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Masafumi Ikeda, Akihiro Sato, Nobuo Mochizuki, Kayo Toyosaki, Chika Miyoshi, Rumi Fujioka, Shuichi Mitsunaga, Izumi Ohno, Yusuke Hashimoto, Hideaki Takahashi, Hiromi Hasegawa, Shogo Nomura, Ryuji Takahashi, Satoshi Yomoda, Katsuya Tsuchihara, Satoshi Kishino, Hiroyasu Esumi
GBS-01, an extract from the fruit of Arctium lappa Linné is an orally administered drug rich in arctigenin, which has been reported to exert antitumor activity by attenuating the tolerance of cancer cells to glucose deprivation. We investigated the maximum tolerated dose of GBS-01 based on the frequency of the dose-limiting toxicities (DLT) and pharmacokinetics in patients with advanced pancreatic cancer refractory to gemcitabine. Patients with advanced pancreatic adenocarcinoma who were refractory to gemcitabine were enrolled...
September 29, 2016: Cancer Science
Zaixiang Lou, Cheng Li, Xingran Kou, Fuhao Yu, Hongxin Wang, Gary M Smith, Song Zhu
First, the antibacterial, antibiofilm effect and chemical composition of burdock (Arctium lappa L.) leaf fractions were studied. Then, the efficiency of burdock leaf fractions in pork preservation was evaluated. The results showed that burdock leaf fraction significantly inhibited the growth and biofilm development of Escherichia coli and Salmonella Typhimurium. MICs of burdock leaf fractions on E. coli and Salmonella Typhimurium were both 2 mg/ml. At a concentration of 2.0 mg/ml, the inhibition rates of the fraction on growth and development of E...
August 2016: Journal of Food Protection
A I Vengerovskii, T V Yakimova, O N Nasanova
Experiments on rats with diabetes mellitus model induced by streptosotocin and high (30%) fat diet showed that the daily treatment with aqueous extracts of great nettle leaves (100 mg/kg) and common burdock roots (25 mg/kg) for a period of 10 days led to a decrease in the glycemic index and triglyceride level and produced protective action on erythrocytes both in animals kept on a fat-rich diet and on the background of a low-caloric ration. Both medicinal plant extracts were comparable with reference drug metformin in reducing the concentration of glycosylated hemoglobin (by 12-31%) and ectoglobular hemoglobin (1...
2016: Eksperimental'naia i Klinicheskaia Farmakologiia
Tugsbaatar Baatartsogt, Vuong N Bui, Dai Q Trinh, Emi Yamaguchi, Dulyatad Gronsang, Rapeewan Thampaisarn, Haruko Ogawa, Kunitoshi Imai
Viral neuraminidase inhibitors are widely used as synthetic anti-influenza drugs for the prevention and treatment of influenza. However, drug-resistant influenza A virus variants, including H5N1 highly pathogenic avian influenza viruses (HPAIVs), have been reported. Therefore, the discovery of novel and effective antiviral agents is warranted. We screened the antiviral effects of 11 herbal tea extracts (hibiscus, black tea, tencha, rosehip tea, burdock tea, green tea, jasmine tea, ginger tea, lavender tea, rose tea and oak tea) against the H5N1 HPAIV in vitro...
May 19, 2016: Journal of Veterinary Medical Science
Z K Vymjatnina, E Y Prosekina, T A Tomova
The aim of the real research was a study influence of leu-enkephalin and extracts from the leaves of goose-grass large, of burdock of felted and root of chicory on the motor function of stomach for dogs. The study was carried out on 6 outbred dogs-males, by mass 14-17 kg, with the fistula of stomach by Basov. A leu-enkephalin ("Vector", Russia) was entered intravenously in a dose 7 mcg/kg. The corresponding plant-based preparations entered perorally during 10-14 days to beginning of experiments, on an empty stomach, in a volume a no more than 20 ml...
2015: Experimental & Clinical Gastroenterology
Krystal Melich Trinkle
As indicated in the 2010 United States Religion Census, there are approximately 251,000 Amish people in the United States and Ontario. This census also demonstrated that a new Amish community is founded on average about every three-and-a-half weeks, suggesting that this religious culture is the fastest-growing religion throughout the United States. Because of the rapid growth of the Amish population, it is essential for health care workers to understand their background, cultural, and health care beliefs, especially in the treatment of burns...
