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Keywords White blood cells normal and p...

White blood cells normal and pathology

https://read.qxmd.com/read/38468329/evaluation-of-the-embopipe-flow-diverter-device-in-vivo-and-in-vitro-experiments
#1
JOURNAL ARTICLE
Yongnan Zhu, Fanyan Zeng, Jian Liu, Shiqing Mu, Xinjian Yang, Ying Zhang
BACKGROUND: Although flow diverter device (FDD) has brought revolutionized advances in endovascular treatment of intracranial aneurysms, it also presents considerable drawbacks as well, as the innovation for novel device has never stopped. This preclinical research aims to evaluate the safety and efficacy of a newly developed FDD, the EMBOPIPE, through in vivo and in vitro experiments. METHODS: Aneurysms were induced in 20 New Zealand white rabbits which were randomized to three follow-up groups according to the time elapsed after EMBOPIPE implantation (28, 90, and 180 days)...
March 12, 2024: Chinese Neurosurgical Journal
https://read.qxmd.com/read/38452643/a-case-report-of-primary-pancreatic-lymphoma-revealed-by-an-acute-pancreatitis
#2
Rahma Daoud, Sadok Ben Jabra, Mohamed Ali Chaouch, Hiba Ben Hassine, Mohamed Zayati, Faouzi Noomen
INTRODUCTION: Primary pancreatic lymphoma (PPL) is a rare malignancy. Diffuse large B-cell lymphoma is the predominant subtype, often affecting the pancreatic head in elderly males. Due to its rarity and nonspecific symptoms, PPL is frequently misdiagnosed, leading to unnecessary surgeries. This case report discusses the diagnosis and management of PPL in a 47-year-old female, emphasizing the challenges in its identification. CASE PRESENTATION: A 47-year-old female with no medical history presented with severe epigastric pain and jaundice...
March 5, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38439725/neutrophilic-dermatosis-of-the-hands-a-case-report
#3
JOURNAL ARTICLE
Reza Yaghoobi, Nooshin Bagherani, Bruce R Smoller, Nader Pazyar
Neutrophilic dermatosis of the hands (NDDH) is a localized variant of Sweet's syndrome which has been recently introduced. Strutton et al.in 1996 and then in Galaria et al. in 2000 reported cases with violaceous papulonodules on the dorsal surfaces of the hands with histopathological findings of a neutrophilic dermatosis in association with leukocytoclasia, but clinically and histologically without true vasculitis findings. Eventually, they proposed the term NDDH for these lesions (1,2). A 46-year-old man was referred to our outpatient dermatology clinic with a painful ulcerative lesion on the dorsal side of the left hand that had been present for one year...
December 2023: Acta Dermatovenerologica Croatica: ADC
https://read.qxmd.com/read/38336016/sub-chronic-oral-toxicity-of-a-water-soluble-extract-of-centella-asiatica-centell-s-in-wistar-rats
#4
JOURNAL ARTICLE
Thammaporn Junsai, Supawit Tangpanithandee, Passaraporn Srimangkornkaew, Kran Suknuntha, Pornpun Vivithanaporn, Phisit Khemawoot
BACKGROUND: Centell-S, a water-soluble extract from Centella asiatica, is predominantly composed of madecassoside and asiaticoside, exceeding 80% w/w. Pursuing its development as an herbal medicinal product, Centell-S underwent sub-chronic toxicity assessment adhering to OECD GLP 408 standards. METHODS: In a study involving 100 Wistar rats, varying doses of Centell-S (50, 200, or 800 mg/kg/day) or a vehicle control were administered orally over 90 days. To evaluate Centell-S's safety profile, assessments included clinical observations, health examinations, clinical biochemistry analyses, and detailed anatomical pathology evaluations were conducted...
February 7, 2024: Food and Chemical Toxicology
https://read.qxmd.com/read/38304474/bilateral-neoureterocystostomy-with-distal-ureteral-tapering-in-a-dog-with-severe-bilateral-hydroureteronephrosis
#5
Agnieszka B Fracka, Jolene Sun, Boel A Fransson
A 3.5-year-old intact male Labrador retriever was seen for hematuria. The results of clinical pathology tests were unremarkable. However, urinalysis revealed dark, cloudy, alkalotic, and isosthenuric urine containing red and white blood cells, epithelial cells, and struvite crystals. Severe bilateral enlargement of ureters and markedly enlarged kidneys were identified on abdominal radiographs. Computerized tomography revealed extensive bilateral hydroureteronephrosis with no definitive cause of obstruction...
