keyword
MENU ▼
Read by QxMD icon Read
search

hydroquinone

keyword
https://www.readbyqxmd.com/read/28712944/a-fe3o4-au-basedpseudo-homogeneous-electrochemical-immunosensor-for-afp-measurement-using-afp-antibody-gnps-hrp-as-detection-probe
#1
Yulin Yuan, Shanshan Li, Yewei Xue, Jintao Liang, Lijie Cui, Qingbo Li, Sufang Zhou, Yong Huang, Guiyin Li, Yongxiang Zhao
In this study, a Fe3O4@Au-based pseudo-homogeneous electrochemical immunosensor was prepared for detection of alpha fetoprotein (AFP), a well-known hepatocellular carcinoma biomarker. The primary antibody (Ab1) was immobilized on Fe3O4@Au NPs as the capture probe. Horseradish peroxidase (HRP) and secondary antibody (Ab2) were conjugated on gold nanoparticles (GNPs) through electrostatic adsorption to form signal-amplifying labels. In the presence of AFP, a sandwich immunocomplex was formed via specific recognition of antigen-antibody in a Fe3O4@Au-basedpseudo-homogeneousreaction system...
July 13, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28710816/electrochemical-and-structural-characterization-of-azotobacter-vinelandii-flavodoxin-ii
#2
Helen M Segal, Thomas Spatzal, Michael G Hill, Andrew K Udit, Douglas C Rees
Azotobacter vinelandii flavodoxin II serves as a physiological reductant of nitrogenase, the enzyme system mediating biological nitrogen fixation. Wildtype A. vinelandii flavodoxin II was electrochemically and crystallographically characterized to better understand the molecular basis for this functional role. The redox properties were monitored on surfactant-modified basal plane graphite electrodes, with two distinct redox couples measured by cyclic voltammetry corresponding to reduction potentials of -483 ± 1 mV and -187 ± 9 mV (vs...
July 14, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28704378/characterizing-properties-of-non-estrogenic-substituted-bisphenol-analogs-using-high-throughput-microscopy-and-image-analysis
#3
Adam T Szafran, Fabio Stossi, Maureen G Mancini, Cheryl L Walker, Michael A Mancini
Animal studies have linked the estrogenic properties of bisphenol A (BPA) to adverse effects on the endocrine system. Because of concerns for similar effects in humans, there is a desire to replace BPA in consumer products, and a search for BPA replacements that lack endocrine-disrupting bioactivity is ongoing. We used multiple cell-based models, including an established multi-parametric, high throughput microscopy-based platform that incorporates engineered HeLa cell lines with visible ERα- or ERβ-regulated transcription loci, to discriminate the estrogen-like and androgen-like properties of previously uncharacterized substituted bisphenol derivatives and hydroquinone...
2017: PloS One
https://www.readbyqxmd.com/read/28698513/anti-inflammatory-activity-of-citric-acid-treated-wheat-germ-extract-in-lipopolysaccharide-stimulated-macrophages
#4
Hee-Yeong Jeong, Yong-Seok Choi, Jae-Kang Lee, Beom-Joon Lee, Woo-Ki Kim, Hee Kang
Until recently, fermentation was the only processing used to improve the functionality of wheat germ. The release of 2,6-dimethoxy-1,4-benzoquinone (DMBQ) from hydroquinone glycosides during the fermentation process is considered a marker of quality control. Here, we treated wheat germ extract with citric acid (CWG) to release DMBQ and examined the anti-inflammatory activity of this extract using a lipopolysaccharide-activated macrophage model. Treatment of wheat germ with citric acid resulted in detectable release of DMBQ but reduced total phenolic and total flavonoid contents compared with untreated wheat germ extract (UWG)...
