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https://www.readbyqxmd.com/read/29746932/prevention-of-carcinogenesis-and-metastasis-by-artemisinin-type-drugs
#1
Mohammed L Abba, Nitin Patil, Jörg Hendrik Leupold, Mohamed E M Saeed, Thomas Efferth, Heike Allgayer
Artemisia annua (sweet wormwood, qinhao) is an ancient Chinese herbal remedy for pyrexia. Nowadays, artemisinin (qinghaosu) and its derivatives belong to the standard therapies against malaria worldwide, and its discovery has led to the Nobel Prize in Physiology and Medicine to Youyou Tu in 2015. While most attention has been paid to the treatment of malaria, there is increasing evidence that Artemisinin-type drugs bear a considerable potential to treat and prevent cancer. Rather than reporting on therapy of cancer, this review gives a comprehensive and timely overview on the chemopreventive effects of artemisinin and its derivatives against carcinogenesis and metastasis formation, following the multistage model of carcinogenesis (initiation, promotion, progression)...
May 7, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29740850/therapeutic-effects-of-artemisia-scoparia-waldst-et-kitaib-in-a-murine-model-of-atopic-dermatitis
#2
K J Ryu, M S Yoou, Y Seo, K W Yoon, H M Kim, H J Jeong
BACKGROUND: Artemisia scoparia Waldst. et Kitaib (AS) (Oriental wormwood, known as Bissuk in Korea) is a plant used in cosmetic and pharmaceutical treatments. However, the effect of AS on atopic dermatitis (AD) has not been described. AIM: To examine the inhibitory effect of AS on AD using a murine model. METHODS: We applied either AS, the butanol-extracted fraction of AS (Bu-OH) or 3,5-dicaffeoyl-epi-quinic acid (DEQA, a major component of Bu-OH) topically for 3 weeks to 2,4-dinitrofluorobenzene (DNFB)-induced skin lesions in BALB/c mice...
May 8, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29703587/the-genome-of-artemisia-annua-provides-insight-into-the-evolution-of-asteraceae-family-and-artemisinin-biosynthesis
#3
Qian Shen, Lida Zhang, Zhihua Liao, Shengyue Wang, Tingxiang Yan, Pu Shi, Meng Liu, Xueqing Fu, Qifang Pan, Yuliang Wang, Zongyou Lv, Xu Lu, Fangyuan Zhang, Weimin Jiang, Yanan Ma, Minghui Chen, Xiaolong Hao, Ling Li, Yueli Tang, Gang Lv, Yan Zhou, Xiaofen Sun, Peter E Brodelius, Jocelyn K C Rose, Kexuan Tang
Artemisia annua, commonly known as sweet wormwood or Qinghao, is a shrub native to China and has long been used for medicinal purposes. A. annua is now cultivated globally as the only natural source of a potent anti-malarial compound, artemisinin. Here, we report a high-quality draft assembly of the 1.74-gigabase genome of A. annua, which is highly heterozygous, rich in repetitive sequences, and contains 63 226 protein-coding genes, one of the largest numbers among the sequenced plant species. We found that, as one of a few sequenced genomes in the Asteraceae, the A...
April 20, 2018: Molecular Plant
https://www.readbyqxmd.com/read/29674964/botanical-provenance-of-traditional-medicines-from-carpathian-mountains-at-the-ukrainian-polish-border
#4
REVIEW
Weronika Kozlowska, Charles Wagner, Erin M Moore, Adam Matkowski, Slavko Komarnytsky
Plants were an essential part of foraging for food and health, and for centuries remained the only medicines available to people from the remote mountain regions. Their correct botanical provenance is an essential basis for understanding the ethnic cultures, as well as for chemical identification of the novel bioactive molecules with therapeutic effects. This work describes the use of herbal medicines in the Beskid mountain ranges located south of Krakow and Lviv, two influential medieval centers of apothecary tradition in the region...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29663255/structural-characterization-and-disulfide-assignment-of-spider-peptide-ph%C3%AE-1%C3%AE-by-mass-spectrometry
#5
Kelly L Wormwood, Armand Gatien Ngounou Wetie, Marcus Vinicius Gomez, Yue Ju, Paul Kowalski, Marius Mihasan, Costel C Darie
Native Phα1β is a peptide purified from the venom of the armed spider Phoneutria nigriventer that has been shown to have an extensive analgesic effect with fewer side effects than ω-conotoxin MVIIA. Recombinant Phα1β mimics the effects of the native Phα1β. Because of this, it has been suggested that Phα1β may have potential to be used as a therapeutic for controlling persistent pathological pain. The amino acid sequence of Phα1β is known; however, the exact structure and disulfide arrangement has yet to be determined...
