keyword
https://read.qxmd.com/read/36537278/the-2019-2020-dengue-fever-epidemic-genomic-markers-indicating-severity-in-dominican-republic-children
#21
JOURNAL ARTICLE
Brittany N Simpson, Miguel E Mejía Sang, Yonairy Collado Puello, Elvira J Diaz Brockmans, María F Díaz Soto, Stephanie M Rivera Defilló, Karla M Taveras Cruz, Javier O Santiago Pérez, Ammar Husami, Melissa E Day, Valentina Pilipenko, Rafael Mena, Cesár Mota, Margaret K Hostetter, Louis J Muglia, Elizabeth Schlaudecker, Javier Gonzalez Del Rey, Lisa J Martin, Carlos E Prada
We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and severe DF (n = 80/488, p = 0.006) and identified novel associations needing further investigation.
April 18, 2023: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/36340716/high-prevalence-of-arthralgia-among-infants-with-chikungunya-disease-during-the-2019-outbreak-in-northern-region-of-the-state-of-rio-de-janeiro
#22
JOURNAL ARTICLE
Patrícia Damião Gomes, Rayane Figueiredo Silva Moreira Carvalho, Milena Moulin Massini, Rafael Hauaji Garzon, Pollianny Louzada Schiavo, Regina Célia de Souza Campos Fernandes, Thaís Louvain de Souza
Introduction: In a low-income setting with simultaneous presence of Dengue virus, Zika virus, and Chikungunya virus (CHIKV) in the same region, the difficulty of establishing a clinical diagnosis when the molecular test is not a possibility. Thus, it is important to identify signs and symptoms of Chikungunya that can be used to differentiate it from other arboviruses in children. Methods: This is a cross-sectional study, which was developed in Rio de Janeiro State, Brazil, with the analysis of pediatric medical records regarding arboviruses...
2022: Frontiers in Pediatrics
https://read.qxmd.com/read/36252798/repeated-rapid-active-sampling-surveys-demonstrated-a-rapidly-changing-zika-seroprevalence-among-children-in-a-rural-dengue-endemic-region-in-southwest-guatemala-during-the-zika-epidemic-2015-2016
#23
JOURNAL ARTICLE
Molly M Lamb, Alejandra Paniagua-Avila, Alma Zacarias, Neudy Rojop, Andrea Chacon, Muktha S Natrajan, Jesse J Waggoner, Maria Renee Lopez, Celia Cordon-Rosales, James W Huleatt, Matthew I Bonaparte, Edwin J Asturias, Daniel Olson
Although Central America is largely dengue virus (DENV)-endemic, the 2015-2016 Zika virus (ZIKV) pandemic brought new urgency to develop surveillance approaches capable of characterizing the rapidly changing disease burden in resource-limited settings. We conducted a pediatric DENV surveillance study in rural Guatemala, including serial cross-sectional surveys from April through September 2015 (Survey 1), in October-November 2015 (Survey 2), and January-February 2016 (Survey 3). Serum underwent DENV IgM MAC ELISA and polymerase chain reaction testing...
November 14, 2022: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36149107/dengue-and-scrub-typhus-co-infection-in-children-experience-of-a-teaching-hospital-in-an-endemic-area
#24
JOURNAL ARTICLE
Priya Jose, Nishanth Rajan, Peter Prasanth Kumar Kommu, Lalitha Krishnan
BACKGROUND: Dengue fever and scrub typhus are considered an endemic disease in the Indian subcontinent. The epidemiology and clinical presentations are complex and vary each year. OBJECTIVE: The objective of this study was to estimate the prevalence of coinfection with scrub typhus in children diagnosed with dengue fever. METHODS: A retrospective hospital-based, cross-sectional study was done in the Department of Pediatrics of a teaching hospital in Puducherry...
