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https://www.readbyqxmd.com/read/28536531/caffeine-and-bicarbonate-for-speed-a-meta-analysis-of-legal-supplements-potential-for-improving-intense-endurance-exercise-performance
#1
REVIEW
Peter M Christensen, Yusuke Shirai, Christian Ritz, Nikolai B Nordsborg
A 1% change in average speed is enough to affect medal rankings in intense Olympic endurance events lasting ~45 s to 8 min which for example includes 100 m swimming and 400 m running (~1 min), 1,500 m running and 4000 m track cycling (~4 min) and 2,000 m rowing (~6-8 min). To maximize the likelihood of winning, athletes utilizes legal supplements with or without scientifically documented beneficial effects on performance. Therefore, a continued systematic evidence based evaluation of the possible ergogenic effects is of high importance...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28536214/safe-administration-of-s-1-after-5-fluorouracil-induced-cardiotoxicity-in-a-patient-with-colorectal-cancer
#2
Caspar Franck, Peter Malfertheiner, Marino Venerito
Cardiotoxicity is a rare but challenging complication of 5-fluorouracil (5-FU) therapy. Compared with 5-FU, after application of S-1 lower plasma levels of the cardiotoxic metabolite alpha-fluoro-beta-alanine have been reported. Evidence for safe administration of S-1 following 5-FU cardiotoxicity is limited to a case report in an Asian patient. Herein we report the first case of S-1 application after 5-FU cardiotoxicity in a Caucasian patient.A 67-year-old man with right-sided metastatic colorectal cancer and history of 5-FU cardiotoxicity had a progressive disease after 8-month therapy with irinotecan and bevacizumab...
May 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28448086/effects-of-running-wheel-activity-and-dietary-hmb-and-%C3%AE-alanine-co-supplementation-on-muscle-quality-in-aged-male-rats
#3
D W Russ, C Acksel, K W McCorkle, N K Edens, S M Garvey
OBJECTIVE: Loss of skeletal muscle function is linked to increased risk for loss of health and independence in older adults. Dietary interventions that can enhance aging muscle function, alone or in combination with exercise, may offer an effective way to reduce these risks. The goal of this study was to evaluate the muscular effects of beta-hydroxy-beta-methylbutyrate (HMB) and beta-alanine (β-Ala) co-supplementation in aged Sprague-Dawley rats with voluntary access to running wheels (RW)...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28448083/are-dietary-supplements-and-nutraceuticals-effective-for-musculoskeletal-health-and-cognitive-function-a-scoping-review
#4
G Iolascon, R Gimigliano, M Bianco, A De Sire, A Moretti, A Giusti, N Malavolta, S Migliaccio, A Migliore, N Napoli, P Piscitelli, G Resmini, U Tarantino, F Gimigliano
OBJECTIVE: The aim of our scoping review was to summarize the state of the art regarding micronutrients in order to identify which of them might effectively improve health status in the areas typically impaired in older people: bone, skeletal muscle, and cognitive function. DESIGN: Scoping review. METHODS: The Italian Study Group on Healthy Aging by Nutraceuticals and Dietary Supplements (HANDS) performed this scoping review, based on the following steps: doing a list of micronutrients related with musculoskeletal or cognitive functions, included in dietary supplements and nutraceuticals commercialized in Italy; planning a research on PubMed, according to an evidence-based approach, in order to the most relevant positive study for each micronutrient into each of the three areas involved (bone, skeletal muscle and cognitive function); identifying the micronutrients effective in maintaining or achieving an adequate health status in older people, specifying the effective and safe daily doses, according to the selected studies...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28442910/targeted-delivery-of-thymosin-beta-4-to-the-injured-myocardium-using-creka-conjugated-nanoparticles
#5
Zheyong Huang, Yanan Song, Zhiqing Pang, Bo Zhang, Hongbo Yang, Hongtao Shi, Jing Chen, Hui Gong, Juying Qian, Junbo Ge
PURPOSE: Thymosin beta 4 (Tβ4) has multiple beneficial facets for myocardial injury, but its efficiency is limited by the low local concentration within the infarct. Here, we established a Tβ4 delivery system for cardiac repair based on the interaction between the abundant fibrin in the infarct zone and the fibrin-targeting moiety clot-binding peptide cysteine-arginine-glutamic acid-lysine-alanine (CREKA). METHODS AND RESULTS: CREKA and Tβ4 were conjugated to nanoparticles (CNP-Tβ4)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28428133/epidemiological-study-of-common-diseases-and-their-risk-factors-in-camels-in-south-punjab-pakistan
#6
Aneela Zameer Durrani, Zubair Bashir, Imran Rasheed, Noor-Ul-Ain Sarwar
Bacteriological study of mastitis along with common blood protozoan diseases were studied in dromedary camels in Cholistan, Dera Ismail Khan and Rahim Yar Khan districts in South Punjab, Pakistan. For this purpose 300 camels were sampled randomly at different common grazing and watering point. For study of blood parasites clinically suspected and apparently healthy camels, 150 each, were sampled. An overall prevalence of 15%and 5% was recorded for trypanosomiasis and Anaplasmosis respectively. Trypanosoma evansi was identified with 280 bp product on polymerase chain reaction test...
