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Red blood cells and pathology

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https://www.readbyqxmd.com/read/29898202/association-of-perioperative-red-blood-cell-transfusions-with-venous-thromboembolism-in-a-north-american-registry
#1
Ruchika Goel, Eshan U Patel, Melissa M Cushing, Steven M Frank, Paul M Ness, Clifford M Takemoto, Ljiljana V Vasovic, Sujit Sheth, Marianne E Nellis, Beth Shaz, Aaron A R Tobian
Importance: Increasing evidence supports the role of red blood cells (RBCs) in physiological hemostasis and pathologic thrombosis. Red blood cells are commonly transfused in the perioperative period; however, their association with postoperative thrombotic events remains unclear. Objective: To examine the association between perioperative RBC transfusions and postoperative venous thromboembolism (VTE) within 30 days of surgery. Design, Setting, and Participants: This analysis used prospectively collected registry data from the American College of Surgery National Surgical Quality Improvement Program (ACS-NSQIP) database, a validated registry of 525 teaching and nonteaching hospitals in North America...
June 13, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29894675/-features-of-red-blood-indexes-in-elderly-patients-with-ischemic-heart-disease-and-pathology-of-heart-valves-before-and-after-surgical-correction
#2
L A Nikolenko, E S Shopova, E S Golovneva, E S Nikolenko
Due to current options of cardiac surgery, operations on the heart of elderly patients have become routine in specialized cardiosurgical centers. The issue of pre- and postoperative anemia of different nature is essential in surgical correction of heart valves and coronary bypass. AIM: To study indexes of red blood in elderly patients with ischemic heart disease (IHD) and pathology of heart valves before and after surgical correction, including the relationship with position and type of the prosthesis...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29884179/expression-kinetics-of-natural-resistance-associated-macrophage-protein-nramp-genes-in-salmonella-typhimurium-infected-chicken
#3
Mashooq Ahmad Dar, Raashid Ahmed, Uneeb Urwat, Syed Mudasir Ahmad, Pervaiz Ahmad Dar, Zahid Amin Kushoo, Tanveer Ali Dar, Peerzada Tajamul Mumtaz, Shakil Ahmad Bhat, Umar Amin, Nadeem Shabir, Hina Fayaz Bhat, Riaz Ahmad Shah, Nazir Ahmad Ganai, Mohammad Heidari
BACKGROUND: Salmonella enterica serovar Typhimurium (Salmonella Typhimurium) is a zoonotic pathogen responsible for severe intestinal pathology in young chickens. Natural resistance-associated macrophage protein (NRAMP) family has been shown to be associated with resistance to intracellular pathogens, including Salmonella Typhimurium. The role of NRAMP proteins in macrophage defence against microbial infection has been ascribed to changes in the metal-ion concentrations inside the bacteria-containing phagosomes...
June 8, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29867516/on-the-effects-of-reactive-oxygen-species-and-nitric-oxide-on-red-blood-cell-deformability
#4
Lukas Diederich, Tatsiana Suvorava, Roberto Sansone, T C Stevenson Keller, Frederik Barbarino, Thomas R Sutton, Christian M Kramer, Wiebke Lückstädt, Brant E Isakson, Holger Gohlke, Martin Feelisch, Malte Kelm, Miriam M Cortese-Krott
The main function of red blood cells (RBCs) is the transport of respiratory gases along the vascular tree. To fulfill their task, RBCs are able to elastically deform in response to mechanical forces and, pass through the narrow vessels of the microcirculation. Decreased RBC deformability was observed in pathological conditions linked to increased oxidative stress or decreased nitric oxide (NO) bioavailability, like hypertension. Treatments with oxidants and with NO were shown to affect RBC deformability ex vivo , but the mechanisms underpinning these effects are unknown...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29850568/local-hematocrit-fluctuation-induced-by-malaria-infected-red-blood-cells-and-its-effect-on-microflow
#5
Tong Wang, Zhongwen Xing
We investigate numerically the microscale blood flow in which red blood cells (RBCs) are partially infected by Plasmodium falciparum , the malaria parasite. The infected RBCs are modeled as more rigid cells with less deformability than healthy ones. Our study illustrates that, in a 10  μ m microvessel in low-hematocrit conditions (18% and 27%), the Plasmodium falciparum -infected red blood cells ( Pf -IRBCs) and healthy ones first form a train of cells. Because of the slow moving of the Pf -IRBCs, the local hematocrit ( H ct ) near the Pf -IRBCs is then increased, to approximately 40% or even higher values...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29806773/selective-substrates-and-activity-based-probes-for-imaging-of-the-human-constitutive-20s-proteasome-in-cells-and-blood-samples
