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https://www.readbyqxmd.com/read/29144812/increased-bone-turnover-in-type-2-diabetes-patients-randomized-to-bariatric-surgery-vs-medical-therapy-at-5-years
#1
Megan R Crawford, Nathan Pham, Leila Khan, James F Bena, Philip R Schauer, Sangeeta R Kashyap
OBJECTIVE: The aim of our study was to determine the 5 year outcomes of bariatric surgery vs. intensive medical therapy on bone turnover in patients with type 2 diabetes (T2DM) from the STAMPEDE trial. METHODS: This is an ancillary investigation of a 5 year randomized control trial at a single tertiary care center involving 95 patients aged 48.5 ± 8 years with obesity (BMI: 36.5±3.6 kg/m(2)) and uncontrolled T2DM (HbA1C: 9.3 ±1.6%). Patients were randomized to intensive medical therapy (IMT; N=25), Roux-en-Y gastric bypass (RYGB; N=37), or sleeve gastrectomy (SG; N=33) for diabetes treatment...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29144799/parathyroid-function-after-total-thyroidectomy-a-randomized-clinical-trial-concerning-the-influence-of-the-surgical-technique
#2
Theodossis S Papavramidis, Olympia Anastasiou, Ioannis Pliakos, George Kotsovolis, Stavros Panidis, Antonios Michalopoulos
Background Thyroidectomy impairs parathyroid function, even if it does not necessarily lead to postoperative clinical hypocalcaemia. This study is prospective and evaluates the PTH function in non-clinically symptomatic patients after total thyroidectomy performed by two different techniques. Materials and Methods Prospective randomized clinical trial including 269 patients undergoing classic (group A) or harmonic scalpel (group B) total thyroidectomy. Preoperatively and at 48 hours biochemical analysis was performed...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29135297/-vitamin-d-and-calcium-supplementation-in-elderly-patients-with-hip-fracture
#3
Antal Salamon, Erzsébet Toldy, Csaba Biró, Ákos Mátrai, Tibor Balassa, Zoltán Lőcsei
Vitamin D plays an important role in maintaining calcium and bone metabolism, a risk factor of osteoporosis, fall and fracture in old age. Reduction in D-vitamin levels associated with compensatory increased level of parathyroid hormone causes significant loss of bone matrix, so substitutions of vitamin D and calcium are very important. Many authors publish their recommended doses used for prevention of hip fracture during the last years. Some authors are satisfied only with vitamin D supplementation while others have better experiences with vitamin D and calcium substitution...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29134690/faecal-calcium-excretion-does-not-decrease-during-long-term-feeding-of-a-low-calcium-diet-in-adult-dogs
#4
S Schmitt, J Mack, E Kienzle, L G Alexander, P J Morris, A Colyer, B Dobenecker
According to a previous meta-analysis, adult dogs do not notably increase calcium absorption from the gastrointestinal tract when calcium intake is decreased. This results in a negative calcium balance even with a moderate calcium reduction. In this study we wanted to verify (i) whether a negative calcium balance occurs at a calcium intake equivalent to NRC (2006) (Nutrient requirements of dogs and cats, 2006, The National Academies Press, Washington, DC) minimal requirements, and if so (ii) whether the negative calcium balance will persist for up to 6 months on a low-calcium diet...
November 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29107998/impact-of-surgical-parathyroidectomy-on-chronic-kidney-disease-mineral-and-bone-disorder-ckd-mbd-a-systematic-review-and-meta-analysis
#5
Mugurel Apetrii, David Goldsmith, Ionut Nistor, Dimitrie Siriopol, Luminita Voroneanu, Dragos Scripcariu, Marc Vervloet, Adrian Covic
For more than 6 decades, many patients with advanced chronic kidney disease (CKD) have undergone surgical parathyroidectomy (sPTX) for severe secondary hyperparathyroidism (SHPT) mainly based historical clinical practice patterns, but not on evidence of outcome.We aimed in this meta-analysis to evaluate the benefits and harms of sPTX in patients with SHPT. We searched MEDLINE (inception to October 2016), EMBASE and Cochrane Library (through Issue 10 of 12, October 2016) and website clinicaltrials.gov (October 2016) without language restriction...
