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Keywords White blood cells normal and p...

White blood cells normal and pathology

https://read.qxmd.com/read/37401712/-experience-in-the-use-of-confocal-laser-endomicroscopy-for-the-diagnosis-of-bladder-papillary-tumors
#21
JOURNAL ARTICLE
M A Shoaydarov, A G Martov, A S Andronov, S V Dutov, V M Pominalnaya
INTRODUCTION: Visual confirmation of suspicious changes in the urinary tract mucosa is the cornerstone in the diagnosis of urothelial cancer. However, with bladder tumors, it is impossible to obtain histopathological data during cystoscopy both in white light and in photodynamic and narrow-spectrum modes, as well as with computerized chromoendoscopy. Confocal laser endomicroscopy (probe-based confocal laser endomicroscopy - pCLE) is an optical imaging technique that provides high-resolution in vivo imaging and real-time evaluation of urothelial lesions...
May 2023: Urologii︠a︡
https://read.qxmd.com/read/37383124/ruptured-teratoma-mimicking-a-pelvic-inflammatory-disease-and-ovarian-malignancy-a-case-report
#22
Pei-Hsuan Lai, Dah-Ching Ding
BACKGROUND: We report a case of ruptured ovarian teratoma mimicking pelvic inflammatory disease (PID) and ovarian malignancy. The case indicates the need for reviewing the information on ovarian teratomas, as the symptoms are vague, and, therefore, diagnosis and treatment had to be structured accordingly. CASE SUMMARY: A 60-year-old woman was admitted to the emergency department with acute lower abdominal pain. She experienced weight loss and increased abdominal girth...
June 6, 2023: World Journal of Clinical Cases
https://read.qxmd.com/read/37239250/effect-of-spontaneous-subarachnoid-hemorrhage-on-cerebrospinal-fluid-indicators
#23
JOURNAL ARTICLE
Huichao You, Wenqi Li, Qianxue Chen
The cerebrospinal fluid (CSF) analysis in ruptured aneurysms can be greatly affected by subarachnoid hemorrhage (SAH), making the diagnosis of intracranial infection more difficult after surgery. This study aimed to identify the reference value range of CSF in the pathological state following spontaneous SAH. A retrospective analysis of demographic and CSF data of all spontaneous SAH patients treated between January 2018 and January 2023 was conducted. A total of 101 valid CSF specimen data were collected for analysis...
May 10, 2023: Brain Sciences
https://read.qxmd.com/read/37131732/non-metastatic-axillary-lymph-nodes-have-distinct-morphology-and-immunophenotype-in-obese-breast-cancer-patients-at-risk-for-metastasis
#24
Qingyuan Song, Kristen E Muller, Liesbeth M Hondelink, Roberta M diFlorio-Alexander, Margaret Karagas, Saeed Hassanpour
Obese patients have worse breast cancer outcomes than normal weight women including a 50% to 80% increased rate of axillary nodal metastasis. Recent studies have shown a potential link between increased lymph node adipose tissue and breast cancer nodal metastasis. Further investigation into potential mechanisms underlying this link may reveal potential prognostic utility of fat-enlarged lymph nodes in breast cancer patients. In this study, a deep learning framework was developed to identify morphological differences of non-metastatic axillary nodes between node-positive and node-negative obese breast cancer patients...
April 17, 2023: medRxiv
https://read.qxmd.com/read/37128797/carl-weigert-s-pioneer-definition-of-heart-infarction-as-myocardial-coagulative-necrosis-due-to-obstruction-of-atherosclerotic-coronary-arteries-in-1880-overshadowed-by-subsequent-secondary-publications-in-the-field
#25
JOURNAL ARTICLE
Andrzej Wincewicz, Piotr Woltanowski
In 1880, a German Jewish Professor of Pathology, Carl Weigert (1845-1904) first defined heart infarction as myocardial, coagulative necrosis ("Coagulationsnekrose") due to obliteration of atherosclerotic coronary arteries thanks, at least, partially to his great diligence in vascular staining methods. Histochemical techniques made his name eponymic as Weigert's Hematoxylin or Weigert's and Van Gieson's elastic stains are still used in routine practice to visualize, e.g., the framework of vessels. However, his discovery has been overshadowed by far more frequently cited in recent decades, subsequent but secondary, 214-page-long book dated on 1896 and titled "L'infarctus du myocarde et ses conséquences - ruptures, plaques fibreuses, anévrismes du coeur", in which René Marie repeated Carl Weigert's words that dead cardiomyocytes lost their cellular nuclei...
