Hannah J Brown, Sarah Khalife, Veena Ganesan, Pedro Escobedo, Peter Filip, Jill Jeffe, Anatoli Karas, Peter Papagiannopoulos, Paolo Gattuso, Pete S Batra, Bobby A Tajudeen
BACKGROUND: Adult and pediatric patients with chronic rhinosinusitis (CRS) may have differing philosophies in therapeutic management. Few studies have examined sinonasal tissue-level comparisons of these groups. This study examines histopathologic differences between children and adults with CRS, with the goal of understanding disease pathogenesis and optimizing medical management for both populations. METHODS: In a retrospective cohort of CRS patients who underwent functional endoscopic sinus surgery (FESS), demographic factors, pertinent comorbidities, and a structured histopathologic report of 13 variables were compared across pediatric and adult CRS patients with and without nasal polyps (pCRSwNP, pCRSsNP, aCRSwNP, aCRSsNP, respectively)...
January 2023: International Forum of Allergy & Rhinology