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https://www.readbyqxmd.com/read/28730989/users-guide-to-the-surgical-literature-how-to-assess-an-article-using-surrogate-end-points
#1
Lucas Gallo, Cagla Eskicioglu, Luis H Braga, Forough Farrokhyar, Achilleas Thoma
Phase 3 randomized controlled trials are the widely accepted gold standard through which treatment decisions are made, as they assess the efficacy of a novel treatment against the control on the relevant patient population. The effectiveness of the novel treatment should be derived by measuring patient-important outcomes; however, to accurately assess these outcomes, clinical trials often require extensive patient follow-up and large sample sizes that can incur substantial expense. For this reason, investigators substitute surrogate end points to reduce the sample size and duration of a trial, ultimately reducing cost...
August 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28720004/antinociceptive-synergistic-interaction-between-achillea-millefolium-and-origanum-vulgare-l-extract-encapsulated-in-liposome-in-rat
#2
Farshad Hassanzadeh-Kiabi, Babak Negahdari
AIM: This study aims to evaluate the antinociceptive effect of combined Achillea millefolium and Origanum extract encapsulated in liposome. METHODS: The effect of Achillea millefolium and Origanum vulgare L. extract, and their liposome-incorporated form was assessed using 3% formalin test in rat. 12 male Wistar rats, 4 in each group, were used in this study, and increasing doses of Achillea millefolium (31.6, 100, 178, and 316 mg/kg) and Origanum vulgare L. extract (5...
July 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28713431/an-unexpected-cause-of-bradycardia-in-a-patient-with-bacterial-meningitis
#3
Petros Ioannou, Magdalini Velegraki, Stella Soundoulounaki, Achilleas Gikas, Diamantis P Kofteridis
Sinus bradycardia which is a sinus rhythm with a resting heart rate of less than 60 bpm is caused by intrinsic cardiac disorders like sick sinus syndrome or inferior myocardial infarction, metabolic and environmental causes (such as hypothyroidism and electrolyte disorders), medications (such as beta-blockers and amiodarone), infection (such as myocarditis), increased intracranial pressure, and toxic exposure, while it can sometimes be a normal phenomenon, especially during sleep, in athletes, and during pregnancy...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28692190/dupuytren-s-contracture-and-handwork-a-case-control-study
#4
Alfred Haines, Carolyn Levis, Charles H Goldsmith, Manraj Kaur, Eric Duku, Richard Wells, Stephen D Walter, Cheryl Rook, Susan Stock, Gary Liss, Jessica Murphy, Achilleas Thoma
OBJECTIVE: The objective of this study was to examine the association between Dupuytren's contracture (DC), repetitive handwork (RHW), heavy handwork (HHW), and/or vibration exposure. METHODS: Frequency and intensity of the three types of handwork were collected and compared between DC patients and controls. Hours of work were weighted by average "frequency," for RHW, and average "intensity," for HHW and use of vibrating tool. Logistic regression was used to evaluate risk of developing DC associated with the above-mentioned factors...
August 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28680617/a-case-of-severe-unprovoked-hemorrhage-in-an-elderly-male-a-case-report
#5
Petros Ioannou, Emmanouela Tsagkaraki, Constantinos Tsioutis, Maria Devetzoglou, Irene Xylouri, Achilleas Gikas, Symeon Panagiotakis
Acquired hemophilia is a rare but potentially fatal clinical condition requiring clinical suspicion to reach to a diagnosis, especially in elder patients. This diagnosis should be suspected in patients that present with unexplained persistent bleeding from skin, soft tissues, and mucosa and have a prolonged aPTT.
July 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28676018/can-serum-uric-acid-lowering-therapy-contribute-to-the-prevention-or-treatment-of-nonalcoholic-fatty-liver-disease
#6
Paschalis Paschos, Vasilios G Athyros, Achilleas Tsimperidis, Anastasia Katsoula, Nikolaos Grammatikos, Olga Giouleme
Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease in Western countries with potential progression to nonalcoholic steatohepatitis (NASH) and cirrhosis, is associated with cardiovascular disease (CVD) mortality. Several studies have reported a relationship between uric acid and NAFLD/NASH and it seems that serum uric acid (SUA) is a significant independent factor for the development of NAFLD. Potential mediating mechanisms include insulin resistance, endothelial dysfunction, and activation of inflammasome, especially NLRP3...
June 20, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28671702/sample-to-answer-acoustic-detection-of-dna-in-complex-samples
#7
George Papadakis, Pasquale Palladino, Dimitra Chronaki, Achilleas Tsortos, Electra Gizeli
The present study demonstrates the sensitive and label-free acoustic detection of dsDNA amplicons produced from whole Salmonella Thyphimurium cells without employing any DNA extraction and/or purification step, in the presence of the lysed bacterial cells and in a hybridization-free assay. A sample-to-answer assay is also shown during DNA detection directly in milk.
