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Kung-Yen Chen, Jui-An Lin, Han-Yun Yao, An-Chih Hsu, Yu-Ting Tai, Jui-Tai Chen, Mao-Chih Hsieh, Tang-Long Shen, Ren-Yi Hsu, Hong-Tan Wu, Guey Horng Wang, Bing-Ying Ho, Yu-Pei Chen
Arctigenin (ATG), a lignin extracted from Arctium lappa (L.), exerts antioxidant and anti-inflammatory effects. We hypothesized that ATG exerts a protective effect on hepatocytes by preventing nonalcoholic fatty liver disease (NAFLD) progression associated with lipid oxidation-associated lipotoxicity and inflammation. We established an in vitro NAFLD cell model by using normal WRL68 hepatocytes to investigate oleic acid (OA) accumulation and the potential bioactive role of ATG. The results revealed that ATG inhibited OA-induced lipid accumulation, lipid peroxidation, and inflammation in WRL68 hepatocytes, as determined using Oil Red O staining, thiobarbituric acid reactive substance assay, and inflammation antibody array assays...
February 11, 2018: Nutrition Research
Chi-Hua Yen, Hui-Fang Chiu, Su-Yu Huang, Yan-Ying Lu, Yi-Chun Han, You-Cheng Shen, Kamesh Venkatakrishnan, Chin-Kun Wang
BACKGROUND: Burdock complex (BC) constitutes of burdock (Arctium lappa), angelica (Angelica sinensis), gromwell (Lithospermum erythrorhizon), and sesame (Sesamum indicum) oil, which are commonly used in traditional Chinese medicine (TCM) for treating various disorders. This study intended to examine the anti-H. pylori activity of BC on AGS cell model as well as in asymptomatic H. pylori-infected subjects. MATERIALS AND METHODS: AGS cell incubated with H. pylori and treated with BC to evaluate the minimum inhibition concentration (MIC), cell viability (MTT) anti-adhesion activity, and inflammatory markers...
March 8, 2018: Helicobacter
Zhenjia Zheng, Xiao Wang, Pengli Liu, Meng Li, Hongjing Dong, Xuguang Qiao
Burdock roots are healthy dietary supplements and a kind of famous traditional Chinese medicine, which contains large amounts of caffeoylquinic acid derivatives. However, little research has been reported on the preparative separation of these compounds from burdock roots. In the present study, a combinative method of HSCCC and semi-preparative HPLC was developed for the semi-preparative separation of caffeoylquinic acid derivatives from the burdock roots. The ethyl acetate extract of burdock roots was first fractionated by MCI macroporous resin chromatography and give three fractions (Fr...
February 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yingying Gao, Chenchen Gu, Kai Wang, Haiying Wang, Kefeng Ruan, Zhaohui Xu, Yi Feng
Fructus Arctii (great burdock achene) is the dried ripe fruit of Arctium lappa L. (family Asteraceae) and is included in the Chinese pharmacopoeia. It has been reported that the clinical use of Fructus Arctii resulted in a satisfactory hypoglycemic effect in diabetic patients. This study aimed to investigate antidiabetic activity and mechanism of total lignans from Fructus Arctii (TLFA) in KKAy mice, a spontaneous Type 2 diabetic rodent model that exhibits marked obesity. In this study, KKAy mice were gavaged once daily with solvents (0...
December 13, 2017: Phytotherapy Research: PTR
Yusuke Baba, Zenpei Shigemi, Naoko Hara, Misato Moriguchi, Marina Ikeda, Tadashi Watanabe, Masahiro Fujimuro
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of primary effusion lymphoma (PEL) and Kaposi's sarcoma. PEL is a type of non-Hodgkin's B-cell lymphoma, affecting immunosuppressed individuals, such as post-transplant or AIDS patients. However, since PEL is resistant to chemotherapeutic regimens, new effective treatment strategies are required. Arctigenin, a natural lignan compound found in the plant Arctium lappa, has been widely investigated as a potential anticancer agent in the clinical setting...
