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https://www.readbyqxmd.com/read/29235180/the-effects-of-hypoglycemia-and-weight-loss-of-total-lignans-from-fructus-arctii-in-kkay-mice-and-its-mechanisms-of-the-activity
#1
Yingying Gao, Chenchen Gu, Kai Wang, Haiying Wang, Kefeng Ruan, Zhaohui Xu, Yi Feng
Fructus Arctii (great burdock achene) is the dried ripe fruit of Arctium lappa L. (family Asteraceae) and is included in the Chinese pharmacopoeia. It has been reported that the clinical use of Fructus Arctii resulted in a satisfactory hypoglycemic effect in diabetic patients. This study aimed to investigate antidiabetic activity and mechanism of total lignans from Fructus Arctii (TLFA) in KKAy mice, a spontaneous Type 2 diabetic rodent model that exhibits marked obesity. In this study, KKAy mice were gavaged once daily with solvents (0...
December 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29154814/effects-of-aquarobic-exercise-and-burdock-intake-on-serum-blood-lipids-and-vascular-elasticity-in-korean-elderly-women
#2
Min-Seong Ha, Ji-Hyeon Kim, You-Sin Kim, Do-Yeon Kim
BACKGROUND: The elderly's health issues are often complex and tend to lead to chronic diseases; such issues can be due to a fitness decline resulting from a lack of physical activities. The burdock root is a blood purifier, lymphatic system strengthener, and natural diuretic. The purpose of this study was to analyze the effects of aquarobic exercise and burdock intake on serum blood lipids and vascular elasticity in elderly women by implementing a 12-week program with these interventions...
November 14, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29126799/mitodepressive-antioxidant-antifungal-and-anti-inflammatory-effects-of-wild-growing-romanian-native-arctium-lappa-l-asteraceae-and-veronica-persica-poiret-plantaginaceae
#3
Radu Claudiu Fierascu, Milen I Georgiev, Irina Fierascu, Camelia Ungureanu, Sorin Marius Avramescu, Alina Ortan, Mihaela Ioana Georgescu, Anca Nicoleta Sutan, Anca Zanfirescu, Cristina Elena Dinu-Pirvu, Bruno Stefan Velescu, Valentina Anuta
The present study aims to evaluate the potential uses of hydroalcoholic extracts obtained from Romanian native wild-growing plants. The hydroalcoholic extracts were obtained from the burdock roots and respectively the aerial parts of birdeye speedwell. The extracts were characterised by HPLC (quantifying 13 compounds in the V. persica extract, 6 compounds in the A. lappa extract and confirming the presence of arctiin and arctigenin in the burdock extract). The antioxidant potential of the crude extracts was evaluated using two methods: the DPPH assay (79...
November 7, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29108833/arctiin-protects-against-cardiac-hypertrophy-through-inhibiting-mapks-and-akt-signaling-pathways
#4
Jing Li, Yu-Pei Yuan, Si-Chi Xu, Ning Zhang, Chun-Ru Xu, Chun-Xia Wan, Jie Ren, Xiao-Feng Zeng, Qi-Zhu Tang
PURPOSE: The mitogen-activated protein kinases (MAPKs) and protein kinase B (AKT) pathways have emerged as essential intracellular signaling pathways in eukaryotic cells, particularly as regulators of cardiac hypertrophy. Previous studies indicated that arctiin, an active ingredient of biennial dried ripe burdock, could exhibit potent anti-inflammatory and anti-allergic activities via down-regulating the activation of MAPKs and AKT pathways. However, little is known about its effects on cardiac hypertrophy...
August 10, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29058588/effect-of-infla-kine-supplementation-on-the-gene-expression-of-inflammatory-markers-in-peripheral-mononuclear-cells-and-on-c-reactive-protein-in-blood
#5
Nina A Mikirova, Santosh Kesari, Thomas E Ichim, Neil H Riordan
BACKGROUND: Chronic inflammation is a predisposing factor to numerous degenerative diseases including cancer, heart failure and Alzheimer's disease. Infla-Kine is a natural supplement comprised of a proprietary blend of Lactobacillus fermentum extract, burdock seed (arctigenin), zinc, alpha lipoic acid, papaya enzyme and an enhanced absorption bio-curcumin complex (BCM-95®). METHODS: Infla-Kine was administered twice daily to 24 health volunteers for 4 weeks. Quantitative RT-PCR was used to assess mRNA transcripts of IL-1b, IL8, IL-6, NF-κB, and TNF-α from peripheral blood mononuclear cells (PBMC)...
