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https://www.readbyqxmd.com/read/28098776/distinguishing-benign-from-malignant-pancreatic-and-periampullary-lesions-using-combined-use-of-%C3%A2-h-nmr-spectroscopy-and-gas-chromatography-mass-spectrometry
#1
Yarrow J McConnell, Farshad Farshidfar, Aalim M Weljie, Karen A Kopciuk, Elijah Dixon, Chad G Ball, Francis R Sutherland, Hans J Vogel, Oliver F Bathe
Previous work demonstrated that serum metabolomics can distinguish pancreatic cancer from benign disease. However, in the clinic, non-pancreatic periampullary cancers are difficult to distinguish from pancreatic cancer. Therefore, to test the clinical utility of this technology, we determined whether any pancreatic and periampullary adenocarcinoma could be distinguished from benign masses and biliary strictures. Sera from 157 patients with malignant and benign pancreatic and periampullary lesions were analyzed using proton nuclear magnetic resonance (¹H-NMR) spectroscopy and gas chromatography-mass spectrometry (GC-MS)...
January 13, 2017: Metabolites
https://www.readbyqxmd.com/read/28076393/alder-nitrogen-and-lake-ecology-terrestrial-aquatic-linkages-in-the-postglacial-history-of-lone-spruce-pond-southwestern-alaska
#2
Bianca B Perren, Yarrow Axford, Darrell S Kaufman
Diatoms, combined with a multiproxy study of lake sediments (organic matter, N, δ15N, δ13C, biogenic silica, grain size, Cladocera and chironomids, Alnus pollen) from Lone Spruce Pond, Alaska detail the late-glacial to Holocene history of the lake and its response to regional climate and landscape change over the last 14.5 cal ka BP. We show that the immigration of alder (Alnus viridis) in the early Holocene marks the rise of available reactive nitrogen (Nr) in the lake as well as the establishment of a primarily planktonic diatom community...
2017: PloS One
https://www.readbyqxmd.com/read/28070303/using-species-distribution-models-to-define-nesting-habitat-of-the-eastern-metapopulation-of-double-crested-cormorants
#3
Kate L Sheehan, Samuel T Esswein, Brian S Dorr, Greg K Yarrow, Ron J Johnson
When organisms with similar phenotypes have conflicting management and conservation initiatives, approaches are needed to differentiate among subpopulations or discrete groups. For example, the eastern metapopulation of the double-crested cormorant (Phalacrocorax auritus) has a migratory phenotype that is culled because they are viewed as a threat to commercial and natural resources, whereas resident birds are targeted for conservation. Understanding the distinct breeding habitats of resident versus migratory cormorants would aid in identification and management decisions...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28032105/evaluation-of-some-plant-essential-oils-against-the-brown-banded-cockroach-supella-longipalpa-blattaria-ectobiidae-a-mechanical-vector-of-human-pathogens
#4
Mona Sharififard, Farhad Safdari, Amir Siahpoush, Hamid Kassiri
BACKGROUND: Essential oils, as secondary plant compounds, present a safer alternative to conventional insecticides in insect control programs. So five essential oils including eucalyptus, mint, yarrow, oregano and rosemary oils were evaluated against the brown-banded cockroach Supella longipalpa. METHODS: Evaluation was done against the 3(rd) and 4(th) instar nymphs using three bioassay methods; continuous contact toxicity, fumigant toxicity and repellent activity...
December 2016: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/27772806/maternal-follicular-lymphoma-presenting-with-multiple-aneuploidy-on-noninvasive-prenatal-testing
#5
Xuan Ni Tan, Rosemary Harrup, Penny Yarrow
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27729224/crystal-structures-of-the-co-and-nobound-doss-gaf-a-domain-and-implications-for-doss-signaling-in-mycobacterium-tuberculosis
#6
Yarrow Madrona, Christopher A Waddling, Paul R Ortiz de Montellano
DosS is a sensor in Mycobacterium tuberculosis that differentially responds to O2, NO, and CO, as well as to changes in the redox state of the prosthetic heme iron atom. The ferrous protein and its Fe(II)NO and Fe(II)CO complexes undergo autophosphorylation and subsequently transfer the phosphate group to DosR, a nuclear factor, to activate it. In contrast, autophosphorylation is negligible with the ferric protein and the Fe(II)O2 complex. To clarify the basis for this differential response to gases, we have determined the crystal structures of the NO and COcomplexes of the DosS GAF-A domain, which contains the heme to which the gases bind...
