Xiaodong Liu, Ke Zhang, Neslihan A Kaya, Zhe Jia, Dafei Wu, Tingting Chen, Zhiyuan Liu, Sinan Zhu, Axel M Hillmer, Torsten Wuestefeld, Jin Liu, Yun Shen Chan, Zheng Hu, Liang Ma, Li Jiang, Weiwei Zhai
Solid tumors are complex ecosystems with heterogeneous 3D structures, but the spatial intra-tumor heterogeneity (sITH) at the macroscopic (i.e., whole tumor) level is under-explored. Using a phylogeographic approach, we sequence genomes and transcriptomes from 235 spatially informed sectors across 13 hepatocellular carcinomas (HCC), generating one of the largest datasets for studying sITH. We find that tumor heterogeneity in HCC segregates into spatially variegated blocks with large genotypic and phenotypic differences...
April 12, 2024: Nature Communications