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https://www.readbyqxmd.com/read/28634532/cellularizing-hydrogel-based-scaffolds-to-repair-bone-tissue-how-to-create-a-physiologically-relevant-micro-environment
#1
Mathieu Maisani, Daniele Pezzoli, Olivier Chassande, Diego Mantovani
Tissue engineering is a promising alternative to autografts or allografts for the regeneration of large bone defects. Cell-free biomaterials with different degrees of sophistication can be used for several therapeutic indications, to stimulate bone repair by the host tissue. However, when osteoprogenitors are not available in the damaged tissue, exogenous cells with an osteoblast differentiation potential must be provided. These cells should have the capacity to colonize the defect and to participate in the building of new bone tissue...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28631715/-concurrence-of-acute-graft-rejection-and-polyomavirus-nephropathy-a-clinical-case
#2
Yu G Motin, O V Omelchenko, T P Bukiy, N P Bgatova, A Yu Gryzlov
The paper describes a case of diagnosing acute renal graft rejection concurrent with polyomavirus nephropathy. Histochemical and electron microscopic methods were used to examine biopsy specimens, which showed morphological changes occurring in the allograft, the ultrastructural characteristics of polyomavirus and the features of its spread in kidney tissue structures.
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28631040/biomarkers-to-detect-rejection-after-kidney-transplantation
#3
Vikas R Dharnidharka, Andrew Malone
Detecting acute rejection in kidney transplantation has been traditionally done using histological analysis of invasive allograft biopsies, but this method carries a risk and is not perfect. Transplant professionals have been working to develop more accurate or less invasive biomarkers that can predict acute rejection or subsequent worse allograft survival. These biomarkers can use tissue, blood or urine as a source. They can comprise individual molecules or panels, singly or in combination, across different components or pathways of the immune system...
June 19, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28623079/restoration-of-articular-geometry-using-current-graft-options-for-large-glenoid-bone-defects-in-anterior-shoulder-instability
#4
Laurent B Willemot, Mohsen Akbari-Shandiz, Joaquin Sanchez-Sotelo, Kristin Zhao, Olivier Verborgt
PURPOSE: The purpose of this cadaveric study was to compare standard and modified coracoid transfer procedures, bicortical and tricortical iliac crest autografts, and tibial plafond and glenoid allografts with respect to glenoid surface curvature restoration. METHODS: Computed tomography scans of 8 cadaveric shoulders were acquired in 9 conditions: (1) intact, (2) 25% width defect, (3) classic Latarjet, (4) modified congruent-arc Latarjet, (5) tricortical iliac crest inner table, (6) outer table, (7) bicortical iliac crest, (8) distal tibia, and (9) glenoid allograft...
June 13, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28620643/activin-biology-after-lung-transplantation
#5
Glen P Westall, Gregory I Snell, Monika Loskot, Bronwyn Levvey, Robyn O'Hehir, Mark P Hedger, David M de Kretser
BACKGROUND: Activins A and B, members of the TGF-β superfamily, are produced as part of the physiological response to tissue damage and the resulting proinflammatory response. Given that lung allograft reperfusion results in an inflammatory response, it is likely that the activins and their binding protein follistatin will form part of the regulatory response. There is a need to document the response of these proteins to allograft reperfusion to determine if there is a role for the use of follistatin to control the biological actions of the activins because some of these are potentially damaging...
June 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28616759/is-dual-semitendinosus-allograft-stronger-than-turndown-for-achilles-tendon-reconstruction-an-in-vitro-analysis
#6
Michael C Aynardi, Lara C Atwater, Roshan Melvani, Brent G Parks, Adrian G Paez, Stuart D Miller
BACKGROUND: Large Achilles tendon defects pose a treatment challenge. The standard treatment with a turndown flap requires a large extensile incision, puts the sural nerve at risk, and demands slow, careful rehabilitation. Dual allograft semitendinosus reconstruction is a new clinical alternative that has the theoretical advantages of a smaller incision, less dissection, and a stronger construct that may allow for faster rehabilitation. QUESTIONS/PURPOSES: In a cadaver biomechanical model, we compared the dual allograft semitendinosus reconstruction with the myofascial turndown in terms of (1) mechanical strength and resistance to deformation and (2) failure mechanisms in reconstruction of large segmental Achilles defects...
June 14, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28615040/immunohistochemical-and-immunocytochemical-study-of-mechanoreceptors-in-anterior-cruciate-ligament-reconstruction-with-the-remnant-preserving-technique-using-achilles-tendon-allografts
#7
Keun Churl Chun, Sung Hyun Lee, Jeong Woo Kim, Eun Jung Jin, Kwang Mee Kim, Churl Hong Chun
BACKGROUND: Attempts have been made to validate the significance of remnant preservation with anterior cruciate ligament (ACL) reconstruction using immunohistochemical and immunocytochemical techniques. The purpose of this study was to examine the expression of mechanoreceptors in the remnant tissue of ACL reconstruction performed with the remnant-preserving technique. METHODS: Tissue samples were obtained from 10 patients who underwent ACL reconstruction with the remnant-preserving technique...
