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Red blood cells and pathology

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https://www.readbyqxmd.com/read/29642424/on-chip-cell-staining-and-counting-platform-for-the-rapid-detection-of-blood-cells-in-cerebrospinal-fluid
#1
Yujin Lee, Byeongyeon Kim, Sungyoung Choi
Counting blood cells in cerebrospinal fluid (CSF) is indispensable for diagnosing several pathological conditions in the central nervous system, such as meningitis, even though collecting CSF samples is invasive. Cell counting methods, such as hemocytometer chambers and flow cytometers, have been used for CSF cell counting, but they often lack the sensitivity to detect low blood cell numbers. They also depend on off-chip, manual sample preparation or require bulky, costly equipment, thereby limiting their clinical utility...
April 7, 2018: Sensors
https://www.readbyqxmd.com/read/29625893/interleukin-15-complex-treatment-protects-mice-from-cerebral-malaria-by-inducing-interleukin-10-producing-natural-killer-cells
#2
Kristina S Burrack, Matthew A Huggins, Emily Taras, Philip Dougherty, Christine M Henzler, Rendong Yang, Sarah Alter, Emily K Jeng, Hing C Wong, Martin Felices, Frank Cichocki, Jeffrey S Miller, Geoffrey T Hart, Aaron J Johnson, Stephen C Jameson, Sara E Hamilton
Cerebral malaria is a deadly complication of Plasmodium infection and involves blood brain barrier (BBB) disruption following infiltration of white blood cells. During experimental cerebral malaria (ECM), mice inoculated with Plasmodium berghei ANKA-infected red blood cells develop a fatal CM-like disease caused by CD8+ T cell-mediated pathology. We found that treatment with interleukin-15 complex (IL-15C) prevented ECM, whereas IL-2C treatment had no effect. IL-15C-expanded natural killer (NK) cells were necessary and sufficient for protection against ECM...
March 20, 2018: Immunity
https://www.readbyqxmd.com/read/29614634/nitric-oxide-pathology-and-therapeutics-in-sickle-cell-disease
#3
Daniel B Kim-Shapiro, Mark T Gladwin
Sickle cell disease is caused by a mutant form of hemoglobin that polymerizes under hypoxic conditions which leads to red blood cell (RBC) distortion, calcium-influx mediated RBC dehydration, increased RBC adhesivity, reduced RBC deformability, increased RBC fragility, and hemolysis. These impairments in RBC structure and function result in multifaceted downstream pathology including inflammation, endothelial cell activation, platelet and leukocyte activation and adhesion, and thrombosis, all of which contribute vascular occlusion and substantial morbidity and mortality...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29614631/simple-chronic-transfusion-therapy-a-crucial-therapeutic-option-for-sickle-cell-disease-improves-but-does-not-normalize-blood-rheology-what-should-be-our-goals-for-transfusion-therapy
#4
Jon A Detterich
Sickle cell anemia is characterized by a mutation resulting in the formation of an abnormal beta-hemoglobin called hemoglobin S. Hemoglobin S polymerizes upon deoxygenation, causing impaired red blood cell deformability and increased blood viscosity at equivalent hematocrits. Thus, sickle cell disease is a hemorheologic disease that results in various pathologic processes involving multiple organ systems including the lungs, heart, kidneys and brain. Red blood cell mechanics and the perturbations on blood flow-endothelial interaction underlie much of the pathology found in sickle cell disease...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29608790/increase-in-perfused-boundary-region-of-endothelial-glycocalyx-is-associated-with-higher-prevalence-of-ischemic-heart-disease-and-lesions-of-microcirculation-and-vascular-wall
#5
Alexander Y Gorshkov, Marina V Klimushina, Sergei A Boytsov, Alexander Y Kots, Nadezhda G Gumanova
OBJECTIVE: Perfused boundary region (PBR) characterizes penetration of red blood cells inside glycocalyx and its thickness can have profound impact on microcirculation and other vascular parameters. The goal of our study was to reliably quantify PBR and assess its potential use as a new marker of cardiovascular pathology. METHODS: The study included 208 patients (123 men and 85 women from 40 to 65 years of age) with various grades of cardiovascular SCORE risk index and ischemic heart disease...