April 18, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28428069/assessment-of-non-derivatized-%C3%AE-n-methylamino-l-alanine-bmaa-neurotoxin-in-free-form-in-urine-of-patients-with-nonspecific-neurological-symptoms
#7
L Bláhová, J Kohoutek, E Kadlecová, L Kozáková, L Bláha
The beta-N-methylamino-l-alanine (BMAA) is a non-proteinogenic amino acid discussed to be produced by cyanobacteria forming harmful blooms. Since BMAA is suspected etiological agent in neurodegenerative diseases, there is a need to study and validate whether and in what concentrations can BMAA be present in human tissues. The aim of the present study was to validate analytical and extraction procedures for quantification of non-derivatized BMAA in the urine using liquid chromatography and commercial ELISA Kit...
April 17, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28421415/a-tyrosine-residue-along-with-a-glutamic-acid-of-the-omega-like-loop-governs-the-beta-lactamase-activity-of-msmeg_4455-in-mycobacterium-smegmatis
#8
Ankita Bansal, Debasish Kar, Satya Deo Pandey, Ashok Matcha, N Ganesh Kumar, Soshina Nathan, Anindya S Ghosh
Mycobacterial beta-lactamases are involved in exerting beta-lactam resistance, though many of these proteins remain uncharacterized. Here, we have characterized MSMEG_4455 of Mycobacterium smegmatis as a beta-lactamase using molecular, biochemical and mutational techniques. To elucidate its nature in vivo and in vitro, and to predict its structure-function relationship in silico analysis is done. The MSMEG_4455 is cloned and expressed ectopically in a beta-lactamase deficient Escherichia coli mutant to establish the in vivo beta-lactamase like nature via minimum inhibitory concentration (MIC) determination...
April 19, 2017: Protein Journal
https://www.readbyqxmd.com/read/28420467/-study-of-plasma-amino-acid-related-metabolites-of-septic-rats-using-gas-chromatography-mass-spectrometry
#9
Jin Su, Yimin Zhu, Yu Jiang, Lianhong Zou, Xiaoliang Liu, Yixiao Xu
OBJECTIVE: To reveal the pathophysiological changes of sepsis, the plasma metabonomics of septic rats was determined and differential metabolites were determined by gas chromatography-mass spectrometry (GC-MS). METHODS: Male Spraguee-Dawley (SD) rats about 8 weeks were randomly divided into sham group (n = 18) and sepsis group (n = 24). Cecal ligation and puncture (CLP) was used to build sepsis model, while cecum was kept intact only in the sham group. 6 hours after the operation, rats were anesthetized, and blood was harvested through heart thoracotomy...
April 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28411054/salidroside-protects-rat-liver-against-ischemia-reperfusion-injury-by-regulating-the-gsk-3%C3%AE-nrf2-dependent-antioxidant-response-and-mitochondrial-permeability-transition
#10
Linlin Cai, Yonghua Li, Qingqing Zhang, Haijing Sun, Xiaodi Yan, Tong Hua, Qiufeng Zhu, Haitao Xu, Hailong Fu
Salidroside (Sal) is a natural antioxidant that elicits cardioprotective and neuroprotective effects in vivo and in vitro; however, its impact on hepatic ischemia/reperfusion (I/R) injury remains unclear. The purpose of this study was to investigate the hepatoprotective effects of salidroside against segmental (70%) warm hepatic I/R injury in rats. Animals were randomized into Sham, Sham+salidroside pretreatment (Sal), Sham+Sal+carboxyatractyloside (CATR), Sham+CATR, I/R, I/R+Sal, I/R+Sal+CATR and I/R+CATR groups...