2022: Indian Journal of Public Health
https://read.qxmd.com/read/35878144/false-positivity-of-anti-sars-cov-2-antibodies-in-patients-with-acute-tropical-diseases-in-thailand
#25
JOURNAL ARTICLE
Viravarn Luvira, Pornsawan Leaungwutiwong, Narin Thippornchai, Charin Thawornkuno, Supawat Chatchen, Wiwat Chancharoenthana, Sarunporn Tandhavanant, Sant Muangnoicharoen, Watcharapong Piyaphanee, Narisara Chantratita
Serology remains a useful indirect method of diagnosing tropical diseases, especially in dengue infection. However, the current literature regarding cross-reactivity between SARS-CoV-2 and dengue serology is limited and revealed conflicting results. As a means to uncover relevant serological insight involving antibody classes against SARS-CoV-2 and cross-reactivity, anti-SARS-CoV-2 IgA, IgM, and IgG ELISA, based on spike and nucleocapsid proteins, were selected for a fever-presenting tropical disease patient investigation...
July 12, 2022: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/35780359/clinical-profile-and-lab-findings-of-dengue-fever-in-children-admitted-in-a-tertiary-care-hospital
#26
JOURNAL ARTICLE
M Mutanabbi, S S Shova, M Kibtiar, T Mosleh
Dengue is an arboviral infection dengue virus (DENV 1-4) transmitted by Aedes mosquito. It shows a wide range of clinical presentation from asymptomatic cases to undifferentiated fever, dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS) or non-severe and severe dengue. Most cases of dengue are self-limiting; however, severe dengue has high mortality if not diagnosed and managed early during the disease. Dengue virus (DENV) infection is a serious global public health challenge resulting approximately 200 million cases of morbidity and 50,000 cases of mortality annually...
July 2022: Mymensingh Medical Journal: MMJ
https://read.qxmd.com/read/35767652/antibody-fc-characteristics-and-effector-functions-correlate-with-protection-from-symptomatic-dengue-virus-type-3-infection
#27
JOURNAL ARTICLE
Antonio G Dias, Caroline Atyeo, Carolin Loos, Magelda Montoya, Vicky Roy, Sandra Bos, Parnal Narvekar, Tulika Singh, Leah C Katzelnick, Guillermina Kuan, Douglas A Lauffenburger, Angel Balmaseda, Galit Alter, Eva Harris
Preexisting cross-reactive antibodies have been implicated in both protection and pathogenesis during subsequent infections with different dengue virus (DENV) serotypes (DENV1-4). Nonetheless, humoral immune correlates and mechanisms of protection have remained elusive. Using a systems serology approach to evaluate humoral responses, we profiled plasma collected before inapparent or symptomatic secondary DENV3 infection from our pediatric cohort in Nicaragua. Children protected from symptomatic infections had more anti-envelope (E) and anti-nonstructural protein 1 (NS1) total immunoglobulin G (IgG), IgG4, and greater Fc effector functions than those with symptoms...
June 29, 2022: Science Translational Medicine
https://read.qxmd.com/read/35381822/predictors-of-severe-dengue-amongst-children-as-per-the-revised-who-classification
#28
JOURNAL ARTICLE
Shilpa Khanna Arora, Devki Nandan, Anu Sharma, Pronita Benerjee, Dhirendra Pratap Singh
BACKGROUND & OBJECTIVES: World Health Organization (WHO) revised its guidelines for classification and management of dengue in 2009. This revised system was found out to have good sensitivity and negative predictive value but poor specificity as well as positive predictive value. METHODS: This retrospective study was carried out in a tertiary care hospital of Delhi, India to assess factors predicting the occurrence of severe dengue in children as per the revised classification...
