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https://www.readbyqxmd.com/read/28664654/acne-keloidalis-nuchae-risk-factors-and-associated-disorders-a-retrospective-study
#1
Althea D C East-Innis, Kaderina Stylianou, Alexandra Paolino, Jonathan D Ho
BACKGROUND: Acne keloidalis nuchae (AKN) is a chronic scarring folliculitis which usually occurs in young adult males of African descent. Studies have suggested that AKN may be associated with other dermatologic conditions and even general medical disorders. The aim of this study was to identify cutaneous and extracutaneous associated disorders and to examine risk factors in our population for developing AKN. METHODS: The study was a retrospective, descriptive, and analytical study conducted at the Dermatology Outpatient department of the University Hospital of the West Indies...
August 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28591573/phosphorylation-of-txnip-by-akt-mediates-acute-influx-of-glucose-in-response-to-insulin
#2
Althea N Waldhart, Holly Dykstra, Anderson S Peck, Elissa A Boguslawski, Zachary B Madaj, Jennifer Wen, Kelsey Veldkamp, Matthew Hollowell, Bin Zheng, Lewis C Cantley, Timothy E McGraw, Ning Wu
Growth factors, such as insulin, can induce both acute and long-term glucose uptake into cells. Apart from the rapid, insulin-induced fusion of glucose transporter (GLUT)4 storage vesicles with the cell surface that occurs in muscle and adipose tissues, the mechanism behind acute induction has been unclear in other systems. Thioredoxin interacting protein (TXNIP) has been shown to be a negative regulator of cellular glucose uptake. TXNIP is transcriptionally induced by glucose and reduces glucose influx by promoting GLUT1 endocytosis...
June 6, 2017: Cell Reports
https://www.readbyqxmd.com/read/28532548/mtorc1-in-agrp-neurons-integrates-exteroceptive-and-interoceptive-food-related-cues-in-the-modulation-of-adaptive-energy-expenditure-in-mice
#3
Luke K Burke, Tamana Darwish, Althea R Cavanaugh, Sam Virtue, Emma Roth, Joanna Morro, Shun-Mei Liu, Jing Xia, Jeffrey W Dalley, Keith Burling, Streamson Chua, Toni Vidal-Puig, Gary J Schwartz, Clémence Blouet
Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain to adjust iBAT activity and maintain energy homeostasis. Here, we provide evidence that AGRP inhibitory tone to iBAT represents an energy-sparing circuit that integrates environmental food cues and internal signals of energy availability. We establish a role for the nutrient-sensing mTORC1 signaling pathway within AGRP neurons in the detection of environmental food cues and internal signals of energy availability, and in the bi-directional control of iBAT thermogenesis during nutrient deficiency and excess...
May 23, 2017: ELife
https://www.readbyqxmd.com/read/28523850/n-aryl-groups-are-ubiquitous-in-cross-dehydrogenative-couplings-because-they-stabilize-reactive-intermediates
#4
Althea S-K Tsang, A Stephen K Hashmi, Peter Comba, Marion Kerscher, Bun Chan, Matthew H Todd
The mechanism of cross-dehydrogenative coupling (CDC) reactions has been examined by experimental and computational methods. We provide a rationale for the ubiquity of the N-aryl group in these reactions. The aryl substituent stabilizes two intermediates and the high-energy transition state that connects them, which together represent the rate-determining step. This knowledge has enabled us to predict whether new CDC substrates will react either well or poorly.
May 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28396796/evolutionary-medicine-carpal-tunnel-syndrome
#5
Althea Anne D Perez, Scott W Simpson
No abstract text is available yet for this article.
2017: Evolution, Medicine, and Public Health
https://www.readbyqxmd.com/read/28392993/patterns-of-marijuana-and-tobacco-use-associated-with-suboptimal-self-rated-health-among-us-adult-ever-users-of-marijuana
#6
James Tsai, Italia V Rolle, Tushar Singh, Sheree L Boulet, Timothy A McAfee, Althea M Grant
The purpose of this study was to examine the patterns of marijuana and tobacco use and their associations with suboptimal self-rated health (SRH) among US adults who reported "ever, even once, using marijuana or hashish." Data came from the 2009-2012 National Health and Nutrition Examination Survey, restricting to respondents aged 20 years and older who reported using marijuana at least once in their lifetime (n = 3,210). We assessed the age-adjusted prevalence of mutually exclusive groups of regular (at least once a month for more than one year) and non-regular marijuana smoking by current (serum cotinine ≥ 3...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28348753/delayed-recognition-of-fatal-invasive-meningococcal-disease-in-adults
#7
Frederick W Nagel, Ifeoma Ezeoke, Mike Antwi, Paula E Del Rosso, Marie Dorsinville, Beth M Isaac, Althea Hayden, Robert S Hoffman, Scott D Weingart, Don Weiss
INTRODUCTION: Invasive meningococcal disease can be difficult to detect early in its course when patients may appear well and the severity of their illness is obscured by non-specific complaints. CASE PRESENTATION: We report five cases of meningococcal sepsis in adult patients who presented to an emergency department early in the course of their disease, but whose severity of illness was not recognized. CONCLUSION: Suspicion of meningococcal sepsis should be heightened in the setting of hypotension, tachycardia, elevated shock index, leukopaenia with left shift, thrombocytopaenia and hypokalaemia, prompting early sepsis care...
