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https://www.readbyqxmd.com/read/28343034/bioactivities-of-achillea-phrygia-and-bupleurum-croceum-based-on-the-composition-of-phenolic-compounds-in-vitro-and-in-silico-approaches
#1
Gokhan Zengin, Gizem Bulut, Adriano Mollica, Mehmet Zeki Haznedaroglu, Ahmet Dogan, Abdurrahman Aktumsek
This study presents the effects of the Achillea phrygia Boiss. et Bal. and Bupleurum croceum Fenzl. extracts obtained by different solvents (ethyl acetate, methanol and water) on selected enzyme inhibitory effects and antioxidant ability with screening bioactive compounds. Total and individual bioactive compounds were detected by spectrophotometric and HPLC-DAD techniques. Antioxidant abilities were evaluated by different methods including free radical scavenging (ABTS and DPPH), reducing power (CUPRAC and FRAP), phosphomolybdenum and metal chelating...
March 22, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28342707/clinical-characteristics-microbiology-and-outcomes-of-external-ventricular-drainage-associated-infections-the-importance-of-active-treatment
#2
Constantinos Tsioutis, Spyridon A Karageorgos, Soultana Stratakou, Stella Soundoulounaki, Dimitrios Karambetsos, George Kouyentakis, Achilleas Gikas
Data concerning clinical characteristics, microbiology, treatment and outcomes of external ventricular drainage-associated infections (EVDAI) are limited. All hospitalized patients with EVDAI in a University Hospital between January 2009 and December 2015 were retrospective recorded. Only the first episode per patient was included. An antibiotic was considered "active" when its pharmacokinetic properties were appropriate for EVDAI and the implicated microorganism was in vitro susceptible. During the 7-year study period, 36 EVDAI were identified...
March 22, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28334066/effect-of-drive-row-ground-covers-on-hop-rosales-cannabaceae-yard-arthropod-pests-in-vermont-usa
#3
L Calderwood, J Cubins, D Vesty, H Darby
Alternatives to pesticides are necessary for the management of hop (Humulus lupulus L.) arthropod pests. The three major arthropod pests in northeastern US hop production include two-spotted spider mite, Tetranychus urticae Koch, hop aphid Phorodon humuli (Schrank), and potato leafhopper, Empoasca fabae Harris. This 3-yr study (2012-2014) in Vermont investigated the effect of flowering ground covers on arthropod pest abundance. Hop cultivars 'Nugget' and 'Cascade' were evaluated under a strip-split plot experimental design...
February 17, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28317793/how-should-i-treat-a-tavi-eligible-patient-with-a-left-ventricular-thrombus-and-rapid-clinical-deterioration
#4
Spyridon Deftereos, Georgios Giannopoulos, Konstantinos Raisakis, Agathi-Rosa Vrettou, Fotios Kolokathis, Achilleas Zacharoulis, Dimitrios Angouras, Dimitrios Alexopoulos, John Lekakis, Holger Eggebrecht, Johannes Lämmer, Nestoras Papadopoulos, Jean-Philippe Collet
No abstract text is available yet for this article.
March 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28300864/whole-exome-sequencing-in-the-framingham-heart-study-identifies-rare-variation-in-hyal2-that-influences-platelet-aggregation
#5
John D Eicher, Ming-Huei Chen, Achilleas N Pitsillides, Honghuang Lin, Narayanan Veeraraghavan, Jennifer A Brody, Ginger A Metcalf, Donna M Muzny, Richard A Gibbs, Diane M Becker, Lewis C Becker, Nauder Faraday, Rasika A Mathias, Lisa R Yanek, Eric Boerwinkle, L Adrienne Cupples, Andrew D Johnson
Inhibition of platelet reactivity is a common therapeutic strategy in secondary prevention of cardiovascular disease. Genetic and environmental factors influence inter-individual variation in platelet reactivity. Identifying genes that contribute to platelet reactivity can reveal new biological mechanisms and possible therapeutic targets. Here, we examined rare coding variation to identify genes associated with platelet reactivity in a population-based cohort. To do so, we performed whole exome sequencing in the Framingham Heart Study and conducted single variant and gene-based association tests against platelet reactivity to collagen, adenosine diphosphate (ADP), and epinephrine agonists in up to 1,211 individuals...
