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Red blood cells and pathology

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https://www.readbyqxmd.com/read/28524175/modulators-of-microglial-activation-and-polarization-after-intracerebral-haemorrhage
#1
REVIEW
Xi Lan, Xiaoning Han, Qian Li, Qing-Wu Yang, Jian Wang
Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks effective treatment. Microglia are among the first non-neuronal cells on the scene during the innate immune response to ICH. Microglia respond to acute brain injury by becoming activated and developing classic M1-like (proinflammatory) or alternative M2-like (anti-inflammatory) phenotypes. This polarization implies as yet unrecognized actions of microglia in ICH pathology and recovery, perhaps involving microglial production of proinflammatory or anti-inflammatory cytokines and chemokines...
May 19, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28504711/the-stabilizing-effect-of-an-oligomeric-proanthocyanidin-on-red-blood-cell-membrane-structure-of-poorly-controlled-type-ii-diabetes
#2
J Visser, P J van Staden, P Soma, A V Buys, E Pretorius
Type II diabetes (T2D) is a pandemic characterized by pathological circulating inflammatory markers, high-glucose levels and oxidative stress. The hematological system is especially vulnerable to these aberrant circulating molecules, and erythrocytes (RBCs) show aberrant rheology properties, owing to the direct contact with these molecules. Pathological levels of circulating inflammatory markers in T2D therefore have a direct effect on the molecular and cellular structure of RBCs. Previous research has suggested that antioxidants may reduce oxidative stress that results from the pathological inflammatory markers...
May 15, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28501110/arachidonic-acid-causes-hidden-blood-loss-like-red-blood-cell-damage-through-oxidative-stress-reactions
#3
Tao Yuan, Yu Cong, Jia Meng, Hong Qian, Wei Ye, Wen-Shuang Sun, Jian-Ning Zhao, Ni-Rong Bao
BACKGROUND: Hidden blood loss (HBL) often occurs in the prosthetic replacement for joint, but the mechanism is still not clear. MATERIALS AND METHODS: This study tried to establish an animal model of HBL by injecting arachidonic acid (AA) into the Sprague-Dawley rats. Different concentrations of AA were injected into the tail veins of the rats, and blood samples were collected before and after administration at 24, 48, and 72 h. A complete blood count was obtained by to find the hemoglobin (Hb) and red blood cell (RBC) count changes...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28497572/relationship-between-red-blood-cell-distribution-width-bilirubin-and-clinical-characteristics-of-patients-with-gastric-cancer
#4
T-T Wei, L-L Wang, J-R Yin, Y-T Liu, B-D Qin, J-Y Li, X Yin, L Zhou, R-Q Zhong
INTRODUCTION: Red blood cell distribution width (RDW) and bilirubin have been proved to be prognostic factors for various types of cancer. However, their prognostic value in patients with gastric cancer (GC) remains largely unknown. METHODS: To verify whether RDW and bilirubin are prognostic factors for patients with GC, we performed a cross-sectional study to analyze the relationship between RDW, bilirubin, and the clinical characteristics of patients with GC. Medical records of all newly diagnosed and pathologically proved patients with GC admitted to Changzheng Hospital between January 2016 and July 2016 were retrospectively reviewed...
May 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28483400/autophagy-a-necessary-event-during-erythropoiesis
#5
REVIEW
Rubén Grosso, Claudio M Fader, María I Colombo
Autophagy is a well-known cellular process involved in many physiological and pathological processes. During erythropoiesis, autophagy plays an important role participating in the clearance of unnecessary organelles such as ribosomes and mitochondria (mitophagy) allowing the correct formation of mature red blood cells. The dysfunction of autophagy proteins hamper the correct erythroid maturation, leading to anemia, the release of immature cells from the bone marrow and other hematological abnormalities. Autophagy plays different roles depending on the type of pathology...
April 22, 2017: Blood Reviews
https://www.readbyqxmd.com/read/28468674/icam-1-is-a-key-receptor-mediating-cytoadherence-and-pathology-in-the-plasmodium-chabaudi-malaria-model
#6
Deirdre A Cunningham, Jing-Wen Lin, Thibaut Brugat, William Jarra, Irene Tumwine, Garikai Kushinga, Jai Ramesar, Blandine Franke-Fayard, Jean Langhorne
BACKGROUND: Parasite cytoadherence within the microvasculature of tissues and organs of infected individuals is implicated in the pathogenesis of several malaria syndromes. Multiple host receptors may mediate sequestration. The identity of the host receptor(s), or the parasite ligand(s) responsible for sequestration of Plasmodium species other than Plasmodium falciparum is largely unknown. The rodent malaria parasites may be useful to model interactions of parasite species, which lack the var genes with their respective hosts, as other multigene families are shared between the species...
