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https://www.readbyqxmd.com/read/27870576/airway-management-strategies-for-brain-injured-patients-meeting-standard-criteria-to-consider-extubation-a-prospective-cohort-study
#1
Victoria A McCredie, Niall D Ferguson, Ruxandra L Pinto, Neill Kj Adhikari, Robert A Fowler, Martin G Chapman, Althea Burrell, Andrew J Baker, Deborah J Cook, Maureen O Meade, Damon C Scales
RATIONALE: Patients with acute brain injury are frequently capable of breathing spontaneously with minimal ventilatory support despite persistent neurological impairment. OBJECTIVES: We sought to describe factors associated with extubation timing, success and primary tracheostomy in these patients. METHODS: We conducted a prospective multicenter observational cohort study in three academic hospitals in Toronto, Canada. Consecutive brain-injured adults receiving mechanical ventilation for at least 24 hours in 3 ICUs were screened by study personnel daily for extubation consideration criteria...
November 21, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27739873/role-of-ni-tolerant-bacillus-spp-and-althea-rosea-l-in-the-phytoremediation-of-ni-contaminated-soils
#2
Waheed Ullah Khan, Nasim Ahmad Yasin, Sajid Rashid Ahmad, Aamir Ali, Shakil Ahmed, Aqeel Ahmad
In our current study four nickel tolerant (Ni-tolerant) bacterial species viz: Bacillus thuringiensis 002, Bacillus fortis 162, Bacillus subtilis 174 and Bacillus farraginis 354 were screened by using Ni contaminated media. The screened microbes exhibited positive results for synthesis of indole acetic acid (IAA), siderophore production and phosphate solubilization. The effects of these screened microbes on Ni mobility in the soil, root elongation, plant biomass and Ni uptake in Althea rosea plants grown in Ni contaminated soil (200 mg Ni kg(-1)) were evaluated...
October 14, 2016: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/27584586/national-estimates-of-marijuana-use-and-related-indicators-national-survey-on-drug-use-and-health-united-states-2002-2014
#3
Alejandro Azofeifa, Margaret E Mattson, Gillian Schauer, Tim McAfee, Althea Grant, Rob Lyerla
PROBLEM/CONDITION: In the United States, marijuana is the most commonly used illicit drug. In 2013, 7.5% (19.8 million) of the U.S. population aged ≥12 years reported using marijuana during the preceding month. Because of certain state-level policies that have legalized marijuana for medical or recreational use, population-based data on marijuana use and other related indicators are needed to help monitor behavioral health changes in the United States. PERIOD COVERED: 2002-2014...
September 2, 2016: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/27583699/monitoring-marijuana-use-in-the-united-states-challenges-in-an-evolving-environment
#4
COMMENT
Alejandro Azofeifa, Margaret E Mattson, Althea Grant
No abstract text is available yet for this article.
November 1, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27531917/genetic-modifiers-for-the-long-qt-syndrome-how-important-is-the-role-of-variants-in-the-3-untranslated-region-of-kcnq1
#5
Lia Crotti, Annukka M Lahtinen, Carla Spazzolini, Elisa Mastantuono, Maria Cristina Monti, Caterina Morassutto, Gianfranco Parati, Marshall Heradien, Althea Goosen, Peter Lichtner, Thomas Meitinger, Paul A Brink, Kimmo Kontula, Heikki Swan, Peter J Schwartz
BACKGROUND: Long-QT syndrome is an inherited cardiac channelopathy characterized by delayed repolarization, risk of life-threatening arrhythmia, and significant clinical variability even within families. Three single-nucleotide polymorphisms (SNPs) in the 3' untranslated region of KCNQ1 were recently suggested to be associated with suppressed gene expression and hence decreased disease severity when located on the same haplotype with a disease-causing KCNQ1 mutation. We sought to replicate this finding in a larger and a genetically more homogeneous population of KCNQ1 mutation carriers...
