keyword
MENU ▼
Read by QxMD icon Read
search

Circadian misalignment

keyword
https://www.readbyqxmd.com/read/28211649/insufficient-sleep-in-adolescents-causes-and-consequences
#1
Judith A Owens, Miriam R Weiss
Insufficient sleep poses an important and complicated set of health risks in the adolescent population. Not only is deficient sleep (defined as both sleep duration inadequate to meet sleep needs and sleep timing misaligned with the body's circadian rhythms) at epidemic levels in this population, but the contributing factors are both complex and numerous and there are a myriad of negative physical and mental health, safety and performance consequences. Causes of inadequate sleep identified in this population include internal biological processes such as the normal shift (delay) in circadian rhythm that occurs in association with puberty and a developmentally-based slowing of the "sleep drive", and external factors including extracurricular activities, excessive homework load, evening use of electronic media, caffeine intake and early school start times...
February 17, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28164449/role-of-sleep-and-circadian-disruption-on-energy-expenditure-and-in-metabolic-predisposition-to-human-obesity-and-metabolic-disease
#2
REVIEW
A W McHill, K P Wright
Weight gain, obesity and diabetes have reached alarming levels in the developed world. Traditional risk factors such as over-eating, poor nutritional choices and lack of exercise cannot fully account for the high prevalence of metabolic disease. This review paper examines the scientific evidence on two novel risk factors that contribute to dys-regulated metabolic physiology: sleep disruption and circadian misalignment. Specifically, fundamental relationships between energy metabolism and sleep and circadian rhythms and the impact of sleep and circadian disruption on metabolic physiology are examined...
February 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28128995/later-chronotype-is-associated-with-higher-hemoglobin-a1c-in-prediabetes-patients
#3
Thunyarat Anothaisintawee, Dumrongrat Lertrattananon, Sangsulee Thamakaison, Kristen L Knutson, Ammarin Thakkinstian, Sirimon Reutrakul
The circadian system is known to play a role in glucose metabolism. Chronotype reflects the interindividual variability in the phase of entrainment. Those with later chronotype typically prefer later times in the day for different activities such as sleep or meals. Later chronotype has been shown to be associated with metabolic syndrome, increased diabetes risk and poorer glycemic control in type 2 diabetes patients. In addition, "social jetlag", a form of circadian misalignment due to a mismatch between social rhythms and the circadian clock, has been shown to be associated with insulin resistance...
January 27, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28115724/how-jet-lag-impairs-major-league-baseball-performance
#4
Alex Song, Thomas Severini, Ravi Allada
Laboratory studies have demonstrated that circadian clocks align physiology and behavior to 24-h environmental cycles. Examination of athletic performance has been used to discern the functions of these clocks in humans outside of controlled settings. Here, we examined the effects of jet lag, that is, travel that shifts the alignment of 24-h environmental cycles relative to the endogenous circadian clock, on specific performance metrics in Major League Baseball. Accounting for potential differences in home and away performance, travel direction, and team confounding variables, we observed that jet-lag effects were largely evident after eastward travel with very limited effects after westward travel, consistent with the >24-h period length of the human circadian clock...
February 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28095256/evaluation-of-a-psychomotor-vigilance-task-for-touch-screen-devices
#5
Lucia Arsintescu, Jeffrey B Mulligan, Erin E Flynn-Evans
OBJECTIVE: Our goals were to compare three techniques for performing a psychomotor vigilance task (PVT) on a touch screen device (fifth-generation iPod) and to determine the device latency. BACKGROUND: The PVT is a reaction-time test that is sensitive to sleep loss and circadian misalignment. Several PVT tests have been developed for touch screen devices, but unlike the standard PVT developed for laboratory use, these tests allow for touch responses to be recorded at any location on the device, with contact from any finger...
