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https://www.readbyqxmd.com/read/27882370/anti-obesity-effects-of-arctii-fructus-arctium-lappa-in-white-brown-adipocytes-and-high-fat-diet-induced-obese-mice
#1
Yo-Han Han, Ji-Ye Kee, Dae-Seung Kim, Jinbong Park, Mi-Young Jeong, Jung-Geon Mun, Sung-Joo Park, Jong-Hyun Lee, Jae-Young Um, Seung-Heon Hong
Arctii Fructus is traditionally used in oriental pharmacies as an anti-inflammatory medicine. Although several studies have shown its anti-inflammatory effects, there have been no reports on its use in obesity related studies. In this study, the anti-obesity effect of Arctii Fructus was investigated in high-fat diet (HFD)-induced obese mice, and the effect was confirmed in white and primary cultured brown adipocytes. Arctii Fructus inhibited weight gain and reduced the mass of white adipose tissue in HFD-induced obese mice...
November 24, 2016: Food & Function
https://www.readbyqxmd.com/read/27882222/gastroprotective-effects-of-arctigenin-of-arctium-lappa-l-on-a-rat-model-of-gastric-ulcers
#2
Xiao-Mei Li, Yu Miao, Qin-Yong Su, Jing-Chun Yao, Hong-Hua Li, Gui-Min Zhang
In the present study, the gastroprotective effects of arctigenin of Fructus Arctii were evaluated and the possible underlying mechanisms of action were elucidated. Arctigenin (high-performance liquid chromatography purity, >99.0%) was isolated and purified from the seeds of Arctium lappa L. The anti-ulcerogenic activity of arctigenin against ulcers induced by absolute ethanol and acetic acid was evaluated in a Sprague-Dawley rat model. In addition, the antioxidant activity was assessed by measuring malondialdehyde (MDA) levels in an ethanol-induced model and the anti-inflammatory effects were assessed by measuring five factors in an acetic acid-induced model...
November 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27878294/arctigenin-a-lignan-from-arctium-lappa-l-inhibits-metastasis-of-human-breast-cancer-cells-through-the-downregulation-of-mmp-2-9-and-heparanase-in-mda-mb-231-cells
#3
Chenghua Lou, Zhihui Zhu, Yaping Zhao, Rui Zhu, Huajun Zhao
Arctigenin is a bioactive lignan isolated from the seeds of Arctium lappa L. which has been widely used as a diuretic and a diaphoretic in Traditional Chinese Medicine. In the present study, the authors investigated the effects of arctigenin on tumor migration and invasion in aggressive human breast cancer cells. The MTT assay results showed that arctigenin did not show a significant cytotoxic effect on the cell viability of MDA-MB-231 cells. However, wound healing migration and Boyden chamber invasion assays demonstrated that arctigenin significantly inhibited in vitro migration and invasion of the MDA-MB-231 cells...
November 23, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27876925/therapeutic-effect-of-arctium-lappa-in-schistosoma-haematobium-associated-kidney-disturbance-biochemical-and-molecular-effects
#4
Khaled M M Koriem, Zulzamri H Idris, Hasniza F Haron, Nurulhuda A Omar, Halita S Lazain
Schistosoma haematobium (S. haematobium) infection has been found to be strongly associated with bladder cancer, which necessitates for discover of a natural new therapeutic agent. The aim of this study was to evaluate the therapeutic effect of Arctium lappa seed extract in S. haematobium associated kidney disturbance. Forty male albino mice were used and divided into four equal groups; group 1 control includes non-infected healthy mice, groups 2, 3 and 4 subcutaneous infected with S. haematobium cercariae...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27861147/arctigenin-inhibits-stat3-and-exhibits-anticancer-potential-in-human-triple-negative-breast-cancer-therapy
#5
Tingting Feng, Wei Cao, Wanxiang Shen, Liang Zhang, Xinsheng Gu, Yang Guo, Hsiang-I Tsai, Xuewen Liu, Jian Li, Jingxuan Zhang, Shan Li, Fuyun Wu, Ying Liu
Triple-negative breast cancers (TNBCs) are the most aggressive and hard-to-treat breast tumors with poor prognosis, and exploration for novel therapeutic drugs is impending. Arctigenin (Atn), a bioactive lignan isolated from seeds of Arctium lappa L, has been reported to inhibit many cancer types; however, the effect of Atn on TNBC remains unclear. In this study, we demonstrated that Atn decreased proliferation, and induced apoptosis in TNBC cells. Furthermore, we explored the underlying mechanism of Atn inhibition on TNBC cells...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27860087/the-effect-of-burdock-leaf-fraction-on-adhesion-biofilm-formation-quorum-sensing-and-virulence-factors-of-p-aeruginosa
#6
Zaixiang Lou, Hongxin Wang, Yuxia Tang
AIMS: This study aimed to evaluate the effect of a fraction of burdock (Arctium lappa L.) leaf on the initial adhesion, biofilm formation, quorum sensing and virulence factors of P. aeruginosa. METHODS AND RESULTS: Anti-biofilm activity of the burdock leaf fraction was studied by the method of crystal violet staining. When the concentration of the burdock leaf fraction was 2.0 mg mL(-1) , the inhibition rates on biofilm formation of P. aeruginosa were 100%. The burdock leaf fraction was found to inhibit the formation of biofilm by reducing bacterial surface hydrophobicity, decreasing bacterial aggregation ability and inhibiting swarming motility Interestingly, the burdock leaf fraction inhibited the secretion of quorum sensing (QS) signaling molecule 3-oxo-C12-HSL and interfered quorum sensing...