May 3, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28465251/danshen-injection-prevents-heart-failure-by-attenuating-post-infarct-remodeling
#7
Lingyan Wang, Jiahui Yu, Patrick Asare Fordjour, Xiaoxue Xing, Hui Gao, Yanyan Li, Lingyan Li, Yan Zhu, Xiumei Gao, Guanwei Fan
ETHNOPHARMACOLOGICAL RELEVANCE: Danshen Injection (DSI) is a traditional Chinese medicine extracted from Danshen, prepared from the dried root and rhizome of Salvia miltiorrhiza Bunge. Danshen is an ancient antipyretic traditional Chinese medicine which is mostly used to improve blood circulation and dispel blood stasis. Danshen decoction or liquor-fried Danshen (with grain-based liquor) which is cool in nature is traditionally used to 'cool the blood' and reduce the swelling of sores and abscesses...
April 29, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28464263/urised-3-and-ux-2000-automated-urine-sediment-analyzers-vs-manual-microscopic-method-a-comparative-performance-analysis
#8
Sathima Laiwejpithaya, Preechaya Wongkrajang, Kanit Reesukumal, Chonticha Bucha, Suriya Meepanya, Chanutchaya Pattanavin, Varanya Khejonnit, Achara Chuntarut
BACKGROUND: Fully automated urine analyzers now play an important role in routine urinalysis in most laboratories. The recently introduced UriSed 3 has a new automated digital imaging urine sediment analyzer with a phase contrast feature. The aim of this study was to compare the performance of the UriSed 3 and UX-2000 automated urine sediment analyzers with each other and with the results of the manual microscopic method. METHODS: Two hundred seventy-seven (277) samples of leftover fresh urine from our hospital's central laboratory were evaluated by two automated urine sediment analyzers-UriSed 3 and UX-2000...
May 2, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28458720/role-of-red-blood-cells-in-haemostasis-and-thrombosis
#9
Rustem I Litvinov, John W Weisel
In contrast to an obsolete notion that erythrocytes, or red blood cells (RBCs), play a passive and minor role in hemostasis and thrombosis, over the past decades there has been increasing evidence that RBCs have biologically and clinically important functions in blood clotting and its disorders. This review summarizes the main mechanisms that underlie the involvement of RBCs in hemostasis and thrombosis in vivo, such as rheological effects on blood viscosity and platelet margination, aggregation and deformability of RBCs; direct adhesion and indirect biochemical interactions with endothelial cells and platelets, etc...
February 2017: ISBT Science Series
https://www.readbyqxmd.com/read/28452895/c-peptide-attenuates-acute-lung-inflammation-in-a-murine-model-of-hemorrhagic-shock-and-resuscitation-by-reducing-gut-injury
#10
Raymond Lc Kao, Xuemei Xu, Anargyros Xenocostas, Neil Parry, Tina Mele, Claudio M Martin, Tao Rui
BACKGROUND: The study aims to evaluate whether C-peptide can reduce gut injury during hemorrhagic shock and resuscitation (HS/R) therefore attenuate shock-induced inflammation and subsequent acute lung injury. METHODS: Twelve-week-old male mice (C57/BL6) were hemorrhaged (mean arterial blood pressure maintained at 35 mmHg for 60 minutes) and then resuscitated with Ringer's lactate, followed by red blood cell transfusion with (HS/R) or without C-peptide (HS/R+C-peptide)...
