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https://www.readbyqxmd.com/read/28079144/igf-ir-cooperates-with-er%C3%AE-to-inhibit-breast-cancer-cell-aggressiveness-by-regulating-the-expression-and-localisation-of-ecm-molecules
#1
Nikolaos A Afratis, Panagiotis Bouris, Spyros S Skandalis, Hinke A Multhaupt, John R Couchman, Achilleas D Theocharis, Nikos K Karamanos
IGF-IR is highly associated with the behaviour of breast cancer cells. In ERα-positive breast cancer, IGF-IR is present at high levels. In clinical practice, prolonged treatment with anti-estrogen agents results in resistance to the therapy with activation of alternative signaling pathways. Receptor Tyrosine Kinases, and especially IGF-IR, have crucial roles in these processes. Here, we report a nodal role of IGF-IR in the regulation of ERα-positive breast cancer cell aggressiveness and the regulation of expression levels of several extracellular matrix molecules...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28074206/synthesis-reactivity-and-characterization-of-pt-ii-complexes-with-n-n-chelating-ligands-structure-and-dimethylsulfoxide-reactivity-relationship
#2
Konstantinos Ypsilantis, Theodoros Tsolis, Andreas Kourtellaris, Manolis J Manos, John C Plakatouras, Achilleas Garoufis
Platinum(ii) complexes of the formula PtLCl2 [L = 2-(2'-pyridyl)quinoxaline, (pqx) (1), 2,(2'-pyridyl)benzo[g]quinoxaline, (pbqx) (3) and 2,(2'-pyridyl)quinoline, (pqn) (5)] were synthesized and characterized by spectroscopic and X-ray diffraction methods. Also, monodentate coordination of the ligands pqx and pbqx formed the complexes trans-Pt(DMSO)pqxCl2 (2) and trans-Pt(DMSO)pbqxCl2 (4) as it is indicated from X-ray crystal structure and NMR studies. The reaction of the complexes (1), (3) and (5) with DMSO-d6 revealed a ligand-release solvolysis, which was studied by means of NMR techniques...
January 11, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28058628/a-pilot-study-on-plasma-levels-of-micro-rnas-involved-in-angiogenesis-and-vascular-maturation-in-patients-with-breast-cancer
#3
Emmanuel Kontomanolis, Achilleas Mitrakas, Alexandra Giatromanolaki, Dimitra Kareli, Marianthi Panteliadou, Stamatia Pouliliou, Michael I Koukourakis
Micro-RNAs (miRNAs) have a complex role in carcinogenesis and tumour progression. Several miRNAs, such as miR-221, miR-27b and miR-132, have been implicated in the regulation of VEGF tumour angiogenic activity. In this pilot study, we assessed angiogenesis and DLL4+ vascular maturation index (VMI) in breast cancer tissues, in parallel with the plasma levels of the above-mentioned miRNAs. Significantly higher than control samples pre-operative levels were recorded in 10/11, 7/11 and 9/11 cases for the miR-221, miR-27b and miR-132, respectively...
February 2017: Medical Oncology
https://www.readbyqxmd.com/read/28035281/good-bye-to-tropical-alpine-plant-giants-under-warmer-climates-loss-of-range-and-genetic-diversity-in-lobelia-rhynchopetalum
#4
Desalegn Chala, Christian Brochmann, Achilleas Psomas, Dorothee Ehrich, Abel Gizaw, Catherine A Masao, Vegar Bakkestuen, Niklaus E Zimmermann
The main aim of this paper is to address consequences of climate warming on loss of habitat and genetic diversity in the enigmatic tropical alpine giant rosette plants using the Ethiopian endemic Lobelia rhynchopetalum as a model. We modeled the habitat suitability of L. rhynchopetalum and assessed how its range is affected under two climate models and four emission scenarios. We used three statistical algorithms calibrated to represent two different complexity levels of the response. We analyzed genetic diversity using amplified fragment length polymorphisms and assessed the impact of the projected range loss...
December 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28027682/the-effect-of-achillea-millefolium-and-hypericum-perforatum-ointments-on-episiotomy-wound-healing-in-primiparous-women
#5
Maryam Hajhashemi, Zinat Ghanbari, Minoo Movahedi, Mahmoud Rafieian, Atefeh Keivani, Fedyeh Haghollahi
BACKGROUND: The purpose of this study was assessed the efficacy of Achillea millefolium and Hypericum perforatum ointments on episiotomy wound healing in primiparous women. MATERIALS AND METHODS: This is double blind clinical trial study that was performed on 140 primiparous women. They were randomly divided into four groups each one containing 35 women: 2control groups including non-intervention and placebo ointment; and 2case groups including Hypericum perforatum ointment, and Achillea millefolium ointment...
