Philip M Ashton, Angeziwa Chunga Chirambo, James E Meiring, Priyanka D Patel, Maurice Mbewe, Niza Silungwe, Kenneth Chizani, Happy Banda, Robert S Heyderman, Zoe A Dyson, Peter MacPherson, Marc Y R Henrion, Kathryn E Holt, Melita A Gordon
BACKGROUND: Ciprofloxacin is the first-line drug for treating typhoid fever in many countries in Africa with a high disease burden, but the emergence of non-susceptibility poses a challenge to public health programmes. Through enhanced surveillance as part of vaccine evaluation, we investigated the occurrence and potential determinants of ciprofloxacin non-susceptibility in Blantyre, Malawi. METHODS: We conducted systematic surveillance of typhoid fever cases and antibiotic prescription in two health centres in Blantyre, Malawi, between Oct 1, 2016, and Oct 31, 2019, as part of the STRATAA and TyVAC studies...
February 14, 2024: The Lancet. Microbe