December 15, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27701115/thanks-to-the-glass-ceiling-breakers
#7
Yarrow Axford
No abstract text is available yet for this article.
September 2, 2016: Science
https://www.readbyqxmd.com/read/27677375/the-influence-of-geographical-location-host-maturity-and-sex-on-intestinal-helminth-communities-of-the-double-crested-cormorant-phalacrocorax-auritus-from-the-eastern-united-states
#8
K L Sheehan, K C Hanson-Dorr, B S Dorr, G K Yarrow, R J Johnson
Here the intestinal helminth infracommunities of 218 double-crested cormorants (Phalacrocorax auritus) from 11 locations in Alabama, Minnesota, Mississippi and Vermont are documented. Trematode infections were present in 98% of hosts; 65% of cormorants carried cestode infections, 4% were infected with acanthocephalans and 66% had nematode intestinal parasites. Parasite infracommunities of hosts collected on wintering grounds had higher richness and diversity than did birds collected on breeding grounds. Differences in parasite richness and diversity between male and female P...
September 28, 2016: Journal of Helminthology
https://www.readbyqxmd.com/read/27606357/complicated-spastic-paraplegia-in-patients-with-ap5z1-mutations-spg48
#9
Jennifer Hirst, Marianna Madeo, Katrien Smets, James R Edgar, Ludger Schols, Jun Li, Anna Yarrow, Tine Deconinck, Jonathan Baets, Elisabeth Van Aken, Jan De Bleecker, Manuel B Datiles, Ricardo H Roda, Joachim Liepert, Stephan Züchner, Caterina Mariotti, Peter De Jonghe, Craig Blackstone, Michael C Kruer
OBJECTIVE: Biallelic mutations in the AP5Z1 gene encoding the AP-5 ζ subunit have been described in a small number of patients with hereditary spastic paraplegia (HSP) (SPG48); we sought to define genotype-phenotype correlations in patients with homozygous or compound heterozygous sequence variants predicted to be deleterious. METHODS: We performed clinical, radiologic, and pathologic studies in 6 patients with biallelic mutations in AP5Z1. RESULTS: In 4 of the 6 patients, there was complete loss of AP-5 ζ protein...
October 2016: Neurology. Genetics
https://www.readbyqxmd.com/read/27604891/companion-planting-with-white-yarrow-or-with-feverfew-for-squash-bug-anasa-tristis-hemiptera-coreidae-management-on-summer-squash
#10
Brian A Kahn, Eric J Rebek, Lynn P Brandenberger, Keith Reed, Mark E Payton
BACKGROUND: The squash bug, Anasa tristis (De Geer) is a major insect pest of cucurbits. Control of squash bugs with insecticidal chemicals is difficult to achieve. We investigated the potential of companion planting with white yarrow (Achillea millefolium L.) or feverfew [Tanacetum parthenium (L.) Sch. Bip.] for squash bug management in field plantings of summer squash (Cucurbita pepo L.). RESULTS: Companion planting with white yarrow had few effects. Companion planting with feverfew tended to reduce squash bug populations, but results often were not statistically significant (P ≥ 0...