April 16, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29607928/mechanisms-of-the-ph-and-oxygen-dependent-oxidation-activities-of-artesunate
#6
Katsunori Tsuda, Licht Miyamoto, Shuichi Hamano, Yuri Morimoto, Yumi Kangawa, Chika Fukue, Yoko Kagawa, Yuya Horinouchi, Wenting Xu, Yasumasa Ikeda, Toshiaki Tamaki, Koichiro Tsuchiya
Artemisinin was discovered in 1971 as a constituent of the wormwood genus plant (Artemisia annua). This plant has been used as an herbal medicine to treat malaria since ancient times. The compound artemisinin has a sesquiterpene lactone bearing a peroxide group that offers its biological activity. In addition to anti-malarial activity, artemisinin derivatives have been reported to exert antitumor activity in cancer cells, and have attracted attention as potential anti-cancer drugs. Mechanisms that might explain the antitumor activities of artemisinin derivatives reportedly induction of apoptosis, angiogenesis inhibitory effects, inhibition of hypoxia-inducible factor-1α (HIF-1α) activation, and direct DNA injury...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29549352/health-promoting-potential-of-herbal-teas-and-tinctures-from-artemisia-campestris-subsp-maritima-from-traditional-remedies-to-prospective-products
#7
Catarina Guerreiro Pereira, Luísa Barreira, Sebastiaan Bijttebier, Luc Pieters, Cátia Marques, Tamára F Santos, Maria João Rodrigues, João Varela, Luísa Custódio
This work explored the biotechnological potential of the medicinal halophyte Artemisia campestris subsp. maritima (dune wormwood) as a source of health promoting commodities. For that purpose, infusions, decoctions and tinctures were prepared from roots and aerial-organs and evaluated for in vitro antioxidant, anti-diabetic and tyrosinase-inhibitory potential, and also for polyphenolic and mineral contents and toxicity. The dune wormwood extracts had high polyphenolic content and several phenolics were identified by ultra-high performance liquid chromatography-photodiode array-mass-spectrometry (UHPLC-PDA-MS)...
March 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29485945/seeing-what-you-feel-affect-drives-visual-perception-of-structurally-neutral-faces
#8
Erika H Siegel, Jolie B Wormwood, Karen S Quigley, Lisa Feldman Barrett
Affective realism, the phenomenon whereby affect is integrated into an individual's experience of the world, is a normal consequence of how the brain processes sensory information from the external world in the context of sensations from the body. In the present investigation, we provided compelling empirical evidence that affective realism involves changes in visual perception (i.e., affect changes how participants see neutral stimuli). In two studies, we used an interocular suppression technique, continuous flash suppression, to present affective images outside of participants' conscious awareness...
April 2018: Psychological Science
https://www.readbyqxmd.com/read/29459314/the-desert-wormwood-artemisia-herba-alba-from-arabian-folk-medicine-to-a-source-of-green-and-effective-nanoinsecticides-against-mosquito-vectors
#9
Al Thabiani Aziz, Mohammed Ali Alshehri, Chellasamy Panneerselvam, Kadarkarai Murugan, Subrata Trivedi, Jazem A Mahyoub, Mo'awia Mukhtar Hassan, Filippo Maggi, Stefania Sut, Stefano Dall'Acqua, Angelo Canale, Giovanni Benelli
The development of eco-friendly and effective insecticides is crucial for public health worldwide. Herein, we focused on the desert wormwood (Artemisia herba-alba), a plant widely used in Arabian traditional medicine, as a source of green nanoinsecticides against mosquito vectors, as well as growth inhibitors to be employed against microbial pathogens. Ag nanoparticles (AgNPs) fabricated with the A. herba-alba extract were tested on Indian and Saudi Arabian strains of Anopheles, Aedes and Culex mosquitoes. The chemical profile of the A...