August 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/27499191/prospective-observational-study-on-central-line-associated-bloodstream-infections-and-central-venous-catheter-occlusions-using-a-negative-displacement-connector-with-an-alcohol-disinfecting-cap
#6
Parul A Patel, Susan Boehm, Ying Zhou, Catherine Zhu, Kari E Peterson, Althea Grayes, Lance R Peterson
BACKGROUND: Major complications of central venous catheter (CVC) use include bloodstream infection and occlusion. We performed a prospective, observational study to determine the rate of central line-associated bloodstream infection (CLABSI) and CVC occlusion using a negative displacement connector with an alcohol disinfecting cap. METHODS: Patients were followed from the time of CVC insertion through 2 days after removal, at the time of hospital discharge if there was no documentation of removal, or 90 days after the insertion of the CVC if it was not removed...
August 4, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27477581/factors-associated-with-opioid-dose-increases-a-chart-review-of-patients-first-year-on-long-term-opioids
#7
Christopher A Bautista, Ana-Maria Iosif, Barth L Wilsey, Joy A Melnikow, Althea Crichlow, Stephen G Henry
OBJECTIVE:  To examine encounter-level factors associated with opioid dose increases during patients' first year on opioid therapy for chronic pain. DESIGN:  Case-control study analyzing all opioid prescriptions for patients with chronic pain during their first year after opioid initiation. Cases were patients who experienced an overall dose escalation of ≥ 30 mg morphine equivalents over the 1-year period; controls did not experience overall dose escalation...
July 31, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27324480/antifungal-activity-of-plasmacytoid-dendritic-cells-against-cryptococcus-neoformans-in-vitro-requires-expression-of-dectin-3-clec4d-and-reactive-oxygen-species
#8
Camaron R Hole, Chrissy M Leopold Wager, Andrew S Mendiola, Karen L Wozniak, Althea Campuzano, Xin Lin, Floyd L Wormley
Conventional dendritic cells (cDCs) are critical for protection against pulmonary infection with the opportunistic fungal pathogen Cryptococcus neoformans; however, the role of plasmacytoid dendritic cells (pDCs) is unknown. We show for the first time that murine pDCs have direct activity against C. neoformans via reactive oxygen species (ROS), a mechanism different from that employed to control Aspergillus fumigatus infections. The anticryptococcal activity of murine pDCs is independent of opsonization but appears to require the C-type lectin receptor Dectin-3, a receptor not previously evaluated during cryptococcal infections...
September 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27268043/medicinal-plants-prophylactic-and-therapeutic-options-for-gastrointestinal-and-respiratory-diseases-in-calves-and-piglets-a-systematic-review
#9
Hannah Ayrle, Meike Mevissen, Martin Kaske, Heiko Nathues, Niels Gruetzner, Matthias Melzig, Michael Walkenhorst
BACKGROUND: Gastrointestinal and respiratory diseases in calves and piglets lead to significant economic losses in livestock husbandry. A high morbidity has been reported for diarrhea (calves ≤ 35%; piglets ≤ 50%) and for respiratory diseases (calves ≤ 80%; piglets ≤ 40%). Despite a highly diverse etiology and pathophysiology of these diseases, treatment with antimicrobials is often the first-line therapy. Multi-antimicrobial resistance in pathogens results in international accordance to strengthen the research in novel treatment options...
2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27090687/community-engagement-to-inform-the-development-of-a-sickle-cell-counselor-training-and-certification-program-in-ghana
#10
Kofi A Anie, Marsha J Treadwell, Althea M Grant, Jemima A Dennis-Antwi, Mabel K Asafo, Mary E Lamptey, Jelili Ojodu, Careema Yusuf, Ayo Otaigbe, Kwaku Ohene-Frempong
Sickle cell disease (SCD) and sickle cell trait (SCT) are highly prevalent in Africa. Despite public health implications, there is limited understanding of community issues for implementing newborn screening and appropriate family counseling. We conducted a 3-day workshop in Kumasi, Ghana, with community leaders as lay program development advisors to assist the development and implementation of a Sickle Cell Counselor Training and Certification Program. We employed qualitative methods to understand cultural, religious, and psychosocial dimensions of SCD and SCT, including the advisors' attitudes and beliefs in relation to developing a culturally sensitive approach to family education and counseling that is maximally suited to diverse communities in Ghana...
