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Zhenghui Hu, Pengyu Ni, Qun Wan, Yan Zhang, Pengcheng Shi, Qiang Lin
Changes in BOLD signals are sensitive to the regional blood content associated with the vasculature, which is known as V0 in hemodynamic models. In previous studies involving dynamic causal modeling (DCM) which embodies the hemodynamic model to invert the functional magnetic resonance imaging signals into neuronal activity, V0 was arbitrarily set to a physiolog-ically plausible value to overcome the ill-posedness of the inverse problem. It is interesting to investigate how the V0 value influences DCM. In this study we addressed this issue by using both synthetic and real experiments...
2016: Scientific Reports
Tezcan Kaya, Savas Sipahi, Hakan Cinemre, Cengiz Karacaer, Ceyhun Varim, Ahmet Nalbant, Ali Tamer
BACKGROUND: Some studies have shown an increased relative risk of death for patients with higher levels of Kt/V, which may be associated with marked malnutrition. OBJECTIVE: The aim of this study was to investigate the relationship between the target dose for hemodialysis adequacy, as measured by Kt/V, and various nutritional parameters in hemodialysis patients. DESIGN: Cross-sectional. SETTINGS: Sakarya University Faculty of Medicine, Turkey between February 2014 and March 2014...
March 2016: Annals of Saudi Medicine
John S Thurlow, Christina M Yuan
Intradialytic hypotension is the most common complication associated with hemodialysis. We describe a case of severe intradialytic hypotension during routine chronic dialysis, the presenting symptom of hypocalcemia due to a procedural error involving a zero calcium liquid acid dialysate concentrate. Although human factors were the root cause of this event, we discuss physical and procedural controls that may help to minimize the risk of human error. Citrate anticoagulation for renal replacement therapy is increasingly used, particularly in acute kidney injury...
April 2016: Hemodialysis International
M Ryuzaki, H Nakamoto, K Hosoya, M Komatsu, Y Hibino
OBJECTIVE: Blood pressure (BP) variability correlates with cardio-vascular disease as BP level itself. There is not known easy way to evaluate the BP variability in clinic.To evaluate the usefulness of maximum-minimum difference (MMD) of BP in a month compared to standard deviation (SD), as an index of BP variability. DESIGN AND METHOD: Study-1: Twelve patients (age 65.9 ± 12.1 y/o) were enrolled. Measurements of home systolic (S) BP were required in the morning...
June 2015: Journal of Hypertension
Ling-Yu Tsai, Chiu-Chu Lin
When a patient aggressively receives treatment and looks forward to returning home, the prolonging of meaningful life is difficult, even with medical treatment. It is typically very challenging at this juncture for the members of the medical team to fully disclose to the patient the true extent of his / her condition and to recommend the withdrawal of life-support medical treatment. This article describes a nursing care experience with a renal cell carcinoma patient with subcutaneous metastasis. Her pain was induced by an edema and subcutaneous tumor in her lower limbs, which diminished the effectiveness of hemodialysis...
June 2015: Hu Li za Zhi the Journal of Nursing
Yasuo Kudoh, Shinya Aoyama, Takaaki Torii, Qijie Chen, Daigo Nagahara, Hiromi Sakata, Akihiko Nozawa
BACKGROUND: The therapeutic role of L-carnitine (LC) on the anemia of chronic hemodialized patients is still controversial. In order to clarify the long-term effects of LC administration on renal anemia, an open, observational 12-month study was performed. METHODS: Twenty stable outpatients undergoing hemodialysis were administered LC 900 mg p.o. daily for 12 months. The recombinant human erythropoietin (rHuEPO) dose was adjusted monthly when necessary to maintain the target hemoglobin (Hb) levels...
April 2014: Cardiorenal Medicine
Veronica Tisato, Giorgio Zauli, Sergio Gianesini, Erica Menegatti, Laura Brunelli, Roberto Manfredini, Paolo Zamboni, Paola Secchiero
The expression of proinflammatory cytokines/chemokines has been reported in in vitro/ex vivo settings of chronic venous insufficiency (CVI), but the identification of circulating mediators that might be associated with altered hemodynamic forces or might represent innovative biomarkers is still missing. In this study, the circulating levels of 31 cytokines/chemokines involved in inflammatory/angiogenic processes were analysed in (i) CVI patients at baseline before surgical hemody namic correction, (ii) healthy subjects, and (iii) CVI patients after surgery...