December 27, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27999783/percutaneous-tracheostomy-beware-of-the-thyroidea-ima-artery
#6
Pagona Kamparoudi, Dimitrios Paliouras, Apostolos S Gogakos, Thomas Rallis, Nikolaos C Schizas, Achilleas Lazopoulos, Fotios Chatzinikolaou, Pavlos Sarafis, Paschalitsa Serchan, Nikolaos Katsikogiannis, Eirini Sarika, Paul Zarogoulidis, Ilias Karapantzos, Nikolaos Barbetakis
Percutaneous tracheostomy is a minimally invasive operation performed in patients, in order to provide an air passage through the windpipe. A rare cause of severe bleeding during such operation is the injury of the thyroidea-ima artery. This case report presents a patient with hemorrhage after thyroidea-ima injury during percutaneous dilatational tracheostomy. Surgeons should always be aware of such anatomic variation, in order to prevent urgent sternotomy.
November 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27999782/successful-surgical-treatment-of-a-complicated-esophageal-perforation-by-use-of-primary-closure-and-lung-parenchyma-reinforcement
#7
Nikolaos C Schizas, Dimitrios Paliouras, Thomas Rallis, Apostolos S Gogakos, Achilleas Lazopoulos, Fotios Chatzinikolaou, Pavlos Sarafis, Paul Zarogoulidis, Nikolaos Katsikogiannis, Eirini Sarika, Ιlias Karapantzos, Charalampos Charalampidis, Nikolaos Barbetakis
Esophageal perforation (EP) is a medical condition which demands urgent confrontation with significant complications. The cause of the perforation may be common, spontaneous or iatrogenic, with conservative or surgical therapeutic strategy, which is needed in the majority of incidents, depending on the characteristics of the lesion. We report a case of a 68-year-old man, with the existence of an ulcerative lesion 31 cm approximately from the dental barrier, and a coexistent stenosis, diagnosed through esophagogastroduodenoscopy, which evolved to an extensive purulent necrotic mediastinitis, diagnosed through a thorax CT scan after the patient began to complain of asphyxiation during eating...
November 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27999778/burnout-syndrome-and-job-satisfaction-in-greek-residents-exploring-differences-between-trainees-inside-and-outside-the-country
#8
Ilias I Salpigktidis, Dimitrios Paliouras, Apostolos S Gogakos, Thomas Rallis, Nikolaos C Schizas, Fotios Chatzinikolaou, Dimitrios Niakas, Pavlos Sarafis, Panagiotis Bamidis, Achilleas Lazopoulos, Sophia Triadafyllidou, Paul Zarogoulidis, Nikolaos Barbetakis
BACKGROUND: The purpose of this study is to investigate the levels of burnout among Greek residents, highlighting potential differences between those practicing at home and abroad, as well as to investigate correlations with demographic, individual and labor factors. METHODS: The research was conducted on a sample of 131 residents, using an anonymous questionnaire which included demographic, individual and labor characteristics, Maslach's Burnout Inventory, questions regarding job and life satisfaction levels, working conditions and the impacts of the economic recession...
November 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27988154/estimation-of-health-related-quality-of-life-depends-on-which-utility-measure-is-selected-for-patients-with-carpal-tunnel-syndrome
#9
Goris Nazari, Joy C MacDermid, James Bain, Carolyn M Levis, Achilleas Thoma
STUDY DESIGN: Cross-sectional. INTRODUCTION: Carpal tunnel syndrome (CTS) refers to the compression neuropathy of the median nerve at the wrist. PURPOSE OF THE STUDY: To establish the interinstrument reliability, convergent construct validity, and the levels of agreement of health utility indexes 2 and 3 (HUI-2 and HUI-3), EuroQol 5-dimensions (EQ-5D), EuroQol-visual analog scale (EQ-VAS) and to determine the difference of these utility measures based on age and gender in patients with carpal tunnel syndrome...
