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https://www.readbyqxmd.com/read/29221324/the-role-of-sympathectomy-in-long-qt-syndrome
#1
REVIEW
Achilleas Antonopoulos, David Lawrence, Davide Patrini, Marco Scarci, Robert George, Martin Hayward, Sofoklis Mitsos, Nikolaos Panagiotopoulos
Long QT syndrome (LQTS) is an uncommon and potentially fatal cardiac channelopathy. Treatment options can be medical with β-blockers or surgical with implantable cardioverter defibrillator (ICD) implantations and left cardiac sympathetic denervation (LCSD). Purpose of this paper is through a literature review to identify the management algorithm and the role of sympathectomy in LQTS.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29217361/major-adipokines-and-the-420c-g-resistin-gene-polymorphism-as-predictors-of-acute-ischemic-stroke-severity-and-in-hospital-outcome
#2
Styliani D Bouziana, Konstantinos Tziomalos, Antonios Goulas, Timoleon-Achilleas Vyzantiadis, Athanasia Panderi, Apostolos Ι Ηatzitolios
BACKGROUND: The role of adiponectin, leptin, and resistin and the -420C>G polymorphism of the resistin gene promoter in the pathogenesis of ischemic stroke are controversial. We aimed to evaluate whether serum levels of these adipokines and the -420C>G polymorphism are associated with ischemic stroke severity and in-hospital outcome. METHODS: We prospectively studied 93 patients who were consecutively hospitalized for acute ischemic stroke (39.8% males, age 79...
December 4, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29201870/factors-that-influence-blood-loss-and-need-for-transfusion-following-total-knee-arthroplasty
#3
Achilleas Boutsiadis, Ryan Jacob Reynolds, Mo Saffarini, Jean-Claude Panisset
Background: Blood loss during total knee arthroplasty (TKA) remains a concern, as many patients require blood transfusions, which increase risks of allergic reactions, disease transmission, and thromboembolisms. The purpose was to determine factors associated with blood loss and need for transfusion in patients receiving routine TKA. Methods: The authors prospectively analyzed 150 consecutive uncemented TKAs for age, gender, body mass index (BMI), anticoagulant medication, type of anesthesia, tranexamic acid (TXA) administration, tourniquet inflation, drain placement, pre- and post-operative Haemoglobin (Hb) level (g/dL), and whether transfusion was necessary...
November 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29191238/ethnopharmacological-studies-of-indigenous-plants-in-kel-village-neelum-valley-azad-kashmir-pakistan
#4
Khawaja Shafique Ahmad, Abdul Hamid, Fahim Nawaz, Mansoor Hameed, Farooq Ahmad, Jiabin Deng, Noreen Akhtar, Ambreen Wazarat, Sehrish Mahroof
BACKGROUND: This explorative study was undertaken for the first time in Kel village located in the Upper Neelum Valley, Azad Kashmir, Pakistan. The purpose was to document the indigenous knowledge of the native people used in the preparation of herbal medicines. METHODS: To get the data on traditional uses of medicinal plants, 20 informants were interviewed. Quantitative ethnobotanical indices, i.e., use value (UV), relative frequencies of citation (RFC), informant consensus factor (Fic), fidelity level (FL), data matrix ranking (DMR), preference ranking (PR), and jaccard index (JI), were calculated for the recorded medicinal plants...
December 1, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29179776/translation-and-cultural-adaptation-of-the-cleft-q-for-use-in-colombia-chile-and-spain
#5
Elena Tsangaris, Karen W Y Wong Riff, Federico Vargas, Mirta Palomares Aguilera, Macarena Miranda Alarcón, Asteria Albert Cazalla, Lehana Thabane, Achilleas Thoma, Anne F Klassen
BACKGROUND: Cleft lip and/or palate (CL/P) is a common congenital craniofacial anomaly that may negatively affect an individual's appearance, health-related quality of life, or speech. In Spain, Colombia, and Chile the overall prevalence of CL/P ranges from 0.53 to 1.59 cases per 1000 live births. Currently, there is no patient-reported outcome (PRO) instrument that is specific for patients with CL/P. The CLEFT-Q is a new PRO instrument developed to measure outcomes of treatment in patients 8 to 29 years of age with CL/P...
