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https://www.readbyqxmd.com/read/28101244/celery-extract-inhibits-mouse-cyp2a5-and-human-cyp2a6-activities-via-different-mechanisms
#1
Xiao Deng, Qianghong Pu, Erhao Wang, Chao Yu
Human cytochrome P450 (CYP) 2A6 participates in the metabolism of nicotine and precarcinogens, thus the deliberate inhibition of CYP2A6 may reduce cigarette consumption and therefore reduce the risk of developing the types of cancer associated with smoking. The inhibitory effects and mechanisms of celery (Apium graveolens) extract on mouse CYP2A5 and human CYP2A6 activity remain unclear. These effects were investigated in mouse and human liver microsomes using coumarin 7-hydroxylation in a probe reaction. Celery extract reduced CYP2A5 and CYP2A6 activities in vitro in a dose-dependent manner...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28043416/antidiarrhoeal-investigation-of-apium-leptophyllum-pers-by-modulation-of-na-k-atpase-nitrous-oxide-and-intestinal-transit-in-rats
#2
Himanshu Bhusan Sahoo, Rakesh Sagar, Anjan Kumar, Amrita Bhaiji, Subrat Kumar Bhattamishra
BACKGROUND: Apium leptophyllum (Pers.) is an annual herb with traditional appreciation for various pharmacological properties; however, the scientific information on this herb is insufficient. The aim of the present investigation was undertaken to evaluate flavonoidal fraction of A. leptophyllum fruit (FFALF) against diarrhoea on albino rats. METHODS: The antidiarrhoeal study was conducted by castor oil induce diarrhoea, prostaglandin E2 (PGE2) induced enteropooling and intestinal transit by charcoal meal test...
December 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27982754/apium-graveolens-extract-inhibits-cell-proliferation-and-expression-of-vascular-endothelial-growth-factor-and-induces-apoptosis-in-the-human-prostatic-carcinoma-cell-line-lncap
#3
Tülay Köken, Buğra Koca, Mete Özkurt, Nilüfer Erkasap, Gökhan Kuş, Mustafa Karalar
Apium graveolens has been shown to inhibit the growth of a variety of cancer tissues. In this study, we investigated the anticancer effect of A. graveolens on the human prostatic carcinoma cell line LNCaP. LNCaP cells were treated with increasing concentrations of an ethanolic extract of A. graveolens ranging from 1000 to 3000 μg/mL, and viability was determined after 24 and 48 h using the XTT cell proliferation assay. The levels of cleaved poly (ADP-ribose) polymerase (PARP), one of the best biomarkers of apoptosis, were analyzed...
December 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27976117/antiadhesive-and-cytoprotective-effects-of-hydroalcoholic-extract-of-apium-graveolens-seeds-against-uropathogenic-e-coli
#4
S Sarshar, M R Asadi Karam, M Habibi, S Bouzari, X Qin, F M Goycoolea, A Hensel
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27862988/isolation-purification-and-identification-of-the-main-phenolic-compounds-from-leaves-of-celery-apium-graveolens-l-var-dulce-mill-pers
#5
Guoyan Liu, Linwu Zhuang, Dandan Song, Chunliang Lu, Xin Xu
We developed a simple and meaningful preparative method for the separation and purification of the main phenolic compounds from the leaves of celery (Apium graveolens L. var. dulce Mill./Pers.) and we established an accurate and specific analytical method for the identification of the main phenolic compounds from celery leaves. The crude extract from celery leaves was prefractioned by polyamide resin to enrich the phenolic compounds. They were then purified further by preparative high-performance liquid chromatography, and seven main phenolic compounds were obtained: including chlorogenic acid, luteolin 7-O-β-d-apiofuranosyl(1→2)-β-d-glucopyranoside, luteolin 7-O-β-d-glucopyranoside, apiin, chrysoeriol 7-O-β-d-apiofuranosyl(1→2)-β-d-glucopyranoside, luteolin 7-O-[β-d-apiofuranosyl(1→2)-(6''-O-malonyl)]-β-d-glucopyranoside, and apigenin 7-O-[β-d-apiofuranosyl(1→2)-(6''-O-malonyl)]-β-d-glucopyranoside...