December 14, 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/27987996/synthesis-of-modified-gum-tragacanth-graphene-oxide-composite-hydrogel-for-heavy-metal-ions-removal-and-preparation-of-silver-nanocomposite-for-antibacterial-activity
#10
Razieh Sahraei, Mousa Ghaemy
New composite hydrogels were synthesized based on gum tragacanth (GT) carbohydrate and graphene oxide (GO). GT was sulfonic acid-functionalized and cross-linked by using 2-acrylamido-2-methylpropanesulfonic acid (AMPS) and N,N'-methylenebisacrylamide (MBA) monomers and ceric ammonium nitrate (CAN) as an initiator. The prepared hydrogels were characterized by Fourier transform infrared spectrum (FT-IR), field emission scanning electron microscope (FE-SEM), energy dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD) and thermogravimetric analysis (TGA)...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27975806/active-compounds-from-achillea-biebersteinii-and-determination-of-their-antigenotoxic-potentials
#11
H G Sevindik, Z Güvenalp, M Karadayı, M Güllüce, L Ö Demirezer
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975805/antimutagenic-potentials-of-flavonoids-from-achillea-millefolium-l-subsp-millefolium
#12
H G Sevindik, Z Güvenalp, M Karadayı, M Güllüce, L Ö Demirezer
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27913788/safety-assessment-of-achillea-millefolium-as-used-in-cosmetics
#13
Lillian C Becker, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
Cosmetic ingredients derived from Achillea millefolium function in cosmetics as skin-conditioning agents-miscellaneous, skin-conditioning agents-humectants, and fragrance ingredients. The Cosmetic Ingredient Review Expert Panel (Panel) reviewed relevant animal and human data to determine their safety in cosmetics and raised concerns about cosmetics containing linalool, thujone, quercetin, hydroquinone, or α-peroxyachifolid. Because final product formulations may contain multiple botanicals, each containing similar constituents of concern, formulators are advised to be aware of these components and to avoid reaching levels that may be hazardous to consumers...
November 2016: International Journal of Toxicology
https://www.readbyqxmd.com/read/27885754/adaptive-and-plastic-responses-of-quercus-petraea-populations-to-climate-across-europe
#14
Cuauhtémoc Sáenz-Romero, Jean-Baptiste Lamy, Alexis Ducousso, Brigitte Musch, François Ehrenmann, Sylvain Delzon, Stephen Cavers, Władysław Chałupka, Said Dağdaş, Jon Kehlet Hansen, Steve J Lee, Mirko Liesebach, Hans-Martin Rau, Achilleas Psomas, Volker Schneck, Wilfried Steiner, Niklaus E Zimmermann, Antoine Kremer
How temperate forests will respond to climate change is uncertain; projections range from severe decline to increased growth. We conducted field tests of sessile oak (Quercus petraea), a widespread keystone European forest tree species, including more than 150,000 trees sourced from 116 geographically diverse populations. The tests were planted on 23 field sites in six European countries, in order to expose them to a wide range of climates, including sites reflecting future warmer and drier climates. By assessing tree height and survival, our objectives were twofold: (1) to identify the source of differential population responses to climate (genetic differentiation due to past divergent climatic selection versus plastic responses to ongoing climate change), (2) to explore which climatic variables (temperature or precipitation) trigger the population responses...
November 25, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27879146/chemical-composition-and-antifungal-activity-of-essential-oils-from-medicinal-plants-of-kazakhstan
#15
Diego A Sampietro, Analía de Los A Gomez, Cristina M Jimenez, Emilio F Lizarraga, Zharkyn A Ibatayev, Yerlan M Suleimen, Cesar A Catalán
The composition of essential oils from leaves of Kazakhstan medicinal plants was analysed by GC-MS. The major compounds identified were 1,8-cineole (34.2%), myrcene (19.1%) and α-pinene (9.4%) in Ajania fruticulosa; 1,8-cineole (21.0%), β-thujone (11.0%), camphor (8.5%), borneol (7.3%) and α-thujone (6.5%), in Achillea nobilis; camphor (47.3%), 1,8-cineole (23.9%), camphene (9.8%) and β-thujone (6.0%) in Artemisia terrae-albae; 1,8-cineole(55.8%) and β-pinene (6.2%) in Hyssopus ambiguus; α-thuyene(46...
