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https://www.readbyqxmd.com/read/29722624/cross-talk-between-androgen-and-wnt-signaling-potentially-contributes-to-age-related-skeletal-muscle-atrophy-in-rats
#1
Petey W Mumford, Matthew A Romero, Xuansong Mao, C Brooks Mobley, Wesley C Kephart, Cody T Haun, Paul A Roberson, Kaelin C Young, Jeffrey S Martin, Joshua F Yarrow, Darren T Beck, Michael D Roberts
We sought to determine whether age-related gastrocnemius muscle mass loss was associated with parallel decrements in androgen receptor (AR) or select Wnt signaling markers. To test this hypothesis, serum free and total testosterone (TEST) as well as gastrocnemius AR and Wnt signaling markers were analyzed in male Fischer 344 rats that were 3/6/12/18 and 24 months (mo) old (n=9 per group). Free and total TEST were greatest in 6 mo rats, and AR protein and Wnt5 protein levels linearly declined with aging. There were associations between Wnt5 protein levels and relative gastrocnemius mass (r=0...
May 3, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29674964/botanical-provenance-of-traditional-medicines-from-carpathian-mountains-at-the-ukrainian-polish-border
#2
REVIEW
Weronika Kozlowska, Charles Wagner, Erin M Moore, Adam Matkowski, Slavko Komarnytsky
Plants were an essential part of foraging for food and health, and for centuries remained the only medicines available to people from the remote mountain regions. Their correct botanical provenance is an essential basis for understanding the ethnic cultures, as well as for chemical identification of the novel bioactive molecules with therapeutic effects. This work describes the use of herbal medicines in the Beskid mountain ranges located south of Krakow and Lviv, two influential medieval centers of apothecary tradition in the region...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29651127/testosterone-deficiency-weakness-and-multimorbidity-in-men
#3
Mark D Peterson, Aleksandr Belakovskiy, Ryan McGrath, Joshua F Yarrow
The purposes of this study were to evaluate the association between total testosterone (TT) deficiency and weakness on multimorbidity in men. Analyses were performed to examine the prevalence of multimobidity among young, middle-aged, and older men, with and without testosterone deficiency. Multivariate logistic models were also used to determine the association between age-specific TT tertiles and multimorbidity, adjusting for key sociodemographic variables, as well as a secondary analysis adjusted for grip strength...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29584602/effect-of-a-new-purified-collagen-matrix-with-polyhexamethylene-biguanide-on-recalcitrant-wounds-of-various-etiologies-a-case-series
#4
Dimitrios Lintzeris, Karen Vernon, Heather Percise, Andy Strickland, Kari Yarrow, Amber White, Mary Gurganus, Susan Sherrod, Kathleen Vergin, Laura Johnson
INTRODUCTION: The management of chronic, nonhealing wounds in patients with multiple comorbidities continues to be a challenge for health care practitioners. Chronic wounds typically do not progress through the normal phases of wound healing and generally remain stagnant during the inflammatory phase, resulting in an increase in proteolytic enzymes with degradation of the extracellular matrix. Bacterial biofilm has been documented to be one of the main factors delaying wound healing, resulting in the prolongation of the inflammatory phase...
March 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29579075/effects-of-pharmacologic-sclerostin-inhibition-or-testosterone-administration-on-soleus-muscle-atrophy-in-rodents-after-spinal-cord-injury
#5
Ean G Phillips, Luke A Beggs, Fan Ye, Christine F Conover, Darren T Beck, Dana M Otzel, Payal Ghosh, Anna C F Bassit, Stephen E Borst, Joshua F Yarrow
Sclerostin is a circulating osteocyte-derived glycoprotein that negatively regulates Wnt-signaling after binding the LRP5/LRP6 co-receptors. Pharmacologic sclerostin inhibition produces bone anabolic effects after spinal cord injury (SCI), however, the effects of sclerostin-antibody (Scl-Ab) on muscle morphology remain unknown. In comparison, androgen administration produces bone antiresorptive effects after SCI and some, but not all, studies have reported that testosterone treatment ameliorates skeletal muscle atrophy in this context...
