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https://www.readbyqxmd.com/read/29222261/symptomatic-subsegmental-pulmonary-embolism-to-treat-or-not-to-treat
#1
REVIEW
Marc Carrier, Fredrikus A Klok
The introduction of computed tomographic pulmonary angiography and its recent increasing availability has led to a significant rise in its use to help clinicians diagnose acute pulmonary embolism (PE). This has led to a significant increase in the incidence of PE diagnoses. Simultaneously, the case fatality rate of acute PE has been decreasing and no significant change in its mortality has been noted, suggesting that the additional PE diagnoses are less severe and these patients might not benefit from anticoagulation therapy...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29112137/subacute-sclerosing-panencephalitis-of-the-brainstem-as-a-clinical-entity
#2
REVIEW
Pavan S Upadhyayula, Jason Yang, John K Yue, Joseph D Ciacci
Subacute sclerosing panencephalitis (SSPE) is a rare progressive neurological disorder of early adolescence caused by persistent infection of the measles virus, which remains prevalent worldwide despite an effective vaccine. SSPE is a devastating disease with a characteristic clinical course in subcortical white matter; however, atypical presentations of brainstem involvement may be seen in rare cases. This review summarizes reports to date on brainstem involvement in SSPE, including the clinical course of disease, neuroimaging presentations, and guidelines for treatment...
November 7, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29062617/marked-atrophic-changes-of-the-brain-in-a-patient-with-subacute-sclerosing-panencephalitis
#3
Faizan Yasin, Salman Assad, Muhammad Nadeem, Mehr Zahid
Subacute Sclerosing Panencephalitis (SSPE) is a debilitating disorder associated with the measles infection in childhood. It is a very rare manifestation in children. It usually presents with measles before the age of two. We report a similar case of SSPE in a 14-year-old girl who developed this life-threatening condition in spite of receiving the measles vaccination. Despite the vaccination, the patient had suffered from measles before the age of two. This highlights the dilemma of ineffective vaccinations in developing countries...
August 21, 2017: Curēus
https://www.readbyqxmd.com/read/28954393/insulin-like-growth-factors-in-the-pathogenesis-of-neurological-diseases-in-children
#4
REVIEW
Raili Riikonen
Insulin-like growth factors play a key role for neuronal growth, differentiation, the survival of neurons and synaptic formation. The action of IGF-1 is most pronounced in the developing brain. In this paper we will try to give an answer to the following questions: Why are studies in children important? What clinical studies in neonatal asphyxia, infantile spasms, progressive encephalopathy-hypsarrhythmia-optical atrophy (PEHO) syndrome, infantile ceroid lipofuscinosis (INCL), autistic spectrum disorders (ASD) and subacute sclerosing encephalopathy (SSPE) have been carried out? What are IGF-based therapeutic strategies? What are the therapeutic approaches? We conclude that there are now great hopes for the therapeutic use of IGF-1 for some neurological disorders (particularly ASD)...
September 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28852257/subacute-sclerosing-panencephalitis-presenting-with-isolated-positive-psychotic-and-catatonic-symptoms
#5
Arpit Parmar, Rajeev Ranjan, Rajesh Sagar
Subacute sclerosing panencephalitis (SSPE) is a rare slowly progressing neurological illness. Although patients with SSPE initially present with symptoms such as myoclonic jerks, cognitive decline, and personality/behavioral changes usually, rarely pure psychiatric symptoms (e.g., mania, psychosis, and catatonia) have also been reported during the initial course of the illness. We report an unusual case of an adolescent with SSPE presenting with prominent positive psychotic and catatonic symptoms with the absence of classical symptoms of SSPE in initial course of illness and further discussed the relevant literature...
July 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28750182/subacute-sclerosing-panencephalitis-should-be-eliminated-by-measles-vaccination
#6
Wei-Liang Liu, Zhi-Xu He, Fang Li, Dian He, Rong Ai
1 patient with SSPE at 4 y. He had had measles and measles encephalitis at 7.5 months. In China, the first and the second measles immunizations are recommended at 8 months and at 18-24 months, respectively. We recommend above immunizations should be given separately at 6 months and at 12-15 months.