November 28, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29173262/users-guide-to-the-surgical-literature-how-to-assess-a-noninferiority-trial
#6
Achilleas Thoma, Forough Farrokhyar, Daniel Waltho, Luis H Braga, Sheila Sprague, Charlie H Goldsmith
A well-planned randomized controlled trial (RCT) is the most optimal study design to determine if a novel surgical intervention is any different than a prevailing one. Traditionally, when we want to show that a new surgical intervention is superior to a standard one, we analyze data from an RCT to see if the null hypothesis of "no difference" can be rejected (i.e., the 2 surgical interventions have the same effect). A noninferiority RCT design seeks to determine whether a new intervention is not worse than a prevailing (standard) one within an acceptable margin of risk or benefit, referred to as the "noninferiority margin...
December 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/29162403/cope-s-sign-and-complete-heart-block-in-a-78-year-old-patient-with-biliary-colic
#7
Panteleimon E Papakonstantinou, Natalia I Asimakopoulou, Emmanuel Kanoupakis, Spyridon Maragkoudakis, Simeon Panagiotakis, Achilleas Gikas
INTRODUCTION: Acute cholecystitis and biliary colic may have signs and symptoms similar to those of Acute Coronary Syndrome(ACS) along with ischemic ECG changes. Cholecystitis and/or biliary colic have been both reported as trigger factors for bradyarrhythmia in the literature. CASE REPORT: A 78-year-old male patient was admitted to our Emergency Department (ED) due to acute abdominal pain. The ECG on admission showed sinus bradycardia with a rate of 40 beats per minute (bpm) without signs of acute ischemia and a brief period (7 s) of complete atrioventricular (AV) block...
November 18, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/29160111/new-cytotoxic-sesquiterpene-lactones-from-achillea-cretica-l-growing-in-tunisia
#8
Fayçal Hichri, Mansour Znati, Jalloul Bouajila, Hichem Ben Jannet
The phytochemical study of Achillea cretica growing in Tunisia led to the isolation of two novel sesquiterpene lactones, which have been designated achicretin 1 and achicretin 2. Their chemical structures were further confirmed by mass spectroscopy (ESI-MS) and by extensive application of one- and two-dimensional NMR spectroscopy. The isolated compounds were tested for their cytotoxic activity against four human cancer cell lines, IGROV-1, OVCAR-3, MCF-7, and HCT-116 using the MTT assay. It has been found that achicretin 2 exhibited more potent inhibitory activity with IC50 = values of 14...
November 21, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29149357/recommendations-for-mechanical-thrombectomy-in-patients-with-acute-ischemic-stroke-a%C3%A2-clinical-guide-by-the-hellenic-stroke-organization
#9
REVIEW
Panagiotis Papanagiotou, George Ntaios, Vasileios Papavasileiou, Klearchos Psychogios, Marios Psychogios, Anastasios Mpotsaris, Timolaos Rizos, Konstantinos Spengos, Miltiadis Gravanis, Sofia Vassilopoulou, Christos Gkogkas, Petros Zampakis, Panagiotis Zis, Apostolos Karantanas, Michail Karygiannis, Georgios Karydas, Eleni Korompoki, Konstantinos Makaritsis, Konstantinos Marmagkiolis, Haralambos Milionis, Dimos Mitsikostas, Dimitrios Nikas, Androniki Plomaritoglou, Maria Politi, Nikolaos Ptochis, Christos Savopoulos, Konstantinos Takis, Nikolaos Tsamopoulos, Dimitrios Tsetis, Adam Hatzidakis, Achilleas Chatziioannou, Apostolos Hatzitolios, Konstantinos Vemmos
This document presents the consensus recommendations of the Hellenic Stroke Organization which can be of assistance to the treating stroke physicians.
November 17, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29132119/how-tall-buildings-affect-turbulent-air-flows-and-dispersion-of-pollution-within-a-neighbourhood
#10
Elsa Aristodemou, Luz Maria Boganegra, Laetitia Mottet, Dimitrios Pavlidis, Achilleas Constantinou, Christopher Pain, Alan Robins, Helen ApSimon
The city of London, UK, has seen in recent years an increase in the number of high-rise/multi-storey buildings ("skyscrapers") with roof heights reaching 150 m and more, with the Shard being a prime example with a height of ∼310 m. This changing cityscape together with recent plans of local authorities of introducing Combined Heat and Power Plant (CHP) led to a detailed study in which CFD and wind tunnel studies were carried out to assess the effect of such high-rise buildings on the dispersion of air pollution in their vicinity...
