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Sen Zhang, Huan Chen, An Wang, Yong Liu, Hongwei Hou, Qingyuan Hu
To evaluate the genotoxic effects of formaldehyde, acetaldehyde, acrolein and benzene on A549 cells, the in vitro γH2AX assay was used in combination with high content screening (HCS) technology. All aldehydes showed a significant genotoxicity in a dose/time-dependent effect on the induction of γH2AX. Benzene failed to show a significant genotoxicity based on the γH2AX assay. However, hydroquinone (one of metabolites of benzene) showed a significant genotoxicity in vitro. Based on the dose-response of γH2AX and Hill model, the ability to induce DNA double-strand break can be evaluated as acrolein>formaldehyde>acetaldehyde>benzene...
July 18, 2017: Environmental Toxicology and Pharmacology
Gangbing Zhu, Heng Sun, Junjuan Qian, Xiangyang Wu, Yinhui Yi
The simultaneous and sensitive electrochemical detection of dihydroxybenzene isomers (hydroquinone, HQ; catechol, CC; resorcinol, RS) is of great significance because such isomers can be awfully harmful to the environment and human health. In this paper, by preparing poly(L-arginine) modified glassy carbon electrode (P-L-Arg/GCE) with a simple method, a highly sensitive electrochemical sensor for simultaneously detecting HQ, CC and RS was constructed successfully due to the large surface area, good electronic properties and catalytic ability of P-L-Arg/GCE and the electrostatic action between P-L-Arg (positive) and targets (negative)...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Xin Liu, Yuhan Zhu, Kai Yan, Jingdong Zhang
Photovoltammetric behaviors of irreversible, quasi-reversible and reversible electrochemical systems represented by 2,4-dichlophenol (DCP), hydroquinone (HQ) and K3[Fe(CN)6], respectively, were investigated on a CdS-graphene hybrid film electrode. The cyclic voltammetric (CV) curves of HQ and K3[Fe(CN)6] showing a pair of redox peaks became sigmoidal in shape under visible light irradiation. In contrast, the CV curve shape of DCP showing an oxidation peak was not changed under photoirradiation, although the oxidation peak current was enhanced by the photoelectrocatalysis...
August 8, 2017: Chemistry: a European Journal
Yan Tai, Chuan Wang, Zhihua Wang, Yi Liang, Junying Du, Dongwei He, Xiaoyan Fan, Sven-Eric Jordt, Boyi Liu
Hydroquinone (HQ) is one of the most frequently used and effective skin-lightening products to treat skin hyperpigmentation disorders, including postinflammatory hyperpigmentation, melasma and solar lentigines. HQ is also widely used in cosmetic products for skin whitening. However, HQ treatment can evoke substantial skin irritation, a side effect that remains poorly understood. Here we demonstrate that HQ is an activator of the peripheral irritant receptor transient receptor potential (TRP) cation channel member A1 (TRPA1)...
August 8, 2017: Scientific Reports
Song Wu, Guodong Fang, Yu-Jun Wang, Yue Zheng, Chao Wang, Feng Zhao, Deb P Jaisi, Dongmei Zhou
Carbonaceous materials are commonly used in agronomic and environmental applications primarily as geosorbents but their redox properties that may affect biogeochemical reactions are rarely documented. Herein, the role of activated carbon (AC) mediating microbial reduction of ferrihydrite is studied. Our batch experiment results show that ACs facilitated the reduction of ferrihydrite by Shewanella oneidensis MR-1, but the pretreatment of ACs with HNO3 further increased the rate of reduction. The redox active oxygen-containing functional groups in ACs were found to be responsible for the enhancement of the microbial reduction of ferrihydrite...
August 7, 2017: Environmental Science & Technology
Braddock A Sandoval, Andrew J Meichan, Todd K Hyster
Flavin has long been known to function as a single electron reductant in biological settings, but this reactivity has rarely been observed with flavoproteins used in organic synthesis. Here we describe the discovery of an enantioselective radical dehalogenation pathway for α-bromoesters using flavin-dependent 'ene'-reductases. Mechanistic experiments support the role of flavin hydroquinone as a single electron reductant, flavin semiquinone as the hydrogen atom source, and the enzyme as the source of chirality...
August 11, 2017: Journal of the American Chemical Society
You Zhang, Xiuguo Cui, Lei Zu, Xiaomin Cai, Yang Liu, Xiaodong Wang, Huiqin Lian
Redox electrolytes can provide significant enhancement of capacitance for supercapacitors. However, more important promotion comes from the synergetic effect and matching between the electrode and electrolyte. Herein, we report a novel electrochemical system consisted of a polyanilline/carbon nanotube composite redox electrode and a hydroquinone (HQ) redox electrolyte, which exhibits a specific capacitance of 7926 F/g in a three-electrode system when the concentration of HQ in H₂SO₄ aqueous electrolyte is 2 mol/L, and the maximum energy density of 114 Wh/kg in two-electrode symmetric configuration...
