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https://www.readbyqxmd.com/read/27918384/twelve-years-of-kawasaki-disease-in-portugal-epidemiology-in-hospitalized-children
#1
Fátima F Pinto, Sérgio Laranjo, Miguel Mota Carmo, Maria João Brito, Rui Cruz Ferreira
BACKGROUND: Kawasaki disease (KD) became the leading cause of acquired heart disease in developed countries. Reported incidences vary worldwide, but it hasn't been established in Portugal. AIM: To describe the epidemiologic characteristics and estimate incidence rates of KD among hospitalized children in Portugal. METHODS: Descriptive, population-based study, using hospital discharge records with KD diagnosis, for patients <20 years selected from the Hospital Register database from 2000-2011...
November 30, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27918378/safety-of-infliximab-following-live-virus-vaccination-in-kawasaki-disease-patients
#2
Aaron M Lee, Jane C Burns, Adriana H Tremoulet
No published data are available regarding infliximab use in Kawasaki Disease (KD) patients with recent live virus vaccination. We investigated 38 acute KD patients who received infliximab within 90 days of receiving MMR, VZV, or Rotavirus vaccines. There were no adverse events or serious infections, which suggests that infliximab use in acute KD patients with recent live viral vaccinations is safe.
December 1, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27893416/the-effect-of-fc%C3%AE-riia-and-fc%C3%AE-riib-on-coronary-artery-lesion-formation-and-intravenous-immunoglobulin-treatment-responses-in-children-with-kawasaki-disease
#3
Ling-Sai Chang, Mao-Hung Lo, Sung-Chou Li, Ming-Yu Yang, Kai-Sheng Hsieh, Ho-Chang Kuo
Previous research has found patients with the FcγRIIIB NA1 variant having increased risk of intravenous immunoglobulin (IVIG) resistance in Kawasaki disease (KD). Our previous studies revealed that elevated FcγRIIA expression correlated with the susceptibility of KD patients. We conducted this research to determine whether and how Fcγ receptors affect the susceptibility, IVIG treatment response, and coronary artery lesions (CAL) of KD patients. The activating FcγRIIA and inhibitory FcγRIIB methylation levels of seven patients with KD and four control subjects were examined using HumanMethylation27 BeadChip...
November 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27889739/concomitant-infections-should-not-deter-clinicians-from-diagnosing-kawasaki-disease
#4
Gowda Parameshwara Prashanth, Ganji Shivalingam
No abstract text is available yet for this article.
November 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27889733/steroid-pulse-therapy-for-kawasaki-disease-complicated-with-myocarditis
#5
Tomomi Sato, Junpei Somura, Yoshihiro Maruo
BACKGROUND: The clinical management of intravenous immunoglobulin-resistant Kawasaki disease shock syndrome (KDSS) is obscure. CASE CHARACTERISTICS: Three children presented with intravenous immunoglobulin-resistant KDSS complicated with myocarditis. OUTCOME: All cases were successfully managed with steroid pulse therapy. MESSAGE: Steroid pulse therapy is effective in immunoglobulin-resistant KDSS.
November 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27889547/clinical-outcomes-of-non-curative-endoscopic-submucosal-dissection-with-negative-resected-margins-r0-resection-for-gastric-cancer
#6
Yosuke Toya, Masaki Endo, Shotaro Nakamura, Risaburo Akasaka, Takashi Kosaka, Shunichi Yanai, Keisuke Kawasaki, Keisuke Koeda, Tamotsu Sugai, Takayuki Matsumoto
BACKGROUND AND AIMS: There has been little information about the long-term outcomes of patients with early gastric cancer (EGC) treated by non-curative endoscopic submucosal dissection (ESD) with negative resected margins (R0 resection). We aimed to compare clinical outcomes of non-curative ESD with R0 resection between patients who underwent additional gastrectomy and those who did not. METHODS: Among EGC patients treated by ESD from 2000 to 2015, 66 patients were treated by non-curative ESD with R0 resection...
