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Xuan Ni Tan, Rosemary Harrup, Penny Yarrow
No abstract text is available yet for this article.
February 2016: Pathology
Yarrow Madrona, Christopher A Waddling, Paul R Ortiz de Montellano
DosS is a sensor in Mycobacterium tuberculosis that differentially responds to O2, NO, and CO, as well as to changes in the redox state of the prosthetic heme iron atom. The ferrous protein and its Fe(II)NO and Fe(II)CO complexes undergo autophosphorylation and subsequently transfer the phosphate group to DosR, a nuclear factor, to activate it. In contrast, autophosphorylation is negligible with the ferric protein and the Fe(II)O2 complex. To clarify the basis for this differential response to gases, we have determined the crystal structures of the NO and COcomplexes of the DosS GAF-A domain, which contains the heme to which the gases bind...
December 15, 2016: Archives of Biochemistry and Biophysics
Yarrow Axford
No abstract text is available yet for this article.
September 2, 2016: Science
K L Sheehan, K C Hanson-Dorr, B S Dorr, G K Yarrow, R J Johnson
Here the intestinal helminth infracommunities of 218 double-crested cormorants (Phalacrocorax auritus) from 11 locations in Alabama, Minnesota, Mississippi and Vermont are documented. Trematode infections were present in 98% of hosts; 65% of cormorants carried cestode infections, 4% were infected with acanthocephalans and 66% had nematode intestinal parasites. Parasite infracommunities of hosts collected on wintering grounds had higher richness and diversity than did birds collected on breeding grounds. Differences in parasite richness and diversity between male and female P...
September 28, 2016: Journal of Helminthology
Jennifer Hirst, Marianna Madeo, Katrien Smets, James R Edgar, Ludger Schols, Jun Li, Anna Yarrow, Tine Deconinck, Jonathan Baets, Elisabeth Van Aken, Jan De Bleecker, Manuel B Datiles, Ricardo H Roda, Joachim Liepert, Stephan Züchner, Caterina Mariotti, Peter De Jonghe, Craig Blackstone, Michael C Kruer
OBJECTIVE: Biallelic mutations in the AP5Z1 gene encoding the AP-5 ζ subunit have been described in a small number of patients with hereditary spastic paraplegia (HSP) (SPG48); we sought to define genotype-phenotype correlations in patients with homozygous or compound heterozygous sequence variants predicted to be deleterious. METHODS: We performed clinical, radiologic, and pathologic studies in 6 patients with biallelic mutations in AP5Z1. RESULTS: In 4 of the 6 patients, there was complete loss of AP-5 ζ protein...
October 2016: Neurology. Genetics
Brian A Kahn, Eric J Rebek, Lynn P Brandenberger, Keith Reed, Mark E Payton
BACKGROUND: The squash bug, Anasa tristis (De Geer) is a major insect pest of cucurbits. Control of squash bugs with insecticidal chemicals is difficult to achieve. We investigated the potential of companion planting with white yarrow (Achillea millefolium L.) or feverfew [Tanacetum parthenium (L.) Sch. Bip.] for squash bug management in field plantings of summer squash (Cucurbita pepo L.). RESULTS: Companion planting with white yarrow had few effects. Companion planting with feverfew tended to reduce squash bug populations, but results often were not statistically significant (P ≥ 0...
September 8, 2016: Pest Management Science
Joshua F Yarrow
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Joshua F Yarrow, Hale Z Toklu, Alex Balaez, Ean G Phillips, Dana M Otzel, Cong Chen, Thomas J Wronski, J Ignacio Aguirre, Yasemin Sakarya, Nihal Tumer, Phillip J Scarpace
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Evy Paulsen
Patients with Compositae sensitization are routinely warned against the ingestion of vegetables, spices, teas and herbal remedies from this family of plants. The evidence for the occurrence of systemic allergic dermatitis caused by sesquiterpene lactone-containing plants is mostly anecdotal and based on statements from patients rather than scientific data. However, a few clinical reports on accidental sensitization and exposure and oral challenge prove the existence of this kind of reaction, most convincingly for strong contact allergens such as costunolide in bay leaves, and less so for weak allergens such as those of lettuce...