August 29, 2016: Materials
Jessica M Sapiro, Terrence J Monks, Serrine S Lau
Although all-trans-retinoic acid (ATRA) provides protection against a variety of conditions in vivo, particularly ischemia, the molecular mechanisms underpinning these effects remain unclear. The present studies were designed to assess potential mechanisms by which ATRA affords cytoprotection against renal toxicants in LLC-PK1 cells. Pretreatment of LLC-PK1 cells with ATRA (25 μM) for 24 hr afforded cytoprotection against oncotic cell death induced by p-aminophenol (PAP), 2-(glutathion-S-yl)hydroquinone (MGHQ), and iodoacetamide but not against apoptotic cell death induced by cisplatin...
August 2, 2017: American Journal of Physiology. Renal Physiology
Carolina V Uliana, Camila R Peverari, André S Afonso, Marcia R Cominetti, Ronaldo C Faria
A novel fully disposable microfluidic electrochemical array device (µFED) was developed and successfully applied for detection of the biomarker estrogen receptor alpha (ERα). The µFED was constructed using low-cost materials and an inexpensive home cutter printer enabled the manufacture of dozens of µFEDs in less than 2h, at a cost of less than US$ 0.20 in material per device. The µFED incorporates counter and reference electrodes and eight carbon-based working electrodes, which were modified with DNA sequences known as estrogen response elements (DNA-ERE), where ERα binds specifically...
July 20, 2017: Biosensors & Bioelectronics
Olga Taran
Long-distance electron transfer in marine environments couples physically separated redox half-reactions, impacting biogeochemical cycles of iron, sulfur and carbon. Bacterial bio-electrochemical systems that facilitate electron transfer via conductive filaments or across man-made electrodes are well-known, but the impact of abiotic currents across naturally occurring conductive and semiconductive minerals is poorly understood. In this paper I use cyclic voltammetry to explore electron transfer between electrodes made of common iron minerals (magnetite, hematite, pyrite, pyrrhotite, mackinawite, and greigite), and hydroquinones-a class of organic molecules found in carbon-rich sediments...
2017: Frontiers in Chemistry
Najmolsadat Atefi, Behzad Dalvand, Mahammadreza Ghassemi, Golnaz Mehran, Amir Heydarian
INTRODUCTION: Few studies have focused on therapeutic as well as side effects of tranexamic acid (TXA) as a topical drug compared to other topical drugs in treating melasma. The present study aimed to assess and compare the beneficial therapeutic effects and also side effects of local TXA in comparison with hydroquinone in treating women with melasma. METHODS: This randomized double-blinded clinical trial was performed on 60 women who suffered from melasma and were referred to the skin disorders clinic at the Rasoul-e-Akram hospital in Tehran in 2015...
July 26, 2017: Dermatology and Therapy
Bo Xu, Caiyun Xiong, Meng Deng, Junjun Li, Xianghua Tang, Qian Wu, Junpei Zhou, Yunjuan Yang, Junmei Ding, Nanyu Han, Zunxi Huang
Catechol 1,2-dioxygenase is the key enzyme that catalyzes the cleavage of the aromatic ring of catechol. We explored the genetic diversity of catechol 1,2-dioxygenase in the fecal microbial metagenome by PCR with degenerate primers. A total of 35 gene fragments of C12O were retrieved from microbial DNA in the feces of pygmy loris. Based on phylogenetic analysis, most sequences were closely related to C12O sequences from Acinetobacter. A full-length C12O gene was directly cloned, heterologously expressed in Escherichia coli, and biochemically characterized...
July 26, 2017: Journal of Basic Microbiology
Nicole K Scharko, Erin T Martin, Yaroslav Losovyj, Dennis G Peters, Jonathan D Raff
Humic acid (HA) is thought to promote NO2 conversion to nitrous acid (HONO) on soil surfaces during the day. However, it has proven difficult to identify the reactive sites in natural HA substrates. The mechanism of NO2 reduction on soil surrogates composed of HA and clay minerals was studied by use of a coated-wall flow reactor and cavity-enhanced spectroscopy. Conversion of NO2 to HONO in the dark was found to be significant and correlated to the abundance of C-O moieties in HA determined from the X-ray photoelectron spectra of the C 1s region...
August 10, 2017: Environmental Science & Technology
Min Deng, Shourui Lin, Xiangjie Bo, Liping Guo
The zirconium-based MOF (UiO-66)/mesoporous carbon (MC) composite was synthesized using conventional hydrothermal method for the first time. The surface morphology and structure of UiO-66/MC composite were characterized by scanning electron microscopy (SEM), transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). A novel electrochemical sensor based on UiO-66/MC was constructed for simultaneous and sensitive determination of dihydroxybenzene isomers (DBIs) of hydroquinone (HQ), catechol (CT) and resorcinol (RS)...