October 2021: Journal of Vector Borne Diseases
https://read.qxmd.com/read/35003998/dengue-induced-hemophagocytic-lymphohistiocytosis-a-case-report-and-literature-review
#29
Adeeb Munshi, Anas Alsuraihi, Marwan Balubaid, Mohammad Althobaiti, Abdulhakeem Althaqafi
Hemophagocytic lymphohistiocytosis (HLH) is an uncommon fatal disease of otherwise normal but hyperactive lymphocytes and histocytes. HLH could be primary (hereditary) or secondary (acquired). Fever, hepatosplenomegaly, lymphadenopathy, and neurologic dysfunction are among the common symptoms of HLH. The diagnosis of HLH is based on clinical and biochemical findings. We report here a case of a patient infected with the dengue virus who developed HLH during hospitalization. A 63-year-old female known case of asthma on inhalers, chronic hepatitis B virus, gastritis on proton pump inhibitors, and hemoglobin H disease presented to the emergency department (ED) with a history of high-grade fever (highest recorded temperature 40° C/ 104° F), which was relieved partially by antipyretics, generalized fatigability, body aches, headache and mosquito bites for four days...
December 2021: Curēus
https://read.qxmd.com/read/34982768/dengue-virus-seroprevalence-study-in-bangphae-district-ratchaburi-thailand-a-cohort-study-in-2012-2015
#30
JOURNAL ARTICLE
Kriengsak Limkittikul, Pornthep Chanthavanich, Kang Sung Lee, Jung-Seok Lee, Supawat Chatchen, Sl-Ki Lim, Watcharee Arunsodsai, In-Kyu Yoon, Jacqueline Kyungah Lim
BACKGROUND: To determine the seroprevalence and transmission dynamics of dengue virus (DENV), age-stratified longitudinal serological surveys were conducted in Bangphae district, Ratchaburi province, Thailand, for 3 years between April 2012 and April 2015. METHODOLOGY: The surveys enrolled 2012 healthy children and adults between 1 and 55 years-of-age, and a longitudinal serosurvey of six repeated bleeds of the same cohort of individuals was conducted every 8 months for the first 2 years (M0, M8, M16) and every half a year (M24, M30, M36) for the rest of the study period...
January 2022: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/34865711/etiology-and-outcome-of-febrile-children-coming-from-the-tropics
#31
JOURNAL ARTICLE
David Torres-Fernandez, Luis Manuel Prieto Tato, Ana Perez-Ayala, Cinta Moraleda, Elisa Fernandez Cooke, Daniel Blazquez-Gamero, Pablo Rojo, Alfredo Perez Rivilla, Cristina Epalza
INTRODUCTION: International travelers have grown significantly over last years, as well as imported diseases from tropical areas. Information in pediatric population is scarce. We describe demographic and clinical characteristics of febrile children coming from the tropics. METHODS: Retrospective review of patients under 18 years old, presenting at a tertiary hospital and surrounding primary health care centers between July 2002 and July 2018 with a stay in a tropical region during the previous year...
December 2021: Enfermedades infecciosas y microbiologia clinica
https://read.qxmd.com/read/34808091/novel-assay-to-measure-seroprevalence-of-zika-virus-in-the-philippines
#32
JOURNAL ARTICLE
Cameron Adams, Ramesh Jadi, Bruno Segovia-Chumbez, Jedas Daag, Michelle Ylade, Freddy A Medina, Tyler M Sharp, Jorge L Munoz-Jordan, In-Kyu Yoon, Jacqueline Deen, Anna Lena Lopez, Aravinda M de Silva, Lakshmanane Premkumar
Zika virus (ZIKV) is a member of the Flaviviridae family, which includes other clinically notable viruses such as the 4 dengue virus serotypes (DENV-1-4). Distinguishing DENVs from ZIKV using the established serologic assays widely used for monitoring DENV transmission is difficult because of antibody cross-reactivity between these closely related flaviviruses. We describe a modified and improved recombinant envelope domain III-based serologic assay for detecting ZIKV type-specific antibodies in regions with endemic DENV transmission...