August 29, 2016: Contact Dermatitis
A Maleah Holland, Michael D Roberts, Petey W Mumford, C Brooks Mobley, Wesley C Kephart, Christine F Conover, Luke A Beggs, Alexander Balaez, Dana M Otzel, Joshua F Yarrow, Stephen E Borst, Darren T Beck
The influence of the aromatase enzyme on the chronic fat-sparing effects of testosterone requires further elucidation. Our purpose was to determine whether chronic anastrozole (AN, an aromatase inhibitor) treatment alters testosterone-mediated lipolytic/lipogenic gene expression in visceral fat. Ten-month-old Fischer 344 rats (n = 6/group) were subjected to sham surgery (SHAM), orchiectomy (ORX), ORX + treatment with testosterone enanthate (TEST, 7.0 mg/wk), or ORX + TEST + AN (0.5 mg/day), with drug treatment beginning 14 days postsurgery...
September 1, 2016: Journal of Applied Physiology
Ivana Generalić Mekinić, Danijela Skroza, Ivica Ljubenkov, Višnja Katalinić
Over the last years, great interest has arisen concerning plant stilbenes, especially resveratrol, which has a whole spectrum of positive biological activities. In this study, we investigated the presence of resveratrol monomers (trans- and cis- form) and naturally occurring derivatives of trans-resveratrol (piceid, astringin and isorhapontin) in phenolic extracts of twenty medicinal plants traditionally used in Croatian folk medicine. The investigated compounds were present in the samples, in free form or as glucosides, and the highest share was found in immortelle, common yarrow and Lamiaceae plants...
June 2016: Natural Product Communications
Aviad A Hadar, Paula Rowe, Steven Di Costa, Alexander Jones, Kielan Yarrow
Many everyday activities require time-pressured sensorimotor decision making. Traditionally, perception, decision, and action processes were considered to occur in series, but this idea has been successfully challenged, particularly by neurophysiological work in animals. However, the generality of parallel processing requires further elucidation. Here, we investigate whether the accumulation of a decision can be observed intrahemispherically within human motor cortex. Participants categorized faces as male or female, with task difficulty manipulated using morphed stimuli...
November 2016: Psychophysiology
Xianyong Gui, Ziran Meng, Yarrow J McConnell, Shuhong Liu, Vincent G Falck, Lloyd A Mack, Walley J Temple
BACKGROUND: Tumours of appendix, including classic carcinoid tumour (CCT), goblet cell carcinoid (GCC), low-grade appendiceal mucinous neoplasm, high-grade appendiceal mucinous neoplasm/mucinous carcinoma (MCA) and non-mucinous adenocarcinoma (NMA), show different and sometimes mixed morphological features. It was hypothesised that these tumours originate from common tumour stem cell(s) with potential of various cell lineage differentiation. In normal intestinal epithelium, absorptive lineage (enterocytes) differentiation is driven by Notch-Hes1 pathway, while secretory lineage is driven by Wnt-Math1 pathway and further separated by different downstream signallings into three sublineages (Gfi1-Klf4/Elf3 for goblet cells, Gfi1-Sox9 for Paneth cells and Ngn3-Pdx1/Beta2/Pax4 for enteroendocrine cells)...
July 1, 2016: Journal of Clinical Pathology
Yarrow Dunham, Ron Dotsch, Amelia R Clark, Elena V Stepanova
We examined the development of racial categorizations of faces spanning the European-East Asian ("White-Asian") categorical continuum in children between the ages of four and nine as well as adults. We employed a stimulus set that independently varied skin color and other aspects of facial physiognomy, allowing the contribution of each to be assessed independently and in interaction with each other. Results demonstrated substantial development across this age range in children's ability to draw on both sorts of cue, with over twice as much variance explained by stimulus variation in adults than children...
2016: PloS One
V J Dalbo, M D Roberts, C B Mobley, C Ballmann, W C Kephart, C D Fox, V A Santucci, C F Conover, L A Beggs, A Balaez, F J Hoerr, J F Yarrow, S E Borst, D T Beck
The androgen-induced alterations in adult rodent skeletal muscle fibre cross-sectional area (fCSA), satellite cell content and myostatin (Mstn) were examined in 10-month-old Fisher 344 rats (n = 41) assigned to Sham surgery, orchiectomy (ORX), ORX + testosterone (TEST; 7.0 mg week(-1) ) or ORX + trenbolone (TREN; 1.0 mg week(-1) ). After 29 days, animals were euthanised and the levator ani/bulbocavernosus (LABC) muscle complex was harvested for analyses. LABC muscle fCSA was 102% and 94% higher in ORX + TEST and ORX + TREN compared to ORX (p < ...