January 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28090585/circadian-forced-desynchrony-of-the-master-clock-leads-to-phenotypic-manifestation-of-depression-in-rats
#6
Miriam Ben-Hamo, Tracy A Larson, Leanne S Duge, Carl Sikkema, Charles W Wilkinson, Horacio O de la Iglesia, Mónica M C González
In mammals, a master circadian clock within the suprachiasmatic nucleus (SCN) of the hypothalamus maintains the phase coherence among a wide array of behavioral and physiological circadian rhythms. Affective disorders are typically associated with disruption of this fine-tuned "internal synchronization," but whether this internal misalignment is part of the physiopathology of mood disorders is not clear. To date, depressive-like behavior in animal models has been induced by methods that fail to specifically target the SCN regulation of internal synchronization as the mode to generate depression...
November 2016: ENeuro
https://www.readbyqxmd.com/read/27997888/rasd1-knockdown-results-in-failure-of-oocyte-maturation
#7
Youngeun Lee, Kyeoung-Hwa Kim, Hyemin Yoon, Ok-Hee Lee, Eunyoung Kim, Miseon Park, Hoon Jang, Kwonho Hong, Hyuk Song, Jung Jae Ko, Woo Sik Lee, Kyung-Ah Lee, Eun Mi Chang, Youngsok Choi
BACKGROUND: Ras dexamethasone-induced protein (RASD1) is a member of Ras superfamily of small GTPases. RASD1 regulates various signaling pathways involved in iron homeostasis, growth hormone secretion, and circadian rhythm. However, RASD1 function in oocyte remains unknown. METHODS: Using immunohistochemistry, immunofluorescence, and quantitative real-time RT-PCR, RASD1 expression in mouse ovary and RASD1 role in oocyte maturation-related gene expression, spindle formation, and chromosome alignment were analyzed...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27929109/a-novel-method-to-visualise-and-quantify-circadian-misalignment
#8
Dorothee Fischer, Céline Vetter, Till Roenneberg
The circadian clock governs virtually all processes in the human body, including sleep-wake behaviour. Circadian misalignment describes the off-set between sleep-wake cycles and clock-regulated physiology. This strain is predominantly caused by external (societal) demands including shift work, early school start times and fast travels across time zones. Sleeping at the 'wrong' internal time can jeopardise health and safety, and we therefore need a good quantification of this phenomenon. Here, we propose a novel method to quantify the mistiming of sleep-wake rhythms and demonstrate its versatility in day workers and shift workers...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27829142/sensory-conflict-disrupts-activity-of-the-drosophila-circadian-network
#9
Ross E F Harper, Peter Dayan, Joerg T Albert, Ralf Stanewsky
Periodic changes in light and temperature synchronize the Drosophila circadian clock, but the question of how the fly brain integrates these two input pathways to set circadian time remains unanswered. We explore multisensory cue combination by testing the resilience of the circadian network to conflicting environmental inputs. We show that misaligned light and temperature cycles can lead to dramatic changes in the daily locomotor activities of wild-type flies during and after exposure to sensory conflict...
November 8, 2016: Cell Reports
https://www.readbyqxmd.com/read/27819313/circadian-rhythms-of-european-and-african-americans-after-a-large-delay-of-sleep-as-in-jet-lag-and-night-work
#10
Charmane I Eastman, Victoria A Tomaka, Stephanie J Crowley
Jet travel and night shift work produce large changes in when people sleep, work and eat; a challenge that was not encountered during most of our evolution. Successful adaptation would require the internal, master, circadian clock to make large phase shifts to reduce the circadian misalignment between circadian rhythms and the times for sleep, work and meals. We compared African-Americans and non-Hispanic European-Americans in how much their circadian clocks shifted after a 9 hour phase delay of the light/dark, sleep/wake and meal schedule, which has similarities to flying west or sleeping in the daytime after night shifts...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27763782/circadian-rhythm-and-sleep-disruption-causes-metabolic-consequences-and-countermeasures
#11
Gregory D M Potter, Debra J Skene, Josephine Arendt, Janet E Cade, Peter J Grant, Laura J Hardie
Circadian (∼24-hour) timing systems pervade all kingdoms of life and temporally optimize behavior and physiology in humans. Relatively recent changes to our environments, such as the introduction of artificial lighting, can disorganize the circadian system, from the level of the molecular clocks that regulate the timing of cellular activities to the level of synchronization between our daily cycles of behavior and the solar day. Sleep/wake cycles are intertwined with the circadian system, and global trends indicate that these, too, are increasingly subject to disruption...