February 2018: International Journal of Oncology
Radu Claudiu Fierascu, Milen I Georgiev, Irina Fierascu, Camelia Ungureanu, Sorin Marius Avramescu, Alina Ortan, Mihaela Ioana Georgescu, Anca Nicoleta Sutan, Anca Zanfirescu, Cristina Elena Dinu-Pirvu, Bruno Stefan Velescu, Valentina Anuta
The present study aims to evaluate the potential uses of hydroalcoholic extracts obtained from Romanian native wild-growing plants. The hydroalcoholic extracts were obtained from the burdock roots and respectively the aerial parts of birdeye speedwell. The extracts were characterised by HPLC (quantifying 13 compounds in the V. persica extract, 6 compounds in the A. lappa extract and confirming the presence of arctiin and arctigenin in the burdock extract). The antioxidant potential of the crude extracts was evaluated using two methods: the DPPH assay (79...
January 2018: Food and Chemical Toxicology
Donia Anvari, Rashid Jamei
BACKGROUND: Medicinal plants contain large amount of natural antioxidant compounds, which enable them to neutralize free radicals. Asteraceae family is important source of phytochemical compounds. OBJECTIVE: The objective of this research is to find out the antioxidant potential and radical scavenging from leaf and flowers of five species (Artemisia absinthium L., Arctium lappa L., Silybum marianum L., Centaurea cyanus L. and Echinops ritro L.) of the Asteraceae family...
October 23, 2017: Recent Patents on Food, Nutrition & Agriculture
Piwen Wang, Walter Solorzano, Tanya Diaz, Clara E Magyar, Susanne M Henning, Jaydutt V Vadgama
The low bioavailability of most phytochemicals limits their translation to humans. We investigated whether arctigenin, a novel anti-inflammatory lignan from the seeds of Arctium lappa, has favorable bioavailability/potency against prostate cancer. The anticarcinogenic activity of arctigenin was investigated both in vitro using the androgen-sensitive LNCaP and LAPC-4 human prostate cancer cells and pre-malignant WPE1-NA22 cells, and in vivo using xenograft mouse models. Arctigenin at lower doses (< 2μM) significantly inhibited the proliferation of LNCaP and LAPC-4 cells by 30-50% at 48h compared to control, and inhibited WPE1-NA22 cells by 75%, while did not affect normal prostate epithelial cells...
June 2017: Clinical Nutrition Experimental
So-Hyeon Bok, Seung Sik Cho, Chun-Sik Bae, Dae-Hun Park, Kyung-Mok Park
Recently, worldwide dietary reference intakes have been considered an important guideline for public health. Some governments and the World Health Organization (WHO) provide guidelines concerning dietary intake. Although an ingredient may have a history of use as a culinary material, changes in the environment over time suggest that the acceptable maximum intake each of food/culinary material should be regularly evaluated. Arctium lappa L. has been used as a culinary material for many centuries in Korea and Japan and some recent studies have reported related therapeutic effects...
September 2017: Laboratory Animal Research
Asma Suliman Al-Gebaly
BACKGROUND AND OBJECTIVE: Cadmium (Cd) is a non-essential metal whose dispersion in the environment has increased recently, Cd may enhance cell oxidative stress that leads to DNA damage and apoptotic cell death. The study aimed to evaluate the antioxidative capability of Burdock root 'Arctium lappa' on cadmium-induced oxidative stress and histopathology of the kidney of Wistar rats. METHODOLOGY: Cadmium was applied in a form of cadmium chloride to three groups (15 mg Cd kg-1) for five weeks with two groups pre-treated with 'Arctium lappa' administration, 100 and 200 mg kg-1 b...