April 2, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29604099/evaluation-of-complete-blood-count-parameters-to-predict-endometrial-cancer
#6
Cigdem Yayla Abide, Evrim Bostanci Ergen, Ebru Cogendez, Cetin Kilicci, Faik Uzun, Enis Ozkaya, Ates Karateke
BACKGROUND: Complete blood count parameters have been introduced to be diagnostic biomarkers for many cancer-related diseases associated with inflammatory process. The aim of our study was to detect whether there is any relationship between benign or malignant endometrial pathologies and complete blood count parameters. METHODS: Four hundred and sixteen patients with a complaint of abnormal uterine bleeding who admitted to Zeynep Kamil Women and Children's Health Training and Research hospital between 2013 and 2016 and undergoing endometrial biopsy were included in the study...
March 31, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29594877/granulocyte-colony-stimulating-factor-producing-lung-cancer-with-severe-anemia-of-inflammation
#7
Koutaro Murakami, Yujin Kudo, Masatoshi Kakihana, Jun Matsubayashi, Tetsuya Okano, Yoshihisa Shimada, Toshitaka Nagao, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
Granulocyte colony stimulating factor (G-CSF)-producing lung cancer occasionally induces severe inflammation with an abnormally high white blood cell count. Herein, we report a 49-year-old man who suffered from resectable G-CSF-producing non-small cell lung cancer with continuous fever and severe anemia. Red blood cell transfusion was necessary for the anemia of inflammation. The patient underwent complete surgical tumor resection. The histopathological diagnosis was a pleomorphic carcinoma at pathological stage IIB...
March 28, 2018: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29590085/factors-affecting-mortality-in-elderly-patients-who-underwent-surgery-for-gastric-cancer
#8
Selami Ilgaz Kayılıoglu, Ufuk Utku Göktug, Tolga Dinc, Isa Sozen, Zeynep Yavuz, Faruk Coskun
AIM: The aim of this study was to determine factors affecting overall mortality in patients over 60 years of age who underwent surgery for gastric cancer in our clinic. MATERIAL AND METHODS: Data on histopathological diagnosis (tumor size, lymph node status, and number), pathological stage, serum albumin level, tumor markers, complete blood count, and demographic information of 109 patients over 60 years of age who had surgery for gastric cancer between January 2011 and July 2016 were obtained retrospectively from the patient files...
March 5, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29581782/a-novel-risk-prediction-model-for-patients-with-combined-hepatocellular-cholangiocarcinoma
#9
Meng-Xin Tian, Wen-Jun He, Wei-Ren Liu, Jia-Cheng Yin, Lei Jin, Zheng Tang, Xi-Fei Jiang, Han Wang, Pei-Yun Zhou, Chen-Yang Tao, Zhen-Bin Ding, Yuan-Fei Peng, Zhi Dai, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Ying-Hong Shi
Backgrounds: Regarding the difficulty of CHC diagnosis and potential adverse outcomes or misuse of clinical therapies, an increasing number of patients have undergone liver transplantation, transcatheter arterial chemoembolization (TACE) or other treatments. Objective: To construct a convenient and reliable risk prediction model for identifying high-risk individuals with combined hepatocellular-cholangiocarcinoma (CHC). Methods: 3369 patients who underwent surgical resection for liver cancer at Zhongshan Hospital were enrolled in this study...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29572498/a-single-high-fat-meal-provokes-pathological-erythrocyte-remodeling-and-increases-myeloperoxidase-levels-implications-for-acute-coronary-syndrome
#10
Tyler W Benson, Neal L Weintraub, Ha Won Kim, Nichole Seigler, Sanjiv Kumar, Jonathan Pye, Tetsuo Horimatsu, Rod Pellenberg, David W Stepp, Rudolf Lucas, Vladimir Y Bogdanov, Sheldon E Litwin, Julia E Brittain, Ryan A Harris
High-fat meal (HFM) consumption can produce acute lipemia and trigger myocardial infarction in patients with atherosclerosis, but the mechanisms are poorly understood. Erythrocytes (red blood cells, RBCs) intimately interact with inflammatory cells and blood vessels and play a complex role in regulating vascular function. Chronic high-fat feeding in mice induces pathological RBC remodeling, suggesting a novel link between HFM, RBCs, and vascular dysfunction. However, whether acute HFM can induce RBC remodeling in humans is unknown...