2017: PloS One
https://www.readbyqxmd.com/read/29104158/moderate-salt-restriction-with-or-without-paricalcitol-in-type-2-diabetes-and-losartan-resistant-macroalbuminuria-proceed-a-randomised-double-blind-placebo-controlled-crossover-trial
#6
Aneliya Parvanova, Matias Trillini, Manuel A Podestà, Ilian Petrov Iliev, Barbara Ruggiero, Manuela Abbate, Annalisa Perna, Francesco Peraro, Olimpia Diadei, Nadia Rubis, Flavio Gaspari, Fabiola Carrara, Nadia Stucchi, Antonio Belviso, Antonio C Bossi, Roberto Trevisan, Giuseppe Remuzzi, Martin de Borst, Piero Ruggenenti
BACKGROUND: Macroalbuminuria predicts renal and cardiovascular events in patients with type 2 diabetes. We aimed to assess the albuminuria-lowering effects of salt restriction, paricalcitol therapy, or both, in this population. METHODS: In this randomised, double-blind, placebo-controlled, crossover trial, we recruited adult patients with type 2 diabetes from six diabetology outpatient clinics in northern Italy, with 24 h albuminuria of more than 300 mg despite 100 mg per day losartan therapy, blood pressure of less than 140/90 mm Hg, serum creatinine concentration of less than 2 mg/dL, stable renal function on stable renin-angiotensin system inhibitor therapy with a fixed dose of losartan, parathyroid hormone concentration of 20 pg/mL to <110 pg/mL, serum calcium concentration of less than 9·5 mg/dL, and serum phosphate concentration of less than 5 mg/dL, who had been more than 80% compliant with placebo treatment during a 1 month placebo run-in...
November 2, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29099939/pth-1-34-for-surgical-hypoparathyroidism-a-2-year-prospective-open-label-investigation-of-efficacy-and-quality-of-life
#7
Andrea Palermo, Assunta Santonati, Gaia Tabacco, Daniela Bosco, Antonio Spada, Claudio Pedone, Bruno Raggiunti, Tina Doris, Daria Maggi, Franco Grimaldi, Sivlia Manfrini, Fabio Vescini
Context: Daily PTH(1-34) administrations can reduce the required total daily dose of calcium/calcitriol and restore normocalcemia in refractory hypoparathyroidism. However, most of the PTH(1-34) trials were conducted on small cohorts including subjects with hypoparathyroidism of various etiologies and quality of life(QOL) was not investigated. Objective: To investigate the effects of 24 month PTH(1-34) treatment in a homogeneous cohort of adult subjects with postoperative hypoparathyroidism and to evaluate quality of life(QOL) changes...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29077944/association-of-serum-magnesium-with-all-cause-mortality-in-patients-with-and-without-chronic-kidney-disease-in-the-dallas-heart-study
#8
Silvia Ferrè, Xilong Li, Beverley Adams-Huet, Naim M Maalouf, Khashayar Sakhaee, Robert D Toto, Orson W Moe, Javier A Neyra
Background: Low serum magnesium (SMg) has been linked to increased mortality and cardiovascular disease (CVD) in the general population. We examined whether this association is similar in participants with versus without prevalent chronic kidney disease (CKD) in the multiethnic Dallas Heart Study (DHS) cohort. Methods: SMg was analyzed as a continuous variable and divided into tertiles. Study outcomes were all-cause death, cardiovascular (CV) death or event, and CVD surrogate markers, evaluated using multivariable Cox regression models adjusted for demographics, comorbidity, anthropometric and biochemical parameters including albumin, phosphorus and parathyroid hormone, and diuretic use...
October 25, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29067923/effect-of-vitamin-d-therapy-on-urinary-albumin-excretion-renal-functions-and-plasma-renin-among-patients-with-diabetic-nephropathy-a-randomized-double-blind-clinical-trial
#9
Plgc Liyanage, S Lekamwasam, T P Weerarathna, C Liyanage
BACKGROUND: Despite different management strategies, progression of proteinuria occurs in a sizable category of patients with diabetic nephropathy (DN). Increase in serum renin levels induced by the renin-angiotensin system (RAS) may contribute to this. Vitamin D therapy is found to have an inhibitory effect on the RAS. We aimed to study the effects of Vitamin D therapy on renal functions of patients with DN. METHODS: This was a double-blind, randomized, placebo-controlled study...
October 23, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/29044707/the-effect-of-vitamin-d-supplementation-on-bone-metabolic-markers-in-chronic-kidney-disease
#10
Ashok Kumar Yadav, Vivek Kumar, Vinod Kumar, Debasish Banerjee, Krishan Lal Gupta, Vivekanand Jha
Use of active forms of vitamin D is advocated in patients with chronic kidney disease (CKD) for treatment of mineral bone disease because of the presumption that native forms of vitamin D would not undergo significant activation to calcitriol, the most active biological form of vitamin D. We present secondary analysis looking at bone turnover in subjects who completed the randomized, double blind, placebo-controlled trial investigating the effect of cholecalciferol supplementation on vascular function in nondiabetic CKD stage G3-G4 and vitamin D ≤20 ng/mL (Clinical Trials Registry of India: CTRI/2013/05/003648)...