July 3, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28671286/structural-characterization-of-the-nap-the-major-adhesion-complex-of-the-human-pathogen-mycoplasma-genitalium
#8
Margot P Scheffer, Luis Gonzalez-Gonzalez, Anja Seybert, Mercè Ratera, Michael Kunz, José M Valpuesta, Ignacio Fita, Enrique Querol, Jaume Piñol, Jaime Martín-Benito, Achilleas S Frangakis
Mycoplasma genitalium, the causative agent of non-gonococcal urethritis and pelvic inflammatory disease in humans, is a small eubacterium that lacks a peptidoglycan cell wall. On the surface of its plasma membrane is the major surface adhesion complex, known as NAP, that is essential for adhesion and gliding motility of the organism. Here, we have performed cryo-electron tomography of intact cells and detergent permeabilized M. genitalium cell aggregates, providing sub-tomogram averages of free and cell-attached NAPs respectively, revealing a tetrameric complex with two-fold rotational (C2) symmetry...
July 3, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28660636/pulmonary-co-infections-by-pneumocystis-jirovecii-and-aspergillus-fumigatus-in-non-hiv-patients-a-report-of-two-cases-and-literature-review
#9
REVIEW
Anthi-Marina Markantonatou, Aliki Ioakimidou, Kostoula Arvaniti, Eleni Manou, Vassilios Papadopoulos, Parthena Kiriklidou, Konstantinos Samaras, Anna Kioumi, Timoleon-Achilleas Vyzantiadis
Pneumocystis jirovecii is the causative agent of Pneumocystis pneumonia (PcP), a common and often life-threatening opportunistic infection in HIV-infected patients. However, non-HIV, immunocompromised patients are at risk of PcP as well, whereas the mortality appears to be higher among these patients. Pneumocystis co-infections with other microorganisms are less frequent and only sparse reports of combined PcP and invasive pulmonary fungal infections exist in the literature, especially in the non-HIV patients...
June 28, 2017: Mycoses
https://www.readbyqxmd.com/read/28654597/involvement-of-the-interosseous-and-lumbrical-muscle-tendon-units-in-the-lateral-and-spiral-cords-in-dupuytren-s-disease-of-the-middle-fingers
#10
Achilleas Thoma, Marta Karpinski
BACKGROUND: The nature of intrinsic muscle involvement in Dupuytren's disease of the middle fingers (long and ring) remains poorly characterized. Over the years, the authors have observed that both the spiral and lateral digital cords in the middle fingers receive contribution from intrinsic muscle-tendon units. This report describes the anatomical characteristics and frequency of intrinsic muscle-tendon unit involvement in Dupuytren's disease of the middle fingers. METHODS: Intrinsic muscle involvement in the middle digits was recorded in the operative reports of patients undergoing Dupuytren's surgery between October of 2013 and February of 2016...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28653921/conservation-of-indigenous-knowledge-of-medicinal-plants-of-western-himalayan-region-rawalakot-azad-kashmir-pakistan
#11
Sajjad Hussain, Ghulam Murtaza, Ansar Mehmood, Rizwana Aleem Qureshi
The aim of present was to document indigenous knowledge of medicinal plants traditionally used by inhabitants of Rawalakot Azad Kashmir and to screen selected medicinal plants for their antibacterial potential. Several field surveys were conducted to document indigenous knowledge of medicinal plants through interviews from local inhabitants during 2010-2013. During the study, 58 plant species, belonging to 37 families, were identified and their medicinal uses were recorded. Ethnobotanical data indicates that inhabitants of Rawalakot use medicinal plant mainly for the treatment of stomach, liver and sexual disorders...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28645294/3-5-4-trihydroxy-6-7-3-trimethoxyflavone-protects-against-beta-amyloid-induced-neurotoxicity-through-antioxidative-activity-and-interference-with-cell-signaling
#12
Alona Telerman, Rivka Ofir, Yoel Kashman, Anat Elmann
BACKGROUND: Alzheimer's disease is a neurodegenerative disease, characterized by progressive decline in memory and cognitive functions, that results from loss of neurons in the brain. Amyloid beta (Aβ) protein and oxidative stress are major contributors to Alzheimer's disease, therefore, protecting neuronal cells against Aβ-induced toxicity and oxidative stress might form an effective approach for treatment of this disease. 3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone (TTF) is a flavonoid we have purified from the plant Achillea fragrantissima; and the present study examined, for the first time, the effects of this compound on Aβ-toxicity to neuronal cells...
June 23, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28618131/pharmacognosy-phytochemistry-and-pharmacological-properties-of-achillea-millefolium-l-a-review
#13
REVIEW
Sofi Imtiyaz Ali, B Gopalakrishnan, V Venkatesalu
Achillea millefoilum L. (Yarrow) is an important species of Asteraceae family with common utilization in traditional medicine of several cultures from Europe to Asia for the treatment of spasmodic gastrointestinal disorders, hepatobiliary, gynecological disorders, against inflammation and for wound healing. An extensive review of literature was made on A. millefoilum L. using ethno botanical text books, published articles in peer-reviewed journals, unpublished materials and scientific databases. The Plant List, International Plant Name Index and Kew Botanical Garden databases were used to authenticate the scientific names...