March 23, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29569901/bio-derived-three-dimensional-hierarchical-nanostructures-as-efficient-sers-substrates-for-cell-membrane-probing
#11
Stefano Manag Ograve, Gianluigi Zito, Alessandra Rogato, Maurizio Casalino, Emanuela Esposito, Anna Chiara De Luca, Edoardo De Tommasi
In this work, we propose the use of complex, bio-derived nanostructures as efficient surface-enhanced Raman scattering (SERS) substrates for chemical analysis of cellular membranes. These structures were directly obtained from a suitable gold metalization of Pseudonitzchia multistriata diatom silica shell (the so called frustule), whose grating-like geometry provides large light coupling with external radiation, whereas its extruded, sub-wavelength lateral edge provides excellent interaction with cells without steric hindrance...
March 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29564354/assessment-of-clinical-and-pathological-features-of-patients-who-underwent-thyroid-surgery-a-retrospective-clinical-study
#12
Arif Emre, Sami Akbulut, Mehmet Sertkaya, Muharrem Bitiren, Ilhami Taner Kale, Ertan Bulbuloglu, Cemil Colak
AIM: To evaluate whether there was any correlation between the clinical parameters and final pathological results among patients who underwent thyroid surgery. METHODS: We retrospectively analyzed parameters, including age, sex, complete blood cell count parameters, nodule diameter, nodule localization, thyroid function testing, and pathology reports, in patients who underwent thyroid surgery. The patients were divided into malignant ( n = 92) and benign ( n = 413) groups depending on the final pathological results...
March 16, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29530009/kidney-stone-formers-have-more-renal-parenchymal-crystals-than-non-stone-formers-particularly-in-the-papilla-region
#13
Atsushi Okada, Shuzo Hamamoto, Kazumi Taguchi, Rei Unno, Teruaki Sugino, Ryosuke Ando, Kentaro Mizuno, Keiichi Tozawa, Kenjiro Kohri, Takahiro Yasui
BACKGROUND: We investigated the renoprotective ability of healthy people against kidney stone formation. To clarify intratubular crystal kinetics and processing in human kidneys, we performed a quantitative and morphological observation of nephrectomized renal parenchyma tissues. METHODS: Clinical data and pathological samples from 60 patients who underwent radical nephrectomy for renal cancer were collected from June 2004 to June 2010. The patients were retrospectively classified as stone formers (SFs; n = 30, kidney stones detected by preoperative computed tomography) and non-stone formers (NSFs; n = 30, no kidney stone history)...
March 12, 2018: BMC Urology
https://www.readbyqxmd.com/read/29520218/%C3%AE-synuclein-heterocomplexes-with-%C3%AE-amyloid-are-increased-in-red-blood-cells-of-parkinson-s-disease-patients-and-correlate-with-disease-severity
#14
Simona Daniele, Daniela Frosini, Deborah Pietrobono, Lucia Petrozzi, Annalisa Lo Gerfo, Filippo Baldacci, Jonathan Fusi, Chiara Giacomelli, Gabriele Siciliano, Maria Letizia Trincavelli, Ferdinando Franzoni, Roberto Ceravolo, Claudia Martini, Ubaldo Bonuccelli
Neurodegenerative disorders (NDs) are characterized by abnormal accumulation/misfolding of specific proteins, primarily α-synuclein (α-syn), β-amyloid1-42 (Aβ1-42 ) and tau, in both brain and peripheral tissues. In addition to oligomers, the role of the interactions of α-syn with Aβ or tau has gradually emerged. Nevertheless, despite intensive research, NDs have no accepted peripheral markers for biochemical diagnosis. In this respect, Red Blood Cells (RBCs) are emerging as a valid peripheral model for the study of aging-related pathologies...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29513907/hematology-ris-for-captive-and-wild-arabian-sand-gazelles-gazella-subgutturosa-marica-of-the-kingdom-of-saudi-arabia
#15
Gian Lorenzo D'Alterio, Chris Barichievy, William Macasero
BACKGROUND: The Arabian Sand Gazelle (Gazella subgutturosa marica, Thomas, 1897) has been extirpated throughout the Arabian Peninsula. Captive breeding and reintroduction for conservation purposes require veterinary support and the use of hematology RIs. OBJECTIVES: The purpose of the study was to establish hematological RIs for the Arabian Sand Gazelle. METHODS: Blood from 231 clinically healthy captive and 22 wild (reintroduced) Arabian Sand Gazelles were sampled...