2018: PloS One
https://www.readbyqxmd.com/read/29542875/muscular-responses-to-testosterone-replacement-vary-by-administration-route-a-systematic-review-and-meta-analysis
#6
Jared W Skinner, Dana M Otzel, Andrew Bowser, Daniel Nargi, Sanjay Agarwal, Mark D Peterson, Baiming Zou, Stephen E Borst, Joshua F Yarrow
BACKGROUND: Inconsistent fat-free mass (FFM) and muscle strength responses have been reported in randomized clinical trials (RCTs) administering testosterone replacement therapy (TRT) to middle-aged and older men. Our objective was to conduct a meta-analysis to determine whether TRT improves FFM and muscle strength in middle-aged and older men and whether the muscular responses vary by TRT administration route. METHODS: Systematic literature searches of MEDLINE/PubMed and the Cochrane Library were conducted from inception through 31 March 2017 to identify double-blind RCTs that compared intramuscular or transdermal TRT vs...
March 15, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29526022/volatiles-of-grape-inoculated-with-microorganisms-modulation-of-grapevine-moth-oviposition-and-field-attraction
#7
Marco Tasin, Sebastian Larsson Herrera, Alan L Knight, Wilson Barros-Parada, Eduardo Fuentes Contreras, Ilaria Pertot
Semiochemicals released by plant-microbe associations are used by herbivorous insects to access and evaluate food resources and oviposition sites. Adult insects may utilize microbial-derived nutrients to prolong their lifespan, promote egg development, and offer a high nutritional substrate to their offspring. Here, we examined the behavioral role of semiochemicals from grape-microbe interactions on oviposition and field attraction of the grapevine moth Lobesia botrana (Denis & Schiffermüller). The volatile constituents released by grape inoculated with yeasts (Hanseniaspora uvarum (Niehaus), Metschnikowia pulcherrima (Pitt...
March 10, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/29462090/breslow-density-is-a-novel-prognostic-feature-that-adds-value-to-melanoma-staging
#8
Gerald Saldanha, Jeremy Yarrow, Jay Pancholi, Katarina Flatman, Kah Wee Teo, Somaia Elsheik, Rebecca Harrison, Marie O'Riordan, Mark Bamford
Histomorphologic prognostic biomarkers that can be measured using only an hematoxylin and eosin stain are very attractive because they are simple and cheap. We conceived an entirely novel biomarker of this type, the Breslow density (BD), which measures invasive melanoma cell density at the site where Breslow thickness (BT) is measured. This study assessed BD's prognostic value. In this study, BD was measured in 1329 melanoma patients. Measurement accuracy and precision was assessed using intraclass correlation coefficient (ICC)...
June 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29396245/combined-immunosuppression-and-radiotherapy-in-thyroid-eye-disease-cirted-a-multicentre-2-%C3%A3-2-factorial-double-blind-randomised-controlled-trial
#9
Rathie Rajendram, Peter N Taylor, Victoria J Wilson, Nicola Harris, Olivia C Morris, Marjorie Tomlinson, Sue Yarrow, Helen Garrott, Helen M Herbert, Andrew D Dick, Anne Cook, Rao Gattamaneni, Rajni Jain, Jane Olver, Steven J Hurel, Fion Bremner, Suzannah R Drummond, Ewan Kemp, Diana M Ritchie, Nichola Rumsey, Daniel Morris, Carol Lane, Nachi Palaniappan, Chunhei Li, Julie Pell, Robert Hills, Daniel G Ezra, Mike J Potts, Sue Jackson, Geoffrey E Rose, Nicholas Plowman, Catey Bunce, Jimmy M Uddin, Richard W J Lee, Colin M Dayan
BACKGROUND: Standard treatment for thyroid eye disease is with systemic corticosteroids. We aimed to establish whether orbital radiotherapy or antiproliferative immunosuppression would confer any additional benefit. METHODS: CIRTED was a multicentre, double-blind, randomised controlled trial with a 2 × 2 factorial design done at six centres in the UK. Adults with active moderate-to-severe thyroid eye disease associated with proptosis or ocular motility restriction were recruited to the trial...