2014: Journal of Immunology Research
Ferenc Sztanek, Ildikó Seres, Mariann Harangi, Lajos Lőcsey, Péter Koncsos, György Paragh
BACKGROUND/METHODS: The association between nutritional status, antioxidant human paraoxonase-1 (PON1) activity and low grade inflammation in hemodialized (HD) patients with chronic kidney disease (CKD) is unclear. The aim of this study was to determine PON1 paraoxonase and lactonase activities, ADMA, adiponectin and leptin concentrations, and to clarify the relationship between paraoxonase activity and a set of cardiovascular risk factors in malnourished, normal weight and obese HD patients; 114 HD patients with end-stage renal failure were enrolled...
2012: Kidney & Blood Pressure Research
Marcin Krzanowski, Katarzyna Janda, Eve Chowaniec, Władysław Sułowicz
UNLABELLED: Infectious complications associated with vascular access are a well known cause of increased morbidity and mortality in hemodialysis patients. The aim of the study was to evaluate the incidence of hemodialysis vascular access infections and patients survival in the group of maintenance hemodialysis patients during a one year observation period. The study group consisted of 213 patients (126 male, 87 female; aged 57.4 +/- 14.9 years being on renal replacement therapy for 54 months; range: 2 to 384 months) treated by maintenance hemodialysis at the Nephrology Department of the University Hospital...
2011: Przegla̧d Lekarski
Chrisoula Pipili, Eirini Grapsa, Kostas Vasilopoulos, Helen Tzanatos
Pruritus is an alarming symptom in patients with end-stage renal disease (ESRD) accompanied by sleep disturbances and physical and mental disorders. Although its prevalence is very high among hemodialysis patients (90%), its etiology and its successful treatment have been unconfirmed (Melo N, Elias R, Castro M, Romao G, Abensur H. Pruritus in hemodialysis patients: The problem still remains. Hemodial Int. 2009;13:38-42.). Common pruritus etiologies, such as high parathyroid hormone levels, dialysis inadequacy, and iron deficiency are matters of conflict...
2012: Renal Failure
Arthur V Iansavichus, R Brian Haynes, Salimah Z Shariff, Matthew Weir, Nancy L Wilczynski, Ann McKibbon, Faisal Rehman, Amit X Garg
BACKGROUND: EMBASE is a popular database used to retrieve biomedical information. Our objective was to develop and test search filters to help clinicians and researchers efficiently retrieve articles with renal information in EMBASE. STUDY DESIGN: We used a diagnostic test assessment framework because filters operate similarly to screening tests. SETTINGS & PARTICIPANTS: We divided a sample of 5,302 articles from 39 journals into development and validation sets of articles...
July 2010: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Gianluigi Lunardi, Andrea Armirotti, Maurizio Nicodemo, Lucia Cavallini, Gianluca Damonte, Maria O Vannozzi, Marco Venturini
BACKGROUND: Intravenous temsirolimus, an inhibitor of the mammalian target of rapamycin (mTOR), is approved for the treatment of advanced renal cell carcinoma (RCC). Sirolimus, the principal metabolite of temsirolimus in humans, also exhibits mTOR inhibitory activity. OBJECTIVE: The purpose of this study was to compare the pharmacokinetics of temsirolimus and its metabolite, sirolimus, among patients with RCC not receiving dialysis and those receiving hemodialysis...
August 2009: Clinical Therapeutics
Bo-Hyung Kim, SoJeong Yi, JaeWoo Kim, Kyoung Soo Lim, Kyu-pyo Kim, BongYong Lee, Sang-Goo Shin, In-Jin Jang, Kyung-Sang Yu
BACKGROUND: Mirodenafil is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. Mirodenafil has the possibility of being administered with alcohol. OBJECTIVE: This study assessed the hemodynamic effects and pharmacokinetic properties of mirodenafil administered with alcohol. METHODS: This single-dose, randomized-sequence, open-label, crossover study was conducted in healthy male volunteers at the Clinical Trials Center, Seoul National University Hospital, Seoul, Korea...
June 2009: Clinical Therapeutics
Eva Varga, Ildikó Seres, Mariann Harangi, Ferenc Sztanek, László Asztalos, Lajos Lõcsey, Béla Borbás, János Szegedi, István Kárpáti, Gyórgy Paragh
BACKGROUND: Human paraoxonase-1 (PON1) inhibits LDL-oxidation and atherogenesis, and possesses lactonase activity. Decreased PON1 activity was found in hemodialyzed and renal transplanted patients. Cystatin C plays a protective role in atherosclerosis, and is a new, sensitive marker of renal function. The relationship between these two markers in renal failure has not been investigated. AIMS: The goal of this study was to clarify the relationship between PON1 activity, cystatin C and homocysteine in chronic renal failure...