September 2, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28713662/subacute-sclerosing-panencephalitis-in-a-child-suffering-from-human-immunodeficiency-virus-on-highly-active-antiretroviral-therapy-can-this-be-another-instance-of-immune-reconstitution-inflammatory-syndrome
#7
Ashutosh Gupta, Suman Kushwaha, Mushbiq Manzoor, Shah Faisal Ahmad Tarfarosh
We report a 12-year-old boy with human immunodeficiency virus (HIV) who presented with rapidly progressive difficulty in ambulation. The symptoms started to worsen when he was put on antiretroviral therapy (ART). Our findings show that the dynamics of HIV-related immune suppression and highly active antiretroviral therapy (HAART) have an impact on the clinical course of Subacute sclerosing panencephalitis (SSPE). Slow progression is expected in children on HAART but in our case, we observe a complex interaction of the virus with the immune system and modification of disease course of SSPE with ART...
June 13, 2017: Curēus
https://www.readbyqxmd.com/read/28617265/a-case-of-fulminant-subacute-sclerosing-panencephalitis-presenting-with-acute-myoclonic-astatic-epilepsy
#8
Fabio Magurano, Gian Luca Marella, Antonella Marchi, Antonietta Filia, Luigi Tonino Marsella, Saverio Potenza, Roberto Massa, Paola Bucci, Melissa Baggieri, Loredana Nicoletti
The neurologic sequelae post-measles are less common than other complications measles-related and can lead to severe disability or death: primary measles encephalitis (PME), acute post-infectious measles encephalomyelitis (APME), measles inclusion body encephalitis (MIBE), and subacute sclerosing panencephalitis (SSPE). SSPE syndrome can affect people years from the acute measles virus infection, as result of the persistence of defective viral particles in brain cells. Clinical onset typically manifests with progressive intellectual deterioration, behavioral changes, and myoclonic jerks...
April 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28512208/chorioretinitis-a-potential-clue-to-the-early-diagnosis-of-subacute-sclerosing-panencephalitis
#9
Vijayabala Jeevagan, Athula Dissanayake
We describe a 36-year-old man with subacute sclerosing panencephalitis (SSPE) presenting with chorioretinitis two years before onset of other neurological features. He had neither myoclonus nor the typical EEG features of SSPE. The diagnosis was confirmed in the appropriate clinical setting by detecting elevated measles antibody titres in cerebrospinal fluid and serum. Clinicians should consider SSPE among the differential diagnoses in chorioretinitis. This is particularly so if there is macular or perimacular involvement with concurrent involvement of the optic nerve in young patients, even without other characteristic neurological symptoms...
August 2017: Practical Neurology
https://www.readbyqxmd.com/read/28387784/subacute-sclerosing-panencephalitis-the-devastating-measles-complication-that-might-be-more-common-than-previously-estimated
#10
Kristen A Wendorf, Kathleen Winter, Jennifer Zipprich, Rob Schechter, Jill K Hacker, Chris Preas, James D Cherry, Carol Glaser, Kathleen Harriman
Background: Subacute sclerosing panencephalitis (SSPE) is a fatal complication of measles. We reviewed California cases from 1998-2015 to understand risk factors for SPPE and estimate incidence. Methods: SSPE cases had clinically compatible symptoms and measles antibody detection in cerebrospinal fluid (CSF) or medical record documentation of SSPE. Cases were identified though a state death certificate search, Centers for Disease Control and Prevention reports, or investigations for undiagnosed neurologic disease...
July 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28370398/tau-aggregates-where-when-why-and-what-consequences
#11
EDITORIAL
M P Frosch
No abstract text is available yet for this article.