April 12, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28388281/the-vitamin-d-receptor-functional-variant-rs2228570-c-t-does-not-associate-with-type-2-diabetes-mellitus
#11
Laura Bertoccini, Federica Sentinelli, Frida Leonetti, Diego Bailetti, Danila Capoccia, Flavia A Cimini, Ilaria Barchetta, Michela Incani, Andrea Lenzi, Efisio Cossu, M Gisella Cavallo, Marco G Baroni
AIM: Vitamin D acts through the binding to the vitamin D receptor (VDR). Several polymorphisms in VDR gene have been studied. Among these, the rs2228570 C>T (FokI) variant has been demonstrated to be functional, leading to a protein with a different size and activity. So far, genetic studies on the association between VDR gene rs2228570 single nucleotide polymorphism (SNP) and type 2 diabetes mellitus (T2DM) showed contradictory results. Thus, we performed an association study in a large cohort of adult Italian subjects with T2DM and in nondiabetic controls...
April 7, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28365686/chronic-stress-contributes-to-cognitive-dysfunction-and-hippocampal-metabolic-abnormalities-in-app-ps1-mice
#12
Bing Han, Jin-Hua Wang, Yuan Geng, Li Shen, Hua-Long Wang, Yan-Yong Wang, Ming-Wei Wang
BACKGROUND/AIMS: Stress response is determined by the brain, and the brain is a sensitive target for stress. Our previous experiments have confirmed that once the stress response is beyond the tolerable limit of the brain, particularly that of the hippocampus, it will have deleterious effects on hippocampal structure and function; however, the metabolic mechanisms for this are not well understood. METHODS: Here, we used morris water maze, elisa and gas chromatography-time of flight/mass spectrometry to observe the changes in cognition, neuropathology and metabolomics in the hippocampus of APP/PS1 mice and wild-type (C57) mice caused by chronic unpredictable mild stress (CUMS), we also further explored the correlation between cognition and metabolomics...
March 31, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28343993/discovering-key-residues-of-dengue-virus-ns2b-ns3-protease-new-binding-sites-for-antiviral-inhibitors-design
#13
D Aguilera-Pesantes, L E Robayo, P E Méndez, D Mollocana, Y Marrero-Ponce, F J Torres, M A Méndez
The NS2B-NS3 protease is essential for the Dengue Virus (DENV) replication process. This complex constitutes a target for efficient antiviral discovery because a drug could inhibit the viral polyprotein processing. Furthermore, since the protease is highly conserved between the four Dengue virus serotypes, it is probable that a drug would be equally effective against all of them. In this article, a strategy is reported that allowed us to identify influential residues on the function of the Dengue NS2b-NS3 Protease...
March 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28332956/high-urinary-aspartate-aminotransferase-in-the-late-posttransplant-period-predicts-rapid-progressive-decline-in-kidney-allograft-function
#14
Andriy V Trailin, Marina V Pleten, Tatiana I Ostapenko, Nadia F Iefimenko, Olexander S Nikonenko
OBJECTIVES: Scant information is available on factors for predicting the rate of decline in kidney allograft function beyond 1 year posttransplant.We investigated whether urinary enzymes (alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, N-acetyl-β-D-hexosaminidase, and ε-glutamyl transpeptidase) in the late postoperative period can predict the decline in estimated glomerular filtration rate. MATERIALS AND METHODS: In 79 kidney allograft recipients 1 to 17 years after kidney transplant, we assessed a value of urinary enzymes single measurement for predicting the slope of estimated glomerular filtration rate, rapid decline in estimated glomerular filtration rate (> 5 mL/min/1...