November 12, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27800716/pretreatment-of-mqa-a-caffeoylquinic-acid-derivative-compound-protects-against-h2o2-induced-oxidative-stress-in-sh-sy5y-cells
#7
Xing Tian, Lingyue Gao, Li An, Xiaowen Jiang, Junpeng Bai, Jian Huang, Weihong Meng, Qingchun Zhao
OBJECTIVES: Compound MQA (1,5-O-dicaffeoyl-3-O-[4-malic acid methyl ester]-quinic acid) is a natural caffeoylquinic acid derivative isolated from Arctium lappa L. roots. This study aims to explore the neuroprotective effects of MQA against hydrogen peroxide (H2O2)-induced oxidative stress in SH-SY5Y neuroblastoma cells. METHODS: The SH-SY5Y cells were divided into four groups, including control, 20 μM MQA, 200 μM H2O2, 200 μM H2O2 + 20 μM MQA groups. The effects of MQA on H2O2-induced cell death were measured by MTT and LDH assays...
November 1, 2016: Neurological Research
https://www.readbyqxmd.com/read/27685612/a-phase-i-trial-of-gbs-01-for-advanced-pancreatic-cancer-refractory-to-gemcitabine
#8
Masafumi Ikeda, Akihiro Sato, Nobuo Mochizuki, Kayo Toyosaki, Chika Miyoshi, Rumi Fujioka, Shuichi Mitsunaga, Izumi Ohno, Yusuke Hashimoto, Hideaki Takahashi, Hiromi Hasegawa, Shogo Nomura, Ryuji Takahashi, Satoshi Yomoda, Katsuya Tsuchihara, Satoshi Kishino, Hiroyasu Esumi
GBS-01, an extract from the fruit of Arctium lappa Linné is an orally administered drug rich in arctigenin, which has been reported to exert antitumor activity by attenuating the tolerance of cancer cells to glucose deprivation. We investigated the maximum tolerated dose of GBS-01 based on the frequency of the dose-limiting toxicities (DLT) and pharmacokinetics in patients with advanced pancreatic cancer refractory to gemcitabine. Patients with advanced pancreatic adenocarcinoma who were refractory to gemcitabine were enrolled...
September 29, 2016: Cancer Science
https://www.readbyqxmd.com/read/27623718/new-phytochemicals-as-potential-human-anti-aging-compounds-reality-promise-and-challenges
#9
Rubia C G Corrêa, Rosane M Peralta, Charles W I Haminiuk, Giselle Maria Maciel, Adelar Bracht, Isabel C F R Ferreira
Aging is an inevitable process influenced by genetic, lifestyle and environmental factors. Indirect evidence shows that several phytochemicals can have anti-aging capabilities, although direct evidence in this field is still limited. This report aims to provide a critical review on aspects related to the use of novel phytochemicals as anti-aging agents, to discuss the obstacles found when performing most anti-aging study protocols in humans, and to analyze future perspectives. In addition to the extensively studied resveratrol, epicatechin, quercetin and curcumin, new phytochemicals have been reported to act as anti-aging agents, such as the amino acid L-theanine isolated from green tea, and the lignans arctigenin and matairesinol isolated from Arctium lappa seeds...
September 13, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27539316/the-immunomodulatory-potential-of-selected-bioactive-plant-based-compounds-in-breast-cancer-a-review
#10
Yusha U Shu Aibu Baraya, Kah Keng Wong, Nik Soriani Yaacob
Breast cancer has continued to cause high cancer death rates among women worldwide. The use of plants' natural products in breast cancer treatment has received more attention in recent years due to their potentially wider safety margin and the potential to complement conventional chemotherapeutic drugs. Plant-based products have demonstrated anticancer potential through different biological pathways including modulation of the immune system. Immunomodulatory properties of medicinal plants have been shown to mitigate breast cancer cell growth...