2023: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/37014943/further-characterization-of-multi-organ-deare-and-protection-by-16-16-dimethyl-prostaglandin-e2-in-a-mouse-model-of-the-hematopoietic-acute-radiation-syndrome
#26
JOURNAL ARTICLE
Tong Wu, Louis M Pelus, P Artur Plett, Carol H Sampson, Hui Lin Chua, Alexa Fisher, Hailin Feng, Liqiong Liu, Hongge Li, Miguel Ortiz, Supriya Chittajallu, Qianyi Luo, Ashay D Bhatwadekar, Timothy B Meyer, Xin Zhang, Daohong Zhou, Kathryn D Fischer, David L McKinzie, Steven J Miller, Christie M Orschell
Survivors of acute radiation exposure suffer from the delayed effects of acute radiation exposure (DEARE), a chronic condition affecting multiple organs, including lung, kidney, heart, gastrointestinal tract, eyes, and brain, and often causing cancer. While effective medical countermeasures (MCM) for the hematopoietic-acute radiation syndrome (H-ARS) have been identified and approved by the FDA, development of MCM for DEARE has not yet been successful. We previously documented residual bone marrow damage (RBMD) and progressive renal and cardiovascular DEARE in murine survivors of H-ARS, and significant survival efficacy of 16,16-dimethyl prostaglandin E2 (dmPGE2) given as a radioprotectant or radiomitigator for H-ARS...
May 1, 2023: Radiation Research
https://read.qxmd.com/read/36906591/melanoma-of-unknown-primary-origin-with-skeletal-muscle-metastasis-a-case-report
#27
JOURNAL ARTICLE
Ny Ony Tiana Florence Andrianandrasana, Rova Malala Fandresena Randrianarisoa, Patty Navoly, Mirana Andoniaina Christiana Ranaivoson, Hanta Marie Danielle Vololontiana, Florine Rafaramino
BACKGROUND: Melanoma is usually discovered from an irregular skin patch or a modification of a preexisting patch. Cutaneous and lymph node metastases are common. Muscle metastases are rare. We report a case of melanoma with infiltration of the gluteus maximus, which had normal dermatological examination. CASE PRESENTATION: A 43-year-old Malagasy man with no history of skin surgery was admitted with progressively worsening dyspnea. On admission, he presented with superior vena cava syndrome, painless cervical lymphadenopathy, and a painful swelling in the right buttock...
March 12, 2023: Journal of Medical Case Reports
https://read.qxmd.com/read/36859329/bilateral-tubal-pregnancies-presenting-11-days-apart-a-case-report
#28
JOURNAL ARTICLE
Leyla S Farshidpour, David R Vinson, Edward J Durant
INTRODUCTION: Ectopic pregnancy is the most common cause of maternal mortality in the first trimester. Bilateral tubal pregnancy is the rarest subset with an estimated incidence of one in 725 to 1,580 ectopic pregnancies. Of the cases of bilateral tubal pregnancy reported in the literature, most were associated with the use of assisted reproductive techniques. Here we present the case of a patient, without a prior history of reproductive technology use, who underwent treatment for a tubal pregnancy and was subsequently found to have a second, contralateral tubal pregnancy 11 days later...
February 2023: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/36849353/-risk-factors-of-childhood-systemic-lupus-erythematosus-with-thyroid-dysfunction
#29
JOURNAL ARTICLE
Y Y Zhang, L M Huang, L Cao, Y Z Zhi, J J Zhang
Objective: To investigate the risk factors of childhood systemic lupus erythematosus (SLE) with thyroid dysfunction and to explore the relationship between thyroid hormone and kidney injury of lupus nephritis (LN). Methods: In this retrospective study, 253 patients who were diagnosed with childhood SLE and hospitalized in the First Affiliated Hospital of Zhengzhou University from January 2019 to January 2021 were enrolled in the case group, and 70 healthy children were the control cases. The patients in the case group were divided into the normal thyroid group and the thyroid dysfunction group...
March 2, 2023: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/36804285/role-of-lipocalin-2-in-stroke
#30
REVIEW
Ruo-Yu Zhao, Peng-Ju Wei, Xin Sun, Dian-Hui Zhang, Qian-Yan He, Jie Liu, Jun-Lei Chang, Yi Yang, Zhen-Ni Guo
Stroke is the second leading cause of death worldwide; however, the treatment choices available to neurologists are limited in clinical practice. Lipocalin 2 (LCN2) is a secreted protein, belonging to the lipocalin superfamily, with multiple biological functions in mediating innate immune response, inflammatory response, iron-homeostasis, cell migration and differentiation, energy metabolism, and other processes in the body. LCN2 is expressed at low levels in the brain under normal physiological conditions, but its expression is significantly up-regulated in multiple acute stimulations and chronic pathologies...