April 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29337773/prognostic-factors-for-locoregional-recurrence-in-neuroendocrine-tumors-of-the-rectum
#10
Erica S Tsang, Yarrow J McConnell, David F Schaeffer, Yaling Yin, Caroline H Speers, Hagen F Kennecke
BACKGROUND: Optimal management of rectal neuroendocrine tumors is not yet well defined. Various pathologic factors, particularly tumor size, have been proposed as prognostic markers. OBJECTIVE: We characterized sequential patients diagnosed with rectal neuroendocrine tumors in a population-based setting to determine whether tumor size and other pathologic markers could be useful in guiding locoregional management. DESIGN: This study is a retrospective analysis of data from the British Columbia provincial cancer registry...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29211364/insights-into-novel-anticancer-applications-for-apigenin
#11
REVIEW
Adam Kowalczyk, Agnieszka Bodalska, Marta Miranowicz, Katarzyna Karłowicz-Bodalska
Flavonoids, naturally occuring derivatives of 2-phenyl-benzo-γ-pyrone, are widespread in plants as coloring substances. Apigenin (4',5,7,-trihydroxyflavone (5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one), molecular formula C₁₅H₁₀O⁵, is a flavonoid present in many fruits and vegetables, primarily in citrus fruits, apples, parsley and celery leaves. It is also found in some medicinal plants, including chamomile flowers, thyme, oregano, peppermint, lemon balm and yarrow, as a 7-O-glycoside with anti-inflammatory and antioxidant activity...
October 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29121223/health-system-strengthening-prospects-and-threats-for-its-sustainability-on-the-global-health-policy-agenda
#12
Joseph F Naimoli, Sweta Saxena, Laurel E Hatt, Kristina M Yarrow, Trenton M White, Temitayo Ifafore-Calfee
In 2013, Hafner and Shiffman applied Kingdon's public policy process model to explain the emergence of global attention to health system strengthening (HSS). They questioned, however, HSS's sustainability on the global health policy agenda, citing various concerns. Guided by the Grindle and Thomas interactive model of policy implementation, we advance and elaborate a proposition: a confluence of developments will contribute to maintaining HSS's prominent place on the agenda until at least 2030. Those developments include (1) technical, managerial, financial, and political responses to unpredictable public health crises that imperil the routine functioning of health systems, such as the 2014-2015 Ebola virus disease (Ebola) epidemic in West Africa; (2) similar responses to non-crisis situations requiring fully engaged, robust health systems, such as the pursuit of the new Sustainable Development Goal for health (SDG3); and (3) increased availability of new knowledge about system change at macro, meso, and micro levels and its effects on people's health and well-being...
January 1, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29108562/support-for-the-thermal-coadaptation-hypothesis-from-the-growth-rates-of-sceloporus-jarrovii-lizards
#13
L D Patterson, C-A Darveau, G Blouin-Demers
The thermal coadaptation hypothesis posits that ectotherms thermoregulate behaviorally to maintain body temperatures (Tb) that maximize performance, such as net energy gain. Huey's (1982) energetics model describes how food availability and Tb interact to affect net energy gain. We tested the thermal coadaptation hypothesis and Huey's energetics model with growth rates of juvenile Yarrow's spiny lizards (Sceloporus jarrovii). We compared the preferred (selected) Tb range (Tsel) of lizards in high and low energy states to their optimal temperature (To) for growth over nine weeks, and determined whether the To for growth depended on food availability...
December 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29064437/the-assessment-of-toxic-metals-in-plants-used-in-cosmetics-and-cosmetology
#14
Agnieszka Fischer, Barbara Brodziak-Dopierała, Krzysztof Loska, Jerzy Stojko
Heavy metals polluting the natural environment are absorbed by plants. The use of herbs as components of cosmetics may pose a health risk for humans. The aim of the study was to determine the concentrations of Pb, Cd and Hg in selected species of herbs (horsetail Equisetum arvense , nettle Urtica dioica , St. John's wort Hypericum perforatum , wormwood Artemisia absinthium , yarrow Achillea millefolium , cottonwood Solidago virgaurea ) self-collected from the natural environment in two different locations, and purchased in stores on the territory of Poland...
October 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28961430/the-emerging-causal-understanding-of-institutional-objects
#15
Alexander Noyes, Frank C Keil, Yarrow Dunham
Institutional objects, such as money, drivers' licenses, and borders, have functions because of their social roles rather than their immediate physical properties. These objects are causally different than standard artifacts (e.g. hammers, chairs, and cars), sharing more commonality with other social roles. Thus, they inform psychological theories of human-made objects as well as children's emerging understanding of social reality. We examined whether children (N=180, ages 4-9) differentiate institutional objects from standard artifacts...