July 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28698451/phenolics-from-mikania-micrantha-and-their-antioxidant-activity
#5
Li-Mei Dong, Xu-Chao Jia, Qing-Wen Luo, Qiang Zhang, Bi Luo, Wen-Bin Liu, Xu Zhang, Qiao-Lin Xu, Jian-Wen Tan
A phytochemical study on the aerial parts of Mikania micrantha led to the isolation of two new phenolic compounds, benzyl 5-O-β-d-glucopyranosyl-2,5-dihydroxybenzoate (1) and (7S,8R)-threo-dihydroxydehydrodiconiferyl alcohol 9-acetate (2), together with twelve known compounds, benzyl 2-O-β-d-glucopyranosyl-2,6-dihydroxybenzoate (3), 4-allyl-2,6-dimethoxyphenol glucoside (4), (+)-isolariciresinol (5), icariol A₂ (6), 9,10-dihydroxythymol (7), 8,9,10-trihydroxythymol (8), caffeic acid (9), p-coumaric acid (10), ethyl protocatechuate (11), procatechuic aldehyde (12), 4-hydroxybenzoic acid (13), and hydroquinone (14)...
July 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28697309/identification-of-natural-products-that-inhibit-the-catalytic-function-of-human-tyrosyl-dna-phosphodiesterase-tdp1
#6
Alun Bermingham, Edmund Price, Christophe Marchand, Adel Chergui, Alena Naumova, Emily L Whitson, Lauren R H Krumpe, Ekaterina I Goncharova, Jason R Evans, Tawnya C McKee, Curtis J Henrich, Yves Pommier, Barry R O'Keefe
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an enzyme crucial for cleavage of the covalent topoisomerase 1-DNA complex, an intermediate in DNA repair. TDP1 plays a role in reversing inhibition of topoisomerase I by camptothecins, a series of potent and effective inhibitors used in the treatment of colorectal, ovarian, and small-cell lung cancers. It is hypothesized that inhibition of TDP1 activity may enhance camptothecin sensitivity in tumors. Here, we describe the design, development, and execution of a novel assay to identify inhibitors of TDP1 present in natural product extracts...
July 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28692300/selected-mutations-revealed-intermediates-and-key-precursors-in-the-biosynthesis-of-polyketide-terpenoid-hybrid-sesquiterpenyl-epoxy-cyclohexenoids
#7
Lin-Lin Teng, Tian-Yang Song, Zi-Fei Xu, Xiao Liu, Rong Dai, Yong-Hong Chen, Sheng-Hong Li, Ke-Qin Zhang, Xue-Mei Niu
Sesquiterpenyl epoxy-cyclohexenoids (SECs) show impressive biological activities. However, the key pathways for SECs still remain unambiguous. Unexpectedly, 11 new SECs and derivatives with diverse oxidation patterns were isolated after the deletion of gene 274. A high accumulation of toluquinol and its new glycosides in mutant Δ276 and further isolation of the most crucial precursors farnesyl hydroquinone, farnesyl quinone, and three new derivatives from mutant Δ278 confirm that farnesylation at toluquinol is the key step for SECs...
July 10, 2017: Organic Letters
https://www.readbyqxmd.com/read/28691796/oxidation-of-a-dimethoxyhydroquinone-by-ferrihydrite-and-goethite-nanoparticles-iron-reduction-versus-surface-catalysis
#8
Lelde Krumina, Gry Lyngsie, Anders Tunlid, Per Persson
Hydroquinones are important mediators of electron transfer reactions in soils with a capability to reduce Fe(III) minerals and molecular oxygen, and thereby generating Fenton chemistry reagents. This study focused on 2,6-dimethoxy hydroquinone (2,6-DMHQ), an analogue to a common fungal metabolite, and its reaction with ferrihydrite and goethite under variable pH and oxygen concentrations. Combined wet-chemical and spectroscopic analyses showed that both minerals effectively oxidized 2,6-DMHQ in the presence of oxygen...
July 10, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28676942/-dangerous-cosmetic-products-in-germany-analysis-of-the-rapex-database-of-the-european-commission
#9
P Elsner, S Schliemann
BACKGROUND: Cosmetic products are subject to the European Cosmetics Regulation: They shall not harm human health when used under "normal or reasonably foreseeable conditions". Hazardous cosmetic products are reported by the EU Member States to the EU Commission and are listed in the database of the European Rapid Alert System RAPEX. MATERIAL AND METHODS: The reports from Germany on dangerous cosmetic products from the years 2005-3/2017 in the European RAPEX database were systematically analyzed...