March 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29380567/-metabolic-engineering-of-e-%C3%AE-farnesene-synthase-genes-for-aphid-resistant-genetically-modified-plants
#10
Dianyong Jia, Shiqing Gao, Pengfei Duan, Jibao Chen, Fengxia Tian, Xiudao Yu
Aphids are major agricultural pests that cause significant yield losses of crops each year. (E)-β-farnesene (EβF), as the main component of the aphid alarm pheromones, can interrupt aphid feeding and cause other conspecies in the vicinity to become agitated or disperse from their host plant. Furthermore, EβF can function as a kairomone in attracting aphid predators. EβF synthase genes, which encode enzymes that convert farnesyl diphosphate (FPP) to the acyclic sesquiterpene EβF, have been isolated and characterized from peppermint (Mentha × piperita and Mentha asiatica), Yuzu (Citrus junos), Douglas fir (Pseudotsuga menziesii), sweet wormwood (Artemisia annua) and chamomile (Matricaria recutita), respectively...
January 25, 2018: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/29369657/facial-expression-predictions-as-drivers-of-social-perception
#11
Lorena Chanes, Jolie Baumann Wormwood, Nicole Betz, Lisa Feldman Barrett
Emerging perspectives in neuroscience indicate that the brain functions predictively, constantly anticipating sensory input based on past experience. According to these perspectives, prediction signals impact perception, guiding and constraining experience. In a series of six behavioral experiments, we show that predictions about facial expressions drive social perception, deeply influencing how others are evaluated: individuals are judged as more likable and trustworthy when their facial expressions are anticipated, even in the absence of any conscious changes in felt affect...
March 2018: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/29228785/an-overview-on-indications-and-chemical-composition-of-aromatic-waters-hydrosols-as-functional-beverages-in-persian-nutrition-culture-and-folk-medicine-for-hyperlipidemia-and-cardiovascular-conditions
#12
Azadeh Hamedi, Seyed Mahmoud Moheimani, Amirhossein Sakhteman, Hamed Etemadfard, Mahmoodreza Moein
Hydrosol beverages in Persian nutrition culture and ethnomedicine are the side products of essential oil industry that are used as delicious drinks or safe remedies. To investigate indications and chemical composition of hydrosol beverages for hyperlipidemia and cardiovascular conditions, Fars province was selected as the field of study. Ethnomedical data were gathered by questionnaires. The constituents of hydrosols were extracted with liquid/liquid extraction and analyzed by gas chromatography-mass spectrometry...
October 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29064437/the-assessment-of-toxic-metals-in-plants-used-in-cosmetics-and-cosmetology
#13
Agnieszka Fischer, Barbara Brodziak-Dopierała, Krzysztof Loska, Jerzy Stojko
Heavy metals polluting the natural environment are absorbed by plants. The use of herbs as components of cosmetics may pose a health risk for humans. The aim of the study was to determine the concentrations of Pb, Cd and Hg in selected species of herbs (horsetail Equisetum arvense , nettle Urtica dioica , St. John's wort Hypericum perforatum , wormwood Artemisia absinthium , yarrow Achillea millefolium , cottonwood Solidago virgaurea ) self-collected from the natural environment in two different locations, and purchased in stores on the territory of Poland...
October 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28976309/simple-transparent-and-flexible-automated-quality-assessment-procedures-for-ambulatory-electrodermal-activity-data
#14
Ian R Kleckner, Rebecca M Jones, Oliver Wilder-Smith, Jolie B Wormwood, Murat Akcakaya, Karen S Quigley, Catherine Lord, Matthew S Goodwin
OBJECTIVE: Electrodermal activity (EDA) is a non-invasive measure of sympathetic activation often used to study emotions, decision-making, and health. The use of "ambulatory" EDA in everyday life presents novel challenges-frequent artifacts and long recordings-with inconsistent methods available for efficiently and accurately assessing data quality. We developed and validated a simple, transparent, flexible, and automated quality assessment procedure for ambulatory EDA data. METHODS: Twenty individuals with autism (5 females, 5-13 years) provided a combined 181 hours of EDA data in their home using the Affectiva Q Sensor across 8 weeks...