March 22, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28332841/effects-of-diet-quality-and-psychosocial-stress-on-the-metabolic-profiles-of-mice
#15
Tatsuhiko Goto, Shozo Tomonaga, Atsushi Toyoda
There has been an increasing interest in relationship between stress and diet. To address this relationship, we evaluated an animal model of depression: male C57BL/6J mice subjected to subchronic mild social defeat stress (sCSDS) for 10 consecutive days using male ICR mice under two different calorie-adjusted diets conditions-nonpurified (MF) and semipurified (AIN) diets made from natural and chemical ingredients mainly, respectively. Our previous study indicates that diet quality and purity affect stress susceptibility in sCSDS mice...
May 5, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28332111/practical-issues-in-evidence-based-use-of-performance-supplements-supplement-interactions-repeated-use-and-individual-responses
#16
REVIEW
Louise M Burke
Current sports nutrition guidelines recommend that athletes only take supplements following an evidence-based analysis of their value in supporting training outcomes or competition performance in their specific event. While there is sound evidence to support the use of a few performance supplements under specific scenarios (creatine, beta-alanine, bicarbonate, caffeine, nitrate/beetroot juice and, perhaps, phosphate), there is a lack of information around several issues needed to guide the practical use of these products in competitive sport...
March 2017: Sports Medicine
https://www.readbyqxmd.com/read/28321835/teriflunomide-for-multiple-sclerosis-in-real-world-setting
#17
M L Elkjaer, T Molnar, Z Illes
OBJECTIVES: Teriflunomide 14 mg is a once-daily oral disease-modifying treatment for relapsing-remitting multiple sclerosis. We examined adverse event (AE) profile and efficacy in real life. MATERIALS AND METHODS: In this observational cohort study, we retrospectively examined 1521 blood samples and data of 102 patients followed for up to 28 months. RESULTS: The number of female patients starting teriflunomide peaked in the fifth decade, 10 years later compared to male patients (P<...
March 20, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28272219/predictive-value-of-serum-alt-and-t-cell-receptor-beta-variable-chain-for-hbeag-seroconversion-in-chronic-hepatitis-b-patients-during-tenofovir-treatment
#18
Jiezuan Yang, Dong Yan, Renyong Guo, Jiajia Chen, Yongtao Li, Jun Fan, Xuyan Fu, Xinsheng Yao, Hongyan Diao, Lanjuan Li
Effective antiviral therapy plays a key role in slowing the progression of chronic hepatitis B (CHB). Identification of serum indices, including hepatitis B e antigen (HBeAg) expression and seroconversion, will facilitate evaluation of the efficacy of antiviral therapy in HBeAg-positive CHB patients. The biochemical, serological, virological parameters, and the frequency of circulating CD4CD25 regulatory T cell (Treg) in 32 patients were measured at baseline and every 12 weeks during 96 weeks of tenofovir disoproxil fumarate (TDF) treatment...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28250654/insulin-plant-costus-pictus-extract-restores-thyroid-hormone-levels-in-experimental-hypothyroidism
#19
S Ashwini, Zachariah Bobby, M G Sridhar, C C Cleetus
BACKGROUND: The aim of the present study was to investigate the preventive effect of Costus pictus leaf extract in experimental hypothyroidism. MATERIALS AND METHODS: Forty male Wistar rats were randomly divided into four groups with ten rats in each group: Control (C), hypothyroid (H), control+extract (C+E), and hypothyroid+extract (H+E). Rats in C group did not receive any intervention throughout the experimental period. The rats in the C+E and H+E groups received pretreatment with C...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28249376/effects-of-a-specific-blend-of-essential-oils-on-apparent-nutrient-digestion-rumen-fermentation-and-rumen-microbial-populations-in-sheep-fed-a-50-50-alfalfa-hay-concentrate-diet
#20
N Khateri, O Azizi, H Jahani-Azizabadi
OBJECTIVE: An experiment was conducted to investigate the effects of a specific mixture of essential oils (MEO), containing thyme, clove and cinnamon EO, on rumen microbial fermentation, nutrient apparent digestibility and blood metabolites in fistulated sheep. METHODS: Six sheep fitted with ruminal fistulas were used in a repeated measurement design with two 24-d periods to investigate the effect of adding MEO at 0 (control), 0.8, and 1.6 mL/d on apparent nutrient digestibility, rumen fermentation characteristics, rumen microbial population and blood chemical metabolites...
March 2017: Asian-Australasian Journal of Animal Sciences
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