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https://www.readbyqxmd.com/read/29046034/-neurological-manifestations-in-atypical-kawasaki-disease
#1
Edgar Martínez-Guzmán, Luisa Berenise Gámez-González, Francisco Rivas-Larrauri, Giovanni Sorcia-Ramírez, Marco Yamazaki-Nakashimada
BACKGROUND: Kawasaki disease (KD) is a type of systemic vasculitis of unknown etiology. Atypical Kawasaki disease is defined as that where there are signs and symptoms not corresponding to the classical criteria for this nosological entity. Children with atypical Kawasaki disease may present with acute abdominal symptoms, meningeal irritation, pneumonia or renal failure. CLINICAL CASES: We describe 4 children with ages ranging from 2 to 12 years who had atypical Kawasaki disease, with neurological and gastrointestinal symptoms as part of the systemic presentation of the disease...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29040156/accelerated-atheromatosis-and-arteriosclerosis-in-primary-systemic-vasculitides-current-evidence-and-future-perspectives
#2
Ourania D Argyropoulou, Athanase D Protogerou, Petros P Sfikakis
PURPOSE OF REVIEW: Primary systemic vasculitides (PSV) encompass a subset of autoimmune diseases, characterized by inflammation of blood vessels. Atheromatosis and arteriosclerosis may be accelerated in several PSV and account for the increased rate of cardiovascular morbidity that some exhibit. We aimed to summarize recent studies reporting on the acceleration of atheromatosis and/or arteriosclerosis in each type of PSV, using state-of-the-art noninvasive vascular biomarkers with clinical value as end points...
October 16, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29038039/hysteroscopic-transcervical-resection-for-atypical-polypoid-adenomyoma-of-the-uterus-a-valid-fertility-preserving-option
#3
Tatsuyuki Chiyoda, Bao-Liang Lin, Keiko Saotome, Shunki Kiyokawa, Sakura Nakada
STUDY OBJECTIVE: To evaluate hysteroscopic transcervical resection (TCR) for atypical polypoid adenomyoma of the uterus (APA). DESIGN: Retrospective study (Canadian Task Force classification II-2). SETTING: Single tertiary hospital. PATIENTS: Women who underwent TCR for APA at Kawasaki Municipal Hospital between 2003 and 2015. INTERVENTIONS: Clinical records were obtained. MEASUREMENTS AND MAIN RESULTS: Thirty-five APA cases were evaluated...
October 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29036979/-role-of-ash2-absent-small-or-homeotic-like-and-jumonji-domain-containing-protein-3-on-histone-methylation-of-interferon-gamma-gene-and-their-associations-with-vascular-damage-of-kawasaki-disease
#4
J H Mei, G Tang, Q Wang, P Q Wen, M G Xu, D Cui, D L Ma, C Liu, G B Wang
Objective: To investigate the impacts of ash2 (absent, small, or homeotic)-like (Ash2L) and Jumonji domain-containing protein 3 (Jmjd3) on histone methylation of interferon-gamma(IFN-γ) gene and association with vascular damage of Kawasaki disease (KD) in acute phase. Methods: This study was performed among 36 children with KD in acute phase (KD group) and 28 age-matched health children (control group), who were treated or underwent physical examination in our hospital between February 2015 and June 2016. Patients were further divided into KD groups with or without coronary artery lesions (KD-CAL(+) , 16 cases; KD-CAL(-), 20 cases)...
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29036461/mechanisms-to-protect-the-privacy-of-families-when-using-the-transmission-disequilibrium-test-in-genome-wide-association-studies
#5
Meng Wang, Zhanglong Ji, Shuang Wang, Jihoon Kim, Hai Yang, Xiaoqian Jiang, Lucila Ohno-Machado
Motivation: Inappropriate disclosure of human genomes may put the privacy of study subjects and of their family members at risk. Existing privacy-preserving mechanisms for Genome-Wide Association Studies (GWAS) mainly focus on protecting individual information in case-control studies. Protecting privacy in family-based studies is more difficult. The transmission disequilibrium test (TDT) is a powerful family-based association test employed in many rare disease studies. It gathers information about families (most frequently involving parents, affected children and their siblings)...
July 21, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29033763/multiple-small-intestine-ulcers-with-desquamation-of-the-fingers
#6
Azusa Kawasaki, Kunihiro Tsuji, Hisashi Doyama
A 73-year-old female was admitted to our hospital with abdominal pain and diarrhea. Computed tomography detected distension of the small intestine. A palmar erythema, multiple oral ulcers, and desquamation of the fingers appeared after hospitalization. Small-bowel endoscopic images showed multiple ulcers. We attributed this case to infection with Yersinia pseudotuberculosis based on the changes in Y. pseudotuberculosis antibody titers throughout the course of the illness. This report is valuable, as it illustrates the endoscopic characteristics of a Y...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29027525/-gigantic-aneurysm-of-the-coronary-artery
#7
P V Chumachenko, M A Afanasyev, I E Galankina, L N Ilyina, A Yu Postnov
The paper describes a clinical case of gigantic aneurysm of one of the coronary arteries. It considers the morphological and immunohistochemical characteristics of the wall of the blood vessel with the detected signs of coronaritis. The authors have determined that Kawasaki disease could be retrospectively diagnosed in early childhood.