March 2016: Holistic Nursing Practice
Hua Lin, Ye-Heng He, Rui Xu, Wei Zou
The present study was aimed to investigate the effects of exercise and nutrition intervention on rat immune function. Flor-Essence is a kind of health food produced by FLORA company in Canada and certified by Quality Assurance International (QAI). Its main components are burdock root, cress leaves of grass, kelp, Turkish rhubarb root, et al. Flor-Essence has been shown to activate the body detoxification path, improve the physical environment, and inhibit cancer cell growth and proliferation. Sixty male Sprague-Dawley (SD) rats were randomly divided into six groups: control, NS + training, low-dose Flor-Essence + training, low-dose Flor-Essence, high-dose Flor-Essence + training, high-dose Flor-Essence groups...
December 25, 2015: Sheng Li Xue Bao: [Acta Physiologica Sinica]
Kisang Kwon, Hwa-Soo Koong, Kyung-Hee Kang
We investigated the burdock extract on the inhibitions of NO generation, COX-2 expression, and the generations of IL-6 and TNF-α , to find out its anti-inflammatory effect in this study. After the treatment of the burdock extract in the cells, we measured the amount of NO generated in the inflammatory cells developed by LPS and UVB, and confirmed the developments of inflammatory mediators by RT-PCR. Upon the results on the NO generation after the development of inflammation by LPS in Raw 264.7 cell, we found approximately 50% of inhibitory effect at 200 μg/ml concentrations of the burdock extract...
May 18, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Hee Soon Shin, Sun Young Jung, Su Yeon Back, Jeong-Ryong Do, Dong-Hwa Shon
Fructus Arctii is used as a traditional herbal medicine to treat inflammatory diseases in oriental countries. This study aimed to investigate effect of F. Arctii extract on intestinal barrier function in human intestinal epithelial Caco-2 cells and to reveal the active component of F. Arctii. We measured transepithelial electrical resistance (TEER) value (as an index of barrier function) and ovalbumin (OVA) permeation (as an index of permeability) to observe the changes of intestinal barrier function. The treatment of F...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
Li-fei Xie, Kong-jun Wang, Han Cai, Ling Shao
OBJECTIVE: In order to select antistaling agent which had obvious antibacterial effect on Morinda officinalis, the colony counts of microorganism from the surface of Morinda officinalis and the species of bacteria and mycete were analyzed. METHODS: Bacteria and moulds classification identification method were carried out. RESULTS: After using 10 g burdock oligosaccharide, 20 g chitosan and 0. 5 g potassium sorbate treated for 60 d, the total bacteria on the surface of Morinda officinalis was 3...
March 2015: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
Mizue Okada, Yoshinori Okada
Advanced glycation end products' (AGEs) engagement of a cell-surface receptor for AGEs (RAGE) has been causally implicated in the pathogenesis of vascular complications in diabetic patients. Methanolic extracts from edible plants (MEEP) are naturally occurring phenolic compounds. The phenolic compounds have been reported to possess potent radical-scavenging properties. We investigated whether MEEP could inhibit high glucose-induced RAGE production through interference with reactive oxygen species generation in endothelial cells (ECs)...
2015: Bio-medical Materials and Engineering
Naoki Ohkura, Haruna Yokouchi, Mariyo Mimura, Riki Nakamura, Gen-Ichi Atsumi
AIMS: This study aimed to identify new hemostyptics by assessing the coagulation enhancing activity of 114 Chinese herbal extracts in vitro. METHODS: Herbs were boiled in water for 30 min, filtered and then lyophilized filtrates (10 mg/mL) were dissolved in water. Coagulation was assayed as prothrombin time (PT). Plasma diluted in saline was incubated with each extract for 5 min and then PT reagent was added, followed by CaCl2 solution and the time taken to form clots was measured...
January 2015: Journal of Intercultural Ethnopharmacology
Zaixiang Lou, Yuxia Tang, Xinyi Song, Hongxin Wang
Screening of anti-biofilm compounds from the burdock leaf based on metabolomics is reported here. The crystal violet assay indicated 34% ethanol elution fraction of burdock leaf could completely inhibit biofilm formation of Pseudomonas aeruginosa at 1 mg·mL(-1). Then, the chemical composition of burdock leaf fraction was analyzed by ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) and 11 active compounds (chlorogenic acid, caffeic acid, p-coumaric acid, quercetin, ursolic acid, rutin, cynarin, luteolin, crocin, benzoic acid, and Tenacissoside I) were identified...