December 2016: Endocrine Reviews
https://www.readbyqxmd.com/read/27749086/the-functional-and-clinical-significance-of-the-24-h-rhythm-of-circulating-glucocorticoids
#12
Henrik Oster, Etienne Challet, Volker Ott, Emanuela Arvat, E Ronald de Kloet, Derk-Jan Dijk, Stafford Lightman, Alexandros Vgontzas, Eve Van Cauter
Adrenal glucocorticoids are major modulators of multiple functions, including energy metabolism, stress responses, immunity, and cognition. The endogenous secretion of glucocorticoids is normally characterized by a prominent and robust circadian (around 24 hours) oscillation, with a daily peak around the time of the habitual sleep-wake transition and minimal levels in the evening and early part of the night. It has been long recognized that this 24-h rhythm partly reflects the activity of a master circadian pacemaker located in the suprachiasmatic nucleus of the hypothalamus...
October 17, 2016: Endocrine Reviews
https://www.readbyqxmd.com/read/27692050/prevalence-of-circadian-misalignment-and-its-association-with-depressive-symptoms-in-delayed-sleep-phase-disorder
#13
Jade M Murray, Tracey L Sletten, Michelle Magee, Christopher Gordon, Nicole Lovato, Delwyn J Bartlett, David J Kennaway, Leon C Lack, Ronald R Grunstein, Steven W Lockley, Shantha M W Rajaratnam
STUDY OBJECTIVE: To examine the prevalence of circadian misalignment in clinically diagnosed DSPD, and compare mood and daytime functioning in those with and without a circadian basis for the disorder. METHODS: 182 DSPD patients aged 16 to 64 years, engaged in regular employment or school, underwent sleep-wake monitoring in the home, followed by a sleep laboratory visit for assessment of salivary dim light melatonin onset (DLMO). Based on the DLMO assessments, patients were classified into two groups: circadian DSPD, defined as DLMO occurring at or after desired bedtime, or non-circadian DSPD, defined as DLMO occurring before desired bedtime...
September 26, 2016: Sleep
https://www.readbyqxmd.com/read/27607152/the-development-of-lighting-countermeasures-for-sleep-disruption-and-circadian-misalignment-during-spaceflight
#14
George C Brainard, Laura K Barger, Robert R Soler, John P Hanifin
PURPOSE OF REVIEW: The review addresses the development of a new solid-state lighting system for the International Space Station (ISS) that is intended to enhance the illumination of the working and living environment of astronauts and to improve sleep, circadian entrainment, and daytime alertness. RECENT FINDINGS: Spaceflight missions often expose astronauts and mission support ground crews to atypical sleep-wake cycles and work schedules. A recent, extensive study describes the sleep characteristics and use of sleep-promoting pharmaceuticals in astronauts before, during, and after spaceflight...
November 2016: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/27589389/perturbation-of-the-molecular-clockwork-in-the-scn-of-non-obese-diabetic-mice-prior-to-diabetes-onset
#15
Marc Ingenwerth, Anna Lena Reinbeck, Anna Stahr, Hans-Joachim Partke, Michael Roden, Volker Burkart, Charlotte von Gall
Circadian disruption is associated with the development of diabetes. Non-obese diabetic (NOD) mice show abnormal diurnal profiles in energy balance and locomotor activity suggesting circadian misalignment. Therefore, we analyzed cFos and mPER1 as markers for rhythmic neuronal activity within the suprachiasmatic nucleus (SCN) of wildtype (WT) and non-diabetic (nNOD) as well as acutely diabetic NOD (dNOD) mice. cFos levels show a day/night difference in both WT and nNOD but not in dNOD. mPER1 levels did not show a day/night difference in both nNOD and dNOD...