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/29025763/one-size-does-not-fit-all-genetic-prediction-of-kawasaki-disease-treatment-response-in-diverse-populations
#8
EDITORIAL
Michael A Portman, Sadeep Shrestha
No abstract text is available yet for this article.
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29025760/prediction-for-intravenous-immunoglobulin-resistance-by-using-weighted-genetic-risk-score-identified-from-genome-wide-association-study-in-kawasaki-disease
#9
Ho-Chang Kuo, Henry Sung-Ching Wong, Wei-Pin Chang, Ben-Kuen Chen, Mei-Shin Wu, Kuender D Yang, Kai-Sheng Hsieh, Yu-Wen Hsu, Shih-Feng Liu, Xiao Liu, Wei-Chiao Chang
BACKGROUND: Intravenous immunoglobulin (IVIG) is the treatment of choice in Kawasaki disease (KD). IVIG is used to prevent cardiovascular complications related to KD. However, a proportion of KD patients have persistent fever after IVIG treatment and are defined as IVIG resistant. METHODS AND RESULTS: To develop a risk scoring system based on genetic markers to predict IVIG responsiveness in KD patients, a total of 150 KD patients (126 IVIG responders and 24 IVIG nonresponders) were recruited for this study...
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29019754/abnormalities-of-the-coronary-arteries-in-children-looking-beyond-the-origins
#10
Lauren J Saling, Demetrios A Raptis, Keyur Parekh, Toby A Rockefeller, Elizabeth F Sheybani, Sanjeev Bhalla
Coronary arterial abnormalities are uncommon findings in children that have profound clinical implications. Although anomalies of the coronary origins are well described, there are many other disease processes that affect the coronary arteries. Immune system-mediated diseases (eg, Kawasaki disease, polyarteritis nodosa, and other vasculiditides) can result in coronary arterial aneurysms, strictures, and abnormal tapering of the vessels. Because findings at imaging are an important component of diagnosis in these diseases, the radiologist's understanding of them is essential...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28993368/complete-kawasaki-disease-kd-with-peculiar-skin-manifestations
#11
Dimitri Poddighe
No abstract text is available yet for this article.
October 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28991104/international-consensus-statement-on-the-clinical-and-therapeutic-management-of-leber-s-hereditary-optic-neuropathy
#12
Valerio Carelli, Michele Carbonelli, Irenaeus F de Coo, Aki Kawasaki, Thomas Klopstock, Wolf A Lagrèze, Chiara La Morgia, Nancy J Newman, Christophe Orssaud, Jan Willem R Pott, Alfredo A Sadun, Judith van Everdingen, Catherine Vignal-Clermont, Marcela Votruba, Patrick Yu-Wai-Man, Piero Barboni
Leber hereditary optic neuropathy (LHON) is currently estimated as the most frequent mitochondrial disease (1 in 27,000-45,000). Its molecular pathogenesis and natural history is now fairly well understood. LHON also is the first mitochondrial disease for which a treatment has been approved (idebenone-Raxone, Santhera Pharmaceuticals) by the European Medicine Agency, under exceptional circumstances because of the rarity and severity of the disease. However, what remains unclear includes the optimal target population, timing, dose, and frequency of administration of idebenone in LHON due to lack of accepted definitions, criteria, and general guidelines for the clinical management of LHON...
October 3, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28986895/determination-of-mirnas-from-cancer-stem-cells-using-a-low-density-array-platform
#13
Hiromichi Kawasaki, Angela Lombardi, Michele Caraglia
A microarray approach has been extensively used for global gene expression profiles in many biological research fields such as understanding of pathological mechanism in malignancies and defining of molecular biomarkers to monitor disease status. The most attractive advantage of microarray technology is its application to simultaneous analysis of miRNA expression pattern with a large amount of assessments. In this chapter, we provide a facile and universal protocol for divergent miRNA expression profiles in prostate cancer stem cells with a low density array-based microarray analysis...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28985704/extracorporeal-membrane-oxygenation-for-kawasaki-disease-two-case-reports-and-the-extracorporeal-life-support-organization-experience-1999-2015
#14
Derek Best, Johnny Millar, Igor Kornilov, Yury Sinelnikov, Roberto Chiletti, Peter Rycus, Warwick Butt
Kawasaki disease is usually a limited illness of early childhood. However, life-threatening cardiac manifestations can occur, either at acute presentation or as a consequence of coronary arterial involvement. We report the successful use of veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) for cardiac support in two children with Kawasaki disease: one with acute Kawasaki disease shock syndrome, the other with complications of coronary arteritis and subsequent surgery. We also reviewed the reported experience in the ELSO database and available literature...