June 2016: JMM Case Reports
https://www.readbyqxmd.com/read/28289138/health-risk-behaviors-with-synthetic-cannabinoids-versus-marijuana
#8
COMPARATIVE STUDY
Heather B Clayton, Richard Lowry, Carmen Ashley, Amy Wolkin, Althea M Grant
BACKGROUND AND OBJECTIVES: Data are limited on the behavioral risk correlates of synthetic cannabinoid use. The purpose of this study was to compare the behavioral risk correlates of synthetic cannabinoid use with those among marijuana users. METHODS: Data from the 2015 Youth Risk Behavior Survey, a cross-sectional survey conducted in a nationally representative sample of students in grades 9 through 12 (N = 15 624), were used to examine the association between self-reported type of marijuana use (ie, never use of marijuana and synthetic cannabinoids, ever use of marijuana only, and ever use of synthetic cannabinoids) and self-report of 36 risk behaviors across 4 domains: substance use, injury/violence, mental health, and sexual health...
April 2017: Pediatrics
https://www.readbyqxmd.com/read/28251440/screening-and-treatment-for-iron-deficiency-anemia-in-women-results-of-a-survey-of-obstetrician-gynecologists
#9
Lauren H Marcewicz, Britta L Anderson, Vanessa R Byams, Althea M Grant, Jay Schulkin
Objective To better understand the knowledge, attitudes and practices of obstetrician-gynecologists with respect to screening and treatment for iron deficiency anemia (IDA). Methods A total of 1,200 Fellows and Junior Fellows of the American College of Obstetricians and Gynecologists were invited to participate in a survey on blood disorders. Respondents completed a questionnaire regarding their patient population, screening and treatment practices for IDA, and general knowledge about IDA and its risk factors...
February 27, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28192276/abortion-health-services-in-canada-results-of-a-2012-national-survey
#10
MULTICENTER STUDY
Wendy V Norman, Edith R Guilbert, Christopher Okpaleke, Althea S Hayden, E Steven Lichtenberg, Maureen Paul, Katharine O'Connell White, Heidi E Jones
OBJECTIVE: To determine the location of Canadian abortion services relative to where reproductive-age women reside, and the characteristics of abortion facilities and providers. DESIGN: An international survey was adapted for Canadian relevance. Public sources and professional networks were used to identify facilities. The bilingual survey was distributed by mail and e-mail from July to November 2013. SETTING: Canada. PARTICIPANTS: A total of 94 abortion facilities were identified...
April 2016: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28192275/first-trimester-medical-abortion-practices-in-canada-national-survey
#11
MULTICENTER STUDY
Edith R Guilbert, Althea S Hayden, Heidi E Jones, Katharine O'Connell White, E Steven Lichtenberg, Maureen Paul, Wendy V Norman
OBJECTIVE: To understand the current availability and practice of first-trimester medical abortion (MA) in Canada. DESIGN: Using public sources and professional networks, abortion facilities across Canada were identified for a cross-sectional survey on medical and surgical abortion. English and French surveys were distributed by surface or electronic mail between July and November 2013. SETTING: Canada. PARTICIPANTS: A total of 94 abortion facilities were identified...
April 2016: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28183284/study-of-user-experience-of-an-objective-test-qbtest-to-aid-adhd-assessment-and-medication-management-a-multi-methods-approach
#12
RANDOMIZED CONTROLLED TRIAL
Charlotte L Hall, Althea Z Valentine, Gemma M Walker, Harriet M Ball, Heather Cogger, David Daley, Madeleine J Groom, Kapil Sayal, Chris Hollis
BACKGROUND: The diagnosis and monitoring of Attention deficit hyperactivity disorder (ADHD) typically relies on subjective reports and observations. Objective continuous performance tests (CPTs) have been incorporated into some services to support clinical decision making. However, the feasibility and acceptability of adding such a test into routine practice is unknown. The study aimed to investigate the feasibility and acceptability of adding an objective computerised test to the routine assessment and monitoring of attention deficit hyperactivity disorder (ADHD)...
February 10, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28115897/evaluation-of-beer-fermentation-with-a-novel-yeast%C3%A2-williopsis-saturnus
#13
Shao-Quan Liu, Althea Ying Hui Quek
The aim of this study is to evaluate the potential of a novel yeast Williopsis saturnus var. mrakii NCYC 500 to produce fruity beer. Fermentation performance of W. mrakii and beer volatile composition were compared against that fermented with Saccharomyces cerevisiae Safale US-05. (o)Brix, sugar and pH differed significantly between the two types of beer. A total of 8 alcohols, 11 acids, 41 esters, 9 aldehydes, 8 ketones, 21 terpenes and terpenoids, 5 Maillard reaction products and 2 volatile phenolic compounds were detected...