November 1, 2017: Talanta
Boxuan Liang, Yuncong Chen, Weixin Yuan, Fei Qin, Qian Zhang, Na Deng, Xuexing Liu, Xiaoju Ma, Xue Zhang, Bo Zhang, Qifei Deng, Ming Huang, Huanwen Tang, Linhua Liu, Wen Chen, Yongmei Xiao
Exposure to high-dose benzene leads to the inhibition of erythroid differentiation. However, whether lower doses of benzene exposure resemble high-dose effects in erythroid differentiation, as well as the underlying mechanisms, remains largely unknown. To identify the microRNAs (miRNAs) specifically responsible for benzene exposure and their regulatory role in erythroid differentiation, we performed miRNA microarray in CD34(+) hematopoietic progenitor cells isolated from human umbilical cord blood after treatment with hydroquinone (HQ), a metabolite of benzene at concentrations of 0, 1...
July 21, 2017: Archives of Toxicology
Natalia Villota, Jose M Lomas, Luis M Camarero
Analysis of the kinetics of aqueous phenol oxidation by a sono-Fenton process reveals that the via involving ortho-substituted intermediates prevails: catechol (25.0%), hydroquinone (7.7%) and resorcinol (0.6%). During the oxidation, water rapidly acquires color that reaches its maximum intensity at the maximum concentration of p-benzoquinone. Turbidity formation occurs at a slower rate. Oxidant dosage determines the nature of the intermediates, being trihydroxylated benzenes (pyrogallol, hydroxyhydroquinone) and muconic acid the main precursors causing turbidity...
November 2017: Ultrasonics Sonochemistry
Joel Thomas Kirner, Richard G Finke
A planar organic thin-film composed of a perylene diimide dye (N,N´-bis(phosphonomethyl)-3,4,9,10-perylenediimide, PMPDI) with photoelectrochemically deposited cobalt oxide (CoOx) catalyst was previously shown to photoelectrochemically oxidize water (DOI: 10.1021/am405598w). Herein, the same PMPDI dye is studied for the sensitization of different nanostructured metal oxide (nano-MOₓ) films in a dye-sensitized photoelectrochemical cell architecture. Dye adsorption kinetics and saturation decreases in the order TiO₂ > SnO₂ > WO₃...
July 20, 2017: ACS Applied Materials & Interfaces
Matthew Pevarnik, Weibin Cui, Sukru Yemenicioglu, Justin Rofeh, Luke Theogarajan
Voltage gating is essential to the computational ability of neurons. We show this effect can be mimicked in a solid-state nanopore by functionalizing the pore interior with a redox active molecule. We study the integration of an active biological molecule, a quinone, into a solid state nanopore and its subsequent induced voltage gating. We show that the voltage gating effect mimics biological gating systems in its classic sigmoidal voltage response, unlike previous synthetic voltage gating systems. Initially the quinone undergoes a reduction due to radicals in the bulk solution and is converted to the hydroquinone state...
July 20, 2017: Bioinspiration & Biomimetics
Oluwatobi A Ogbechie-Godec, Nada Elbuluk
Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types. Multiple etiologies, including light exposure, hormonal influences, and family history, have been implicated in the pathogenesis of this disorder. Overall prevalence ranges widely at 1-50%, since values are typically calculated within a specific ethnic population within a geographic region. Histologically, melasma can display increased epidermal and/or dermal pigmentation, enlarged melanocytes, increased melanosomes, solar elastosis, dermal blood vessels, and, occasionally, perivascular lymphohistiocytic infiltrates...
July 19, 2017: Dermatology and Therapy
Yulin Yuan, Shanshan Li, Yewei Xue, Jintao Liang, Lijie Cui, Qingbo Li, Sufang Zhou, Yong Huang, Guiyin Li, Yongxiang Zhao
In this study, a Fe3O4@Au-based pseudo-homogeneous electrochemical immunosensor was prepared for detection of alpha fetoprotein (AFP), a well-known hepatocellular carcinoma biomarker. The primary antibody (Ab1) was immobilized on Fe3O4@Au NPs as the capture probe. Horseradish peroxidase (HRP) and secondary antibody (Ab2) were conjugated on gold nanoparticles (GNPs) through electrostatic adsorption to form signal-amplifying labels. In the presence of AFP, a sandwich immunocomplex was formed via specific recognition of antigen-antibody in a Fe3O4@Au-basedpseudo-homogeneousreaction system...
October 1, 2017: Analytical Biochemistry
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