April 27, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28447765/plasma-microrna-451-as-a-novel-hemolytic-marker-for-%C3%AE-0-thalassemia-hbe-disease
#11
Kamonlak Leecharoenkiat, Yuka Tanaka, Yasuko Harada, Porntip Chaichompoo, Orawan Sarakul, Yasunobu Abe, Duncan Richard Smith, Suthat Fucharoen, Saovaros Svasti, Tsukuru Umemura
In Southeast Asia, particularly in Thailand, β0-thalassemia/hemoglobin E (HbE) disease is a common hereditary hematological disease. It is associated with pathophysiological processes, such as the intramedullary destruction of immature erythroid cells and peripheral hemolysis of mature red blood cells. MicroRNA (miR) sequences, which are short non-coding RNA that regulate gene expression in a suppressive manner, serve a crucial role in human erythropoiesis. In the present study, the plasma levels of the erythroid-expressed miRNAs, miR‑451 and miR‑155, were analyzed in 23 patients with β0-thalassemia/HbE and 16 control subjects...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28443948/relapse-of-congenital-thrombotic-thrombocytopenic-purpura-after-spontaneous-remission-in-a-second-trimester-primigravida-case-report-and-review-of-the-literature
#12
Donavan de Souza Lúcio, Jacqueline Foelkel Pignatari, Marcelo Gil Cliquet, Henri Augusto Korkes
CONTEXT: Thrombotic microangiopathy syndrome or thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) describes distinct diseases sharing common pathological features: microangiopathic hemolytic anemia and thrombocytopenia, without any other apparent cause. CASE REPORT: An 18-year-old second-trimester primigravida presented with a history of fifteen days of intense weakness, followed by diarrhea over the past six days. She reported having had low platelets since childhood, but said that she had never had bleeding or menstrual abnormalities...
April 20, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28435265/toxicity-studies-of-six-types-of-carbon-nanoparticles-in-a-chicken-embryo-model
#13
Natalia Kurantowicz, Ewa Sawosz, Gabriela Halik, Barbara Strojny, Anna Hotowy, Marta Grodzik, Radosław Piast, Wanvimol Pasanphan, André Chwalibog
In the present study, the toxicity of six different types of carbon nanoparticles (CNPs) was investigated using a chicken-embryo model. Fertilized chicken eggs were divided into the following treatment groups: placebo, diamond NPs, graphite NPs, pristine graphene, small graphene oxide, large graphene oxide, and reduced graphene oxide. Experimental solutions at a concentration of 500 μg/mL were administrated into the egg albumin. Gross pathology and the rate of survival were examined after 5, 10, 15, and 20 days of incubation...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28421539/%C3%AE-synuclein-aggregates-with-%C3%AE-amyloid-or-tau-in-human-red-blood-cells-correlation-with-antioxidant-capability-and-physical-exercise-in-human-healthy-subjects
#14
Simona Daniele, Deborah Pietrobono, Jonathan Fusi, Caterina Iofrida, Lucia Chico, Lucia Petrozzi, Annalisa Lo Gerfo, Filippo Baldacci, Fabio Galetta, Gabriele Siciliano, Ubaldo Bonuccelli, Gino Santoro, Maria Letizia Trincavelli, Ferdinando Franzoni, Claudia Martini
Neurodegenerative disorders (NDs) are characterized by abnormal accumulation/misfolding of specific proteins, primarily α-synuclein (α-syn), β-amyloid1-42 (Aβ), and tau, in both brain and peripheral tissue. In addition to homo-oligomers, the role of α-syn interactions with Aβ or tau has gradually emerged. The altered protein accumulation has been related to both oxidative stress and physical activity; nevertheless, no correlation among the presence of peripheral α-syn hetero-aggregates, antioxidant capacity, and physical exercise has been discovered as of yet...
April 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28408900/the-thrombopoietin-receptor-structural-basis-of-traffic-and-activation-by-ligand-mutations-agonists-and-mutated-calreticulin
#15
REVIEW
Leila N Varghese, Jean-Philippe Defour, Christian Pecquet, Stefan N Constantinescu
A well-functioning hematopoietic system requires a certain robustness and flexibility to maintain appropriate quantities of functional mature blood cells, such as red blood cells and platelets. This review focuses on the cytokine receptor that plays a significant role in thrombopoiesis: the receptor for thrombopoietin (TPO-R; also known as MPL). Here, we survey the work to date to understand how this receptor functions at a molecular level throughout its lifecycle, from traffic to the cell surface, dimerization and binding cognate cytokine via its extracellular domain, through to its subsequent activation of associated Janus kinases and initiation of downstream signaling pathways, as well as the regulation of these processes...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28404591/intravital-imaging-of-the-kidney-in-a-rat-model-of-salt-sensitive-hypertension
#16
Bradley T Endres, Ruben M Sandoval, George J Rhodes, Silvia B Campos-Bilderback, Malgorzata M Kamocka, Christopher McDermott-Roe, Alexander Staruschenko, Bruce A Molitoris, Aron M Geurts, Oleg Palygin
Hypertension is one of the most prevalent diseases worldwide, and a major risk factor for renal failure and cardiovascular disease. The role of albuminuria, a common feature of hypertension and robust predictor of cardiorenal disorders, remains incompletely understood. The goal of this study was to investigate the mechanisms leading to albuminuria in the kidney of a rat model of hypertension, the Dahl salt-sensitive (SS) rat. To determine the relative contributions of the glomerulus and proximal tubule (PT) to albuminuria, we applied intravital two-photon-based imaging to investigate the complex renal physiological changes that occur during salt-induced hypertension...