November 8, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27810764/levels-of-heavy-metals-in-wetland-and-marine-vascular-plants-and-their-biomonitoring-potential-a-comparative-assessment
#6
Giuseppe Bonanno, Joseph A Borg, Vincenzo Di Martino
The present study investigated the levels of As, Cd, Cr, Cu, Hg, Mn, Ni, Pb and Zn in the seagrasses Posidonia oceanica and Cymodocea nodosa, and in the wetland macrophytes Phragmites australis, Arundo donax, Typha domingensis, Apium nodiflorum, and Nasturtium officinale. Results showed that the bioaccumulation capacity from sediments, translocation, total levels in plant tissues, and bioindication of metals in sediments, are generally species-specific. In particular, the patterns of metals in the aquatic plants studied were overall independent of ecology (coasts vs wetlands), biomass, anatomy (rhizomatous vs non rhizomatous plants), and life form (hemicrytophytes vs hydrophytes)...
January 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27717118/diet-related-gut-bacterial-dysbiosis-correlates-with-impaired-development-increased-mortality-and-nosema-disease-in-the-honeybee-apis-mellifera
#7
Patrick W Maes, Pedro A P Rodrigues, Randy Oliver, Brendon M Mott, Kirk E Anderson
Dysbiosis, defined as unhealthy shifts in bacterial community composition, can lower the colonization resistance of the gut to intrinsic pathogens. Here, we determined the effect of diet age and type on the health and bacterial community composition of the honeybee (Apis mellifera). We fed newly emerged bees fresh or aged diets, and then recorded host development and bacterial community composition from four distinct regions of the hosts' digestive tract. Feeding fresh pollen or fresh substitute, we found no difference in host mortality, diet consumption, development or microbial community composition...
September 26, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/27604234/transcriptional-profiling-of-genes-involved-in-ascorbic-acid-biosynthesis-recycling-and-degradation-during-three-leaf-developmental-stages-in-celery
#8
Wei Huang, Guang-Long Wang, Hui Li, Feng Wang, Zhi-Sheng Xu, Ai-Sheng Xiong
Ascorbic acid (AsA) is an important nutrient in the human body and performs various healthy functions. With considerable medicinal properties, celery (Apium graveolens L.) could be a good source of AsA for human health. However, the biosynthetic, recycling, and degradation pathways of AsA in celery have yet to be characterized. To study the metabolic pathways involved in AsA, the genes involved in AsA biosynthesis, recycling, and degradation were isolated from celery, and their expression profiles and AsA levels were analyzed in the leaf blades and petioles of two celery varieties at three different growth stages...
December 2016: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/27462548/the-effect-of-celery-apium-graveolens-on-reproductive-parameters-in-male-wistar-rat
#9
Wesam Kooti, Najmeh Kafash-Farkhad, Ali Ghorbani Ranjbary, Naim Sharafi-Ahvazi
No abstract text is available yet for this article.
May 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/27439966/l-3-n-butylphthalide-rescues-hippocampal-synaptic-failure-and-attenuates-neuropathology-in-aged-app-ps1-mouse-model-of-alzheimer-s-disease
#10
Yu Zhang, Long-Jian Huang, Si Shi, Shao-Feng Xu, Xiao-Liang Wang, Ying Peng
AIMS: Our previous studies showed that L-3-n-butylphthalide (L-NBP), an extract from seeds of Apium graveolens Linn (Chinese celery), improved cognitive ability in animal models of cerebral ischemia, vascular dementia, and Alzheimer's disease (AD). It is well known that cognitive deficit of AD is caused by synaptic dysfunction. In this study, we investigated the effect of L-NBP on hippocampal synaptic function in APP/PS1 AD transgenic mice and related mechanisms. METHODS: Eighteen-month-old APP/PS1 transgenic (Tg) mice were administrated 15 mg/kg L-NBP by oral gavage for 3 months...