December 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/28107361/dectin-3-is-not-required-for-protection-against-cryptococcus-neoformans-infection
#14
Althea Campuzano, Natalia Castro-Lopez, Karen L Wozniak, Chrissy M Leopold Wager, Floyd L Wormley
C-type lectin receptors (CLRs) are diverse, trans-membrane proteins that function as pattern recognition receptors (PRRs) which are necessary for orchestrating immune responses against pathogens. CLRs have been shown to play a major role in recognition and protection against fungal pathogens. Dectin-3 (also known as MCL, Clecsf8, or Clec4d) is a myeloid cell-specific CLR that recognizes mycobacterial trehalose 6,6'-dimycolate (TDM) as well as α-mannans present in the cell wall of fungal pathogens. To date, a potential role for Dectin-3 in the mediation of protective immune responses against C...
2017: PloS One
https://www.readbyqxmd.com/read/28054156/parental-refusal-of-vitamin-k-and-neonatal-preventive-services-a-need-for-surveillance
#15
Lauren H Marcewicz, Joshua Clayton, Matthew Maenner, Erika Odom, Ekwutosi Okoroh, Deborah Christensen, Alyson Goodman, Michael D Warren, Julie Traylor, Angela Miller, Timothy Jones, John Dunn, William Schaffner, Althea Grant
Objectives Vitamin K deficiency bleeding (VKDB) in infants is a coagulopathy preventable with a single dose of injectable vitamin K at birth. The Tennessee Department of Health (TDH) and Centers for Disease Control and Prevention (CDC) investigated vitamin K refusal among parents in 2013 after learning of four cases of VKDB associated with prophylaxis refusal. Methods Chart reviews were conducted at Nashville-area hospitals for 2011-2013 and Tennessee birthing centers for 2013 to identify parents who had refused injectable vitamin K for their infants...
May 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/27976142/experience-of-cough-patients-with-an-althea-officinalis-cough-syrup-in-germany
#16
C Fink, S Rabini, H Abdel-Aziz
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27870576/airway-management-strategies-for-brain-injured-patients-meeting-standard-criteria-to-consider-extubation-a-prospective-cohort-study
#17
Victoria A McCredie, Niall D Ferguson, Ruxandra L Pinto, Neill K J Adhikari, Robert A Fowler, Martin G Chapman, Althea Burrell, Andrew J Baker, Deborah J Cook, Maureen O Meade, Damon C Scales
RATIONALE: Patients with acute brain injury are frequently capable of breathing spontaneously with minimal ventilatory support despite persistent neurological impairment. OBJECTIVES: We sought to describe factors associated with extubation timing, success, and primary tracheostomy in these patients. METHODS: We conducted a prospective multicenter observational cohort study in three academic hospitals in Toronto, Canada. Consecutive brain-injured adults receiving mechanical ventilation for at least 24 hours in three intensive care units were screened by study personnel daily for extubation consideration criteria...
January 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27739873/role-of-ni-tolerant-bacillus-spp-and-althea-rosea-l-in-the-phytoremediation-of-ni-contaminated-soils
#18
Waheed Ullah Khan, Nasim Ahmad Yasin, Sajid Rashid Ahmad, Aamir Ali, Shakil Ahmed, Aqeel Ahmad
In our current study, four nickel-tolerant (Ni-tolerant) bacterial species viz, Bacillus thuringiensis 002, Bacillus fortis 162, Bacillus subtilis 174, and Bacillus farraginis 354, were screened using Ni-contaminated media. The screened microbes exhibited positive results for synthesis of indole acetic acid (IAA), siderophore production, and phosphate solubilization. The effects of these screened microbes on Ni mobility in the soil, root elongation, plant biomass, and Ni uptake in Althea rosea plants grown in Ni-contaminated soil (200 mg Ni kg(-1)) were evaluated...
May 4, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/27584586/national-estimates-of-marijuana-use-and-related-indicators-national-survey-on-drug-use-and-health-united-states-2002-2014
#19
Alejandro Azofeifa, Margaret E Mattson, Gillian Schauer, Tim McAfee, Althea Grant, Rob Lyerla
PROBLEM/CONDITION: In the United States, marijuana is the most commonly used illicit drug. In 2013, 7.5% (19.8 million) of the U.S. population aged ≥12 years reported using marijuana during the preceding month. Because of certain state-level policies that have legalized marijuana for medical or recreational use, population-based data on marijuana use and other related indicators are needed to help monitor behavioral health changes in the United States. PERIOD COVERED: 2002-2014...
September 2, 2016: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/27583699/monitoring-marijuana-use-in-the-united-states-challenges-in-an-evolving-environment
#20
COMMENT
Alejandro Azofeifa, Margaret E Mattson, Althea Grant
No abstract text is available yet for this article.
November 1, 2016: JAMA: the Journal of the American Medical Association
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