January 2018: Cognition
https://www.readbyqxmd.com/read/28868116/bio-effectiveness-of-the-main-flavonoids-of-achillea-millefolium-in-the-pathophysiology-of-neurodegenerative-disorders-a-review
#16
REVIEW
Fatemeh Ayoobi, Ali Shamsizadeh, Iman Fatemi, Alireza Vakilian, Mohammad Allahtavakoli, Gholamhossein Hassanshahi, Amir Moghadam-Ahmadi
The Achillea millefolium L. (Yarrow) is a common herb which is widely being used, worldwide. Achillea is being used for treatment of many disorders since centuries. It is considered safe for supplemental use and flavonoids such as kaempferol, luteolin and apigenin are of main constituents present in Achillea. Most of both antioxidant and anti-inflammatory properties of this herb have been attributed to its flavonoid content. Oxidative and inflammatory processes play important roles in pathogenesis of neurodegenerative diseases...
June 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28832977/-wealth-makes-many-friends-children-expect-more-giving-from-resource-rich-than-resource-poor-individuals
#17
Richard E Ahl, Yarrow Dunham
Young children show social preferences for resource-rich individuals, although few studies have explored the causes underlying such preferences. We evaluate the viability of one candidate cause: Children believe that resource wealth relates to behavior, such that they expect the resource rich to be more likely to materially benefit others (including themselves) than the resource poor. In Studies 1 and 2 (ages 4-10), American children from predominantly middle-income families (n = 94) and Indian children from lower income families (n = 30) predicted that the resource rich would be likelier to share with others than the resource poor...
August 21, 2017: Child Development
https://www.readbyqxmd.com/read/28701045/investigating-chemical-composition-and-indications-of-hydrosol-soft-drinks-aromatic-waters-used-in-persian-folk-medicine-for-women-s-hormonal-and-reproductive-health-conditions
#18
Azadeh Hamedi, Mehdi Afifi, Hamed Etemadfard
Hydrosol soft drinks in Persian nutrition culture are produced as side products of the essential oil industry to be used as safe remedies for treatment of some ailments. This study investigated hydrosols for women's hormonal health conditions. Detailed information was gathered by questionnaires. Chemical constituents of these mono- or poly-herbal hydrosols were identified after liquid/liquid extraction and gas chromatography-mass spectrometry. Hierarchical cluster and K-means analysis (SPSS software) were used to find their relevance...
October 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/28674934/improvement-of-the-bag-mediated-filtration-system-for-sampling-wastewater-and-wastewater-impacted-waters
#19
Christine Susan Fagnant, Liliana Margarita Sánchez-Gonzalez, Nicolette A Zhou, Jill Christin Falman, Michael Eisenstein, Dylan Guelig, Byron Ockerman, Yifei Guan, Alexandra Lynn Kossik, Yarrow S Linden, Nicola Koren Beck, Robyn Wilmouth, Evans Komen, Benlick Mwangi, James Nyangao, Jeffry H Shirai, Igor Novosselov, Peter Borus, David S Boyle, John Scott Meschke
Environmental surveillance of poliovirus (PV) plays an important role in the global program for eradication of wild PV. The bag-mediated filtration system (BMFS) was first developed in 2014 and enhances PV surveillance when compared to the two-phase grab method currently recommended by the World Health Organization (WHO). In this study, the BMFS design was improved and tested for its usability in wastewater and wastewater-impacted surface waters in Nairobi, Kenya. Modifications made to the BMFS included the size, color, and shape of the collection bags, the filter housing used, and the device used to elute the samples from the filters...
March 2018: Food and Environmental Virology
https://www.readbyqxmd.com/read/28648233/assessing-risk-factors-for-athletic-excellence
#20
Kielan Yarrow
Hardy et al. present a qualitative interview study to identify differences between elite and super-elite athletes, but their approach closely parallels the case-control methodology developed and discussed primarily within the epidemiological literature. The strengths and weaknesses of this approach may be less familiar to a psychological or sports-science audience. Here, I comment on this methodological choice and the implications it has for the robustness and value of the inferences that are drawn. I conclude that while Hardy et al...
2017: Progress in Brain Research
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