April 2023: Neurobiology of Disease
https://read.qxmd.com/read/36759189/neurovascular-development-in-pten-and-tsc2-mouse-mutants
#31
JOURNAL ARTICLE
Mary Dusing, Candi L LaSarge, Angela White, Lilian G Jerow, Christina Gross, Steve C Danzer
Hyperactivation of the mTOR signaling pathway is linked to more than a dozen neurological diseases, causing a range of pathologies, including excess neuronal growth, disrupted neuronal migration, cortical dysplasia, epilepsy and autism. The mTOR pathway also regulates angiogenesis. For the present study, therefore, we queried whether loss of Pten or Tsc2 , both mTOR negative regulators, alters brain vasculature in three mouse models: one with Pten loss restricted to hippocampal dentate granule cells (DGC- Pten KOs), a second with widespread Pten loss from excitatory forebrain neurons (FB- Pten KOs) and a third with focal loss of Tsc2 from cortical excitatory neurons (f- Tsc2 KOs)...
February 9, 2023: ENeuro
https://read.qxmd.com/read/36713336/glutamine-supplementation-attenuates-intestinal-apoptosis-by-inducing-heat-shock-protein-70-in-heatstroke-rats
#32
JOURNAL ARTICLE
Li-Wen Du, Bao-Qing Xu, Kai Xun, Fang-Qi Zhang
BACKGROUND: Heatstroke is the most hazardous heat-related illness and has a high fatality rate. We investigated whether glutamine supplementation could have a protective effect on heatstroke rats. METHODS: Twenty-five 12-week-old male Wistar rats (weight 305±16 g) were randomly divided into a control group (n=5), heatstroke (HS) group (n=10), and heatstroke+glutamine (HSG) group (n=10). Seven days before heat exposure, glutamine (0.4 g/[kg·d]) was administered to the rats in the HSG group by gavage every day...
2023: World Journal of Emergency Medicine
https://read.qxmd.com/read/36709109/-clinical-features-and-prognosis-of-eight-patients-with-splenic-diffuse-red-pulp-small-b-cell-lymphoma
#33
JOURNAL ARTICLE
X L Zhang, J Luo, J J Zhang, L Chen, Y Shen, H M Yi, L Q Fan, J Q Mi
Objective: To investigate the clinical characteristics, response, and prognosis of splenic diffuse red pulp small B-cell lymphoma (SDRPL) . Methods: Eight cases of SDRPL were diagnosed and treated at Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, between May 2017 and April 2022. Data on the clinical features, laboratory results, bone marrow and spleen biopsy results, response, and prognosis were collected and analyzed. Results: The median age at diagnosis was 54 (42-69) years...
December 14, 2022: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/36669034/association-of-paraoxonase-1-and-nt-probnp-with-clinical-clinico-pathologic-and-echocardiographic-variables-in-dogs-with-mitral-valve-disease
#34
JOURNAL ARTICLE
Diana Rammal, Christos K Koutinas, Labrini V Athanasiou, Melpomeni Tangalidi, Camila P Rubio, José J Cerón, Androniki Tamvakis, Michael N Patsikas, Zoe S Polizopoulou
The objective of the present study was to measure the concentration of Paraoxonase-1 (PON-1) and N-terminal-prohormone-B-type natriuretic peptide (NT-proBNP), in the serum of dogs with degenerative Mitral Valve Disease (MVD), in order to identify their association with the clinical stage and specific clinico-pathologic and echocardiographic findings.Eighty dogs diagnosed with MVD and staged according to the ACVIM (American College of Veterinary Internal Medicine) consensus statement (B1, B2, C and D), based on their clinical, radiographic, and echocardiographic findings, were included in the study...
January 1, 2023: Veterinary Sciences
https://read.qxmd.com/read/36649501/umbilical-cord-wharton-s-jelly-derived-mesenchymal-stem-cells-inhibit-the-tgf-%C3%AE-1-pathway-in-hepatic-fibrosis-rats-through-a-paracrine-regulation-process
#35
JOURNAL ARTICLE
Mingliang Li, Ling Yan, Xiaofeng Yuan, Meihai Deng, Yun Xi, Donglin Zhu
BACKGROUND: The aim is to verify the therapeutic effect and possible mechanism of human umbilical cord Wharton's jelly-derived transplantation of mesenchymal stem cells (UMSCs) on CCl4-induced hepatic fibrosis rats through in vivo studies and to explore the regulatory mechanism of UMSCs on fibrosis of hepatic stellate cells (HSCs) through in vitro experiments. METHODS: In vivo experiment: Rats were randomly divided into blank control group and hepatic fibrosis group...