April 12, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28396319/host-resistance-to-plasmodium-induced-acute-immune-pathology-is-regulated-by-il-10-receptor-signalling
#17
Carla Claser, J Brian De Souza, Samuel G Thorburn, Georges Emile Grau, Eleanor M Riley, Laurent Rénia, Julius C R Hafalla
The resolution of malaria infection is dependent on a balance between pro-inflammatory and regulatory immune responses. Whilst early effector T cell responses are required for limiting parasitaemia, these responses need to be switched off by regulatory mechanisms in a timely manner to avoid immune-mediated tissue damage. Interleukin-10 (IL-10) receptor (IL-10R) signalling is considered to be a vital component of regulatory responses although its role in host resistance to severe immune pathology during acute malaria infections is not fully understood...
April 10, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28393240/do-in-seung-gi%C3%A2-tang-extract-suppresses-adipocyte-differentiation-in-3t3%C3%A2-l1-cells
#18
Eun Hyoung Shim, Myeong Soo Lee, Ju-Ah Lee, Hoyoung Lee
Blood stasis syndrome (BSS), additionally called Eohyul, is a basic pathological concept in Traditional Korean Medicine. Do In Seung Gi‑Tang (DISGT) is herbal medicine used for the treatment of BSS. It primarily treats metabolic diseases (MDs) including obesity, hypertension, diabetes mellitus and gynecological diseases, by promoting blood circulation. The present study aimed to investigate the anti‑adipogenesis effect of DISGT in 3T3‑L1 adipocytes using Oil Red O staining, and assessing levels of triglycerides (TGs) and leptin in adipocytes by ELISA and western blot analysis...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28387902/angiogenesis-characteristics-of-infantile-hemangioma-and-feasibility-observation-of-transplantation-model-of-human-hemangioma-on-mice
#19
Y Fu, Z-G Yang, L-Y Zhao
OBJECTIVE: To study pathogenic features of pediatric hemangiomas, we successfully established a model in mice, by transplanting human hemangioma tissues. MATERIALS AND METHODS: The hemangioma from the leg of a two-month-old infant was dissected and sliced into several pieces. During a careful surgical procedure, the hemangioma tissues were individually transplanted into skin incisions in anesthetized mice. The volume of the transplanted tumors was measured and the changes in shape recorded at 1 day, and at 1, 2, 3, 4, 5 and 6 months after the transplantation...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28380252/neutrophil-alterations-in-pregnancy-associated-malaria-and-induction-of-neutrophil-chemotaxis-by-plasmodium-falciparum
#20
Stéphanie Boström, Christentze Schmiegelow, Ulrike Abu Abed, Daniel Tr Minja, John Lusingu, Volker Brinkmann, Yabo J Honkpehedji, Marguerite M Loembe, Ayôla A Adegnika, Benjamin Mordmüller, Marita Troye-Blomberg, Borko Amulic
Pregnancy associated malaria (PAM) is a severe form of the disease caused by sequestration of Plasmodium falciparum-infected red blood cells (iRBCs) in the developing placenta. Pathogenesis of PAM is partially based on immunopathology, with frequent monocyte infiltration into the placenta. Neutrophils are abundant blood cells that are essential for immune defence but may also cause inflammatory pathology. Their role in PAM remains unclear. We analysed neutrophil alterations in the context of PAM to better understand their contribution to disease development...
April 5, 2017: Parasite Immunology
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