Narek Manukjan, Daria Majcher, Peter Leenders, Florian Caiment, Marcel van Herwijnen, Hubert J Smeets, Ernst Suidgeest, Louise van der Weerd, Tim Vanmierlo, Jacobus F A Jansen, Walter H Backes, Robert J van Oostenbrugge, Julie Staals, Daniel Fulton, Zubair Ahmed, W Matthijs Blankesteijn, Sébastien Foulquier
Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood-brain barrier impairments which play a key role in the development of white matter lesions. We hypothesised that cerebral hypoperfusion causes local hypoxia, affecting oligodendrocyte precursor cell-endothelial cell signalling leading to blood-brain barrier dysfunction as an early mechanism for the development of white matter lesions. Bilateral carotid artery stenosis was used as a mouse model for cerebral hypoperfusion...
August 7, 2023: Acta Neuropathologica Communications