July 4, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28675931/new-insights-on-gas-hydroquinone-clathrates-using-in-situ-raman-spectroscopy-formation-dissociation-mechanisms-kinetics-and-capture-selectivity
#10
Romuald Coupan, Eve Péré, Christophe Dicharry, Jean-Philippe Torré
Hydroquinone (HQ) is known to form organic clathrates with different gaseous species over a wide range of pressures and temperatures. However, the enclathration reaction involving HQ is not fully understood to date. This work offers new elements of understanding on HQ clathrate formation and dissociation mechanisms. The kinetics and selectivity of the enclathration reaction were also investigated. The focus was placed on HQ clathrates formed with CO2 and CH4 as guest molecules for potential use in practical applications for the separation of a CO2/CH4 gas mixture...
July 5, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28657098/adsorption-on-graphene-flat-to-edge-to-end-transitions-of-phenyl-hydroquinone
#11
Lifu Chen, Eden E L Tanner, Richard G Compton
The adsorption of phenyl hydroquinone (PHQ) on graphene surfaces at the liquid-solid interface is investigated revealing a flat orientation and two different vertically adsorbed states of PHQ on graphene nanoplatelets (GNPs), namely edgewise or endwise adsorption. The transition between these states is driven by increasing concentrations of PHQ in solution leading to increased absolute coverages on the graphene surface. At low adsorbate concentrations (≤21 mM), the adsorption process is also shown to be Langmuirian with an adsorption constant of (9...
July 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28656942/formulation-characterisation-and-in-vitro-skin-diffusion-of-nanostructured-lipid-carriers-for-deoxyarbutin-compared-to-a-nanoemulsion-and-conventional-cream
#12
Rendra P Tofani, Yeyet C Sumirtapura, Sasanti T Darijanto
The long-term use of topical hydroquinone as an anti-hyperpigmentation treatment has well-known, unwanted effects. Deoxyarbutin (4-[(tetrahydro-2H-pyran-2-yl)oxy]phenol) is a relatively new tyrosinase inhibitor, with stronger inhibitory potency than hydroquinone, that exhibited decreased cytotoxicity against melanocytes and other cells. This study developed novel nanostructured lipid carriers (NLCs) for improved topical delivery of deoxyarbutin (dArb), leading to improved depigmenting efficacy. dArb is a hydrophobic substance, but it easily degrades in aqueous medium and is thermolabile...
July 20, 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28645578/the-electrophilic-character-of-quinones-is-essential-for-the-suppression-of-bach1
#13
Chuanyang Su, Zixuan Liu, Yawen Wang, Yuxin Wang, Erqun Song, Yang Song
The activation of nuclear factor erythroid 2-related factor 2 (Nrf2) is the most important cellular defense mechanisms against oxidative attack. BTB and CNC homology-1 (Bach1), like Kelch-like ECH-associated protein 1 (Keap1), is one of a negative regulator of Nrf2 that control antioxidant response elements (ARE)-dependent gene expressions. In the current study, we found that quinones show greater capacity than hydroquinones in nuclear Bach1 export, as well as ubiquitin-dependent Bach1 degradation in our experimental time frame...
June 20, 2017: Toxicology
https://www.readbyqxmd.com/read/28643461/single-enzyme-biofuel-cells
#14
Chao Ji, Jingwei Hou, Kai Wang, Yun Hau Ng, Vicki Chen
Here, we firstly demonstrate that the intramolecular electron transfer within signle enzyme molecule is an important alternative pathway which can be harnessed to generate electricity. By decoupling the redox reactions within a single type of enzyme (e.g., Trametes versicolor laccase), we harvested electricity efficiently from unconventional fuels including recalcitrant pollutants (e.g. bisphenol-A and hydroquinon) in a single-laccase biofuel cell. The intramolecular electron-harnessing concept was further demonstrated with other enzymes, including power generation during CO2 bioconversion to formate catalyzed by formate dehydrogenase from Candida boidinii...
June 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28613329/mono-and-di-nuclear-re-i-complexes-and-the-role-of-protonable-nitrogen-atoms-in-quenching-emission-by-hydroquinone
#15
Karina P Morelli Frin, Rafael M de Almeida
Mono-nuclear fac-[Re(CO)3(ph2phen)(4,4'-bpy)](+) and di-nuclear [(ph2phen)(CO)3Re(4,4'-bpy)Re(ph2phen)(CO)3](2+) complexes, ph2phen = 4,7-diphenyl-1,10-phenanthroline and 4,4'-bpy = 4,4'-bipyridine, were synthesized and characterized by (1)H NMR, UV-visible and FT-IR spectroscopy. Also, their photophysical properties were investigated using steady-state and time-resolved emission spectroscopy. Both complexes showed UV absorption assigned to intraligand, (1)ILph2phen, and metal-to-ligand charge transfer, (1)MLCTRe→ph2phen, transitions, and typical (3)MLCTRe→ph2phen emission (ϕ = 0...