January 1, 2023: Clinical Laboratory
https://read.qxmd.com/read/36644196/undifferentiated-embryonic-sarcoma-of-the-adult-liver-with-paraneoplastic-syndrome-a-case-report
#36
Tianji Luan, Hongliang Mei, Ling Yuan, Yilin Hu
BACKGROUND: Undifferentiated embryonic sarcoma of the liver (UESL) is a rare primary liver sarcoma that mainly affects children. Since it was first reported in 1978, less than 100 cases of UESL in adults have been reported. Due to the lack of specificity of clinical symptoms and imaging findings, the misdiagnosis rate of UESL is very high, and the definite diagnosis is usually in the late stage. Paraneoplastic syndrome (PNS) is a clinical symptom caused by the production of hormones or hormone-like substances in some tumors...
December 2022: Translational Cancer Research
https://read.qxmd.com/read/36644048/iatrogenic-hypermagnesemia-in-a-patient-with-preeclampsia-caused-by-misinterpretation-of-the-magnesium-reporting-unit-following-magnesium-sulfate-administration
#37
Mohamed S Omer, Syed Latif, Ricky Grisson
Because of the lack of standardization, different laboratories report plasma magnesium sulfate or magnesium level in different units, leading to errors in diagnosis and case management; especially when a patient's workup was done in a hospital and then transferred to another hospital. Failure to recognize or understand the reporting units can confuse clinicians and healthcare workers, leading to erroneous interpretations and, consequently, to misdiagnosis of hypermagnesemia or hypomagnesemia. In this report, we present a 32-year-old female patient at 31 weeks of gestation with a history of a multi-substance use disorder who was transferred to the hospital after taking 2...
December 2022: Curēus
https://read.qxmd.com/read/36549077/from-the-archives-of-md-anderson-cancer-center-aleukemic-t-prolymphocytic-leukemia-a-rare-presentation-and-review-of-the-literature
#38
REVIEW
Karen A Nahmod, Beenu Thakral, F N U Aakash, Swaminathan P Iyer, L Jeffrey Medeiros, Andres E Quesada
T-prolymphocytic leukemia (T-PLL) is a rare, aggressive T-cell leukemia, and patients typically present with marked peripheral blood lymphocytosis. Approximately 15-20 % of patients may present with moderate and relative stable lymphocytosis and an indolent clinical course that can persist for a few years. However, eventually these patients go on to develop marked lymphocytosis and rapidly progressive disease. We report a 72-year-old man who presented with multicompartmental lymphadenopathy and a normal complete blood count...
February 2023: Annals of Diagnostic Pathology
https://read.qxmd.com/read/36533357/-ruxolitinib-as-an-effective-treatment-for-panniculitis-associated-hemophagocytic-syndrome-a-report-of-2-cases-and-literature-review
#39
REVIEW
G M Li, Y B Jin, Y Z Gan, C Chen, Y Jia, C Li
Hemophagocytic syndrome (HPS) is a severe disease characterized by excessive release of inflammatory cytokines caused by abnormal activation of lymphocytes and macrophages, which can cause multiple organ damage and even death. Panniculitis is a disease characterized by inflammation of subcutaneous adipose tissue. We effectively treated 2 patients with panniculitis-associated HPS with ruxolitinib. Case 1: A 70-year-old male started with intermittent plantar swelling and pain, and then developed leukocytosis, mild anemia, multiple red maculopapules with painless subcutaneous nodules on the forehead, neck and bilateral lower legs...
December 18, 2022: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://read.qxmd.com/read/36464841/establishment-of-preliminary-reference-intervals-and-cytochemical-staining-of-blood-cells-in-big-bellied-seahorses-hippocampus-abdominalis
#40
JOURNAL ARTICLE
Claire Vergneau-Grosset, Jean-Philippe Frigon, Marie-Odile Benoit-Biancamano, Juliette Raulic, Marie-Pierre Lessard, Carolyn Gara-Boivin
BACKGROUND: Despite their popularity, hematology reference intervals (RIs) have not been established in big-bellied seahorses (Hippocampus abdominalis). OBJECTIVE: The objectives of this study were to establish hematologic RIs to compare values between sex in regard to cytochemical staining of blood cells. We also sought to compare white blood cell concentrations using the Natt and Herrick technique vs blood smear estimates. METHODS: Forty-three healthy individuals from the Aquarium du Québec (22 females and 21 males) were included...
December 4, 2022: Veterinary Clinical Pathology
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