October 2017: Perfusion
https://www.readbyqxmd.com/read/28980895/systemic-onset-juvenile-idiopathic-arthritis-and-incomplete-kawasaki-disease-may-belong-to-a-single-clinical-syndrome-within-a-spectrum-of-severity
#15
Seung Beom Han, Soo Young Lee
No abstract text is available yet for this article.
October 5, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28977831/epigenetic-hypomethylation-and-upregulation-of-matrix-metalloproteinase-9-in-kawasaki-disease
#16
Ho-Chang Kuo, Sung-Chou Li, Lien-Hung Huang, Ying-Hsien Huang
BACKGROUND: Kawasaki disease (KD) is a type of febrile coronary vasculitis occurring in children. Some researchers have suggested that changes in genetic signatures, such as matrix metalloproteinases (MMPs), are critical markers for cardiovascular diseases. This study aims to provide a comprehensive survey of global DNA methylation levels and MMP transcripts of KD patients compared to control subjects. MATERIALS AND METHODS: For chips studies, we recruited a total of 18 KD patients, prior to receiving intravenous immunoglobulin (IVIG) and at least 3 weeks after IVIG treatment, as well as 18 healthy and 18 febrile control subjects...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28966687/screening-of-differentially-expressed-genes-associated-with-kawasaki-disease-by-microarray-analysis
#17
Jie Jiang, Yi Cai, Zhuoying Li, Lihua Huang, Jia Chen, Lang Tian, Zhixiang Wu, Xin Li, Zhiheng Chen, Chunyuan Chen, Zuocheng Yang
Kawasaki disease (KD) is an autoimmune disorder that can induce coronary artery aneurysms, particularly in the case of delayed diagnosis and/or treatment. Early diagnosis is important for treatment and reduces the risk of heart injury. The aim of the present study was to identify differentially expressed genes by comparing the levels of gene expression in human umbilical vein endothelial cells following treatment with plasma from healthy individuals and patients with acute or convalescent KD. Following comparison of the control and acute KD groups, 385 up-regulated and 537 down-regulated genes were identified in the acute KD group...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28960680/low-risk-of-treatment-resistance-in-down-syndrome-with-kawasaki-disease
#18
Shinichi Takatsuki, Shohei Ogata, Masahiro Ishii, Masato Yokozawa, Masae Ono, Masako Fujiwara, Hiroyuki Ida, Hideki Motomura, Hiroyuki Moriuchi, Mio Taketazu, Yoichi Kawamura, Tatsuya Kawano, Tatsuro Izumi, Junko Shiono, Shiro Tsuchiya, Keiji Tsuchiya, Terufumi Goushi, Fukiko Ichida, Tsutomu Saji
BACKGROUND: Japanese nationwide survey reported that Down syndrome (DS) is less-frequently occurring comorbidity in Kawasaki disease (KD). Although altered immune responses are frequently observed in DS, no studies have focused treatment response and risk for coronary artery abnormalities (CAAs) in DS with KD. The aim of this study was to evaluate clinical manifestations, treatment response and proportion of CAAs in DS with KD. METHODS: We retrospectively reviewed the medical records of DS with KD from 2005 through 2012...
September 27, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28960037/myocardial-assessment-in-school-aged-children-with-past-kawasaki-disease
#19
Heeyoung Lee, Jaeeun Shin, Lucy Eun
Coronary artery involvement remains the most important complication with Kawasaki disease (KD). Additional myocardial injury can be caused by inflammatory response and ischemic event. However, the long-term outcome of myocardial function has not been fully known in KD. The purpose of this study is to evaluate myocardial function in school-aged children who had the past history of KD. Sixty-seven children in the second grade of elementary schools, who had the past history of KD, were included. Echocardiographic measurements of each coronary artery and myocardial function were obtained as the long-term follow-up data, and compared with the baseline data at the time of initial presentation of KD...
November 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28957963/an-update-on-the-role-of-epigenetics-in-systemic-vasculitis
#20
Patrick Coit, Haner Direskeneli, Amr H Sawalha
PURPOSE OF REVIEW: The purpose of this review is to discuss recent observations of epigenetic changes related to the complex pathogenesis of systemic vasculitides and their contribution to the field. RECENT FINDINGS: There have been new observations of epigenetic changes in vasculitis and their potential role in disease pathogenesis in antineutrophil cytoplasmic antibody-associated vasculitis, giant-cell arteritis, Kawasaki disease, Behçet's disease, and IgA vasculitis...
September 27, 2017: Current Opinion in Rheumatology
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