October 17, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29029193/sex-and-iron-modify-fibroblast-growth-factor-23-fgf23-concentration-in-1-year-old-children
#11
Elisa Holmlund-Suila, Maria Enlund-Cerullo, Saara Valkama, Helena Hauta-Alus, Jenni Rosendahl, Otto Helve, Timo Hytinantti, Heli Viljakainen, Sture Andersson, Outi Mäkitie
Context: Fibroblast growth factor 23 (FGF23) plays an important role in phosphate homeostasis but its regulation is inadequately characterized. Objective: To examine regulators of FGF23, especially sex and iron status, in early childhood. Design: A cross-sectional study involving 1-year-old children. Setting and participants: Healthy term infants with a birth weight appropriate for gestational age were recruited to an ongoing vitamin D trial at the Kätilöopisto Maternity Hospital, Helsinki, Finland...
October 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29023178/effect-of-calcium-derived-from-lithothamnion-sp-on-markers-of-calcium-metabolism-in-premenopausal-women
#12
John L Zenk, Joy L Frestedt, Michael A Kuskowski
A double-blind crossover pilot trial tested the hypothesis that botanically derived calcium could demonstrate greater influence over calcium metabolism markers compared with a nonplant-derived calcium carbonate supplement or placebo. Twelve fasting female subjects received a single oral dose of Aquamin F™ (derived from the marine algal Lithothamnion sp.), or calcium carbonate, or placebo. Blood and urine samples were collected at baseline and over 12 h to evaluate ionized and total calcium and parathyroid hormone (PTH)...
October 12, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28992314/nutritional-therapy-reduces-protein-carbamylation-through-urea-lowering-in-chronic-kidney-disease
#13
Biagio R Di Iorio, Stefania Marzocco, Antonio Bellasi, Emanuele De Simone, Fabrizio Dal Piaz, Maria Teresa Rocchetti, Carmela Cosola, Lucia Di Micco, Loreto Gesualdo
Background: Protein carbamylation is one of the non-enzymatic reactions involved in protein molecular ageing. We sought to investigate the relationship between urea levels and protein carbamylation, and whether a Mediterranean diet (MD) and a very low protein diet (VLPD) reduce protein carbamylation through reduction in urea levels in patients with chronic kidney disease (CKD). Methods: This is a prospective, randomized, crossover controlled trial that investigated 60 patients with CKD grades 3B-4 (46 males, mean age of 67 years)...
July 11, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28976989/vitamin-d-and-methylarginines-in-chronic-kidney-disease-ckd
#14
RANDOMIZED CONTROLLED TRIAL
Claudia Torino, Patrizia Pizzini, Sebastiano Cutrupi, Rocco Tripepi, Giovanni Tripepi, Francesca Mallamaci, Carmine Zoccali
BACKGROUND: Vitamin D associates with the plasma concentration of the endogenous inhibitor of the nitric oxide system asymmetric dimethyl arginine (ADMA) and cross-sectional studies in CKD patients treated with the vitamin D receptor activator paricalcitol show that plasma ADMA is substantially less than in those not receiving this drug. METHODS: In the frame of a randomized, double-blind, placebo controlled trial, the Paracalcitol and ENdothelial fuNction in chronic kidneY disease (PENNY), we investigated whether vitamin D receptor activation by paricalcitol (2 μg/day x 12 weeks) affects the plasma concentration of ADMA and symmetric dimethyl arginine (SDMA) in 88 patients with stage 3 to 4 CKD...
2017: PloS One
https://www.readbyqxmd.com/read/28975468/effect-of-restricted-protein-diet-supplemented-with-keto-analogues-in-end-stage-renal-disease-a-systematic-review-and-meta-analysis
#15
REVIEW
Zheng Jiang, Yi Tang, Lichuan Yang, Xuhua Mi, Wei Qin
AIM: To evaluate the efficacy and safety of the restricted protein diet supplemented with keto analogues when applied in end-stage renal disease (ESRD). METHODS: The Cochrane Library, PubMed, Embase, CBM and CENTRAL databases were searched and reviewed up to January 2017. Clinical trials were analyzed using RevMan 5.3 software. RESULTS: Five randomized controlled trials were selected and included in this study according to our inclusion and exclusion criteria...
October 3, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28973622/association-of-biotin-ingestion-with-performance-of-hormone-and-nonhormone-assays-in-healthy-adults
#16
Danni Li, Angela Radulescu, Rupendra T Shrestha, Matthew Root, Amy B Karger, Anthony A Killeen, James S Hodges, Shu-Ling Fan, Angela Ferguson, Uttam Garg, Lori J Sokoll, Lynn A Burmeister
Importance: Biotinylated antibodies and analogues, with their strong binding to streptavidin, are used in many clinical laboratory tests. Excess biotin in blood due to supplemental biotin ingestion may affect biotin-streptavidin binding, leading to potential clinical misinterpretation. However, the degree of interference remains undefined in healthy adults. Objective: To assess performance of specific biotinylated immunoassays after 7 days of ingesting 10 mg/d of biotin, a dose common in over-the-counter supplements for healthy adults...