March 16, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28284627/lumpy-skin-disease-outbreaks-in-greece-during-2015-16-implementation-of-emergency-immunization-and-genetic-differentiation-between-field-isolates-and-vaccine-virus-strains
#6
Eirini I Agianniotaki, Konstantia E Tasioudi, Serafeim C Chaintoutis, Peristera Iliadou, Olga Mangana-Vougiouka, Aikaterini Kirtzalidou, Thomas Alexandropoulos, Achilleas Sachpatzidis, Evangelia Plevraki, Chrysostomos I Dovas, Eleni Chondrokouki
The objective of this study is to present epizootiological data from the lumpy skin disease (LSD) outbreaks in Greece during 2015-16, following the implementation of emergency vaccination and total stamping-out, along with laboratory data regarding the genetic differentiation between field isolates and live attenuated vaccine virus strains. Descriptive geographical chronology analysis was conducted to present the progressive shift of the outbreaks westwards, and at the same time, the absence of further outbreaks in previously affected regional units where high vaccination coverage was achieved...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28284111/characteristics-and-predictors-of-outcome-of-spontaneous-spinal-epidural-abscesses-treated-conservatively-a-retrospective-cohort-study-in-a-referral-center
#7
Nikolaos Spernovasilis, Stelios Demetriou, Maria Bachlitzanaki, Ioannis Gialamas, Kalliopi Alpantaki, Georgios Hamilos, Apostolos Karantanas, Achilleas Gikas
OBJECTIVE: Recent studies have shown that in carefully selected patients, conservative treatment alone can be an option in the management of spinal epidural abscess (SEA). The aim of this study was to identify prognostic factors of outcome in patients with spontaneous SEA treated conservatively. PATIENTS AND METHODS: A retrospective cohort study of all patients with spontaneous SEA treated with antibiotics alone from January 2012 to December 2015 was conducted in a 1200-bed tertiary referral center...
February 27, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28281339/extracting-the-shape-and-size-of-biomolecules-attached-to-a-surface-as-suspended-discrete-nano-particles
#8
Dimitra Milioni, Achilleas Tsortos, Marisela Vélez, Electra Gizeli
The ability to derive information on the conformation of surface attached biomolecules by using simple techniques such as biosensors is currently considered of great importance in the fields of surface science and nanotechnology. Here we present a nano-shape sensitive biosensor where a simple mathematical expression is used to relate acoustic measurements to the geometrical features of a surface-attached biomolecule. The underlying scientific principle is that the acoustic ratio (ΔD/ΔF) is a measure of the hydrodynamic volume of the attached entity, mathematically expressed by its intrinsic viscosity [η]...
March 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28265542/the-effect-of-hydro-alcoholic-extract-of-achillea-millefolium-on-appetite-hormone-in-rats
#9
Mohsen Nematy, Mohsen Mazidi, Atefeh Jafari, Sara Baghban, Hasan Rakhshandeh, Abdolreza Norouzy, Habibollah Esmaily, Leila Etemad, Michael Patterson, Amir Hooshang Mohammadpour
OBJECTIVE: Achillea millefolium (A. millefolium) is known as an orexigenic herb in Iranian traditional medicine. In this study, the possible orexigenic effect of hydro-alcoholic extract of A. millefolium was investigated by measuring plasmaghrelin level. MATERIALS AND METHODS: Thirty male Wistar rats were divided into five groups. Control group received water. Treatment groups received 50, 100 or 150 mg/kg of A. millefolium extract for 7 days via gavage. Before the intervention, daily amount of the food eaten by each rat was measured for 10 days...
January 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28207619/iliac-crest-regeneration-a-retrospective-study-of-14-years-of-follow-up
#10
Anastasios Christodoulou, Achilleas Boutsiadis, Evangellos Christodoulou, Petros Antonarakos, Panagiotis Givissis, Ippokratis Hatzokos
STUDY DESIGN: This is a retrospective study analysis. OBJECTIVE: The purpose of our study was to evaluate the healing process of the ilium after being used as a bone graft donor site in the treatment of adolescent idiopathic scoliosis. SUMMARY OF BACKGROUND DATA: Iliac crest bone grafts have been proven to be the most reliable means for solid fusion in spine surgery. Nevertheless, few reports in the literature describe the ability of the iliac crest to regenerate...