November 23, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27876086/suprascapular-neuropathy-in-the-setting-of-rotator-cuff-tears-study-protocol-for-a-double-blinded-randomized-controlled-trial
#16
Nikolaos Platon Sachinis, Achilleas Boutsiadis, Sotirios Papagiannopoulos, Konstantinos Ditsios, Anastasios Christodoulou, Pericles Papadopoulos
BACKGROUND: It has been indicated that rotator cuff tears, especially large or massive ones, can cause suprascapular neuropathy. When such a diagnosis has been established, it is still unknown whether an arthroscopic release of the superior transverse scapular ligament during cuff repair can change the course of this neuropathy. METHODS/DESIGN: This is a single-center, double-blinded randomized controlled trial for which 42 patients with large or massive repairable rotator cuff tears and suprascapular neuropathy will be recruited and followed up at 6 and 12 months...
November 22, 2016: Trials
https://www.readbyqxmd.com/read/27866235/arthroscopically-assisted-mini-open-partial-synovectomy-for-the-treatment-of-localized-pigmented-villonodular-synovitis-of-the-knee-a-retrospective-comparative-study-with-long-term-follow-up
#17
Dimitrios Georgiannos, Achilleas Boutsiadis, Filon Agathangelidis, Stergios Papastergiou, Dimitrios Karataglis, Ilias Bisbinas
PURPOSE: The purpose of this study was to present the long-term results of treatment of localized pigmented villonodular synovitis (LPVNS) comparing two operative procedures of excision of the lesion-the arthroscopic and the arthroscopically assisted mini-open. We hypothesized that the latter approach allowed for treatment of LPVNS with acceptable recurrence rates, complication rates and functional outcomes. METHODS: Between 1990 and 2006, 21 patients with LPVNS were treated with partial synovectomy through an arthroscopically-assisted mini open technique (group A), and 23 patients were treated with an arthroscopic excision of the lesion (group B)...
November 19, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27834155/whole-genome-fetal-and-maternal-dna-methylation-analysis-using-medip-ngs-for-the-identification-of-differentially-methylated-regions
#18
Anna Keravnou, Marios Ioannides, Kyriakos Tsangaras, Charalambos Loizides, Michael D Hadjidaniel, Elisavet A Papageorgiou, Skevi Kyriakou, Pavlos Antoniou, Petros Mina, Achilleas Achilleos, Maria Neofytou, Elena Kypri, Carolina Sismani, George Koumbaris, Philippos C Patsalis
DNA methylation is an epigenetic marker that has been shown to vary significantly across different tissues. Taking advantage of the methylation differences between placenta-derived cell-free DNA and maternal blood, several groups employed different approaches for the discovery of fetal-specific biomarkers. The aim of this study was to analyse whole-genome fetal and maternal methylomes in order to identify and confirm the presence of differentially methylated regions (DMRs). We have initially utilized methylated DNA immunoprecipitation (MeDIP) and next-generation sequencing (NGS) to identify genome-wide DMRs between chorionic villus sampling (CVS) and female non-pregnant plasma (PL) and peripheral blood (WBF) samples...
November 11, 2016: Genetics Research
https://www.readbyqxmd.com/read/27790852/syndecans-key-regulators-of-cell-signaling-and-biological-functions
#19
REVIEW
Nikolaos A Afratis, Dragana Nikitovic, Hinke A B Multhaupt, Achilleas D Theocharis, John R Couchman, Nikos K Karamanos
Syndecans are a small family of four transmembrane proteoglycans in mammals. They have similar structural organization, consisting of an N-terminal ectodomain, single transmembrane domain and C-terminal cytoplasmic domain. Over the years, the association between syndecans and the actin cytoskeleton has been established, which has consequences for the regulation of cell adhesion and migration. Specifically, ecto- and cytoplasmic domains are responsible for the interaction with extracellular matrix molecules and intracellular kinases, respectively...
October 28, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27778131/the-role-of-heparins-and-nano-heparins-as-therapeutic-tool-in-breast-cancer
#20
Nikos A Afratis, Konstantina Karamanou, Zoi Piperigkou, Demitrios H Vynios, Achilleas D Theocharis
Glycosaminoglycans are integral part of the dynamic extracellular matrix (ECM) network that control crucial biochemical and biomechanical signals required for tissue morphogenesis, differentiation, homeostasis and cancer development. Breast cancer cells communicate with stromal ones to modulate ECM mainly through release of soluble effectors during cancer progression. The intracellular cross-talk between cell surface receptors and estrogen receptors is important for the regulation of breast cancer cell properties and production of ECM molecules...
October 24, 2016: Glycoconjugate Journal
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