August 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28370167/tau-aggregates-where-when-why-and-what-consequences
#12
EDITORIAL
Matthew P Frosch
Neuropathologists have been aware of neurofibrillary tangles for more than a century following their description as part of Alois Alzheimer's initial report. Since those early days, our understanding of the relationship of this particular type of cellular inclusion associated with neurodegeneration has continually broadened. Textbooks, now a partially antiquated concept, commonly list a range of disorders as being associated with tangles -NDASH- including typical neurodegenerative diseases (Alzheimer disease [AD], forms of frontotemporal lobar degenerations [FTLD-tau], progressive supranuclear palsy [PSP], corticobasal degeneration [CBD], primary aged related tauopathy [PART]), secondary degenerative diseases such as chronic traumatic encephalopathy, metabolic disease (Niemann-Pick disease type C) and infections (SSPE)...
March 30, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28116334/ophthalmic-examination-as-a-means-to-diagnose-subacute-sclerosing-panencephalitis-an-optical-coherence-tomography-and-ultrawide-field-imaging-evaluation
#13
Koushik Tripathy, Rohan Chawla, Kanhaiya Mittal, Rajni Farmania, Pradeep Venkatesh, Sheffali Gulati
BACKGROUND: Subacute sclerosing panencephalitis (SSPE) is a potentially fatal complication of measles. The authors report a case of recurrent myoclonic jerks under investigation, whose ophthalmic examination pointed to the diagnosis. CASE PRESENTATION: A 12-year-old boy with recurrent episodes of myoclonic jerks was found to have optic disc pallor and an irregular macular scar with pigmentation in the left eye. The retinal finding proved to be a strong diagnostic clue for SSPE...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/28077023/hiv-associated-sub-acute-sclerosing-panencephalitis-an-emerging-threat
#14
Abi Manesh, Mahesh Moorthy, Rini Bandopadhyay, Priscilla Rupali
Earlier age of measles virus infection predisposes to development of sub-acute sclerosing panencephalitis (SSPE) and this risk is heightened in HIV-infected children. We describe a HIV-infected young adult on antiretroviral therapy, presenting with a non-classical, fulminant form of SSPE to highlight the unpredictable nature of measles presentation. The recent spate of measles outbreaks due to virus introduction in populations with sub-optimal vaccine coverage or waning immunity and co-existing paediatric HIV cohorts is a cause for concern...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27918576/respect-ed-rates-of-pulmonary-emboli-pe-and-sub-segmental-pe-with-modern-computed-tomographic-pulmonary-angiograms-in-emergency-departments-a-multi-center-observational-study-finds-significant-yield-variation-uncorrelated-with-use-or-small-pe-rates
#15
MULTICENTER STUDY
David Mountain, Gerben Keijzers, Kevin Chu, Anthony Joseph, Catherine Read, Gabriel Blecher, Jeremy Furyk, Chrianna Bharat, Karthik Velusamy, Andrew Munro, Kylie Baker, Frances Kinnear, Ahses Mukherjee, Gina Watkins, Paul Buntine, Georgia Livesay, Daniel Fatovich
INTRODUCTION: Overuse of CT Pulmonary Angiograms (CTPA) for diagnosing pulmonary embolism (PE), particularly in Emergency Departments (ED), is considered problematic. Marked variations in positive CTPA rates are reported, with American 4-10% yields driving most concerns. Higher resolution CTPA may increase sub-segmental PE (SSPE) diagnoses, which may be up to 40% false positive. Excessive use and false positives could increase harm vs. benefit. These issues have not been systematically examined outside America...