February 2024: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://read.qxmd.com/read/38247821/the-matrix-receptor-cd44-is-present-in-astrocytes-throughout-the-human-central-nervous-system-and-accumulates-in-hypoxia-and-seizures
#6
JOURNAL ARTICLE
Osama Al-Dalahmah, Alexander A Sosunov, Yu Sun, Yang Liu, Nacoya Madden, E Sander Connolly, Carol M Troy, Guy M McKhann, James E Goldman
In the mammalian isocortex, CD44, a cell surface receptor for extracellular matrix molecules, is present in pial-based and fibrous astrocytes of white matter but not in protoplasmic astrocytes. In the hominid isocortex, CD44+ astrocytes comprise the subpial "interlaminar" astrocytes, sending long processes into the cortex. The hippocampus also contains similar astrocytes. We have examined all levels of the human central nervous system and found CD44+ astrocytes in every region. Astrocytes in white matter and astrocytes that interact with large blood vessels but not with capillaries in gray matter are CD44+, the latter extending long processes into the parenchyma...
January 10, 2024: Cells
https://read.qxmd.com/read/38238810/eosinophilic-enterocolitis-a-case-report
#7
JOURNAL ARTICLE
Hend Smaoui, Abdelwaheb Nakhli, Nesrine Hemdani, Bochra Bouchabou, Rym Ennaifer
BACKGROUND: Eosinophilic enterocolitis is a rare disorder characterized by abnormal eosinophilic infiltration of the small intestine and the colon. CASE PRESENTATION: We report a case of a 29-year-old White man, who presented with an acute bowel obstruction. He had a history of a 2 months non-bloody diarrhea. An abdominal computed tomography (CT) and a MR enterography showed a multifocal extensive ileitis. White blood cell and eosinophilic polynuclei count was elevated (700/mm3 )...
January 19, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38223126/intravoxel-incoherent-motion-diffusion-weighted-mri-for-the-evaluation-of-early-spleen-involvement-in-acute-leukemia
#8
JOURNAL ARTICLE
Wenjin Bian, Qianqian Huang, Jianling Zhang, Jianting Li, Xiaoli Song, Sha Cui, Qian Zheng, Jinliang Niu
BACKGROUND: The spleen is a frequent organ of leukemia metastasis. This study aimed to investigate the value of intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) for assessing pathologic changes in the spleen and identifying early spleen involvement in patients with acute leukemia (AL). METHODS: Patients with newly diagnosed AL and healthy controls were recruited between June 2020 and November 2022. All participants underwent abdominal IVIM diffusion-weighted imaging (DWI) at our hospital...
January 3, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38156747/vortexing-specimens-to-disaggregate-platelet-clumps-in-edta-specimens
#9
JOURNAL ARTICLE
Lillian Mundt
OBJECTIVE: To compare platelet count results of specimens that yield platelet clump flags to platelet count results on these specimens after vortexing. METHOD: Specimens that generated platelet count flags on Sysmex XN 3000 instruments were vortexed and rerun. Only data from specimens demonstrating elimination of platelet clump flags were used in this study. Pearson r analysis was performed on data. RESULTS: Comparison of complete blood count results (white blood cell count, red blood cell count, hemoglobin, hematocrit, and platelet count) all yielded Pearson r scores >0...
December 29, 2023: Laboratory Medicine
https://read.qxmd.com/read/38058776/paradox-inflammatory-reaction-such-as-appendicitis-epiploica-and-diverticulitis-of-the-sigmoid-colon-under-ongoing-immunosuppression-after-previous-liver-transplantation-ltx
#10
Isabella Trautwein, Manuela Petersen, Christine March, Roland S Croner, Frank Meyer
OBJECTIVE: Inflammatory reactions caused by immunosuppression appear a particular interesting disease due to its very specific and partly unclear etiopathogenesis.Based on clinical case-specific management experiences and selective references from the literature, the rare case of an acute intraabdominal inflammation as unusual complication or side effect (at the gastrointestinal [GI] tract) of the ongoing immunosuppressive medication using Mycophenolate mofetil and Tacrolimus after previous liver transplantation is to be illustrated...