March 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28195671/trachycladines-and-analogues-synthesis-and-evaluation-of-anticancer-activity
#11
Zisis V Peitsinis, Achilleas G Mitrakas, Eirini A Nakiou, Dafni A Melidou, Dimitra Kalamida, Christos Kakouratos, Michael I Koukourakis, Alexandros E Koumbis
The synthesis of four new analogues of marine nucleoside trachycladine A was accomplished by direct regio- and stereoselective Vorbrüggen glycosylations of 2,6-dichloropurine and 2-chloropurine with a d-ribose-derived chiron. Naturally occurring trachycladines A and B and a series of analogues were examined for their cytotoxic activity against a number of cancer cell lines (glioblastoma, lung, and cervical cancer). Parent trachycladine A and two analogues (the diacetate of the 2,6-dichloropurine derivative and N-cyclopropyl trachycladine A) resulted in a significant decrease in cell viability, with the latter exhibiting a stronger effect...
February 14, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28190736/diagnosis-and-management-of-phantom-tachycardias-based-on-an-electrophysiologically-guided-approach
#12
Dimitris Tsiachris, Iosif Koutagiar, Konstantinos A Gatzoulis, Petros Arsenos, Aggeliki Rigatou, Polychronis Dilaveris, Skevos Sideris, Achilleas Papadopoulos, Alekos Kritikos, Christodoulos Stefanadis, Dimitris Tousoulis
BACKGROUND: Non-documented palpitations, or phantom tachycardias, are palpitations deemed to be of unknown origin after evaluation with conventional diagnostic tools, such as 12-lead electrocardiogram and Holter recordings. Our aim was to determine the diagnostic value of an electrophysiologic study (EPS) and its role in the management of patients presenting with non-documented palpitations. METHODS: We performed EPS in 78 consecutive patients with repeatable, poorly tolerated symptoms of paroxysmal, non-documented tachycardia, the absence of structural heart disease and at least one 24-h Holter recording...
November 20, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28179115/chemical-composition-of-the-essential-oils-and-extracts-of-achillea-species-and-their-biological-activities-a-review
#13
REVIEW
Majid Mohammadhosseini, Satyajit D Sarker, Abolfazl Akbarzadeh
ETHNOPHARMACOLOGICAL RELEVANCE: The Asteraceae (alt. Compositae) family incorporates a large number of flowering plants, which have been classified under ca. 1600 genera covering more than 23,000 species. The genus Achillea is one of the best-known genera of this family. The Achillea species are important for their uses in the chemical and pharmaceutical purposes, and traditional and folk medicines. From ethnobotanical point of view, they heve been recommended as effective tonic, sedative, diuretic and carminative remedies and extensively prescribed for the treatment of stomachache, inflammation, gastrointestinal, hemorrhoid, hay fever, and wound healing in indigenous medicines...
February 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28174780/shedding-light-on-the-biological-and-chemical-fingerprints-of-three-achillea-species-a-biebersteinii-a-millefolium-and-a-teretifolia
#14
Gokhan Zengin, Abdurrahman Aktumsek, Ramazan Ceylan, Sengul Uysal, Andrei Mocan, Gokalp Ozmen Guler, M Fawzi Mahomoodally, Jasmina Glamočlija, Ana Ćirić, Marina Soković
Representatives of the Achillea genus are widely used as foods or nutraceuticals. Considering the increasing demand for herbal dietary supplements with health promoting effects, the objective of this research was to evaluate the biological and chemical profiles of different extracts (ethyl acetate, methanol and water) obtained from three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia). The antioxidant (free radical scavenging (DPPH and ABTS), reducing power (CUPRAC and FRAP), metal chelating and phosphomolybdenum), enzyme inhibitory (anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glucosidase) and antimicrobial (antibacterial and antifungal) effects were assessed to investigate their biological profiles...