July 2016: Journal of Community Genetics
https://www.readbyqxmd.com/read/27009498/developing-mhealth-remote-monitoring-technology-for-attention-deficit-hyperactivity-disorder-a-qualitative-study-eliciting-user-priorities-and-needs
#11
Lucy Simons, Althea Z Valentine, Caroline J Falconer, Madeleine Groom, David Daley, Michael P Craven, Zoe Young, Charlotte Hall, Chris Hollis
BACKGROUND: Guidelines in the United Kingdom recommend that medication titration for attention deficit hyperactivity disorder (ADHD) should be completed within 4-6 weeks and include regular reviews. However, most clinicians think that weekly clinic contact is infeasible, and audits have shown that this timeline is rarely achieved. Thus, a more effective monitoring and review system is needed; remote monitoring technology (RMT) may be one way to improve current practice. However, little is known about whether patients with ADHD, their families, and clinicians would be interested in using RMT...
2016: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/26999505/carest-multilingual-regional-integration-for-health-promotion-and-research-on-sickle-cell-disease-and-thalassemia
#12
Jennifer Knight-Madden, Marc Romana, Rinaldo Villaescusa, Marvin Reid, Maryse Etienne-Julan, Laurence Boutin, Gisèle Elana, Narcisse Elenga, Gillian Wheeler, Ketty Lee, Rosa Nieves, Althea Jones Lecointe, Marie-Laure Lalanne-Mistrih, Gylna Loko, Lisiane Keclard-Christophe, Marie-Dominique Hardy-Dessources
Sickle cell disease (SCD) is a significant problem in the Caribbean, where many individuals have African and Asian forebears. However, reliable prevalence data and specific health care programs for SCD are often missing in this region. Closer collaboration between Caribbean territories initiated in 2006 to set up strategies to promote better equity in the health care system for SCD patients led to the formation of CAREST: the Caribbean Network of Researchers on Sickle Cell Disease and Thalassemia. We present the effectiveness of collaborations established by CAREST to promote SCD newborn screening programs and early childhood care, to facilitate health worker training and approaches for prevention and treatment of SCD complications, and to carry out inter-Caribbean research studies...
May 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/26984689/the-long-term-effects-of-participant-direction-of-supports-and-services-for-people-with-disabilities
#13
Melissa L Harry, Jooyoung Kong, Lynn M MacDonald, Althea McLuckie, Christina Battista, Ellen K Mahoney, Haesang Jeon, Kevin J Mahoney
Numerous studies have demonstrated the short-term effectiveness of the Cash and Counseling model option of participant-directed home and community-based personal care service programs for Medicaideligible recipients with disabilities requiring long-term care. However, long-term experiences with participant-directed services have yet to be examined for these individuals. We addressed this gap in the literature through participatory action research and qualitative content analysis. Working together as coresearchers with members of the National Participant Network, a peer organization for people interested in or enrolled in participant-directed services, we interviewed 17 adults enrolled in one state's Cash and Counseling-based program...
2016: Care Management Journals: Journal of Case Management ; the Journal of Long Term Home Health Care
https://www.readbyqxmd.com/read/26957672/defining-sickle-cell-disease-mortality-using-a-population-based-surveillance-system-2004-through-2008
#14
Susan T Paulukonis, James R Eckman, Angela B Snyder, Ward Hagar, Lisa B Feuchtbaum, Mei Zhou, Althea M Grant, Mary M Hulihan
OBJECTIVE: Population-based surveillance data from California and Georgia for years 2004 through 2008 were linked to state death record files to determine the all-cause death rate among 12,143 patients identified with sickle cell disease (SCD). METHODS: All-cause death rates, by age, among these SCD patients were compared with all-cause death rates among both African Americans and the total population in the two states. All-cause death rates were also compared with death rates for SCD derived from publicly available death records: the compressed mortality files and multiple cause of death files...