October 2, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28952259/-rapid-characterization-of-chemical-constituents-in-capillary-wormwood-extract-based-on-uhplc-ltq-orbitrap
#15
Wen-Zhu Ouyang, Zhan-Peng Shang, Wen-Jian Wang, Shou-Xu Wang, Jia-Xu Shen, Hao Qian, Zhi-Guo Ma, Jia-Yu Zhang
A rapid and sensitive UHPLC-HR-MSn method was developed for the identification of chemical constituents in capillary wormwood extract. ACQUITY UHPLC HSS T3 chromatography column (2.1 mm×100 mm, 1.7 μm) was used with 0.1% formic acid-acetonitrile solution as the mobile phase in gradient elution. The extract was detected by ESI-LTQ-Orbitrap equipped with an ESI ion source in a negative mode. Based on the accurate mass measurements, retention time, mass fragmentation patterns and literature reports, a total of 50 compounds including 21 flavonoids, 22 phenolic acids, 6 coumarins and 1 other compound were tentatively screened and characterized...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28950151/processing-of-visual-food-cues-during-bitter-taste-perception-in-female-patients-with-binge-eating-symptoms-a-cross-modal-erp-study
#16
Anne Schienle, Wilfried Scharmüller, Daniela Schwab
OBJECTIVE: In healthy individuals, the perception of an intense bitter taste decreased the reward value of visual food cues, as reflected by the reduction of a specific event-related brain potential (ERP), frontal late positivity. The current cross-modal ERP study investigated responses of female patients with binge-eating symptoms (BES) to this type of visual-gustatory stimulation. METHODS: Women with BES (n=36) and female control participants (n=38) viewed food images after they rinsed their mouth with either bitter wormwood tea or water...
November 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28918484/drug-herb-interactions-in-the-elderly-patient-with-ibd-a-growing-concern
#17
REVIEW
Haider Rahman, Marina Kim, Galen Leung, Jesse A Green, Seymour Katz
Inflammatory bowel disease (IBD), which includes conditions such as Crohn's disease and ulcerative colitis, is becoming more prevalent with the elderly being the fastest growing group. Parallel to this, there is an increasing interest in the use of complementary and alternative medicine (CAM). Nearly half of patients with IBD have used CAM at one time. The elderly patients, however, are burdened by comorbid conditions, polypharmacy, and altered functional status. With increasing use of complementary and alternative medicine in our elderly patients with IBD, it is vital for the provider to provide counsel on drug-herb potential interactions...
December 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28880869/differences-in-chemical-constituents-of-artemisia-annua-l-from-different-geographical-regions-in-china
#18
Xiaobo Zhang, Yuping Zhao, Lanping Guo, Zhidong Qiu, Luqi Huang, Xiaobo Qu
BACKGROUND: Daodi-herb is a part of Chinese culture, which has been naturally selected by traditional Chinese medicine clinical practice for many years. Sweet wormwood herb is a kind of Daodi-herb, and comes from Artemisia annua L. Artemisinin is a kind of effective antimalarial drug being extracted from A. annua. Because of artemisinin, Sweet wormwood herb earns a reputation. Based on the Pharmacopoeia of the People's Republic of China (PPRC), Sweet wormwood herb can be used to resolve summerheat-heat, and prevent malaria...
2017: PloS One
https://www.readbyqxmd.com/read/28857266/avoiding-premature-closure-and-reaching-diagnostic-accuracy-some-key-predictive-factors
#19
Edward Krupat, Jolie Wormwood, Richard M Schwartzstein, Jeremy B Richards
CONTEXT: Early studies suggested that experienced clinicians simply generate more accurate diagnoses than those less experienced. However, more recent studies indicate that experienced clinicians may be subject to biases in formulating and confirming hypotheses that lead to inaccuracy. OBJECTIVES: The goal of this study was to identify factors associated with the ability to process information in ways that overcome premature closure and result in accurate diagnosis using a set of vignettes in which inconsistent information was introduced midway...
November 2017: Medical Education
https://www.readbyqxmd.com/read/28761777/antimicrobial-activities-of-widely-consumed-herbal-teas-alone-or-in-combination-with-antibiotics-an-in-vitro-study
#20
Mayram Hacioglu, Sibel Dosler, Ayse Seher Birteksoz Tan, Gulten Otuk
BACKGROUND: Because of increasing antibiotic resistance, herbal teas are the most popular natural alternatives for the treatment of infectious diseases, and are currently gaining more importance. We examined the antimicrobial activities of 31 herbal teas both alone and in combination with antibiotics or antifungals against some standard and clinical isolates of Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, methicillin susceptible/resistant Staphylococcus aureus and Candida albicans...
2017: PeerJ
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