September 8, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27584479/2868
#11
Joshua F Yarrow
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27584283/fructose-consumption-does-not-worsen-bone-deficits-resulting-from-high-fat-feeding-in-young-male-rats-1127-board-1-june-1-3-15-pm-5-15-pm
#12
Joshua F Yarrow, Hale Z Toklu, Alex Balaez, Ean G Phillips, Dana M Otzel, Cong Chen, Thomas J Wronski, J Ignacio Aguirre, Yasemin Sakarya, Nihal Tumer, Phillip J Scarpace
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27568784/systemic-allergic-dermatitis-caused-by-sesquiterpene-lactones
#13
REVIEW
Evy Paulsen
Patients with Compositae sensitization are routinely warned against the ingestion of vegetables, spices, teas and herbal remedies from this family of plants. The evidence for the occurrence of systemic allergic dermatitis caused by sesquiterpene lactone-containing plants is mostly anecdotal and based on statements from patients rather than scientific data. However, a few clinical reports on accidental sensitization and exposure and oral challenge prove the existence of this kind of reaction, most convincingly for strong contact allergens such as costunolide in bay leaves, and less so for weak allergens such as those of lettuce...
January 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/27539493/testosterone-inhibits-expression-of-lipogenic-genes-in-visceral-fat-by-an-estrogen-dependent-mechanism
#14
A Maleah Holland, Michael D Roberts, Petey W Mumford, C Brooks Mobley, Wesley C Kephart, Christine F Conover, Luke A Beggs, Alexander Balaez, Dana M Otzel, Joshua F Yarrow, Stephen E Borst, Darren T Beck
The influence of the aromatase enzyme on the chronic fat-sparing effects of testosterone requires further elucidation. Our purpose was to determine whether chronic anastrozole (AN, an aromatase inhibitor) treatment alters testosterone-mediated lipolytic/lipogenic gene expression in visceral fat. Ten-month-old Fischer 344 rats (n = 6/group) were subjected to sham surgery (SHAM), orchiectomy (ORX), ORX + treatment with testosterone enanthate (TEST, 7.0 mg/wk), or ORX + TEST + AN (0.5 mg/day), with drug treatment beginning 14 days postsurgery...
September 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27534129/insight-into-the-presence-of-stilbenes-in-medicinal-plants-traditionally-used-in-croatian-folk-medicine
#15
Ivana Generalić Mekinić, Danijela Skroza, Ivica Ljubenkov, Višnja Katalinić
Over the last years, great interest has arisen concerning plant stilbenes, especially resveratrol, which has a whole spectrum of positive biological activities. In this study, we investigated the presence of resveratrol monomers (trans- and cis- form) and naturally occurring derivatives of trans-resveratrol (piceid, astringin and isorhapontin) in phenolic extracts of twenty medicinal plants traditionally used in Croatian folk medicine. The investigated compounds were present in the samples, in free form or as glucosides, and the highest share was found in immortelle, common yarrow and Lamiaceae plants...
June 2016: Natural Product Communications
https://www.readbyqxmd.com/read/27526960/motor-evoked-potentials-reveal-a-motor-cortical-readout-of-evidence-accumulation-for-sensorimotor-decisions
#16
Aviad A Hadar, Paula Rowe, Steven Di Costa, Alexander Jones, Kielan Yarrow
Many everyday activities require time-pressured sensorimotor decision making. Traditionally, perception, decision, and action processes were considered to occur in series, but this idea has been successfully challenged, particularly by neurophysiological work in animals. However, the generality of parallel processing requires further elucidation. Here, we investigate whether the accumulation of a decision can be observed intrahemispherically within human motor cortex. Participants categorized faces as male or female, with task difficulty manipulated using morphed stimuli...
November 2016: Psychophysiology
https://www.readbyqxmd.com/read/27371613/differing-expression-profiles-of-notch-enterocyte-and-wnt-secretory-lineage-signallings-are-associated-with-morphological-diversity-of-appendiceal-tumours
#17
Xianyong Gui, Ziran Meng, Yarrow J McConnell, Shuhong Liu, Vincent G Falck, Lloyd A Mack, Walley J Temple
BACKGROUND: Tumours of appendix, including classic carcinoid tumour (CCT), goblet cell carcinoid (GCC), low-grade appendiceal mucinous neoplasm, high-grade appendiceal mucinous neoplasm/mucinous carcinoma (MCA) and non-mucinous adenocarcinoma (NMA), show different and sometimes mixed morphological features. It was hypothesised that these tumours originate from common tumour stem cell(s) with potential of various cell lineage differentiation. In normal intestinal epithelium, absorptive lineage (enterocytes) differentiation is driven by Notch-Hes1 pathway, while secretory lineage is driven by Wnt-Math1 pathway and further separated by different downstream signallings into three sublineages (Gfi1-Klf4/Elf3 for goblet cells, Gfi1-Sox9 for Paneth cells and Ngn3-Pdx1/Beta2/Pax4 for enteroendocrine cells)...