October 20, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29023056/ameliorative-effect-of-arctium-lappa-against-cadmium-genotoxicity-and-histopathology-in-kidney-of-wistar-rat
#6
Asma Suliman Al-Gebaly
BACKGROUND AND OBJECTIVE: Cadmium (Cd) is a non-essential metal whose dispersion in the environment has increased recently, Cd may enhance cell oxidative stress that leads to DNA damage and apoptotic cell death. The study aimed to evaluate the antioxidative capability of Burdock root 'Arctium lappa' on cadmium-induced oxidative stress and histopathology of the kidney of Wistar rats. METHODOLOGY: Cadmium was applied in a form of cadmium chloride to three groups (15 mg Cd kg-1) for five weeks with two groups pre-treated with 'Arctium lappa' administration, 100 and 200 mg kg-1 b...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/28912875/inhibitory-effect-of-burdock-leaves-on-elastase-and-tyrosinase-activity
#7
Chi-Ting Horng, Hsing-Chen Wu, Ni-Na Chiang, Chiu-Fang Lee, Yu-Syuan Huang, Hui-Yun Wang, Jai-Sing Yang, Fu-An Chen
Burdock (Arctium lappa L.) leaves generate a considerable amount of waste following burdock root harvest in Taiwan. To increase the use of burdock leaves, the present study investigated the optimal methods for producing burdock leaf extract (BLE) with high antioxidant polyphenolic content, including drying methods and solvent extraction concentration. In addition, the elastase and tyrosinase inhibitory activity of BLE was examined. Burdock leaves were dried by four methods: Shadow drying, oven drying, sun drying and freeze-drying...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28890521/effect-of-burdock-extract-on-physical-performance-and-physiological-fatigue-in-mice
#8
Wen-Chyuan Chen, Yi-Ju Hsu, Mon-Chien Lee, Hua Shuai Li, Chun-Sheng Ho, Chi-Chang Huang, Fu-An Chen
Burdock (BD) is a common vegetable with many pharmacological properties. However, few studies have examined the effect of BD on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effects of BD on fatigue and ergogenic functions following physical challenge in mice. METHODS: Male ICR mice were divided into four groups to receive either vehicle, or BD at 348.5, 697 or 1,742.5 mg/kg/day, by daily oral gavage for 4 weeks. Exercise performance and fatigue were evaluated from forelimb grip strength, exhaustive swimming time, and post-exercise levels of physical fatigue-related biomarkers serum lactate, ammonia, glucose, and creatine kinase (CK)...
October 7, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28801728/arctium-minus-crude-extract-presents-antinociceptive-effect-in-a-mice-acute-gout-attack-model
#9
Susana Paula Moreira Fischer, Indiara Brusco, Camila Camponogara, Mariana Piana, Henrique Faccin, Luciana Assis Gobo, Leandro Machado de Carvalho, Sara Marchesan Oliveira
Gout is a disorder that triggers a severe inflammatory reaction which generates episodes of intense pain and discomfort to the patient. Arctium minus (Hill) Bernh. (Asteraceae) is known as "burdock" and displays anti-inflammatory, antinociceptive, against rheumatic pain and radical-scavenging activities. Species of the genus Arctium have been used in assistant therapy of gout and other inflammatory processes. We investigated the antinociceptive and anti-edematogenic effects of the crude extract of A. minus seeds in an acute gout attack model induced by intra-articular injection of monosodium urate (MSU) crystals in adult male Swiss mice (25-30 g)...