June 14, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28607861/a-deceptively-simple-solution-for-refractory-melasma-glycolic-acid-peels-and-hydroquinone-at-home
#16
Takanobu Mashiko, Aiko Oka, Ema Osawa, Isao Koshima
Although various treatment methods for melasma have developed, substantial improvement of the condition is sometimes difficult. We have experientially found that some of refractory melasma caused by daily friction can easily be treated by using a combination of a peeling agent (20% glycolic acid) and a depigmenting agent (5% hydroquinone) twice daily at home. And here, by performing skin biopsies, we revealed the pathological mechanism: hyperkeratosis caused by repeated physical stimulus, which prevents infiltration of topical therapeutic agents, was dramatically reduced by chemical peeling, resulting that the melanin pigments were effectively cleared by topical hydroquinone...
May 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28605976/anti-mutagenic-potential-of-algal-extracts-on-chromosomal-aberrations-in-allium-cepa-l
#17
Hoda Anwer Mansour, Hala Mahfouz, Nesma Maher
In the present study, sodium azide (SA) toxicity and the anti-mutagenic effects of different algal extracts at 0.1% and 0.2% concentrations were studied on the mitotic index (MI), chromosomal and nuclear aberrations using Allium cepa L. root assay. Moreover, phytochemical screening of photosynthetic pigments, antioxidants compounds, total antioxidant, DPPH scavenging activity, polysaccharides, and phenolic contents were done for two red seaweeds (Laurencia obtusa (Hudson) Lamouroux and Polysiphonia morrowii Harvey) and for one brown seaweed (Dictyopteris delicatula Lamouroux)...
June 2017: Acta Biologica Hungarica
https://www.readbyqxmd.com/read/28586208/measurement-and-modeling-of-setschenow-constants-for-selected-hydrophilic-compounds-in-nacl-and-cacl2-simulated-carbon-storage-brines
#18
Aniela Burant, Gregory V Lowry, Athanasios K Karamalidis
Carbon capture, utilization, and storage (CCUS), a climate change mitigation strategy, along with unconventional oil and gas extraction, generates enormous volumes of produced water containing high salt concentrations and a litany of organic compounds. Understanding the aqueous solubility of organic compounds related to these operations is important for water treatment and reuse alternatives, as well as risk assessment purposes. The well-established Setschenow equation can be used to determine the effect of salts on aqueous solubility...
June 6, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28585648/the-controlled-synthesis-of-pillar-6-arene-based-hexagonal-cylindrical-structures-on-an-electrode-surface-via-electrochemical-oxidation
#19
Chiaki Tsuneishi, Yuki Koizumi, Ryuta Sueto, Hiroki Nishiyama, Kazuma Yasuhara, Tada-Aki Yamagishi, Tomoki Ogoshi, Ikuyoshi Tomita, Shinsuke Inagi
Electrochemical oxidation of pillar[6]arene containing six hydroquinones resulted in the formation of hexagonal cylindrical structures on an electrode surface driven by charge transfer interaction. The electrochemical approach successfully controlled the size and shape of the structures.
July 4, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28583673/high-level-de-novo-biosynthesis-of-arbutin-in-engineered-escherichia-coli
#20
Xiaolin Shen, Jia Wang, Jian Wang, Zhenya Chen, Qipeng Yuan, Yajun Yan
Arbutin is a hydroquinone glucoside compound existing in various plants. It is widely used in pharmaceutical and cosmetic industries owing to its well-known skin-lightening property as well as anti-oxidant, anti-microbial, and anti-inflammatory activities. Currently, arbutin is usually produced by plant extraction or enzymatic processes, which suffer from low product yield and expensive processing cost. In this work, we established an artificial pathway in Escherichia coli for high-level production of arbutin from simple carbon sources...
June 2, 2017: Metabolic Engineering
keyword
keyword
95158
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"