June 15, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28617743/discussion-gynecomastia-classification-for-surgical-management-a-systematic-review-and-novel-classification-system
#14
Daniel Waltho, Alexandra Hatchell, Achilleas Thoma
No abstract text is available yet for this article.
June 14, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28615416/il-17-receptor-a-maintains-and-protects-the-skin-barrier-to-prevent-allergic-skin-inflammation
#15
Achilleas Floudas, Sean P Saunders, Tara Moran, Christian Schwartz, Emily Hams, Denise C Fitzgerald, James A Johnston, Graham S Ogg, Andrew N McKenzie, Patrick T Walsh, Padraic G Fallon
Atopic dermatitis (AD) is a common inflammatory skin disease affecting up to 20% of children and 3% of adults worldwide and is associated with dysregulation of the skin barrier. Although type 2 responses are implicated in AD, emerging evidence indicates a potential role for the IL-17A signaling axis in AD pathogenesis. In this study we show that in the filaggrin mutant mouse model of spontaneous AD, IL-17RA deficiency (Il17ra(-/-) ) resulted in severe exacerbation of skin inflammation. Interestingly, Il17ra(-/-) mice without the filaggrin mutation also developed spontaneous progressive skin inflammation with eosinophilia, as well as increased levels of thymic stromal lymphopoietin (TSLP) and IL-5 in the skin...
July 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28603131/antipyretic-potential-of-herbal-coded-formulation-pyrexol
#16
Muhammad Sajid Khan, Abdul Hamid, Muhammad Akram, Sodah Bint Mustafa, Abdul Sami, Syed Muhammad Ali Shah, Khan Usmanghani
The antipyretic effect of the aqueous extract of herbal coded formulation containing equal amount of Salix alba, Emblica officinalis, Glycyrrhiza glabra, Adhatoda vasica, Viola odorata, Thea sinensis, Veleriana officinalis, Foeniculum vulgare, Sisymbrium irrio and Achillea millefolium was investigated using the yeast induced pyrexia model in rabbits. Paracetamol was used as a control group. Rectal temperatures of all rabbits were recorded immediately before the administration of the extract or paracetamol and again at 1 hour, after this, temperature was noted at 1 hrs interval for 5 hrs using digital thermometer...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28602757/achillea-asiatica-extract-and-its-active-compounds-induce-cutaneous-wound-healing
#17
Banzragch Dorjsembe, Hee Ju Lee, Myungsuk Kim, Batsuren Dulamjav, Tunsag Jigjid, Chu Won Nho
ETHNOPHARMACOLOGICAL RELEVANCE: Achillea asiatica Serg. is a perennial herb belonging to the Asteraceae family that has long been traditionally used to treat acute intestinal and stomach inflammation, persistent fever, ulcers, wounds, and rheumatism. AIM OF THE STUDY: We investigated the effect of A. asiatica extract (AAE) on cutaneous wound healing. MATERIALS AND METHODS: To assess the effect of AAE on wounds, an incisional Sprague-Dawley (SD) rat model was topically treated with AAE for 2 weeks...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28580262/minimally-invasive-combined-anterior-and-anterolateral-stabilization-of-the-knee-using-hamstring-tendons-and-adjustable-loop-suspensory-fixation-device-surgical-technique
#18
Achilleas Boutsiadis, Paul Brossard, Jean-Claude Panisset, Nicolas Graveleau, Johannes Barth
Despite the numerous techniques described regarding isolated anterior cruciate ligament (ACL) reconstruction, many authors have reported that residual knee rotational instability is not always eliminated. The combination of lateral extra-articular knee tenodesis and ACL reconstruction is an alternative surgical approach with very promising clinical results. The purpose of this article is to describe a reliable and reproducible technique of combined ACL reconstruction and lateral extra-articular knee tenodesis using a continuous looped hamstring tendon autograft...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28528070/thymoma-in-the-middle-mediastinum-with-blood-supply-from-the-left-main-coronary-artery
#19
Michail D Tsimpinos, Meletios A Kanakis, Stavros N Theodorou, Panagiotis A Misthos, Achilleas G Lioulias
No abstract text is available yet for this article.
June 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28516037/zika-virus-infection-in-a-newly-married-greek-couple
#20
Petros Ioannou, Stella Soundoulounaki, Nikolaos Spernovasilis, Elpida Papadopoulou, Anna Papa, Achilleas Gikas
Zika virus (ZIKV) is a member of the Flaviviridae family causing asymptomatic or mildly symptomatic infections with fever, rash, arthralgia and headache. It is transmitted by the Aedes species mosquitoes and also sexually and transplacentally, and has been recently associated with congenital neurologic birth defects in South and Central America. We report the case of a newly married couple from Greece who travelled to Cuba for their honeymoon and developed mild symptoms consistent with arboviral infection. After returning to Greece, they were found to have been infected by Zika virus during their honeymoon...
2017: IDCases
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