#6
Wioletta Rut, Marcin Poreba, Paulina Kasperkiewicz, Scott J Snipas, Marcin Drag
The proteasome is an enzyme complex critical for maintaining protein homeostasis. Perturbed proteasome function leads to pathologies including cancer, autoimmune and neurodegenerative disease. Therefore, the proteasome constitutes an excellent molecular target for pharmaceutical development. Here, using the HyCoSuL approach we designed and synthesized novel and selective fluorogenic substrates for each of these three constitutive 20S proteasome activities and applied them to assess inhibition of proteasome subunits by MG-132 and a clinically-used inhibitor bortezomib...
May 28, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29786814/predictive-value-of-preoperative-neutrophil-to-lymphocyte-ratio-while-detecting-bowel-resection-in-hernia-with-intestinal-incarceration
#7
Hande Köksal, Derviş Ateş, Emet Ebru Nazik, İlknur Küçükosmanoğlu, Serap Melek Doğan, Osman Doğru
BACKGROUND: The aim of this study was to evaluate the relationship between preoperative hematological inflammatory markers of the patients who underwent a surgery for incarcerated hernia and intestinal resection requirement. METHODS: The data of 102 patients who underwent a surgery for incarcerated hernia were retrospectively evaluated. Whole blood cell counts were preoperatively measured, and operation types and pathology results were recorded. The patients with intestinal resections were compared with those without any resection in terms of leukocyte number, neutrophil rate, red cell distribution width (RDW), platelet distribution width, neutrophil-to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV)...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29776631/molecular-pathology-in-transfusion-medicine-new-concepts-and-applications
#8
REVIEW
Matthew B Elkins, Robertson D Davenport, Martin H Bluth
Virtually all the red blood cell and platelet antigen systems have been characterized at the molecular level. Highly reliable methods for red blood cell and platelet antigen genotyping are now available. Genotyping is a useful adjunct to traditional serology and can help resolve complex serologic problems. Although red blood cell and platelet phenotypes can be inferred from genotype, knowledge of the molecular basis is essential for accurate assignment. Genotyping of blood donors is an effective method of identifying antigen-negative and/or particularly rare donors...
June 2018: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/29760995/intravital-imaging-of-a-pulmonary-endothelial-surface-layer-in-a-murine-sepsis-model
#9
Inwon Park, Kibaek Choe, Howon Seo, Yoonha Hwang, Eunjoo Song, Jinhyo Ahn, You Hwan Jo, Pilhan Kim
Direct intravital imaging of an endothelial surface layer (ESL) in pulmonary microcirculation could be a valuable approach to investigate the role of a vascular endothelial barrier in various pathological conditions. Despite its importance as a marker of endothelial cell damage and impairment of the vascular system, in vivo visualization of ESL has remained a challenging technical issue. In this work, we implemented a pulmonary microcirculation imaging system integrated to a custom-design video-rate laser scanning confocal microscopy platform...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29747626/differential-plasma-microvesicle-and-brain-profiles-of-microrna-in-experimental-cerebral-malaria
#10
Amy Cohen, Anna Zinger, Natalia Tiberti, Georges E R Grau, Valery Combes
BACKGROUND: Cerebral malaria (CM) is a fatal complication of Plasmodium infection, mostly affecting children under the age of five in the sub-Saharan African region. CM pathogenesis remains incompletely understood, although sequestered infected red blood cells, inflammatory cells aggregating in the cerebral blood vessels, and the microvesicles (MV) that they release in the circulation, have been implicated. Plasma MV numbers increase in CM patients and in the murine model, where blocking their release, genetically or pharmacologically, protects against brain pathology, suggesting a role of MV in CM neuropathogenesis...