November 10, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29128506/proteoglycans-remodeling-in-cancer-underlying-molecular-mechanisms
#11
REVIEW
Achilleas D Theocharis, Nikos K Karamanos
Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major components of extracellular matrix playing key roles in its structural organization and cell signaling contributing to the control of numerous normal and pathological processes. As multifunctional molecules, proteoglycans participate in various cell functions during morphogenesis, wound healing, inflammation and tumorigenesis. Their interactions with matrix effectors, cell surface receptors and enzymes enable them with unique properties...
November 8, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29108932/improving-anti-trypanosomal-activity-of-alkamides-isolated-from-achillea-fragrantissima
#12
Joseph Skaf, Omar Hamarsheh, Michael Berninger, Srikkanth Balasubramanian, Tobias A Oelschlaeger, Ulrike Holzgrabe
In previous studies the aerial parts of Achillea fragrantissima were found to have substantial antileishmanial and antitrypanosomal activity. A bioassay-guided fractionation of a dichloromethane extract yielded the isolation of the essential anti-trypanosomal compounds of the plant. Seven sesquiterpene lactones (including Achillolide-A), two flavonoids, chrysosplenol-D and chrysosplenetine, and four alkamides (including pellitorine) were identified. This is the first report for the isolation of the sesquiterpene lactones 3 and 4, chrysosplenetine and the group of alkamides from this plant...
November 3, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29107635/predictors-of-need-for-critical-care-support-adverse-events-and-outcome-after-stroke-thrombolysis
#13
Panagiotis Papamichalis, Spyridon Karagiannis, Efthimios Dardiotis, Achilleas Chovas, Dimitrios Papadopoulos, Tilemachos Zafeiridis, Dimitris Babalis, Georgios Paraforos, Vasiliki Zisopoulou, Apostolia-Lemonia Skoura, Ioannis Staikos, Konstantinos Bouliaris, Michail Papamichalis, Georgios Hadjigeorgiou, Apostolos Komnos
BACKGROUND: Results from trials and international registries exhibit heterogeneity regarding safety, efficacy, markers of prognosis, and markers of the need for critical care support after intravenous thrombolysis (IVT) for strokes. The purpose of our study was to indentify such markers after performance of comparisons among patients who received thrombolysis in our intensive care unit. MATERIALS AND METHODS: Our study included 124 patients who received IVT in accordance with international criteria...
October 26, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29097338/expansion-of-kpc-producing-klebsiella-pneumoniae-with-various-mgrb-mutations-giving-rise-to-colistin-resistance-the-role-of-isl3-on-plasmids
#14
Cesira Giordano, Simona Barnini, Constantinos Tsioutis, Monika A Chlebowicz, Effie V Scoulica, Achilleas Gikas, John W Rossen, Alexander W Friedrich, Erik Bathoorn
BACKGROUND: mcr-1 has been reported as first plasmid gene to confer colistin-resistance. In KPC-producing Klebsiella pneumoniae (KPC-KP) isolates, however, colistin resistance is rapidly emerging through other mechanisms. This is frequently the result of disruption of mgrB gene by insertion sequences, for instance ISL3. The aim of this study is to investigate the expansion of mgrB-mutated KPC-KP. In addition, we identify localization and targets of ISL3 sequences within the core and accessory genome of common KPC-KP lineages...
October 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29094054/can-a-drill-guide-improve-the-coracoid-graft-placement-during-the-latarjet-procedure-a-prospective-comparative-study-with-the-freehand-technique
#15
Johannes Barth, Achilleas Boutsiadis, Lionel Neyton, Laurent Lafosse, Gilles Walch
Background: One of the factors that can affect the success of the Latarjet procedure is accurate coracoid graft (CG) placement. Hypothesis: The use of a guide can improve placement of the CG and screw positioning in the sagittal and axial planes as compared with the classic open ("freehand") technique. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 49 patients who underwent a Latarjet procedure for the treatment of recurrent anterior shoulder instability were prospectively included; the procedure was performed with the freehand technique in 22 patients (group 1) and with use of a parallel drill guide during screw placement in 27 patients (group 2)...