2017: Pakistan Journal of Biological Sciences: PJBS
Karam Kim, Sungkwan An, Byung Gon Choi, Dahye Joo, Young Min Choi, Kyu Joong Ahn, In-Sook An, Hwa Jun Cha
Arctiin, a lignin isolated from Arctium lappa, exhibits a variety of biological effects, including anti‑viral, anti‑inflammatory, and anti‑proliferative actions, in mammalian cells. In a previous study, arctiin was demonstrated to induce procollagen type I synthesis and exhibited protective effects against ultraviolet B (UVB) radiation in normal human dermal fibroblasts (nHDFs). However, the underlying molecular mechanism of arctiin‑mediated collagen synthesis remains unknown. In the present study, the mechanism for increased expression of collagen type 1α 1 chain (COL1A1) mRNA in arctiin‑induced nHDFs was identified...
December 2017: Molecular Medicine Reports
Ji-Ye Kee, Seung-Heon Hong
The Arctium lappa seeds (Arctii Fructus) and its major active compound, arctigenin (ARC), are known to have anticancer, antiobesity, antiosteoporosis, and anti-inflammatory activities. However, the effect of Arctii Fructus and ARC on mast cell-mediated allergic inflammation and its associated mechanism have not been elucidated. Therefore, we attempted to investigate the antiallergic activity of Arctii Fructus and ARC on mast cells and experimental mouse models. Arctii Fructus water extract (AFW) or ethanol extract (AFE) and ARC reduced the production of histamine and pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, IL-8, and TNF-α in mast cells...
October 17, 2017: Journal of Agricultural and Food Chemistry
Chi-Ting Horng, Hsing-Chen Wu, Ni-Na Chiang, Chiu-Fang Lee, Yu-Syuan Huang, Hui-Yun Wang, Jai-Sing Yang, Fu-An Chen
Burdock (Arctium lappa L.) leaves generate a considerable amount of waste following burdock root harvest in Taiwan. To increase the use of burdock leaves, the present study investigated the optimal methods for producing burdock leaf extract (BLE) with high antioxidant polyphenolic content, including drying methods and solvent extraction concentration. In addition, the elastase and tyrosinase inhibitory activity of BLE was examined. Burdock leaves were dried by four methods: Shadow drying, oven drying, sun drying and freeze-drying...
October 2017: Experimental and Therapeutic Medicine
Shimeng Zhang, Liangjun Jiang, Fengyuan Che, Yucheng Lu, Zhongxiang Xie, Hao Wang
Arctigenin (ARC), a phenylpropanoid dibenzylbutyrolactone lignan derived from Arctium lappa L, has been reported to protect against cerebral ischemia injury in rats, but the underlying mechanism is unclear. In this study, we investigated whether ARC ameliorated ischemic stroke by inhibiting NLRP3 inflammasome-derived neuroinflammation and whether SIRT1 signaling was involved in this process. ARC (20 mg/kg) or vehicle were intraperitoneally injected to Sprague-Dawley rats for 3 days before middle cerebral artery occlusion (MCAO) surgery performed...
November 4, 2017: Biochemical and Biophysical Research Communications
Susana Paula Moreira Fischer, Indiara Brusco, Camila Camponogara, Mariana Piana, Henrique Faccin, Luciana Assis Gobo, Leandro Machado de Carvalho, Sara Marchesan Oliveira
Gout is a disorder that triggers a severe inflammatory reaction which generates episodes of intense pain and discomfort to the patient. Arctium minus (Hill) Bernh. (Asteraceae) is known as "burdock" and displays anti-inflammatory, antinociceptive, against rheumatic pain and radical-scavenging activities. Species of the genus Arctium have been used in assistant therapy of gout and other inflammatory processes. We investigated the antinociceptive and anti-edematogenic effects of the crude extract of A. minus seeds in an acute gout attack model induced by intra-articular injection of monosodium urate (MSU) crystals in adult male Swiss mice (25-30 g)...