2016: Chronobiology International
https://www.readbyqxmd.com/read/27584008/disturbances-of-sleep-and-circadian-rhythms-novel-risk-factors-for-obesity
#16
Josiane L Broussard, Eve Van Cauter
PURPOSE OF REVIEW: The purpose of this review is to summarize recent developments linking disturbances of sleep and circadian rhythms to an increased risk for obesity, and to review novel research on potential countermeasures. RECENT FINDINGS: Effective treatments for obesity are limited, with long-term adherence to lifestyle changes proving difficult to maintain. Identifying new preventive strategies based on modifiable risk factors is therefore imperative in the fight against obesity...
October 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/27572002/association-between-morningness-and-resilience-in-korean-college-students
#17
So-Jin Lee, Chul-Soo Park, Bong-Jo Kim, Cheol-Soon Lee, Boseok Cha, Yu Jin Lee, Minah Soh, Jin Ah Park, Park So Young, Eun Hye Song
Circadian typology and sleep quality may be essential factors associated with the promotion of resilience. However, previous studies investigating the association between circadian typology and resilience did not analyze the effects of sleep quality on resilience. Thus, the present study evaluated the association between circadian typology and resilience in Korean college students after controlling for sleep quality. Additionally, this study investigated several sleep-related variables, including sleep duration, social jetlag and sunlight exposure during the daytime, to examine the modifiable behavioral features of morningness and also investigated whether the findings regarding morningness-related modifiable habits were associated with resilience...
2016: Chronobiology International
https://www.readbyqxmd.com/read/27568341/the-shift-work-and-health-research-agenda-considering-changes-in-gut-microbiota-as-a-pathway-linking-shift-work-sleep-loss-and-circadian-misalignment-and-metabolic-disease
#18
REVIEW
Amy C Reynolds, Jessica L Paterson, Sally A Ferguson, Dragana Stanley, Kenneth P Wright, Drew Dawson
Prevalence and impact of metabolic disease is rising. In particular, overweight and obesity are at epidemic levels and are a leading health concern in the Western world. Shift work increases the risk of overweight and obesity, along with a number of additional metabolic diseases, including metabolic syndrome and type 2 diabetes (T2D). How shift work contributes to metabolic disease has not been fully elucidated. Short sleep duration is associated with metabolic disease and shift workers typically have shorter sleep durations...
July 11, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27558731/costs-of-clock-environment-misalignment-in-individual-cyanobacterial-cells
#19
Guillaume Lambert, Justin Chew, Michael J Rust
Circadian rhythms are endogenously generated daily oscillations in physiology that are found in all kingdoms of life. Experimental studies have shown that the fitness of Synechococcus elongatus, a photosynthetic microorganism, is severely affected in non-24-h environments. However, it has been difficult to study the effects of clock-environment mismatch on cellular physiology because such measurements require a precise determination of both clock state and growth rate in the same cell. Here, we designed a microscopy platform that allows us to expose cyanobacterial cells to pulses of light and dark while quantitatively measuring their growth, division rate, and circadian clock state over many days...
August 23, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27543154/advanced-circadian-phase-in-mania-and-delayed-circadian-phase-in-mixed-mania-and-depression-returned-to-normal-after-treatment-of-bipolar-disorder
#20
Joung-Ho Moon, Chul-Hyun Cho, Gi Hoon Son, Dongho Geum, Sooyoung Chung, Hyun Kim, Seung-Gul Kang, Young-Min Park, Ho-Kyoung Yoon, Leen Kim, Hee-Jung Jee, Hyonggin An, Daniel F Kripke, Heon-Jeong Lee
Disturbances in circadian rhythms have been suggested as a possible cause of bipolar disorder (BD). Included in this study were 31 mood episodes of 26 BD patients, and 18 controls. Circadian rhythms of BD were evaluated at admission, at 2-week intervals during hospitalization, and at discharge. All participants wore wrist actigraphs during the studies. Saliva and buccal cells were obtained at 8:00, 11:00, 15:00, 19:00, and 23:00 for two consecutive days. Collected saliva and buccal cells were used for analysis of the cortisol and gene circadian rhythm, respectively...
September 2016: EBioMedicine
keyword
keyword
95121
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"