May 11, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29733827/successful-use-of-sternal-sparing-minimally-invasive-surgery-for-proximal-ascending-aortic-pathology
#11
Joseph Lamelas, Peter C Chen, Gabriel Loor, Angelo LaPietra
BACKGROUND: A sternal-sparing approach to surgery of the proximal aorta could decrease postoperative morbidity. METHODS: To determine the potential benefits of using a minimally invasive right thoracotomy approach for the treatment of ascending aortic pathology, we retrospectively reviewed our experience in patients who required circulatory arrest for the treatment of ascending aortic pathology (with or without aortic valve involvement) between January 2009 and November 2014 (N=177)...
May 4, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29731579/evaluation-of-magnesium-levels-in-blood-and-saliva-of-oral-squamous-cell-carcinoma-and-potentially-malignant-disorders-by-xylidyl-blue-method
#12
Niloufa Z Aziz, K Arathi, B Ganesh Prasad, Dinkar Desai, Sharan J Shetty, Mohammed Shahid
Background: Cancer is Latinized from Greek word 'karkinos' meaning crab, denoting how carcinoma extends its claws like a crab into adjacent tissues. It has been well established by researchers that virtually all oral cancer are preceded by visible clinical changes in the oral mucosa usually in the form of white or red patch (two-step process of cancer development). Mg is an essential mineral that is needed for a broad variety of physiological functions. Imbalances in Mg metabolism are common and are associated with different pathological conditions...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29729152/features-of-vascular-dermatoscopic-component-in-various-morphological-types-of-epidermal-dysplasia
#13
Оlena О Оshyvalova
OBJECTIVE: Introduction: Dermatologists of many foreign countries have been successfully using and developing dermatoscopy as a method of early diagnosis of skin tumors for three decades. It is believed that the vascular dermatoscopiccomponent is a promising criterion for the diagnosis of epidermal dysplasia of the skin and can be used for differential diagnosis. The aim of the work was to study the features of the vascular dermatoscopic component in actinic keratosis (AK), non-invasive (squamous cell carcinoma in situ-SCCis) and invasive forms of squamous cell carcinoma (cSCC)...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29727323/selected-case-from-the-arkadi-m-rywlin-international-pathology-slide-club-peritoneal-lipofuscinosis-and-deciduosis-in-pregnancy
#14
Dimuth N Gunawardane, Philip W Allen
Peritoneal lipofuscinosis is a very rarely recognized condition occurring during pregnancy characterized by brown pigmentation of the omentum and peritoneum, a decidual reaction and benign mesothelial cells. The iron negative pigment, which is likely to be confused with hemosiderin in the hematoxylin and eosin stain, is lipofuscin. The seminar case, apparently the third published, arose in a 37-year-old woman who presented in October 2015 at 24 weeks pregnancy with abdominal pain. Investigations revealed a ruptured left ovarian cyst and rising serum carcinoembryonic antige levels...
April 30, 2018: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/29704448/establishment-of-new-complete-blood-count-reference-values-for-healthy-thai-adults
#15
P Wongkrajang, W Chinswangwatanakul, C Mokkhamakkun, N Chuangsuwanich, B Wesarachkitti, B Thaowto, S Laiwejpithaya, O Komkhum
INTRODUCTION: Laboratory reference ranges are essential for diagnostic orientation and treatment decision. As complete blood count parameters are influenced by various factors, including gender, geographic origin, and ethnic origin, it is important to establish specific hematologic reference values for specific populations. METHODS: This study was conducted at the Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand...