August 11, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28780467/in-vitro-schistosomicidal-and-antiviral-activities-of-arctium-lappa-l-asteraceae-against-schistosoma-mansoni-and-herpes-simplex-virus-1
#10
Mirna Meana Dias, Ohana Zuza, Lorena R Riani, Priscila de Faria Pinto, Pedro Luiz Silva Pinto, Marcos P Silva, Josué de Moraes, Ana Caroline Z Ataíde, Fernanda de Oliveira Silva, Alzira Batista Cecílio, Ademar A Da Silva Filho
Schistosomiasis and herpes diseases represent serious issues to the healthcare systems, infecting a large number of people worldwide, mainly in developing countries. Arctium lappa L. (Asteraceae), known as "bardana" and "burdock", is a medicinal plant popularly used for several purposes, including as antiseptic. In this study, we evaluated the in vitro schistosomicidal and antiherpes activities of the crude extract of A. lappa, which have not yet been described. Fruits of A. lappa L. were extracted by maceration with ethanol: H2O (96:4 v/v) in order to obtain the hydroalcoholic extract of A...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28758851/effects-of-aqueous-extract-of-arctium-lappa-l-roots-on-serum-lipid-metabolism
#11
Bo Hou, Wencheng Wang, Hui Gao, Shanglang Cai, Chunbo Wang
Objective To identify potential genes that may be involved in lipid metabolism in rats after treatment with aqueous extract of Arctium lappa L (burdock). Methods Rats were randomly divided into six groups: (i) control (standard diet); (ii) model group (high-fat diet only); (iii) high-fat diet and low-dose aqueous burdock root extract (2 g/kg); (iv) high-fat diet and moderate-dose aqueous burdock root extract (4 g/kg); (v) high-fat diet and high-dose aqueous burdock root extract (8 g/kg); and (vi) a positive control group exposed to a high-fat diet and simvastatin (10 mg/kg)...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28755129/acid-gastric-antisecretory-effect-of-the-ethanolic-extract-from-arctium-lappa-l-root-role-of-h-k-atpase-ca-2-influx-and-the-cholinergic-pathway
#12
Luisa Mota da Silva, Ligia de Moura Burci, Sandra Crestani, Priscila de Souza, Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva, Nessana Dartora, Lauro Mera de Souza, Thales Ricardo Cipriani, José Eduardo da Silva-Santos, Eunice André, Maria Fernanda de Paula Werner
BACKGROUND: Arctium lappa L., popularly known as burdock, is a medicinal plant used worldwide. The antiulcer and gastric-acid antisecretory effects of ethanolic extract from roots of Arctium lappa (EET) were already demonstrated. However, the mechanism by which the extract reduces the gastric acid secretion remains unclear. Therefore, this study was designed to evaluate the antisecretory mode of action of EET. MATERIALS AND METHODS: The effects of EET on H(+), K(+)-ATPase activity were verified in vitro, whereas the effects of the extract on cholinergic-, histaminergic- or gastrinergic-acid gastric stimulation were assessed in vivo on stimulated pylorus ligated rats...
July 28, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28595956/our-unrequited-love-for-natural-ingredients
#13
REVIEW
George A Burdock, Wendan Wang
Naturally sourced food ingredients have been the beneficiary of legal, regulatory and consumer preference as the result of a widely shared assumption of safety. However, the natural substances consumed in modernity may have little to do with the historically consumed part of the plant or even the plant itself. Further, our initial impression of a safe plant derivative may well be false as the result of the use of different growth conditions or, changes in harvesting and processing conditions that may have brought about a higher level of toxic constituents...
September 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28545667/arctigenin-suppresses-renal-interstitial-fibrosis-in-a-rat-model-of-obstructive-nephropathy
#14
Ao Li, Xiaoxun Zhang, Mao Shu, Mingjun Wu, Jun Wang, Jingyao Zhang, Rui Wang, Peng Li, Yitao Wang
BACKGROUND: Renal tubulointerstitial fibrosis (TIF) is commonly the final result of a variety of progressive injuries and leads to end-stage renal disease. There are few therapeutic agents currently available for retarding the development of renal TIF. PURPOSE: The aim of the present study is to evaluate the role of arctigenin (ATG), a lignan component derived from dried burdock (Arctium lappa L.) fruits, in protecting the kidney against injury by unilateral ureteral obstruction (UUO) in rats...
July 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28484137/identification-of-datura-species-involved-in-a-food-poisoning-case-using-lc-ms-ms-and-dna-barcording
#15
Atsuko Ushiyama, Chie Akaboshi, Nobuhiko Ohsawa, Tomomi Shimizu, Yuki Matsushima, Hideaki Shimizu, Shigeki Hashiguchi
A food-poisoning case due to eating the roots of Datura occurred in Kawasaki City, Japan in 2014. The Datura plant was mistakenly collected instead of burdock in a domestic garden. The roots of these plants are quite similar to each other. We presumed that the specimen was the root of Datura, but it was difficult to classify it only from the morphology. Using LC-MS/MS, we detected atropine and scopolamine from the remaining plant specimen. Therefore, we applied the DNA barcoding method. The results showed that the specimen was classified into Solanaceae family, but not Asteraceae family...