June 14, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28614276/wrist-arthrodesis-with-femoral-head-structural-allograft-after-failed-total-wrist-arthroplasty
#8
Louis C Grandizio, Steven Maschke
The failed total wrist arthroplasty represents a challenging reconstructive problem for the upper extremity surgeon. Bone loss, poor bone quality, and soft tissue defects all present technical challenges when considering revision procedures. Our purpose is to describe a technique for wrist arthrodesis after failed total wrist arthroplasty utilizing fresh-frozen femoral head allograft and dorsal plate fixation. We describe a simple method of allograft preparation for this procedure, as graft preparation and implantation can be time consuming and technically challenging...
June 13, 2017: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/28610776/two-stage-late-reconstruction-with-a-fresh-large-osteochondral-shell-allograft-transplantation-flocsat-for-a-large-ostechondral-defect-in-a-non-union-after-a-lateral-tibia-plateau-fracture-2-year-follow-up
#9
C Krettek, J Clausen, M Omar, S Noack, C Neunaber
This is the description of a 58-year-old female patient presenting 8 months after a horse riding accident with significant pain and inability to walk independently. Imaging revealed a large osseous defect of the lateral tibia plateau which was not united posteriorly. The patient refused knee replacement and we developed a patient specific two-step procedure for her. Step 1: Filling of the defect with a large cortico-cancellous autograft from the posterior iliac crest; step 2: Transplantation of a fresh large osteochondral shell allograft (FLOCSAT)...
May 17, 2017: Injury
https://www.readbyqxmd.com/read/28609505/creation-of-a-zone-of-immobile-connective-tissue-with-acellular-dermal-matrix-allografts
#10
Ramzi V Abou-Arraj, Maninder Kaur, Philip J Vassilopoulos, Nicolaas C Geurs
Acellular dermal matrix allografts (ADMs) have been hypothesized to create a zone of immobile connective tissue (ICT) extending apical to the mucogingival junction (MGJ). This 12-month prospective randomized trial investigated the presence of ICT after the use of two commercially available ADMs with coronally advanced flaps in the treatment of Miller Class I and II recession defects. This study demonstrated that the use of either type of ADM resulted in predictable root coverage and a zone of ICT extending apical to the MGJ by 1...
July 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28606481/micropuncture-and-pressure-assisted-schwann-cell-seeding-of-nerve-allograft
#11
Jonathan Isaacs, Nathan Richards, John McMurtry, Satya Mallu, Gaurangkumar Patel, Matthew Thompson, Dorne Yager
BACKGROUND: Tissue processing to create immunotolerant nerve allograft removes neurosupportive cells. Few strategies have been described for implanting new cells into the graft to support axonal regeneration. NEW METHOD: Micropuncture of the nerve allograft surface combined with immersion into a pressurized cell-rich solution to potentiate the introduction of viable Schwann cells (SC) into processed nerve allograft. Allografts were used to repair rodent sciatic nerve defects...
June 9, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28605496/validation-of-microbiological-testing-in-cardiovascular-tissue-banks-results-of-a-quality-round-trial
#12
Theo M M H de By, Carl McDonald, Susanne Süßner, Jill Davies, Wee Ling Heng, Ramadan Jashari, Ad J J C Bogers, Pieter Petit
OBJECTIVES: Surgeons needing human cardiovascular tissue for implantation in their patients are confronted with cardiovascular tissue banks that use different methods to identify and decontaminate micro-organisms. To elucidate these differences, we compared the quality of processing methods in 20 tissue banks and 1 reference laboratory. We did this to validate the results for accepting or rejecting tissue. We included the decontamination methods used and the influence of antibiotic cocktails and residues with results and controls...
June 12, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28604062/cartilage-regeneration-in-full-thickness-patellar-chondral-defects-treated-with-particulated-juvenile-articular-allograft-cartilage-an-mri-analysis
#13
Brian Grawe, Alissa Burge, Joseph Nguyen, Sabrina Strickland, Russell Warren, Scott Rodeo, Beth ShubinStein
Background Full-thickness cartilage lesions of the patella represent a common source of pain and dysfunction. Previously reported surgical treatment options include marrow stimulation, cell-based treatments, and osteochondral transfer. Minced juvenile allograft cartilage is a novel treatment option that allows for a single stage approach for these lesions. Hypothesis Particulated juvenile allograft cartilage (PJAC) for the treatment of chondral defects of the patella would offer acceptable lesion fill rates, mature over time, and not be associated with any negative biologic effects on the surrounding tissue...
June 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28602591/skin-grafts-from-genetically-modified-%C3%AE-1-3-galactosyltransferase-knockout-miniature-swine-a-functional-equivalent-to-allografts
#14
D A Leonard, C Mallard, A Albritton, R Torabi, M Mastroianni, D H Sachs, J M Kurtz, C L Cetrulo
Burn is associated with a considerable burden of morbidity worldwide. Early excision of burned tissue and skin grafting of the resultant wound has been established as a mainstay of modern burn therapy. However, in large burns, donor sites for autologous skin may be limited. Numerous alternatives, from cadaver skin to synthetic substitutes have been described, each with varying benefits and limitations. We previously proposed the use of genetically modified (alpha-1,3-galactosyl transferase knockout, GalT-KO) porcine skin as a viable skin alternative...