2016: PloS One
https://www.readbyqxmd.com/read/27770235/deep-sequencing-reveals-persistence-of-cell-associated-mumps-vaccine-virus-in-chronic-encephalitis
#16
Sofia Morfopoulou, Edward T Mee, Sarah M Connaughton, Julianne R Brown, Kimberly Gilmour, W K 'Kling' Chong, W Paul Duprex, Deborah Ferguson, Mike Hubank, Ciaran Hutchinson, Marios Kaliakatsos, Stephen McQuaid, Simon Paine, Vincent Plagnol, Christopher Ruis, Alex Virasami, Hong Zhan, Thomas S Jacques, Silke Schepelmann, Waseem Qasim, Judith Breuer
Routine childhood vaccination against measles, mumps and rubella has virtually abolished virus-related morbidity and mortality. Notwithstanding this, we describe here devastating neurological complications associated with the detection of live-attenuated mumps virus Jeryl Lynn (MuV(JL5)) in the brain of a child who had undergone successful allogeneic transplantation for severe combined immunodeficiency (SCID). This is the first confirmed report of MuV(JL5) associated with chronic encephalitis and highlights the need to exclude immunodeficient individuals from immunisation with live-attenuated vaccines...
January 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/27720540/best-clinical-practice-current-controversies-in-pulmonary-embolism-imaging-and-treatment-of-subsegmental-thromboembolic-disease
#17
REVIEW
Brit Long, Alex Koyfman
BACKGROUND: Pulmonary embolism (PE) affects >600,000 patients per year in the United States. Evaluation includes clinical decision rules, laboratory tests, and several imaging modalities. The diagnosis of PE has risen in recent years, particularly subsegmental PE (SSPE). Controversy exists concerning the diagnosis and treatment of these lesions. OBJECTIVE: We sought to provide emergency physicians with a review of the controversies surrounding PE testing and the diagnosis and treatment of SSPE...
February 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27634625/subacute-sclerosing-panencephalitis-the-foothold-in-undervaccination
#18
Rebecca L Holt, Dylan Kann, Caroline E Rassbach, Hayden T Schwenk, Jana M Ritter, Paul A Rota, Jorina Elbers
Subacute sclerosing panencephalitis (SSPE) is a fatal complication of measles infection. We present a case of a fully vaccinated 3-year-old boy who was diagnosed with and treated for autoimmune encephalitis before arriving at a diagnosis of SSPE. We discuss the challenges of diagnosing SSPE in developed countries.
December 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27612283/a-novel-peptide-derived-from-the-fusion-protein-heptad-repeat-inhibits-replication-of-subacute-sclerosing-panencephalitis-virus-in-vitro-and-in-vivo
#19
Masahiro Watanabe, Koichi Hashimoto, Yusaku Abe, Eiichi N Kodama, Ryota Nabika, Shinya Oishi, Shinichiro Ohara, Masatoki Sato, Yukihiko Kawasaki, Nobutaka Fujii, Mitsuaki Hosoya
Subacute sclerosing panencephalitis (SSPE) is a persistent, progressive, and fatal degenerative disease resulting from persistent measles virus (MV) infection of the central nervous system. Most drugs used to treat SSPE have been reported to have limited effects. Therefore, novel therapeutic strategies are urgently required. The SSPE virus, a variant MV strain, differs virologically from wild-type MV strain. One characteristic of the SSPE virus is its defective production of cell-free virus, which leaves cell-to-cell infection as the major mechanism of viral dissemination...
2016: PloS One
https://www.readbyqxmd.com/read/27575878/a-new-drug-nanocrystal-self-stabilized-pickering-emulsion-for-oral-delivery-of-silybin
#20
Tao Yi, Chuan Liu, Jiao Zhang, Fan Wang, Jirui Wang, Jifen Zhang
A new silybin nanocrystal self-stabilized Pickering emulsion (SN-SSPE) has been developed using a high pressure homogenization method to improve the oral bioavailability of silybin. Influences of homogenization pressure and drug content on the formation of SN-SSPE were studied. The morphology, structure and size of Pickering emulsion droplets were characterized using a scanning electron micrograph, confocal laser scanning microscopy and atomic force microscopy. The stability, in vitro release and in vivo oral bioavailability of SN-SSPE were investigated...
January 1, 2017: European Journal of Pharmaceutical Sciences
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