March 7, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29507844/acquired-elastotic-hemangioma-case-series-and-comprehensive-literature-review
#16
Philip R Cohen, Brian R Hinds
Background Acquired elastotic hemangioma is a benign vascular proliferation that typically presents as an asymptomatic red plaque on a sun-exposed site of an adult. Material and Methods The PubMed database was used to search the following words: acquired, angioma, arm, basal, carcinoma, cell, elastosis, elastotic, exposed, forearm, hemangioma, solar, sun, and vascular. The relevant papers and reference cited generated by the search were reviewed. The features from a case series of 11 patients with acquired elastotic hemangioma are presented...
December 28, 2017: Curēus
https://www.readbyqxmd.com/read/29506544/experimental-malaria-associated-acute-respiratory-distress-syndrome-is-dependent-on-the-parasite-host-combination-and-coincides-with-normocyte-invasion
#17
Leen Vandermosten, Thao-Thy Pham, Hendrik Possemiers, Sofie Knoops, Evelien Van Herck, Julie Deckers, Blandine Franke-Fayard, Tracey J Lamb, Chris J Janse, Ghislain Opdenakker, Philippe E Van den Steen
BACKGROUND: Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a complication of malaria with a lethality rate of up to 80% despite anti-malarial treatment. It is characterized by a vast infiltration of leukocytes, microhaemorrhages and vasogenic oedema in the lungs. Previously, a mouse model for MA-ARDS was developed by infection of C57BL/6 mice with the Edinburgh line NK65-E of Plasmodium berghei. RESULTS: Here, both host and parasite factors were demonstrated to play crucial roles in the development and severity of lung pathology...
March 5, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29500137/haematuria-in-sport-a-review
#18
REVIEW
Richard Deji Akiboye, Davendra M Sharma
CONTEXT: Haematuria is a common urological presentation associated with patient anxiety and clinically relevant underlying pathology. However, the prevalence and pathophysiology of haematuria following sporting exercise is less well documented. OBJECTIVES: This review paper seeks to clarify the prevalence of microscopic and macroscopic haematuria in association with sporting exercise reported in the literature, and the pathophysiology behind it. We review the relation of haematuria to injury to the urinary tract in sport, as well as the incidence of underlying disease, urological and incidental, following investigation for exercise-induced haematuria...
February 27, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29495809/continuous-stacking-computational-approach-based-automated-microscope-slide-scanner
#19
Swetha Murali, Jayesh Vasudeva Adhikari, Veerendra Kalyan Jagannadh, Sai Siva Gorthi
Cost-effective and automated acquisition of whole slide images is a bottleneck for wide-scale deployment of digital pathology. In this article, a computation augmented approach for the development of an automated microscope slide scanner is presented. The realization of a prototype device built using inexpensive off-the-shelf optical components and motors is detailed. The applicability of the developed prototype to clinical diagnostic testing is demonstrated by generating good quality digital images of malaria-infected blood smears...
February 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29495147/-the-roles-of-tsp-1-and-its-receptor-cd47-in-pathogenesis-of-paraquat-induced-pulmonary-fibrosis-in-rats
#20
J Zhang, K X Liu, W Gao, X S Xie
Objective: To establish a rat model of paraquat (PQ) -induced pulmonary fibrosis and observe the changes in thrombospondin-1 (TSP-1) and its receptor CD47 in lung tissue, and to investigate their roles in the pathogenesis of PQ-induced pulmonary fibrosis. Methods: Fifty-four clean adult male Sprague-Dawley rats were randomly divided into normal control group ( n =6) and 2 h, 12 h, 1 d, 3 d, 7 d, and 14 d PQ poisoning groups ( n =8 per group). A rat model of PQ poisoning was established by a single gavage of 20 wt...
December 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
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