December 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27390722/effects-of-apium-graveolens-extract-on-the-oxidative-stress-in-the-liver-of-adjuvant-induced-arthritic-rats
#11
Wanida Sukketsiri, Pennapa Chonpathompikunlert, Supita Tanasawet, Nutjanat Choosri, Tulaporn Wongtawatchai
Apium graveolens Linn. (Apiaceae) is an indigenous plant of the North and South Americas, Southern Europe, and Asia and has been widely used as a food or a traditional medicine for treatment of inflammation and arthritis. The purpose of this study was to investigate the antioxidant effects of a methanolic extract of A. graveolens (AGE) against liver oxidative stress in an adjuvant-induced arthritic rat model. The AGE (250, 500, and 1,000 mg/kg) was given orally for 24 consecutive days after induction by injecting complete Freund's adjuvant...
June 2016: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/27041871/review-of-scientific-evidence-of-medicinal-convoy-plants-in-traditional-persian-medicine
#12
REVIEW
Seyede Nargess Sadati, Mohammad Reza Shams Ardekani, Nastaran Ebadi, Maryam Yakhchali, Azadeh Raees Dana, Fatemeh Masoomi, Mahnaz Khanavi, Farid Ramezany
One concept used in traditional Persian medicine (TPM) for multidrug therapy is that of the convoy drug (Mobadregh). According to TPM texts, convoy drugs are substances (or drugs), which facilitate the access of drugs or foods to the whole body or to specific organs. This study reviewed some convoy drugs presented in TPM, their biological effects, and their probable interactions with main drugs, considering the increased absorption through inhibition of P-glycoprotein (P-gp) efflux function, bioavailability-enhancing effects, and decreased metabolism of the main drug using electronic databases including PubMed, Scopus, ScienceDirect, and Google Scholar in November and December, 2013...
January 2016: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/27040538/usefulness-of-different-vascular-plant-species-for-passive-biomonitoring-of-mediterranean-rivers
#13
Daniela Baldantoni, Anna Alfani
Choosing native vascular plants as nutrient and toxic element accumulators for passive biomonitoring of urban river quality is not an easy task in Mediterranean rivers, due to the particular climate determining high variations in river hydrology. To identify potential biomonitors for this area, the roots of seven species (Angelica sylvestris, Apium nodiflorum, Tradescantia fluminensis, Nasturtium officinale, Persicaria lapathifolia, Arctium lappa, Typha latifolia), growing in seven sites along the River Irno (Southern Italy), were collected in July 2010 and analyzed regarding their capability to accumulate Cd, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, V, and Zn through atomic absorption spectrometry...
July 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27014330/validation-and-comparison-of-reference-genes-for-qpcr-normalization-of-celery-apium-graveolens-at-different-development-stages
#14
Meng-Yao Li, Feng Wang, Qian Jiang, Guan-Long Wang, Chang Tian, Ai-Sheng Xiong
A suitable reference gene is an important prerequisite for guarantying accurate and reliable results in qPCR analysis. Celery is one of the representative vegetable in Apiaceae and is widely cultivated and consumed in the world. However, no reports have been previously published concerning reference genes in celery. In this study, the expression stabilities of nine candidate reference genes in leaf blade and petiole at different development stages were evaluated using three statistics algorithms geNorm, NormFinder, and BestKeeper...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/26968782/dl-3-n-butylphthalide-suppresses-pdgf-bb-stimulated-vascular-smooth-muscle-cells-proliferation-via-induction-of-autophagy
#15
Haijuan Hu, Bin Liu, Yabei Zuo, Demin Liu, Ruiqin Xie, Wei Cui
AIMS: Vascular smooth muscle cells (VSMCs) played an important role in vascular remodeling. dl-3-n-butylphthalide (NBP) was extracted as a pure component from seeds of Apium graveolens Linn (Chinese celery) for protecting neurons activity, but the role of NBP on VSMCs was not clearly clarified. MAIN METHODS: Cell proliferation was measured by MTS and flow cytometry. Western blot analysis and transmission electron microscopy were performed to analyze the relative protein expression and autophagosome...