2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Akram Ahangarpour, Ali Akbar Oroojan, Hamid Heidari, Ehsan Ghaedi, Reza Taherkhani
BACKGROUND: Reproductive dysfunction is a complication of diabetes. Arctium lappa (burdock) root has hypoglycemic and antioxidative properties, which are traditionally used for treatment of impotence and sterility. Therefore, the aim of this study is to investigate the effects of its hydro alcoholic extract on gonadotropin, testosterone, and sperm parameters in nicotinamide/ streptozotocin-induced diabetic mice. METHODS: In this experimental study, 56 adult male Naval Medical Research Institute (NMRI) mice (30-35 g) were randomly divided into seven groups: control, diabetes, diabetes + glibenclamide (0...
March 2015: Malaysian Journal of Medical Sciences: MJMS
Youngae Jung, Miyoung Ha, Jueun Lee, Yun Gyong Ahn, Jong Hwan Kwak, Do Hyun Ryu, Geum-Sook Hwang
Arctium lappa L. (Asteracease), commonly known as burdock, has a long history of cultivation as a dietary vegetable and as an ingredient in folk medicines worldwide. Stress in plants disrupts metabolic homeostasis and requires adjustment of metabolic pathways. Exposure to heavy metals is one of the most prevalent environmental stresses encountered by plants. In this study, metabolite profiling with multivariate analysis was used to obtain a holistic view of the response of burdock roots to copper stress. A detailed pathway analysis was conducted using 1H NMR and GC-MS...
January 11, 2015: Journal of Agricultural and Food Chemistry
Byulchorong Min, Heejin Lee, Ji Hye Song, Myung Joo Han, Jayong Chung
BACKGROUND/OBJECTIVES: The purpose of this study was to examine the effects and associated mechanisms of arctiin, a lignan compound found in burdock, on adipogenesis in 3T3-L1 cells. Also, the effects of arctiin supplementation in obese mice fed a high-fat diet on adiposity were examined. MATERIALS/METHODS: 3T3-L1 cells were treated with arctiin (12.5 to 100 µM) during differentiation for 8 days. The accumulation of lipid droplets was determined by Oil Red O staining and intracellular triglyceride contents...
December 2014: Nutrition Research and Practice
A Gӧkçe, L L Stelinski, D R Nortman, W W Bryan, M E Whalon
Behavioral and electroantennogram responses of plum curculio, Conotrachelus nenuphar (Herbst) (Coleoptera: Curculionidae), adults were tested for several methanolic plant extracts and organically approved insecticides. Plant extracts were evaluated for their potential as antifeedants or oviposition deterrents. These extract responses were also compared to those elicited by the non-neurotoxic, organic irritant-insecticide kaolin clay. Both sexes of plum curculio exhibited antennal response as measured by electroantennogram, which ranged from 0...
2014: Journal of Insect Science
Leila Maghsoumi-Norouzabad, Beitollah Alipoor, Reza Abed, Bina Eftekhar Sadat, Mehran Mesgari-Abbasi, Mohammad Asghari Jafarabadi
AIM: This study was designed to examine the effect of Burdock root tea on inflammatory markers and oxidative stress indicators in patients with knee osteoarthritis (OA). METHODS: Thirty-six patients (10 men and 26 women) aged 50-70 years old with knee osteoarthritis referred to the Physical Medicine and Rehabilitation Department of the Tabriz University of Medical Sciences Hospitals, were selected for the study and randomly divided into two groups. Anthropometric measurements, including height, weight and body mass index (BMI) were measured...
March 2016: International Journal of Rheumatic Diseases
Shingo Umene, Masahiro Hayashi, Kumiko Kato, Hiroaki Masunaga
Hard, difficult-to-eat root crops (carrots and burdock roots) were homogeneously softened by an enzyme permeation method so that they could be mashed easily by the tongue while retaining appearance, flavor, and nutrients. The appearance, color, and nutritional value of these foods were equivalent to those of normally cooked root crops of the same type. The firmness of the softened root crops was at least 100 times as low as normally cooked root crops and lower than some care food products for patients with swallowing disorders...
April 2015: Dysphagia
Satish Kumar Rajasekharan, Samiraj Ramesh, Dhamodharan Bakkiyaraj, Ramaraj Elangomathavan, Chakkaravarthi Kamalanathan
Bacterial biofilms are serious concern in patients infected with urinary tract infections, complicated urinary tract infections and other device-associated infections. Microbes within the biofilms are effectively shielded from antibiotics and host immune cells, hence can be treated only with agents which has the potential to disassemble the biofilms. The study is focused on the root extracts of Arctium lappa Linn. as a source for complementary medicine against three major biofilm forming clinical isolates of Escherichia coli, Proteus mirabilis, and Serratia marcescens...
February 2015: Urolithiasis
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