November 23, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27881777/temporal-profiling-of-astrocyte-precursors-reveals-parallel-roles-for-asef-during-development-and-after-injury
#7
Lesley S Chaboub, Jeanne M Manalo, Hyun Kyoung Lee, Stacey M Glasgow, Fengju Chen, Yoshihiro Kawasaki, Tetsu Akiyama, Chay T Kuo, Chad J Creighton, Carrie A Mohila, Benjamin Deneen
: Lineage development is a stepwise process, governed by stage-specific regulatory factors and associated markers. Astrocytes are one of the principle cell types in the CNS and the stages associated with their development remain very poorly defined. To identify these stages, we performed gene-expression profiling on astrocyte precursor populations in the spinal cord, identifying distinct patterns of gene induction during their development that are strongly correlated with human astrocytes...
November 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27881022/elevated-serum-ykl-40-levels-in-patients-with-kawasaki-disease
#8
K Y Kim, Y Ahn, D Y Kim, Ho-Seong Kim, D S Kim
CONTEXT: YKL-40 is an inflammatory biomarker for endothelial dysfunction that may have a role in Kawasaki disease (KD). OBJECTIVES: We investigated the association of serum YKL-40 levels with KD and established laboratory parameters for YKL-40 levels and other inflammatory markers. METHODS: YKL-40 levels and other inflammatory markers of 23 KD patients, 9 disease control patients, and 11 age-matched healthy controls. RESULTS: YKL-40 concentration in the serum of KD patients significantly increased during the acute disease phase compared with those of disease controls and healthy controls...
November 24, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27879540/severe-hemolytic-anemia-following-intravenous-immunoglobulin-in-an-infant-with-kawasaki-disease
#9
Vlad Tocan, Akari Inaba, Tamami Kurano, Motoshi Sonoda, Keiji Soebijanto, Hideki Nakayama
Severe hemolytic anemia (HA) is an uncommon adverse reaction of intravenous immunoglobulin (IVIg) administration. Previous reports assume that antibodies contained in IVIg preparations are the cause of hemolysis. We report a 10-month-old infant with Kawasaki disease who was treated with high-dose IVIg and developed severe HA. The patient's Rh blood type was D+C+c+E-e+. He developed anti-C and anti-e antibodies following treatment with IVIg, and, after considering all possible causes of hemolysis, we concluded that this was a case of autoimmune HA induced by immunoglobulin treatment...
November 22, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27879314/genetic-variation-in-the-slc8a1-calcium-signaling-pathway-is-associated-with-susceptibility-to-kawasaki-disease-and-coronary-artery-abnormalities
#10
Chisato Shimizu, Hariklia Eleftherohorinou, Victoria J Wright, Jihoon Kim, Martin P Alphonse, James C Perry, Rolando Cimaz, David Burgner, Nagib Dahdah, Long T Hoang, Chiea-Chuen Khor, Andrea Salgado, Adriana H Tremoulet, Sonia Davila, Taco W Kuijpers, Martin L Hibberd, Todd A Johnson, Atsushi Takahashi, Tatsuhiko Tsunoda, Michiaki Kubo, Toshihiro Tanaka, Yoshihiro Onouchi, Rae S M Yeung, Lachlan J M Coin, Michael Levin, Jane C Burns
BACKGROUND: -Kawasaki disease (KD) is an acute pediatric vasculitis in which host genetics influence both susceptibility to KD and the formation of coronary artery aneurysms. Variants discovered by genome-wide association studies (GWAS) and linkage studies only partially explain the influence of genetics on KD susceptibility. METHODS AND RESULTS: -To search for additional functional genetic variation, we performed pathway and gene stability analysis on a GWAS dataset...