April 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/26875068/parasaccharibacter-apium-gen-nov-sp-nov-improves-honey-bee-hymenoptera-apidae-resistance-to-nosema
#16
V Corby-Harris, L Snyder, C A D Meador, R Naldo, B Mott, K E Anderson
The honey bee, Apis mellifera L., is host to a variety of microorganisms. The bacterial community that occupies the adult worker gut contains a core group of approximately seven taxa, while the hive environment contains its own distribution of bacteria that is in many ways distinct from the gut. Parasaccharibacter apium, gen. nov., sp. nov., is a hive bacterium found in food stores and in larvae, worker jelly, worker hypopharyngeal glands, and queens. Parasaccharibacter apium increases larval survival under laboratory conditions...
April 2016: Journal of Economic Entomology
https://www.readbyqxmd.com/read/26721552/management-of-usr-i-tamth-menstrual-pain-in-unani-greco-islamic-medicine
#17
Arshiya Sultana, Syed Lamatunoor, Mazherunnisa Begum, Q N Qhuddsia
Usr-i-tamth in Unani (Greco-Arabic) medicine is pain associated with menstruation, and classical manuscripts are enriched with traditional knowledge for the management of usr-i-tamth (menstrual pain/dysmenorrhoea). Hence, a comprehensive search was undertaken to find classical manuscripts for the management of menstrual pain was. We searched the Cochrane database, PubMed/Google Scholar, and other websites for articles on complementary and alternative medicine treatment and management of menstrual pain. The principal management as per Unani manuscripts is to produce analgesia and to treat the cause of usr-i-tamth such as abnormal temperament, menstrual irregularities/uterine diseases, and psychological and environmental factors...
December 30, 2015: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/26717549/comparison-of-celery-apium-graveolens-l-collenchyma-and-parenchyma-cell-wall-polysaccharides-enabled-by-solid-state-13-c-nmr
#18
COMPARATIVE STUDY
Zoran Zujovic, Da Chen, Laurence D Melton
Collenchyma cells with their thickened walls are one of specific mechanical support tissues for plants, while parenchyma cells are thin walled and serve multiple functions. The parenchyma tissue is what you enjoy eating, while collenchyma, because of its fibrous nature, is not so attractive. Celery is a useful model for comparing the cell walls (CWs) of the two cell types such as collenchyma and parenchyma. However, to date, the structural characteristics of collenchyma and parenchyma cell walls from the same plant have not been compared...
February 2016: Carbohydrate Research
https://www.readbyqxmd.com/read/26633337/accurate-mass-gc-lc-quadrupole-time-of-flight-mass-spectrometry-analysis-of-fatty-acids-and-triacylglycerols-of-spicy-fruits-from-the-apiaceae-family
#19
Thao Nguyen, Mario Aparicio, Mahmoud A Saleh
The triacylglycerol (TAG) structure and the regio-stereospecific distribution of fatty acids (FA) of seed oils from most of the Apiaceae family are not well documented. The TAG structure ultimately determines the final physical properties of the oils and the position of FAs in the TAG molecule affects the digestion; absorption and metabolism; and physical and technological properties of TAGs. Fixed oils from the fruits of dill (Anethum graveolens), caraway (Carum carvi), cumin (Cuminum cyminum), coriander (Coriandrum sativum), anise (Pimpinella anisum), carrot (Daucus carota), celery (Apium graveolens), fennel (Foeniculum vulgare), and Khella (Ammi visnaga), all from the Apiaceae family, were extracted at room temperature in chloroform/methanol (2:1 v/v) using percolators...
December 2, 2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26504532/identification-of-ssrs-and-differentially-expressed-genes-in-two-cultivars-of-celery-apium-graveolens-l-by-deep-transcriptome-sequencing
#20
Meng-Yao Li, Feng Wang, Qian Jiang, Jing Ma, Ai-Sheng Xiong
Celery (Apium graveolens L.) is one of the most important and widely grown vegetables in the Apiaceae family. Due to the lack of comprehensive genomic resources, research on celery has mainly utilized physiological and biochemical approaches, rather than molecular biology, to study this crop. Transcriptome sequencing has become an efficient and economic technology for obtaining information on gene expression that can greatly facilitate molecular and genomic studies of species for which a sequenced genome is not available...
2014: Horticulture Research
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