April 28, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29704205/analysis-of-the-relationship-between-hemorheologic-parameters-aluminum-manganese-and-selenium-in-smokers
#16
Fatma Ates Alkan, Denizhan Karis, Gulfidan Cakmak, Alev Meltem Ercan
Smoking is a significant risk factor in fatal pathologies including cardio-cerebrovascular and respiratory diseases. Aluminum (Al) is a toxic element without known biological function, but with recognized toxic effects. Manganese (Mn) and selenium (Se) are essential trace elements involved in cellular antioxidant defense mechanisms. Al, Mn, and Se carry out their metabolic activities via blood flow and tissue oxygenation. The structure and number of red blood cells (RBC) play important role in tissue oxygenation throughout blood flow...
April 27, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29700351/cytokine-storms-are-primarily-responsible-for-the-rapid-death-of-ducklings-infected-with-duck-hepatitis-a-virus-type-1
#17
Jinyan Xie, Mingshu Wang, Anchun Cheng, Xin-Xin Zhao, Mafeng Liu, Dekang Zhu, Shun Chen, Renyong Jia, Qiao Yang, Ying Wu, Shaqiu Zhang, Yunya Liu, Yanling Yu, Ling Zhang, Kunfeng Sun, Xiaoyue Chen
Duck hepatitis A virus type 1 (DHAV-1) is one of the most harmful pathogens in the duck industry. The infection of adult ducks with DHAV-1 was previously shown to result in transient cytokine storms in their kidneys. To understand how DHAV-1 infection impacts the host liver, we conducted animal experiments with the virulent CH DHAV-1 strain and the attenuated CH60 commercial vaccine strain. Visual observation and standard hematoxylin and eosin staining were performed to detect pathological damage in the liver, and viral copy numbers and cytokine expression in the liver were evaluated by quantitative PCR...
April 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29686511/effects-of-scrambling-trumpet-creeper-flavone-on-transient-cerebral-ischemia-model-tia-in-rats
#18
Mingsan Miao, Xu Zhang, Fan Zhang, Can Wang, Xiaoyan Fang, Ming Bai, Cuishan Xu, Leshang Teng
To investigate the effects of Scrambling Trumpet Creeper flavone on neurological function score, brain tissue lesion and related biochemical indexes in rat TIA model. Methods: TIA model was induced by tail vein injection of t-butanol (t-BHP). The rats in each administration group were given large, medium and low dose of Scrambling Trumpet Creeper flavone 0.1% CMC suspension, nimodipine and Yangxueqingnao particles group 0.1% CMC suspension, model group and blank group fed the same volume 0.1% CMC. Once a day, continuous administration of 7d...
March 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29669381/prevalence-of-congenital-cmv-infection-and-antiviral-therapy-in-very-low-birth-weight-infants-observations-of-the-german-neonatal-network
#19
Alexander Humberg, Viola Leienbach, Mats I Fortmann, Tanja K Rausch, Horst Buxmann, Andreas Müller, Egbert Herting, Christoph Härtel, Wolfgang Göpel
BACKGROUND: To determine the prevalence of congenital CMV infection (cCMV) in very-low-birth-weight infants (VLBWI) and to evaluate epidemiological characteristics of VLBWI with antiviral therapy (AT). METHODS: CMV-specific PCR in umbilical cord tissue was performed (n=3330). Univariate analyses and logistic regression models were used to identify associations with outcome. RESULTS: 22/3330 VLBWI received AT (0.66%). 4 of these (0.12%) were PCR positive, with 2 VLBWI showing pathological screening for hearing loss...
April 18, 2018: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29666865/preparation-of-lactic-acid-and-glucose-responsive-poly-%C3%AE%C2%B5-caprolactone-b-poly-ethylene-oxide-block-copolymer-micelles-using-phenylboronic-ester-as-a-sensitive-block-linkage
#20
David Vrbata, Mariusz Uchman
The present study describes the synthesis, self-assembly and responsiveness to glucose and lactic acid of biocompatible and biodegradable block copolymer micelles using phenylboronic ester as the linkage between hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic poly(ethylene oxide) (PEO). The PCL block with pendant phenylboronic acid (PCLBA) was synthesized by combining ε-caprolactone (ε-CL) ring-opening polymerisation (ROP), using 4-hydroxymethyl(phenylboronic) acid pinacolate as the initiator, and pinacol deprotection...
May 10, 2018: Nanoscale
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