December 2021: Emerging Infectious Diseases
https://read.qxmd.com/read/34806672/clinical-manifestations-of-early-childhood-dengue-virus-infection-in-thailand
#33
JOURNAL ARTICLE
O Prommalikit, U Thisyakorn, C Thisyakorn
INTRODUCTION: Clinical manifestations of dengue infection has a wide spectrum. This study aimed to describe and compare the clinical aspects of dengue infection in early childhood and those in older children. MATERIALS AND METHODS: All dengue patients hospitalised at King Chulalongkorn Memorial Hospital, Bangkok, Thailand during 1987-2008 and aged 0-15 years were included. All parameters were compared between patients in two groups: aged 0-2 years and >2-15 years...
November 2021: Medical Journal of Malaysia
https://read.qxmd.com/read/34715835/clinical-spectrum-and-predictors-of-severity-of-dengue-among-children-in-2019-outbreak-a-multicenter-hospital-based-study-in-bangladesh
#34
MULTICENTER STUDY
Md Abdullah Saeed Khan, Abdullah Al Mosabbir, Enayetur Raheem, Ahsan Ahmed, Rashawan Raziur Rouf, Mahmudul Hasan, Fawzia Bente Alam, Nahida Hannan, Sabrina Yesmin, Robed Amin, Nazmul Ahsan, Sayeeda Anwar, Syeda Afroza, Mohammad Sorowar Hossain
BACKGROUND: The mosquito-borne arboviral disease dengue has become a global public health concern. However, very few studies have reported atypical clinical features of dengue among children. Because an understanding of various spectrums of presentation of dengue is necessary for timely diagnosis and management, we aimed to document the typical and atypical clinical features along with predictors of severity among children with dengue during the largest outbreak in Bangladesh in 2019...
October 29, 2021: BMC Pediatrics
https://read.qxmd.com/read/34508989/zika-virus-infection-in-pregnant-women-and-their-children-a-review
#35
REVIEW
Elena Marbán-Castro, Anna Goncé, Victoria Fumadó, Lucía Romero-Acevedo, Azucena Bardají
Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) transmitted primarily by Aedes mosquitoes. ZIKV can be transmitted to humans by non-vector borne mechanisms such as sexual intercourse, maternal-foetal transmission or blood transfusion. In 2015, ZIKV emerged in the Americas, and spread to 87 countries and territories with autochthonous transmission, distributed across four of the six WHO regions. Most ZIKV infections in pregnancy are asymptomatic, but mother to child transmission of the virus can occur in 20 to 30% of cases and cause severe foetal and child defects...
October 2021: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/34367644/detection-of-dengue-virus-serotype-1-in-central-nervous-system-of-a-child-in-bandung-west-java-a-case-report
#36
Dewi Hawani Alisjahbana, Syndi Nurmawati, Dzulfikar Dl Hakim, Mia Milanti, Yora Permata Dewi, Edison Johar, Khin Saw Aye Myint, Jeremy P Lederman, Ann M Powers, Bachti Alisjahbana, Ungke Antonjaya
Central nervous system involvement of dengue virus is increasingly reported from endemic areas. This study describes the clinical characteristics and laboratory features of a pediatric patient enrolled in a central nervous system illness study conducted in 2017-2018 to identify viral and bacterial etiologies in Indonesian children. Dengue diagnostics including molecular and serological testing were performed on an encephalitis patient who presented with both classical dengue and neurological clinical symptoms...