October 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29079535/insights-into-the-key-roles-of-epigenetics-in-matrix-macromolecules-associated-wound-healing
#16
Zoi Piperigkou, Martin Götte, Achilleas D Theocharis, Nikos K Karamanos
Extracellular matrix (ECM) is a dynamic network of macromolecules, playing a regulatory role in cell functions, tissue regeneration and remodeling. Wound healing is a tissue repair process necessary for the maintenance of the functionality of tissues and organs. This highly orchestrated process is divided into four temporally overlapping phases, including hemostasis, inflammation, proliferation and tissue remodeling. The dynamic interplay between ECM and resident cells exerts its critical role in many aspects of wound healing, including cell proliferation, migration, differentiation, survival, matrix degradation and biosynthesis...
October 24, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29074945/analysis-commons-a-team-approach-to-discovery-in-a-big-data-environment-for-genetic-epidemiology
#17
Jennifer A Brody, Alanna C Morrison, Joshua C Bis, Jeffrey R O'Connell, Michael R Brown, Jennifer E Huffman, Darren C Ames, Andrew Carroll, Matthew P Conomos, Stacey Gabriel, Richard A Gibbs, Stephanie M Gogarten, Namrata Gupta, Cashell E Jaquish, Andrew D Johnson, Joshua P Lewis, Xiaoming Liu, Alisa K Manning, George J Papanicolaou, Achilleas N Pitsillides, Kenneth M Rice, William Salerno, Colleen M Sitlani, Nicholas L Smith, Susan R Heckbert, Cathy C Laurie, Braxton D Mitchell, Ramachandran S Vasan, Stephen S Rich, Jerome I Rotter, James G Wilson, Eric Boerwinkle, Bruce M Psaty, L Adrienne Cupples
No abstract text is available yet for this article.
October 27, 2017: Nature Genetics
https://www.readbyqxmd.com/read/29073139/composition-of-the-schistosoma-mansoni-worm-secretome-identification-of-immune-modulatory-cyclophilin-a
#18
Achilleas Floudas, Christopher D Cluxton, Julia Fahel, Adnan R Khan, Sean P Saunders, Sylvie Amu, Antonio Alcami, Padraic G Fallon
The helminth Schistosoma mansoni modulates the infected host's immune system to facilitate its own survival, by producing excretory/secretory molecules that interact with a variety of the host's cell types including those of the immune system. Herein, we characterise the S. mansoni adult male worm secretome and identify 111 proteins, including 7 vaccine candidates and several molecules with potential immunomodulatory activity. Amongst the molecules present in the secretome, a 17-19kDa protein analogous to human cyclophilin A was identified...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29064437/the-assessment-of-toxic-metals-in-plants-used-in-cosmetics-and-cosmetology
#19
Agnieszka Fischer, Barbara Brodziak-Dopierała, Krzysztof Loska, Jerzy Stojko
Heavy metals polluting the natural environment are absorbed by plants. The use of herbs as components of cosmetics may pose a health risk for humans. The aim of the study was to determine the concentrations of Pb, Cd and Hg in selected species of herbs (horsetail Equisetum arvense, nettle Urtica dioica, St. John's wort Hypericum perforatum, wormwood Artemisia absinthium, yarrow Achillea millefolium, cottonwood Solidago virgaurea) self-collected from the natural environment in two different locations, and purchased in stores on the territory of Poland...
October 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29034199/cardioprotective-effects-of-achillea-wilhelmsii-on-the-isolated-rat-heart-in-ischemia-reperfusion
#20
M Mahmoudabady, M Lashkari, S Niazmand, M Soukhtanloo
CONTEXT: There are some reports about protective effects of Achillea on the heart. OBJECTIVE: We investigated the effect of Achillea wilhelmsii extract on cardiac function during ischemia-reperfusion (I/R) injury in the isolated rat heart. MATERIALS AND METHODS: 60 male Wistar rats were randomly divided into 6 groups; 1: Control group, 2: Control-ischemia (CI) 3: vitamin C (10 mg/kg), 4-6: Extract groups (E 100, E 200 and E 400 mg/kg). The animals received normal saline, vitamin C or A...
October 2017: Journal of Traditional and Complementary Medicine
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