September 26, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28922546/single-dose-local-administration-of-teriparatide-with-a-octacalcium-phosphate-collagen-composite-enhances-bone-regeneration-in-a-rodent-critical-sized-calvarial-defect
#17
Fumihiko Kajii, Atsushi Iwai, Hidenori Tanaka, Keiko Matsui, Tadashi Kawai, Shinji Kamakura
Octacalcium phosphate and collagen composite (OCP/Col) achieves stable bone regeneration without cell transplantation in preclinical studies. Recently, a sponsor-initiated clinical trial was conducted to commercialize the material. The present study investigated bone regeneration by OCP/Col with the single local administration of teriparatide (parathyroid hormone 1-34; TPTD). OCP/Col was prepared by mixing sieved granules of OCP and atelocollagen for medical use and a disk was molded. After the creation of a rodent critical-sized calvarial defect, OCP/Col or OCP/Col with dripped TPTD solution (1...
September 18, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28918310/effect-of-eplerenone-on-markers-of-bone-turnover-in-patients-with-primary-hyperparathyroidism-the-randomized-placebo-controlled-epath-trial
#18
Nicolas Verheyen, Martin R Grübler, Andreas Meinitzer, Christian Trummer, Verena Schwetz, Karin Amrein, Hans P Dimai, Winfried März, Cristiana Catena, Dirk von Lewinski, Jakob Voelkl, Ioana Alesutan, Astrid Fahrleitner-Pammer, Helmut Brussee, Stefan Pilz, Andreas Tomaschitz
Mineralocorticoid receptor (MR) antagonism may affect bone turnover via direct and indirect pathways involving parathyroid hormone, but randomized controlled trials are lacking. In a pre-specified analysis of the "Eplerenone in primary hyperparathyroidism" placebo-controlled, randomized trial (ISRCTN 33941607), effects of eight weeks MR-blockade with eplerenone on bone turnover markers in 97 patients with primary hyperparathyroidism were tested. Mean age was 67.5±9.5years, and 76 (78.4%) were females. In analysis of covariance with adjustment for baseline values, eplerenone had no significant effect on isoform 5b of the tartrate-resistant acid phosphatase (TRAP), beta-crosslaps, N-terminal propeptide of procollagen type 1 (P1NP), osteocalcin and bone-specific alkaline phosphatase...
September 14, 2017: Bone
https://www.readbyqxmd.com/read/28906318/nutritional-state-and-feeding-behaviors-of-children-with-eosinophilic-esophagitis-and-gastroesophageal-reflux-disease
#19
Pooja Mehta, Glenn T Furuta, Taryn Brennan, Michelle L Henry, Nancy Creskoff Maune, Shikha S Sundaram, Calies Menard-Katcher, Dan Atkins, Faith Takurukura, Sandra Giffen, Zhaoxing Pan, Angela M Haas
OBJECTIVE: Because both gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) are associated with malnutrition and feeding dysfunction, this study compares growth, nutrition and feeding behaviors in children with GERD and EoE. METHODS: Subjects aged 1-7 with GERD or EoE were enrolled in a prospective study. Assessments included length/height, weight, 3-day food diary, serum biomarkers of nutrition, and the Behavioral Pediatric Feeding Assessment Scale (BPFAS)...
September 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28898923/repurposing-a-novel-parathyroid-hormone-pth-analog-to-treat-hypoparathyroidism
#20
Venkatesh Krishnan, Yanfei L Ma, Catherine Z Chen, Natasha Thorne, Heather Bullock, Gregory Tawa, Christy Javella-Cauley, Shaoyou Chu, Weiming Li, Wayne Kohn, Mary D Adrian, Charles Benson, Lifei Liu, Masahiko Sato, Wei Zheng, Andre M Pilon, N Nora Yang, Henry U Bryant
BACKGROUND AND PURPOSE: Human parathyroid hormone (PTH) is critical for maintaining physiologic calcium homeostasis, and plays an important role in the formation and maintenance of bone. Full-length PTH and a truncated peptide form are approved for treatment of hypoparathyroidism and osteoporosis, respectively. Our initial goal was to develop an improved PTH therapy for osteoporosis, but clinical development was halted. The novel asset was then repurposed as an improved therapy for hypoparathyroidism...
September 12, 2017: British Journal of Pharmacology
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