November 21, 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/27878631/difference-in-risk-factors-for-subtypes-of-acute-cardiac-lesions-resulting-from-kawasaki-disease
#11
Maho Yamashita, Ryusuke Ae, Mayumi Yashiro, Yasuko Aoyama, Takashi Sano, Nobuko Makino, Yosikazu Nakamura
Few studies discuss the risk factors for acute cardiac lesions (within 30 days) resulting from Kawasaki disease (KD). We aimed to clarify the characteristics of patients with cardiac lesions within 30 days and determine the risk factors for acute cardiac lesion subtypes. Using the 23rd nationwide survey of KD in Japan, we analyzed data from patients with or without acute cardiac lesions resulting from KD (n = 31,380). We subdivided patients with acute cardiac lesions into three types: acute valvular lesions, coronary aneurysms, and giant coronary aneurysms (GCA), and calculated the odds ratios of potential risk factors for acute cardiac lesion subtypes...
November 23, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27872783/multimodality-cardiac-imaging-in-a-patient-with-kawasaki-disease-and-giant-aneurysms
#12
Ranjini Srinivasan, Rachel Weller, Anjali Chelliah, Andrew J Einstein
Kawasaki disease is a well-known cause of acquired cardiac disease in the pediatric and adult population, most prevalent in Japan but also seen commonly in the United States. In the era of intravenous immunoglobulin (IVIG) treatment, the morbidity associated with this disease has decreased, but it remains a serious illness. Here we present the case of an adolescent, initially diagnosed with Kawasaki disease as an infant, that progressed to giant aneurysm formation and calcification of the coronary arteries...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27869740/functional-role-of-the-c-terminal-amphipathic-helix-8-of-olfactory-receptors-and-other-g-protein-coupled-receptors
#13
REVIEW
Takaaki Sato, Takashi Kawasaki, Shouhei Mine, Hiroyoshi Matsumura
G protein-coupled receptors (GPCRs) transduce various extracellular signals, such as neurotransmitters, hormones, light, and odorous chemicals, into intracellular signals via G protein activation during neurological, cardiovascular, sensory and reproductive signaling. Common and unique features of interactions between GPCRs and specific G proteins are important for structure-based design of drugs in order to treat GPCR-related diseases. Atomic resolution structures of GPCR complexes with G proteins have revealed shared and extensive interactions between the conserved DRY motif and other residues in transmembrane domains 3 (TM3), 5 and 6, and the target G protein C-terminal region...
November 18, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27867414/the-role-of-family-variables-in-the-length-of-stay-of-psychiatric-in-patients
#14
Satoko Yoneyama, Yudo Makita, Keiko Miyazu, Kazuhiko Katsukawa, Eiichi Yoneyama, Shinji Masuda, Yukiko Nakajima, Yasuhiro Kawasaki, Kenji Miyazu
BACKGROUND: In Japan, the number of beds and average length of stay in a psychiatric ward are greater than in other developed countries. OBJECTIVE: The present study aimed to investigate the association between family variables and the length of stay of patients with mental and behavioural disorders in a private psychiatric hospital in Japan. METHODS: The medical records of patients discharged during a one-year period (n=56: men 50.0% excepting 27 patients discharged due to death were re-examined regarding age, laundry type (self-washing of clothes, family washing or supplier washing), number of family visits per one month while hospitalised, and family structure prior to hospitalisation...
2016: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/27867156/transcriptional-analysis-of-intravenous-immunoglobulin-resistance-in-kawasaki-disease-using-an-induced-pluripotent-stem-cell-disease-model
#15
Kazuyuki Ikeda, Yasutaka Mizoro, Tomonaga Ameku, Yui Nomiya, Shin-Ichi Mae, Satoshi Matsui, Yuki Kuchitsu, Chinatsu Suzuki, Akiko Hamaoka-Okamoto, Tomoyo Yahata, Masakatsu Sone, Keisuke Okita, Akira Watanabe, Kenji Osafune, Kenji Hamaoka
BACKGROUND: Approximately 10-20% of Kawasaki disease (KD) patients are resistant to intravenous immunoglobulin (IVIG) treatment. Further, these patients are at a particularly high risk of having coronary artery abnormalities. The mechanisms of IVIG resistance in KD have been analyzed using patient leukocytes, but not patient vascular endothelial cells (ECs). The present study clarifies the mechanisms of IVIG resistance in KD using an induced pluripotent stem cell (iPSC) disease model...