June 2023: Innovative Surgical Sciences
https://read.qxmd.com/read/38055172/pathological-effects-of-feeding-aflatoxin-contaminated-feed-on-immune-status-and-reproductive-performance-of-juvenile-white-leghorn-males-and-its-mitigation-with-%C3%A2-tocopherol-and-moringa-oleifera
#11
JOURNAL ARTICLE
Muhammad Kashif Saleemi, Ahmad Raza, Aisha Khatoon, Muhammad Zubair, Shafia Tehseen Gul, Xu Yongping, Bilal Murtaza, Faqir Muhammad, Bushra Akhtar, Farhat Jubeen, Farzana Rizvi, Khawar Zubair, Anas Ashraf, Muhammad Nabeel Ijaz, Asim Sultan
This study was planned to detect the adverse pathological consequences of aflatoxin B1 in White Leghorn (WLH) layer breeder males. Eight-week-old male layer cockerels were separated into six experimental categories: A group was kept as negative control, offered with normal feed only; group B was fed with 400 ppb amount of aflatoxin, while groups F and D fed with normal feed and supplemented with vitamin E 100 ppm and 1% Moringa oleifera, respectively, whereas groups E and C were fed with 400 ppb aflatoxin containing feed and ameliorated with vitamin E 100 ppm and 1% Moringa oleifera, respectively...
December 6, 2023: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38051249/idiopathic-granulomatous-mastitis-associated-with-erythema-nodosum-in-a-pregnant-woman
#12
Anissa Zaouak, Chamli Amal, Raboudi Asma, Fatma Daoud, Ehsen Ben Brahim, Houda Hammami, Samy Fenniche
A 32-year-old woman at 17 weeks' gestation presented with fever and a 1-week history of an acute nodular eruption involving her legs, along with bilateral ankle and knee pain. She also had had a recurrent right breast abscess for 2 months for which she had been treated with oral antibiotics and surgical drainage, but with slight improvement. Cultures of the abscess showed no bacteria or fungi. She had no history of tuberculosis, sarcoidosis, trauma to the breast, or a family history of breast pathology. Cutaneous examination revealed multiple, tender, erythematous, subcutaneous nodules on her legs (Figure 1) and an ill-defined tender mass involving the inferior quadrant of the right breast without nipple discharge or retraction...
2023: Skinmed
https://read.qxmd.com/read/38041859/initiative-to-reduce-unnecessary-routine-daily-testing-of-complete-blood-counts-across-11-safety-net-hospitals
#13
JOURNAL ARTICLE
Hyung J Cho, Sigal Israilov, Surafel Tsega, Dan Alaiev, Joseph Talledo, Komal Chandra, Peter Alarcon Manchego, Milana Zaurova, Christopher M Petrilli, Mona Krouss
OBJECTIVES: National societies recommend against performing routine daily laboratory testing without a specific indication. Unnecessary testing can lead to patient harm, such as hospital-acquired anemia. The objective of this study was to reduce repeat complete blood counts (CBCs) after initial testing. METHODS: This was a quality improvement initiative implemented across 11 safety net hospitals in New York City. A best practice advisory (BPA) was implemented that asked the user to remove a CBC if the last 2 CBCs within 72 hours had normal white blood cell and platelet counts and unchanged hemoglobin levels...
December 2, 2023: American Journal of Clinical Pathology
https://read.qxmd.com/read/38029922/non-metastatic-axillary-lymph-nodes-have-distinct-morphology-and-immunophenotype-in-obese-breast-cancer-patients-at-risk-for-metastasis
#14
JOURNAL ARTICLE
Qingyuan Song, Kristen E Muller, Liesbeth M Hondelink, Roberta M diFlorio-Alexander, Margaret Karagas, Saeed Hassanpour
Obese breast cancer patients have worse outcomes than their normal weight counterparts, with a 50% to 80% increased rate of axillary nodal metastasis. Recent studies suggest a link between increased lymph node adipose tissue and breast cancer nodal metastasis. Further investigation into potential mechanisms underlying this link may reveal potential prognostic utility of fat-enlarged lymph nodes in breast cancer patients. This study uses a deep learning model to identify morphological differences in non-metastatic axillary nodes between obese, node-positive and node-negative breast cancer patients...
November 27, 2023: American Journal of Pathology
https://read.qxmd.com/read/37969023/exploring-effect-of-m2-macrophages-on-experimental-full-thickness-wound-healing-in-streptozotocin-induced-diabetic-rats
#15
JOURNAL ARTICLE
Parmis Khoshnoudi, Soroush Sabiza, Mohammad Khosravi, Babak Mohamadian
Diabetes mellitus is one of the most prevalent medical conditions, in both humans and animals. People with diabetes mellitus often experience slower than normal wound healing, making it a serious health concern. This study investigates the effect of M2 differentiated macrophages on full-thickness wound healing in white Westar rats exposed to streptozocin 70 mg/kg. A full-thickness skin defect with dimensions of 2 × 2 cm was created on the back of all the animals, and their blood sugar was simultaneously assessed...