March 2016: Public Health Reports
https://www.readbyqxmd.com/read/26953144/an-evaluation-of-root-phytochemicals-derived-from-althea-officinalis-marshmallow-and-astragalus-membranaceus-as-potential-natural-components-of-uv-protecting-dermatological-formulations
#15
Alison Curnow, Sara J Owen
As lifetime exposure to ultraviolet (UV) radiation has risen, the deleterious effects have also become more apparent. Numerous sunscreen and skincare products have therefore been developed to help reduce the occurrence of sunburn, photoageing, and skin carcinogenesis. This has stimulated research into identifying new natural sources of effective skin protecting compounds. Alkaline single-cell gel electrophoresis (comet assay) was employed to assess aqueous extracts derived from soil or hydroponically glasshouse-grown roots of Althea officinalis (Marshmallow) and Astragalus membranaceus, compared with commercial, field-grown roots...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/26892813/long-term-experiences-in-cash-and-counseling-for-young-adults-with-intellectual-disabilities-familial-programme-representative-descriptions
#16
Melissa L Harry, Lynn MacDonald, Althea McLuckie, Christina Battista, Ellen K Mahoney, Kevin J Mahoney
BACKGROUND: Our aim was to explore previously unknown long-term outcomes of self-directed personal care services for young adults with intellectual disabilities and limitations in activities of daily living. MATERIALS AND METHODS: The present authors utilized participatory action research and qualitative content analysis in interviewing 11 unpaid familial programme representatives of young adults with intellectual disabilities, ages 23-34, who were eligible for income-based Medicaid and enrolled five or more years in a Cash and Counseling-based programme of self-direction in the United States...
February 19, 2016: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/26863035/the-complete-and-updated-rotifer-polyculture-method-for-rearing-first-feeding-zebrafish
#17
Christian Lawrence, Jason Best, Jason Cockington, Eric C Henry, Shane Hurley, Althea James, Christopher Lapointe, Kara Maloney, Erik Sanders
The zebrafish (Danio rerio) is a model organism of increasing importance in many fields of science. One of the most demanding technical aspects of culture of this species in the laboratory is rearing first-feeding larvae to the juvenile stage with high rates of growth and survival. The central management challenge of this developmental period revolves around delivering highly nutritious feed items to the fish on a nearly continuous basis without compromising water quality. Because larval zebrafish are well-adapted to feed on small zooplankton in the water column, live prey items such as brachionid rotifers, Artemia, and Paramecium are widely recognized as the feeds of choice, at least until the fish reach the juvenile stage and are able to efficiently feed on processed diets...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/26822008/managing-and-mitigating-conflict-in-healthcare-teams-an-integrative-review
#18
REVIEW
Joan Almost, Angela C Wolff, Althea Stewart-Pyne, Loretta G McCormick, Diane Strachan, Christine D'Souza
AIM: To review empirical studies examining antecedents (sources, causes, predictors) in the management and mitigation of interpersonal conflict. BACKGROUND: Providing quality care requires positive, collaborative working relationships among healthcare team members. In today's increasingly stress-laden work environments, such relationships can be threatened by interpersonal conflict. Identifying the underlying causes of conflict and choice of conflict management style will help practitioners, leaders and managers build an organizational culture that fosters collegiality and create the best possible environment to engage in effective conflict management...
July 2016: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/26719309/sleep-disturbances-in-neurodevelopmental-disorders
#19
REVIEW
Althea Robinson-Shelton, Beth A Malow
Sleep disturbances are extremely prevalent in children with neurodevelopmental disorders compared to typically developing children. The diagnostic criteria for many neurodevelopmental disorders include sleep disturbances. Sleep disturbance in this population is often multifactorial and caused by the interplay of genetic, neurobiological and environmental overlap. These disturbances often present either as insomnia or hypersomnia. Different sleep disorders present with these complaints and based on the clinical history and findings from diagnostic tests, an appropriate diagnosis can be made...
January 2016: Current Psychiatry Reports
https://www.readbyqxmd.com/read/26675262/factors-that-control-c-c-cleavage-versus-c-h-bond-hydroxylation-in-copper-catalyzed-oxidations-of-ketones-with-o2
#20
Althea S-K Tsang, Ajoy Kapat, Franziska Schoenebeck
The Cu-catalyzed oxidation of ketones with O2 has recently been extensively utilized to cleave the α-C-C bond. This report examines the selective aerobic hydroxylation of tertiary α-C-H bonds in ketones without C-C cleavage. We set out to understand the underlying mechanisms of these two possible reactivity modes. Using experimental, in situ IR spectroscopic, and computational studies, we investigated several mechanisms. Our data suggest that both C-C cleavage and C-H hydroxylation pathways proceed via a common key intermediate, i...
January 20, 2016: Journal of the American Chemical Society
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