M J Martín, C Alarcón, V Motilva
Effects of aescine and aesculine, active principles of the horsechestnut, on urinary excretion of water and electrolytes, were investigated in saline loaded rats. Results indicate that aesculin shows a moderated diuretic activity, increasing significantly the renal loss of sodium, chloride and potassium. Nevertheless, only the highest dose of aescine caused the same degree of minease in saluresis with aesculin, where a doses-response relationship was observed.
1990: Annales Pharmaceutiques Françaises