June 1, 2016: Andrologia
Marianna Madeo, Michelle Stewart, Yuyang Sun, Nadia Sahir, Sarah Wiethoff, Indra Chandrasekar, Anna Yarrow, Jill A Rosenfeld, Yaping Yang, Dawn Cordeiro, Elizabeth M McCormick, Colleen C Muraresku, Tyler N Jepperson, Lauren J McBeth, Mohammed Zain Seidahmed, Heba Y El Khashab, Muddathir Hamad, Hamid Azzedine, Karl Clark, Silvia Corrochano, Sara Wells, Mariet W Elting, Marjan M Weiss, Sabrina Burn, Angela Myers, Megan Landsverk, Patricia L Crotwell, Quinten Waisfisz, Nicole I Wolf, Patrick M Nolan, Sergio Padilla-Lopez, Henry Houlden, Richard Lifton, Shrikant Mane, Brij B Singh, Marni J Falk, Saadet Mercimek-Mahmutoglu, Kaya Bilguvar, Mustafa A Salih, Abraham Acevedo-Arozena, Michael C Kruer
Glutamatergic neurotransmission governs excitatory signaling in the mammalian brain, and abnormalities of glutamate signaling have been shown to contribute to both epilepsy and hyperkinetic movement disorders. The etiology of many severe childhood movement disorders and epilepsies remains uncharacterized. We describe a neurological disorder with epilepsy and prominent choreoathetosis caused by biallelic pathogenic variants in FRRS1L, which encodes an AMPA receptor outer-core protein. Loss of FRRS1L function attenuates AMPA-mediated currents, implicating chronic abnormalities of glutamatergic neurotransmission in this monogenic neurological disease of childhood...
June 2, 2016: American Journal of Human Genetics
Debashree Basudhar, Yarrow Madrona, Erik T Yukl, Santhosh Sivaramakrishnan, Clinton R Nishida, Pierre Moënne-Loccoz, Paul R Ortiz de Montellano
Mycobacterium tuberculosis DosS is critical for the induction of M. tuberculosis dormancy genes in response to nitric oxide (NO), carbon monoxide (CO), or hypoxia. These environmental stimuli, which are sensed by the DosS heme group, result in autophosphorylation of a DosS His residue, followed by phosphotransfer to an Asp residue of the response regulator DosR. To clarify the mechanism of gaseous ligand recognition and signaling, we investigated the hydrogen-bonding interactions of the iron-bound CO and NO ligands by site-directed mutagenesis of Glu-87 and His-89...
July 29, 2016: Journal of Biological Chemistry
Ikuo Masuho, Mingyan Fang, Chunyu Geng, Jianguo Zhang, Hui Jiang, Riza Köksal Özgul, Didem Yücel Yılmaz, Dilek Yalnızoğlu, Deniz Yüksel, Anna Yarrow, Angela Myers, Sabrina C Burn, Patricia L Crotwell, Sergio Padilla-Lopez, Ali Dursun, Kirill A Martemyanov, Michael C Kruer
No abstract text is available yet for this article.
June 2016: Neurology. Genetics
Selwyn Selvendran, Rajkumar Cheluvappa, Vinh Khiêm Tr Ng, Simon Yarrow, Tony C Pang, Davendra Segara, Patsy Soon
INTRODUCTION: Seroma formation in breast cancer patients who have undergone axillary lymph node dissection (ALND) is a source of significant discomfort and morbidity. We aimed to ascertain seroma incidence after ALND, when Harmonic Focus (HF) scalpel is used for dissection instead of conventional diathermy (CD). METHODS(AND PATIENTS): This retrospective study was carried out in a single hospital over 6 years. Patients were allocated into HF group (HFG) or CD group (CDG)...
April 29, 2016: International Journal of Surgery
Yarrow J McConnell
BACKGROUND: Local excision of small (<10 mm) rectal carcinoids is a standard treatment. Actual patterns of care and outcomes are understudied because of the rarity of this tumor. METHODS: Surveillance, Epidemiology, and End Results database (1988 to 2012) was interrogated for rectal carcinoid patients. Chi-square testing and Kaplan-Meier survival analysis were used to compare survival outcomes. RESULTS: Of all, 11,329 patients were identified-9,605 with only localized disease...
May 2016: American Journal of Surgery
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