTH) in various disease states, including chronic kidney disease (CKD). However, the molecular mechanisms underpinning Fgf23 transcription in response to these regulators are largely unknown. We therefore utilized chromatin immunoprecipitation followed by DNA sequencing (ChIP-seq) data from an osteocyte cell line to identify potential regulatory regions of the Fgf23 gene...
January 2018: JBMR Plus
Patricia M Tilney, Magda Nel, Abraham E van Wyk
Ekebergia capensis is a medium-sized to large evergreen to deciduous tree ranging from southern Africa to Ethiopia. Two morphologically-distinct variants of E. capensis , southern and northern, may be recognized in southern Africa. Despite its wide distribution range there appear to be no published reports on the secretory structures occurring on the leaves. In very young leaves, colleters on the petiolules, adjacent portions of the rachis and the midrib of the adaxial leaflet surfaces, secrete fluid which at least partly covers these developing areas...
February 2018: Heliyon
Bryan D Hinck, Ricardo Miyaoka, James E Lingeman, Dean G Assimos, Brian R Matlaga, Rocky Pramanik, John Asplin, Benjamin Cohen, Manoj Monga
INTRODUCTION: To determine if markers of kidney injury correlate with urinary oxalate excretion. If so, such biomarkers might be early predictors of oxalate nephropathy. Gastric bypass surgery for obesity is known to be associated with postoperative hyperoxaluria, which can lead to urolithiasis and kidney damage. MATERIALS AND METHODS: Patients were recruited from four large academic centers > 6 months following completion of gastric bypass surgery. Patients provided a spot urine sample for analysis of three markers of kidney injury: 8-iso-Prostaglandin F2 α, N-acetyl- β -D-Glucosaminidase, and Neutrophil gelatinase-associated lipocalin...
February 2018: Canadian Journal of Urology
Zhuang Guo, Hongbin Cao, Yuxian Wang, Yongbing Xie, Jiadong Xiao, Jin Yang, Yi Zhang
Three kinds of graphitic carbon nitride materials (bulk, porous and nanosheet g-C3 N4 ) were composited with a multiwall carbon nanotube (MWCNT) by a hydrothermal method, and the obtained b-C3 N4 /CNT, p-C3 N4 /CNT and n-C3 N4 /CNT materials were used in the electrodes for electro-peroxone process. It was found that the n-C3 N4 /CNT composite exhibited the highest efficiency in oxalate degradation, though it performed the worst in the oxygen-reduction reaction for H2 O2 production. The n-C3 N4 /CNT composite exhibited higher activity than CNT and other composites in catalytic ozonation experiments, due to the higher pyrrolic-N content modified on the CNT surface and higher surface area...
March 7, 2018: Chemosphere
Harm-Jan de Grooth, Wai-Ping Manubulu-Choo, Anthe S Zandvliet, Angélique M E Spoelstra-de Man, Armand R Girbes, Eleonora L Swart, Heleen M Oudemans-van Straaten
BACKGROUND: Early high-dose intravenous vitamin-C is being investigated as adjuvant therapy in critically ill patients, but the optimal dose and infusion method are unclear. The primary aim of this study was to describe the dose-plasma concentration relationship and safety of four different dosing regimens. METHODS: Four-group randomized pharmacokinetic trial. Critically ill patients with multiple organ dysfunction were randomized to receive 2g/day or 10g/day vitamin-C as a twice daily bolus infusion or continuous infusion for 48 hours...
March 6, 2018: Chest
Chien-Hua Chen, Cheng-Li Lin, Long-Bin Jeng
PURPOSE: Chronic pancreatitis (CP) can cause fat or bile acid malabsorption due to exocrine insufficiency. Fat or bile acid malabsorption has been reported to increase the risk of urolithiasis through increased intestinal oxalate absorption. However, no studies have reported an association between CP and urolithiasis. METHODS: We identified 15,848 patients (age: ≥20 years) diagnosed as having CP between 2000 and 2010 from the National Health Insurance Research Database as the study cohort...
2018: PloS One
Ayse Betul Ergul, Mehmet Kara, Cigdem Karakukcu, Arzu Tasdemir, Humeyra Aslaner, Mehmet Ali Ergul, Sebahattin Muhtaroglu, Gozde Erturk Zararsiz, Yasemin Altuner Torun
Boron plays roles in the metabolism of calcium, vitamin D, steroid hormones, healthy bone development, and maintenance of cell membranes. The biological effects of boron are dose-dependent but follow a U-shaped pattern, rendering it important to define the active range. The studies of Bahadoran et al. on rats and Naghii et al. on humans showed that low doses of boron (3 and 10 mg/day) prevented kidney stone formation. The aim of this study was to determine whether high doses of boron have an anti-urolithiatic or antioxidant effect on nephrolithiasis in an experimental rat model...
March 8, 2018: Biological Trace Element Research
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