2009: Disease Markers
Alejandro Pacheco, Rubén Torres, María Eugenia Sanhueza, Leticia Elgueta, Erico Segovia, Marcelo Cano
BACKGROUND AND OBJECTIVE: Chronic hemodialyzed patients have a low level of aerobic capacity, caused by the pathologies concomitant to renal insufficiency, according with a low level of physical activity. One of the factors that would contribute to this level of aerobic capacity is the L-carnitine deficit on skeletal muscle. However, the value of the supplementation of L-carnitine to improve the physical fitness has been controversial. The objective of this work was to evaluate the effect of the administration of L-carnitine on VO2 max in hemodialyzed patients...
April 5, 2008: Medicina Clínica
V Barrio, C Quereda, J Zamora, F García López
OBJECTIVE: To estimate whether continuous veno-venous hemodiafiltration (CVVHDF) is superior to intermittent hemodialysis (IHD) in terms of survival of adult patients with acute renal failure (ARF) admitted to the Intensive Care Unit. SELECTION OF STUDIES: Controlled clinical trials (CCT) and systematic reviews comparing CWHDF and IHD for managing ARF in adult patients (age > 19 years). Observational and case series were excluded. SEARCH SOURCES: The basic syntax <hemodiafiltration OR continuous hemodi* OR continuous dialysis) and acute renal failure and acute renal insuficiency> was used to search Pub Med and Ovid System databases...
2007: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
S Sakuraba, R Serita, S Kosugi, L I Eriksson, S G E Lindahl, J Takeda
Although it has side effects, succinylcholine is still widely used in rapid sequence induction. The aim of the present study is to evaluate the effects of pretreat ment with magnesium and precurarization of vecuroni um on succinylcholine-induced fasciculation and subse quent tracheal intubation-induced hemodynamic changes during rapid sequence induction. Fifty-five patients were allocated to three groups by a blinded randomization: Group M received saline 100 ml with magnesium 40 mg x kg(-1) for 5 min at 6...
2006: Acta Anaesthesiologica Belgica
Toru Hyodo, Takayasu Taira, Toru Takemura, Sumiko Yamamoto, Mayumi Tsuchida, Kazunari Yoshida, Toyoaki Uchida, Tadasu Sakai, Hideo Hidai, Shiro Baba
We administered 2.5 g of Shakuyaku-kanzo-to granule to 61 patients who had muscle cramp during hemodialysis (HD) sessions and examined its immediate effects. We selected 10 patients who wanted to take the drug at home, out of cases, for whom the drug was effective on the study described above and had them take the drug in the same way at the beginning of muscle cramp at home examined the effects. In the study during HD sessions, muscle cramp and its associated pain disappeared in 5.3 +/- 3.9 min on average in 54 out of 61 cases...
2006: Nephron. Clinical Practice
José Carlos Ferraz da Fonseca, Leila Melo Brasil
The article evaluates available scientific information concerning the prevalence and clinical characteristics of hepatitis C virus infection in the Brazilian Amazon, a know endemic area for hepatitis A, B and D viruses infection. All the information was obtained through extensive analysis of original and review articles and abstracts published in distinguished journals or in scientific meetings. In the Amazon Region, HCV infection prevalence rate in the general population varies from 1.1 to 2.4%. Among blood donators the prevalence rate varies from 0...
2004: Revista da Sociedade Brasileira de Medicina Tropical
Ting-Yu Liu, Wen-Ching Lin, Li-Ying Huang, San-Yuan Chen, Ming-Chien Yang
Plasma proteins were covalently immobilized onto polyacrylonitrile (PAN) membrane to evaluate the hemocompatibility and anaphylatoxin formation. This is used as a model to study the effect of protein-adsorption on the blood-contacting response of hemodializing membranes. The proteins used were either platelet-adhesion-promoting collagen (COL) or platelet-adhesion-inhibiting human serum albumin (HSA). The microstructure and characterization of the protein-immobilizing PAN membranes were evaluated by Coomassie dye assay, atomic force microscopy, X-ray photoelectron spectroscopy and water contact angle measurement...
April 2005: Biomaterials
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