2021: SAGE Open Medical Case Reports
https://read.qxmd.com/read/34339379/clinical-features-of-acute-chikungunya-virus-infection-in-children-and-adults-during-an-outbreak-in-the-maldives
#37
JOURNAL ARTICLE
Hisham Ahmed Imad, Juthamas Phadungsombat, Emi E Nakayama, Keita Suzuki, Ahmed Mifthah Ibrahim, Aminath Afaa, Aminath Azeema, Aminath Nazfa, Aminath Yazfa, Anoosha Ahmed, Athifa Saeed, Azna Waheed, Fathimath Shareef, Mohamed Moinul Islam, Shausha Mohamed Anees, Sana Saleem, Aminath Aroosha, Ibrahim Afzal, Pornsawan Leaungwutiwong, Watcharapong Piyaphanee, Weerapong Phumratanaprapin, Tatsuo Shioda
The chikungunya virus is an arthritogenic arbovirus that has re-emerged in many tropical and subtropical regions, causing explosive outbreaks. This re-emergence is due to a genomic polymorphism that has increased the vector susceptibility of the virus. The majority of those infected with chikungunya virus exhibit symptoms of fever, rash, and debilitating polyarthralgia or arthritis. Symptoms can persist for weeks, and patients can relapse months later. Fatalities are rare, but individuals of extreme age can develop severe infection...
August 2, 2021: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/34280138/serological-differences-after-acute-zika-virus-infections-between-children-and-adults-implication-for-use-of-a-serological-test
#38
JOURNAL ARTICLE
Jurai Wongsawat, Patama Suttha, Sumalee Chanama, Somkid Srisopa, Nichapa Yonchoho, Putiporn Limpanadusadee
Information is limited regarding differential serological responses after acute Zika virus (ZIKV) infections and prevalence of cross-reactivity with anti-dengue virus (DENV) assays comparing children and adults. Early convalescent sera from a cohort of suspected mild DENV cases between December 2016 and September 2018 at Bamrasnaradura Infectious Diseases Institute in Thailand were tested for nonstructural protein 1 (NS1)-based anti-ZIKV IgM and IgG ELISAs (Euroimmun), and in-house anti-DENV IgM- and IgG-capture ELISAs...
July 19, 2021: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/34158814/a-case-series-of-severe-dengue-with-neurological-presentation-in-children-from-a-colombian-hyperendemic-area
#39
Jaime E Castellanos, Paula Esteban, Juanita Panqueba-Salgado, Daniela Benavides-Del-Castillo, Valentina Pastrana, Gladys Acosta, Doris Salgado, Carlos F Narvaez, Sigrid Camacho-Ortega, Eliana Calvo, Myriam L Velandia-Romero
Dengue transmission is sustained in Colombia with increasing prevalence mainly in children. This work aimed to describe a case series of children diagnosed with dengue presenting neurological disease in Huila Province of Colombia. Eleven pediatric febrile patients confirmed for dengue disease and presenting neurological signs were studied in the University Hospital of Neiva, Huila Province. Clinical and laboratory findings, CSF cytochemical analysis, neurology images, and serology and molecular studies were performed...
2021: Case Reports in Medicine
https://read.qxmd.com/read/34086703/detection-of-genotype-1-of-dengue-virus-serotype-3-for-the-first-time-and-complete-genome-analysis-of-dengue-viruses-during-the-2018-epidemic-in-mandalay-upper-myanmar
#40
JOURNAL ARTICLE
Mya Myat Ngwe Tun, Aung Kyaw Kyaw, Takeshi Nabeshima, Aung Min Soe, Khine Mya Nwe, Kyaw Ko Ko Htet, Thet Htoo Aung, Thein Thein Htwe, Thidar Aung, Su Su Myaing, Tu Tu Mar, Ei Phyu Lwin, Hlaing Myat Thu, Kyaw Zin Thant, Kouichi Morita
BACKGROUND: Dengue (DEN) is a neglected tropical disease, and surveillance of dengue virus (DENV) serotypes and genotypes is critical for the early detection of outbreaks. Risk factors for outbreaks include the emergence of new genotypes and serotype shifting. METHODOLOGY AND PRINCIPAL FINDINGS: To understand the genomic and viral characteristics of DENV-infected patients, we conducted a cross-sectional descriptive study among pediatric patients admitted at the 550-bedded Mandalay Children Hospital during the 2018 DEN endemic season...
2021: PloS One
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