2017: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/28450691/acute-encephalopathy-due-to-angel-s-trumpet-intoxication-a-case-report-and-literature-review
#16
REVIEW
Shinichi Takeshima, Shuichiro Neshige, Naoyuki Hara, Tomoshi Kubo, Takahiro Himeno, Masaru Kuriyama
We report two cases (a married couple) of intoxication due to angel's trumpet ingestion. Case 1: A 71-year-old woman was found lying unconscious on the sofa at home and was brought to our hospital by ambulance. She showed mydriatic anisocoria, and an intracerebral lesion was suspected. However, the brain magnetic resonance imaging showed no abnormal lesion and acute encephalopathy of unknown cause was diagnosed. Case 2: A 68-year-old man (husband of the patient of Case 1) showed alteration of consciousness with agitation and was admitted to our hospital on the next day...
May 27, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28426569/salve-and-burdock-a-safe-effective-amish-remedy-for-treatment-of-traumatic-wounds
#17
Mitchell D Flurry, Kelsie L Herring, Logan W Carr, Randy M Hauck, John D Potochny
BACKGROUND: Amish patients show a demonstrated preference for traditional, herbal remedies over modern medical interventions such as skin grafting. One such remedy is a mixture of Burn & Wound Ointment (B & W Ointment; Holistic Acres, LLC; Newcomerstown, Ohio) and steeped burdock leaves. Although both have demonstrated some antimicrobial and wound healing properties, burdock and/or the combination of B & W Ointment and burdock has never been studied to determine its purported ability to reduce pain, prevent infection, and accelerate wound healing...
May 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28401084/influence-of-roasting-treatment-on-the-antioxidant-activities-and-color-of-burdock-root-tea
#18
Darye Lee, Choon Young Kim
The major trend in the antioxidant market is the growing consumer demand for natural antioxidants. Tea, one of the most widely consumed beverages in the world, is an easy way to obtain antioxidant components from a natural source. Our objective was to develop burdock root tea (BRT) with potent antioxidant activity and good color quality. In order to obtain maximum antioxidant activity and quality, the effect of roasting was determined. The antioxidant capacities and total phenolic contents of BRT increased as roasting increased...
March 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28348972/antidiabetic-hypolipidemic-and-hepatoprotective-effects-of-arctium-lappa-root-s-hydro-alcoholic-extract-on-nicotinamide-streptozotocin-induced-type-2-model-of-diabetes-in-male-mice
#19
Akram Ahangarpour, Hamid Heidari, Ali Akbar Oroojan, Farhang Mirzavandi, Khalil Nasr Esfehani, Zeinab Dehghan Mohammadi
OBJECTIVE: Arctium lappa (burdock), (A. lappa) root has hypoglycemic and antioxidative effects, and has been used for treatment of diabetes in tradition medicine. This study was conducted to evaluate the antidiabetic and hypolipidemic properties of A. lappa root extract on nicotinamide-streptozotocin (NA-STZ)-induced type2 diabetes in mice. MATERIALS AND METHODS: In this investigation, 70 adult male NMRI mice (30-35g) randomly divided into 7 groups (n=10) as follow: 1-control, 2-type 2 diabetic mice, 3-diabetic mice that received glibenclamide (0...
March 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28028699/evaluation-of-cotton-burdock-arctium-tomentosum-mill-responses-to-multi-metal-exposure
#20
Waad E Q Al Harbawee, Alina N Kluchagina, Naser A Anjum, Dmitry I Bashmakov, Alexander S Lukatkin, Eduarda Pereira
Plants have immense potential for their use in the minimization of emerging environmental pollution issues. Under simulated laboratory conditions, this work investigated the growth and biochemical responses of 14-day-old cotton burdock (Arctium tomentosum Mill.) seedlings to the body burdens of multi-metals including Pb, Cu, Ni, and Zn (1.0 μM-10 mM). Biochemical traits (superoxide generation, lipid peroxidation, content of total peroxides), growth traits (axial organs growth, dry weight accumulation, leaf area), and also metal body burdens varied with types and concentrations of metals...
February 2017: Environmental Science and Pollution Research International
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