February 8, 2017: Food & Function
https://www.readbyqxmd.com/read/28167484/anti-proliferative-and-apoptosis-inducing-potential-of-hydroalcoholic-achillea-wilhelmsii-c-koch-extract-on-human-breast-adenocarcinoma-cell-lines-mcf-7-and-mda-mb-468
#15
Hamid Reza Galavi, Ramin Saravani, Ali Shahraki, Mojtaba Ashtiani
Achillea wilhelmsii C. Koch contains a variety of components such as flavonoid. The previous studies showed that flavonoid has anti-cancer properties. The aim of the present study was to determine the anti-proliferative and apoptosis-inducing potential of hydroalcoholic Achillea wilhelmsii C. Koch extract (HAWE) on MCF-7 and MDA-Mb-468 human breast carcinoma cell lines. The anti-proliferative activity of HAWE was evaluated using MTT, flowcytometry by annexin V/PI double staining, and caspase-3 activity. The results of MTT showed that the ED50 of MCF-7 and MDA-Mb-468 was 25μg/ml of HAWE, 48h after treatment...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28163113/the-estimation-of-the-traditionally-used-yarrow-achillea-millefolium-l-asteraceae-oil-extracts-with-anti-inflamatory-potential-in-topical-application
#16
Vanja Tadić, Ivana Arsić, Jelena Zvezdanović, Ana Zugić, Dragan Cvetković, Sava Pavkov
ETHNOPHARMACOLOGICAL RELEVANCE: Olive or sunflower oil yarrow extracts have been extensively used against inflammatory disorders and skin wound healing in traditional medicine. AIM OF THE STUDY: To evaluate oil yarrow extracts traditional use in treatment of topical/dermatological skin impairments, sodium lauryl sulfate test was applied, and in vivo measuring of the biophysical parameters (erythema index, skin capacitance and the pH of the skin) in the artificially irritated skin was performed...
February 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28158220/targeted-capture-enrichment-assay-for-non-invasive-prenatal-testing-of-large-and-small-size-sub-chromosomal-deletions-and-duplications
#17
Maria C Neofytou, Kyriakos Tsangaras, Elena Kypri, Charalambos Loizides, Marios Ioannides, Achilleas Achilleos, Petros Mina, Anna Keravnou, Carolina Sismani, George Koumbaris, Philippos C Patsalis
Noninvasive prenatal testing (NIPT) using whole genome and targeted sequencing has become increasingly accepted for clinical detection of Trisomy 21 and sex chromosome aneuploidies. Few studies have shown that sub-chromosomal deletions or duplications associated with genetic syndromes can also be detected in the fetus noninvasively. There are still limitations on these methodologies such as the detection of variants of unknown clinical significance, high number of false positives, and difficulties to detect small aberrations...
2017: PloS One
https://www.readbyqxmd.com/read/28144751/glaucoma-drainage-device-surgery-in-children-and-adults-a-comparative-study-of-outcomes-and-complications
#18
Achilleas Mandalos, Velota Sung
PURPOSE: To compare the postoperative outcomes and complications of glaucoma drainage device (GDD) surgery in pediatric (<18 years old) and adult patients. METHODS: Retrospective, comparative study including all patients who underwent Baervedlt or Molteno device surgery by the same surgeon. Success criteria included postoperative intraocular pressure (IOP) between 6 and 21 mmHg and a 20% reduction from baseline. RESULTS: Fifty-two children (69 eyes) and 130 adults (145 eyes) were included...
February 1, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28138154/corrigendum-mutational-signatures-in-esophageal-adenocarcinoma-define-etiologically-distinct-subgroups-with-therapeutic-relevance
#19
Maria Secrier, Xiaodun Li, Nadeera de Silva, Matthew D Eldridge, Gianmarco Contino, Jan Bornschein, Shona MacRae, Nicola Grehan, Maria O'Donovan, Ahmad Miremadi, Tsun-Po Yang, Lawrence Bower, Hamza Chettouh, Jason Crawte, Núria Galeano-Dalmau, Anna Grabowska, John Saunders, Tim Underwood, Nicola Waddell, Andrew P Barbour, Barbara Nutzinger, Achilleas Achilleos, Paul A W Edwards, Andy G Lynch, Simon Tavaré, Rebecca C Fitzgerald
No abstract text is available yet for this article.
January 31, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28132014/obstetrical-brachial-plexus-injury-obpi-canada-s-national-clinical-practice-guideline
#20
Christopher J Coroneos, Sophocles H Voineskos, Marie K Christakis, Achilleas Thoma, James R Bain, Melissa C Brouwers
OBJECTIVE: The objective of this study was to establish an evidence-based clinical practice guideline for the primary management of obstetrical brachial plexus injury (OBPI). This clinical practice guideline addresses 4 existing gaps: (1) historic poor use of evidence, (2) timing of referral to multidisciplinary care, (3) Indications and timing of operative nerve repair and (4) distribution of expertise. SETTING: The guideline is intended for all healthcare providers treating infants and children, and all specialists treating upper extremity injuries...
January 27, 2017: BMJ Open
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