November 15, 2023: International Journal of Experimental Pathology
https://read.qxmd.com/read/37774533/functions-of-lncrnas-exosomes-derived-mscs-and-immune-regulatory-molecules-in-preeclampsia-disease
#16
REVIEW
Sulieman Ibraheem Shelash Al-Hawary, Nahla A Tayyib, Pushpamala Ramaiah, Rosario Mireya Romero Parra, Ahmed Jaber Ibrahim, Yasser Fakri Mustafa, Beneen M Hussien, Sana A Alsulami, Kamilya Jamel Baljon, Ibtesam Nomani
Modulatory signaling pathway such as T cell immunoreceptor with Ig and ITIM domains (TIGIT), Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA-4), P53 signaling and TIM (T-cell immunoglobin and mucin domain) are important in normal pregnancy and loss of their functions or dysregulation of related genes can lead to some disorders. Inflammation is a process by which your body's white blood cells and the things they make protect you from infection from outside invaders, such as bacteria and viruses. Some cellular and molecular signaling have been categorized to demonstrate the mechanism that protects tolerance to antigens...
September 7, 2023: Pathology, Research and Practice
https://read.qxmd.com/read/37550790/hypoxic-oligodendrocyte-precursor-cell-derived-vegfa-is-associated-with-blood-brain-barrier-impairment
#17
JOURNAL ARTICLE
Narek Manukjan, Daria Majcher, Peter Leenders, Florian Caiment, Marcel van Herwijnen, Hubert J Smeets, Ernst Suidgeest, Louise van der Weerd, Tim Vanmierlo, Jacobus F A Jansen, Walter H Backes, Robert J van Oostenbrugge, Julie Staals, Daniel Fulton, Zubair Ahmed, W Matthijs Blankesteijn, Sébastien Foulquier
Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood-brain barrier impairments which play a key role in the development of white matter lesions. We hypothesised that cerebral hypoperfusion causes local hypoxia, affecting oligodendrocyte precursor cell-endothelial cell signalling leading to blood-brain barrier dysfunction as an early mechanism for the development of white matter lesions. Bilateral carotid artery stenosis was used as a mouse model for cerebral hypoperfusion...
August 7, 2023: Acta Neuropathologica Communications
https://read.qxmd.com/read/37530339/pediatric-and-adolescent-chronic-myeloid-leukemia-a-follow-up-study-in-western-india
#18
JOURNAL ARTICLE
Sangita A Vanik, Dhaval Jetly, Biren Parikh, Karthik Dhandapani, Rukmini Bezbaruah
BACKGROUND: Chronic myeloid leukemia (CML) is relatively rare in pediatric and adolescent age groups. The purpose of this study was to evaluate the clinical, hematopathological, and biochemical parameters of CML in pediatric and adolescent age groups, along with an assessment of the treatment response with first-line tyrosine kinase inhibitors (TKI) and its correlation with the prognostic scoring systems of adults. MATERIALS AND METHODS: A retrospective study of 44 Breakpoint Cluster Region-Abelson leukemia virus (BCR-ABL1)-positive pediatric and adolescent CML cases registered at our hospital was done...
2023: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/37468490/a-high-resolution-large-scale-dataset-of-pathological-and-normal-white-blood-cells
#19
JOURNAL ARTICLE
Alexandra Bodzas, Pavel Kodytek, Jan Zidek
Microscopic examination plays a significant role in the initial screening for a variety of hematological, as well as non-hematological, diagnoses. Microscopic blood smear examination that is considered a key diagnostic technique, is in recent clinical practice still performed manually, which is not only time consuming, but can lead to human errors. Although automated and semi-automated systems have been developed in recent years, their high purchasing and maintenance costs make them unaffordable for many medical institutions...
July 19, 2023: Scientific Data
https://read.qxmd.com/read/37456531/acute-oral-toxicity-assessment-of-galbanic-acid-in-albino-rat-according-to-oecd-425-tg
#20
JOURNAL ARTICLE
Mohammad Hadi Zarei, Zahra Lorigooini, Hossein Amini Khoei, Elham Bijad
In spite of the broad biological and also anticarcinogenic effects which have been reported for galbanic acid in various studies, its toxic effects are not still well characterized. The study was accomplished to evaluate the acute oral toxicity of galbanic acid pursuant to Organisation for Economic Co-operation and Development (OECD) TG No. 425. Female rats were received asafoetida extract and galbanic acid in distilled water by oral gavage. According to the existing information, limit test was done for aqueous extract of asafoetida and main test was done for galbanic acid...
December 2023: Toxicology Reports
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