August 11, 2017: Inflammopharmacology
Mirna Meana Dias, Ohana Zuza, Lorena R Riani, Priscila de Faria Pinto, Pedro Luiz Silva Pinto, Marcos P Silva, Josué de Moraes, Ana Caroline Z Ataíde, Fernanda de Oliveira Silva, Alzira Batista Cecílio, Ademar A Da Silva Filho
Schistosomiasis and herpes diseases represent serious issues to the healthcare systems, infecting a large number of people worldwide, mainly in developing countries. Arctium lappa L. (Asteraceae), known as "bardana" and "burdock", is a medicinal plant popularly used for several purposes, including as antiseptic. In this study, we evaluated the in vitro schistosomicidal and antiherpes activities of the crude extract of A. lappa, which have not yet been described. Fruits of A. lappa L. were extracted by maceration with ethanol: H2O (96:4 v/v) in order to obtain the hydroalcoholic extract of A...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Bo Hou, Wencheng Wang, Hui Gao, Shanglang Cai, Chunbo Wang
Objective To identify potential genes that may be involved in lipid metabolism in rats after treatment with aqueous extract of Arctium lappa L (burdock). Methods Rats were randomly divided into six groups: (i) control (standard diet); (ii) model group (high-fat diet only); (iii) high-fat diet and low-dose aqueous burdock root extract (2 g/kg); (iv) high-fat diet and moderate-dose aqueous burdock root extract (4 g/kg); (v) high-fat diet and high-dose aqueous burdock root extract (8 g/kg); and (vi) a positive control group exposed to a high-fat diet and simvastatin (10 mg/kg)...
January 1, 2017: Journal of International Medical Research
Luisa Mota da Silva, Ligia de Moura Burci, Sandra Crestani, Priscila de Souza, Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva, Nessana Dartora, Lauro Mera de Souza, Thales Ricardo Cipriani, José Eduardo da Silva-Santos, Eunice André, Maria Fernanda de Paula Werner
BACKGROUND: Arctium lappa L., popularly known as burdock, is a medicinal plant used worldwide. The antiulcer and gastric-acid antisecretory effects of ethanolic extract from roots of Arctium lappa (EET) were already demonstrated. However, the mechanism by which the extract reduces the gastric acid secretion remains unclear. Therefore, this study was designed to evaluate the antisecretory mode of action of EET. MATERIALS AND METHODS: The effects of EET on H(+), K(+)-ATPase activity were verified in vitro, whereas the effects of the extract on cholinergic-, histaminergic- or gastrinergic-acid gastric stimulation were assessed in vivo on stimulated pylorus ligated rats...
July 28, 2017: Inflammopharmacology
Ao Li, Xiaoxun Zhang, Mao Shu, Mingjun Wu, Jun Wang, Jingyao Zhang, Rui Wang, Peng Li, Yitao Wang
BACKGROUND: Renal tubulointerstitial fibrosis (TIF) is commonly the final result of a variety of progressive injuries and leads to end-stage renal disease. There are few therapeutic agents currently available for retarding the development of renal TIF. PURPOSE: The aim of the present study is to evaluate the role of arctigenin (ATG), a lignan component derived from dried burdock (Arctium lappa L.) fruits, in protecting the kidney against injury by unilateral ureteral obstruction (UUO) in rats...
July 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Mohamed L Ashour, Fadia S Youssef, Haidy A Gad, Michael Wink
BACKGROUND: Herbal medicine is widely used all over the world for treating various health disorders. It is employed either alone or in combination with synthetic drugs or plants to be more effective. OBJECTIVE: The assessment of the effect of both water and methanol extracts of 57 widely used plants from Traditional Chinese Medicine (TCM) against the main phase I metabolizing enzyme CYP3A4 in vitro for the first time. MATERIALS AND METHODS: The inhibition of cytochrome P450 activity was evaluated using a luminescence assay...
April 2017: Pharmacognosy Magazine
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