August 17, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27497128/antibacterial-antibiofilm-effect-of-burdock-arctium-lappa-l-leaf-fraction-and-its-efficiency-in-meat-preservation
#11
Zaixiang Lou, Cheng Li, Xingran Kou, Fuhao Yu, Hongxin Wang, Gary M Smith, Song Zhu
First, the antibacterial, antibiofilm effect and chemical composition of burdock (Arctium lappa L.) leaf fractions were studied. Then, the efficiency of burdock leaf fractions in pork preservation was evaluated. The results showed that burdock leaf fraction significantly inhibited the growth and biofilm development of Escherichia coli and Salmonella Typhimurium. MICs of burdock leaf fractions on E. coli and Salmonella Typhimurium were both 2 mg/ml. At a concentration of 2.0 mg/ml, the inhibition rates of the fraction on growth and development of E...
August 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/27311502/polysaccharides-from-arctium-lappa-l-chemical-structure-and-biological-activity
#12
Juliane Carlotto, Lauro M de Souza, Cristiane H Baggio, Maria Fernanda de P Werner, Daniele Maria-Ferreira, Guilherme L Sassaki, Marcello Iacomini, Thales R Cipriani
The plant Arctium lappa L. is popularly used to relieve symptoms of inflammatory disorders. A crude polysaccharide fraction (SAA) resulting of aqueous extraction of A. lappa leaves showed a dose dependent anti-edematogenic activity on carrageenan-induced paw edema, which persisted for up to 48h. Sequential fractionation by ultrafiltration at 50kDa and 30kDa cut-off membranes yielded three fractions, namely RF50, RF30, and EF30. All these maintained the anti-edematogenic effect, but RF30 showed a more potent action, inhibiting 57% of the paw edema at a dose of 4...
October 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27275107/natural-cures-for-breast-cancer-treatment
#13
Munazza Shareef, Muhammad Aqeel Ashraf, Maliha Sarfraz
For centuries, herbs and plants have been used for medicinal purposes and as food as well. This review concerns about different types of plants that retain the immune stimulating and anti-tumor properties. Large variety of active phytochemicals such as carotenoids, flavonoids, ligands, polyphenolics, terpenoids, sulfides, lignans and plant sterols has been identified in different types of herbs. These phytochemicals have different mechanisms of action. They either stimulate the protective enzyme like glutathione transferase or prevent the cell proliferation...
May 2016: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/27234554/the-antiviral-activity-of-arctigenin-in-traditional-chinese-medicine-on-porcine-circovirus-type-2
#14
Jie Chen, Wentao Li, Erguang Jin, Qigai He, Weidong Yan, Hanchun Yang, Shiyu Gong, Yi Guo, Shulin Fu, Xiabing Chen, Shengqiang Ye, Yunguo Qian
Arctigenin (ACT) is a phenylpropanoid dibenzylbutyrolactone lignan extracted from the traditional herb Arctium lappa L. (Compositae) with anti-viral and anti-inflammatory effects. Here, we investigated the antiviral activity of ACT found in traditional Chinese medicine on porcine circovirus type 2 (PCV2) in vitro and in vivo. Results showed that dosing of 15.6-62.5μg/mL ACT could significantly inhibit the PCV2 proliferation in PK-15 cells (P<0.01). Dosing of 62.5μg/mL ACT 0, 4 or 8h after challenge inoculation significantly inhibited the proliferation of 1MOI and 10MOI in PK-15 cells (P<0...
June 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27087645/antiallergic-activity-of-ethanol-extracts-of-arctium-lappa-l-undried-roots-and-its-active-compound-oleamide-in-regulating-fc%C3%AE%C2%B5ri-mediated-and-mapk-signaling-in-rbl-2h3-cells
#15
Woong-Suk Yang, Sung Ryul Lee, Yong Joon Jeong, Dae Won Park, Young Mi Cho, Hae Mi Joo, Inhye Kim, Young-Bae Seu, Eun-Hwa Sohn, Se Chan Kang
The antiallergic potential of Arctium lappa L. was investigated in Sprague-Dawley rats, ICR mice, and RBL-2H3 cells. Ethanol extract (90%) of A. lappa (ALE, 100 μg/mL) inhibited the degranulation rate by 52.9%, determined by the level of β-hexosaminidase. ALE suppressed passive cutaneous anaphylaxis (PCA) in rats and attenuated anaphylaxis and histamine release in mice. To identify the active compound of ALE, we subsequently fractionated and determined the level of β-hexosaminidase in all subfractions. Oleamide was identified as an active compound of ALE, which attenuated the secretion of histamine and the production of tumor necrosis factor (TNF)-α and interleukin-4 (IL-4) in cells treated with compound 48/80 or A23187/phorbol myristate acetate (PMA)...