November 19, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27863715/kawasaki-disease-and-immunisation-standardised-case-definition-guidelines-for-data-collection-analysis
#16
Linny Kimly Phuong, Caterina Bonetto, Jim Buttery, Yolanda Brauchli Pernus, Rebecca Chandler, Karen L Goldenthal, Merita Kucuku, Giuseppe Monaco, Barbara Pahud, Stanford T Shulman, Karina A Top, Rolando Ulloa-Gutierrez, Frederick Varricchio, Sarah de Ferranti, Jane W Newburger, Nagib Dahdah, Surjit Singh, Jan Bonhoeffer, David Burgner
No abstract text is available yet for this article.
December 12, 2016: Vaccine
https://www.readbyqxmd.com/read/27857465/unusual-imaging-presentation-of-infantile-atypical-kawasaki-disease
#17
Nishith Kumar, Mahesh Kumar Mittal, Mukul Sinha, Arpita Gupta, Brij Bhushan Thukral
Kawasaki disease is a systemic medium vessel vasculitis of unknown etiology affecting children under 5 years of age. There are no specific diagnostic tests, and thus, the diagnosis of the disease is primarily made on the basis of clinical criteria. Unusual presentations of Kawasaki disease have been variably reported from different parts of the world. However, presentation of the disease in the form of peripheral thromboembolism and florid non-coronary aneurysms has rarely been described This report describes the imaging findings in infantile atypical Kawasaki disease with aneurysms of multiple medium-sized arteries, including coronary arteries, emphasizing the detection of clinically silent aneurysms in the disease...
July 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/27855316/a-high-fat-diet-temporarily-renders-sod1-deficient-mice-resistant-to-an-oxidative-insult
#18
Junitsu Ito, Naoki Ishii, Ryusuke Akihara, Jaeyong Lee, Toshihiro Kurahashi, Takujiro Homma, Ryo Kawasaki, Junichi Fujii
Patients with nonalcoholic fatty liver disease may subsequently develop nonalcoholic steatohepatitis after suffering from a second insult, such as oxidative stress. Aim of this study was to investigate the pathogenesis of the liver injury caused when lipids accumulate under conditions of intrinsic oxidative stress using mice that are deficient in superoxide dismutase 1 (SOD1) and the leptin receptor (Lepr). We established Sod1(-/-)::Lepr(db/db) mice and carried out analyses of four groups of genetically modified mice, namely, wild type, Sod1(-/-), Lepr(db/db) and Sod1(-/-)::Lepr(db/db) mice...
November 3, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27851085/1449-clinical-comparison-of-kawasaki-disease-shock-syndrome-and-septic-shock-in-the-picu
#19
Joseph Treister, Jennifer Foley, Helen Harvey, Adriana Tremoulet, Susan Duthie, Jane Burns
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27829665/the-role-of-common-protective-alleles-hla-drb1-13-among-systemic-autoimmune-diseases
#20
REVIEW
H Furukawa, S Oka, N Tsuchiya, K Shimada, A Hashimoto, S Tohma, A Kawasaki
Associations between human leukocyte antigen (HLA) and susceptibility to systemic autoimmune diseases have been reported. The predisposing alleles are variable among ethnic groups and/or diseases. On the other hand, some HLA alleles are associated with resistance to systemic autoimmune diseases, including systemic sclerosis, systemic lupus erythematosus and rheumatoid arthritis. Interestingly, DRB1*13 alleles are the protective alleles shared by multiple autoimmune diseases. DRB1*13:01 allele is protective in European populations and DRB1*13:02 in Japanese...
November 10, 2016: Genes and Immunity
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