January 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27355683/the-development-of-white-asian-categorization-contributions-from-skin-color-and-other-physiognomic-cues
#18
Yarrow Dunham, Ron Dotsch, Amelia R Clark, Elena V Stepanova
We examined the development of racial categorizations of faces spanning the European-East Asian ("White-Asian") categorical continuum in children between the ages of four and nine as well as adults. We employed a stimulus set that independently varied skin color and other aspects of facial physiognomy, allowing the contribution of each to be assessed independently and in interaction with each other. Results demonstrated substantial development across this age range in children's ability to draw on both sorts of cue, with over twice as much variance explained by stimulus variation in adults than children...
2016: PloS One
https://www.readbyqxmd.com/read/27246614/testosterone-and-trenbolone-enanthate-increase-mature-myostatin-protein-expression-despite-increasing-skeletal-muscle-hypertrophy-and-satellite-cell-number-in-rodent-muscle
#19
V J Dalbo, M D Roberts, C B Mobley, C Ballmann, W C Kephart, C D Fox, V A Santucci, C F Conover, L A Beggs, A Balaez, F J Hoerr, J F Yarrow, S E Borst, D T Beck
The androgen-induced alterations in adult rodent skeletal muscle fibre cross-sectional area (fCSA), satellite cell content and myostatin (Mstn) were examined in 10-month-old Fisher 344 rats (n = 41) assigned to Sham surgery, orchiectomy (ORX), ORX + testosterone (TEST; 7.0 mg week(-1) ) or ORX + trenbolone (TREN; 1.0 mg week(-1) ). After 29 days, animals were euthanised and the levator ani/bulbocavernosus (LABC) muscle complex was harvested for analyses. LABC muscle fCSA was 102% and 94% higher in ORX + TEST and ORX + TREN compared to ORX (p < ...
June 1, 2016: Andrologia
https://www.readbyqxmd.com/read/27236917/loss-of-function-mutations-in-frrs1l-lead-to-an-epileptic-dyskinetic-encephalopathy
#20
Marianna Madeo, Michelle Stewart, Yuyang Sun, Nadia Sahir, Sarah Wiethoff, Indra Chandrasekar, Anna Yarrow, Jill A Rosenfeld, Yaping Yang, Dawn Cordeiro, Elizabeth M McCormick, Colleen C Muraresku, Tyler N Jepperson, Lauren J McBeth, Mohammed Zain Seidahmed, Heba Y El Khashab, Muddathir Hamad, Hamid Azzedine, Karl Clark, Silvia Corrochano, Sara Wells, Mariet W Elting, Marjan M Weiss, Sabrina Burn, Angela Myers, Megan Landsverk, Patricia L Crotwell, Quinten Waisfisz, Nicole I Wolf, Patrick M Nolan, Sergio Padilla-Lopez, Henry Houlden, Richard Lifton, Shrikant Mane, Brij B Singh, Marni J Falk, Saadet Mercimek-Mahmutoglu, Kaya Bilguvar, Mustafa A Salih, Abraham Acevedo-Arozena, Michael C Kruer
Glutamatergic neurotransmission governs excitatory signaling in the mammalian brain, and abnormalities of glutamate signaling have been shown to contribute to both epilepsy and hyperkinetic movement disorders. The etiology of many severe childhood movement disorders and epilepsies remains uncharacterized. We describe a neurological disorder with epilepsy and prominent choreoathetosis caused by biallelic pathogenic variants in FRRS1L, which encodes an AMPA receptor outer-core protein. Loss of FRRS1L function attenuates AMPA-mediated currents, implicating chronic abnormalities of glutamatergic neurotransmission in this monogenic neurological disease of childhood...
June 2, 2016: American Journal of Human Genetics
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