May 11, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27040538/usefulness-of-different-vascular-plant-species-for-passive-biomonitoring-of-mediterranean-rivers
#16
Daniela Baldantoni, Anna Alfani
Choosing native vascular plants as nutrient and toxic element accumulators for passive biomonitoring of urban river quality is not an easy task in Mediterranean rivers, due to the particular climate determining high variations in river hydrology. To identify potential biomonitors for this area, the roots of seven species (Angelica sylvestris, Apium nodiflorum, Tradescantia fluminensis, Nasturtium officinale, Persicaria lapathifolia, Arctium lappa, Typha latifolia), growing in seven sites along the River Irno (Southern Italy), were collected in July 2010 and analyzed regarding their capability to accumulate Cd, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, V, and Zn through atomic absorption spectrometry...
July 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/26981771/two-new-compounds-from-the-fruits-of-arctium-lappa
#17
Jun He, Xiao-Ying Huang, Ya-Nan Yang, Zi-Ming Feng, Jian-Shuang Jiang, Pei-Cheng Zhang
Phytochemical investigation of the extract of Arctii Fructus led to the isolation and characterization of two new compounds, named arctiisesquineolignan B (1) and arctiiphenolglycoside A (2). Their structures were elucidated by means of spectroscopic methods (UV, IR, HR-ESI-MS, 1D and 2D NMR) and chemical evidence, as well as by comparison with known analogs in the literature. Compound 2 exhibited stronger antioxidant activity than the positive control ascorbic acid at a concentration of 10 μM.
May 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/26926909/effects-of-arctium-lappa-on-cadmium-induced-damage-to-the-testis-and-epididymis-of-adult-wistar-rats
#18
Fabricia de Souza Predes, M A S Diamante, M A Foglio, H Dolder
The protective role of Arctium lappa (AL) on the testes of rats acutely exposed to cadmium (Cd) was tested. The rats were randomly divided into a control group (C-group) and three major experimental groups, which were further subdivided into minor groups (n = 6) according to the experimental period (7 or 56 days). The C-group was subdivided into C-7 and C-56 [receiving a single saline solution, intraperitoneal (i.p.), on the first day]; the AL-group, AL-7, and AL-56, received AL extract (300 mg/kg/daily); the Cd group, Cd-7 and Cd-56, received a single i...
October 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/26746431/protective-effects-of-arctium-lappa-l-root-extracts-ares-on-high-fat-diet-induced-quail-atherosclerosis
#19
Zhi Wang, Ping Li, Chenjing Wang, Qixiao Jiang, Lei Zhang, Yu Cao, Weizhen Zhong, Chunbo Wang
BACKGROUND: This study was designed to evaluate the protective effects of Arctium lappa L. root extracts (AREs) from different extraction methods (aqueous, ethanol, chloroform and flavone) on atherosclerosis. METHODS: Quails (Coturnix coturnix) were subjected to high fat diet, with or without one of the four different AREs or positive control simvastatin. Blood samples were collected before treatment, after 4.5 weeks or ten weeks to assess lipid profile (Levels of total cholesterol (TC), Triacylglycerol (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL))...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/26707911/inhibitory-effect-of-fermented-arctium-lappa-fruit-extract-on-the-ige-mediated-allergic-response-in-rbl%C3%A2-2h3-cells
#20
Jae-Myung Yoo, Ju Hye Yang, Hye Jin Yang, Won-Kyung Cho, Jin Yeul Ma
Arctium lappa fruit has been used in traditional medicine, and it is known to exert beneficial effects, such as antioxidant, anti-inflammatory and anticancer effects. However, the effects of the Arctium lappa fruit on the allergic response remain unknown. In this study, we evaluated the anti-allergic effects of Arctium lappa fruit extract (AFE) and its fermented form (F-AFE) using immunoglobulin E (IgE)-activated RBL‑2H3 cells. To investigate the anti-allergic effects of AFE or F-AFE, we examined the release of β-hexosaminidase, a key biomarker of degranulation during an allergic reaction, and the production of pro-inflammatory mediators, such as tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) in the cells treated with or without the above-mentioned extracts...
February 2016: International Journal of Molecular Medicine
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