June 8, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28599980/generalized-hypermobility-knee-hyperextension-and-outcomes-after-anterior-cruciate-ligament-reconstruction-prospective-case-control-study-with-mean-6%C3%A2-years-follow-up
#15
Christopher M Larson, Asheesh Bedi, Mark E Dietrich, Jennifer C Swaringen, Corey A Wulf, David M Rowley, M Russell Giveans
PURPOSE: To determine whether generalized hypermobility and contralateral knee hyperextension affect failure rates and patient-related outcomes after anterior cruciate ligament reconstruction (ACLR). METHODS: A total of 226 consecutive patients presenting with acute ACL tears were prospectively evaluated for generalized hypermobility by a modified Beighton criteria. Minimum 2-year follow-up was achieved for 183 knees (81%). Patients underwent ACLR with either bone-patellar-tendon (BPTB) autograft (n = 46), quadrupled hamstring (HT) autograft (n = 85), or allograft tissue (n = 52)...
June 6, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28595843/analysis-of-risk-factors-associated-with-unplanned-reoperations-following-pediatric-plastic-surgery
#16
Kevin T Jubbal, Dmitry Zavlin, Edward P Buchanan, Larry H Hollier
BACKGROUND/PURPOSE: Unplanned reoperation (UR) is an outcome measure with multiple advantages that can be used as a standardized tool to assess an institution's quality and safety of medical care. This study aimed to identify parameters associated with an increased likelihood of UR following plastic surgery in patients less than 18 years of age by using a large validated national multicenter database. METHODS/DESCRIPTION: We performed a retrospective analysis of the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) Pediatric database between 2012 and 2014 to identify pediatric patients undergoing primary plastic surgery procedures...
May 18, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28594592/alveolar-ridge-preservation-using-allografts-and-dptfe-membranes-with-open-membrane-technique-in-unhealthy-extraction-sockets
#17
Gi-Beom Cheon, Kyung Lhi Kang, Mi-Kyung Yoo, Jeoung-A Yu, Dongwoon Lee
We evaluated the effectiveness of the open membrane technique using a high-density polytetrafluoroethylene (dPTFE) membrane with freeze-dried bone allografts (FDBA) in damaged sockets for alveolar ridge preservation (ARP). This retrospective study included 26 sites from 20 patients who had received ARP for the placement of dental implants. ARP was conducted using dPTFE membrane with allografts on the day of extraction without primary closure. When the membrane was removed after 4 weeks, the newly-formed reddish tissue at the grafted site was checked (1st outcome, clinical evaluation)...
June 8, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28593053/natural-graft-tissues-and-synthetic-biomaterials-for-periodontal-and-alveolar-bone-reconstructive-applications-a-review
#18
REVIEW
Zeeshan Sheikh, Nader Hamdan, Yuichi Ikeda, Marc Grynpas, Bernhard Ganss, Michael Glogauer
Periodontal disease is categorized by the destruction of periodontal tissues. Over the years, there have been several clinical techniques and material options that been investigated for periodontal defect repair/regeneration. The development of improved biomaterials for periodontal tissue engineering has significantly improved the available treatment options and their clinical results. Bone replacement graft materials, barrier membranes, various growth factors and combination of these have been used. The available bone tissue replacement materials commonly used include autografts, allografts, xenografts and alloplasts...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28590380/surgical-treatment-for-hemophilic-pseudotumor-twenty-three-cases-with-an-average-follow-up-of-5-years
#19
Jiliang Zhai, Xisheng Weng, Baozhong Zhang, Yong Liu, Peng Gao, Yan-Yan Bian
BACKGROUND: Hemophilic pseudotumor (HPT) is a rare disease with many challenges. Only a few reports on surgical treatment for HPT have been published. METHODS: The cases of 23 patients with HPT who had surgical treatment from July 1996 to December 2014 were retrospectively reviewed. Demographic data, blood loss and transfusion during surgery, outcomes, and complications after surgery were analyzed. RESULTS: Eleven patients underwent HPT resection; 4 underwent HPT excision, allograft transplantation, and absorbable screw fixation; 3 had HPT resection and metallic internal fixation; 2 had HPT resection, autogenous fibular grafting, and absorbable screw fixation; 2 underwent curettage and bone-grafting; and 1 patient received above-the-knee amputation...
June 7, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28580842/understanding-magnetic-resonance-imaging-of-knee-cartilage-repair-a-focus-on-clinical-relevance
#20
Daichi Hayashi, Xinning Li, Akira M Murakami, Frank W Roemer, Siegfried Trattnig, Ali Guermazi
The aims of this review article are (a) to describe the principles of morphologic and compositional magnetic resonance imaging (MRI) techniques relevant for the imaging of knee cartilage repair surgery and their application to longitudinal studies and (b) to illustrate the clinical relevance of pre- and postsurgical MRI with correlation to intraoperative images. First, MRI sequences that can be applied for imaging of cartilage repair tissue in the knee are described, focusing on comparison of 2D and 3D fast spin echo and gradient recalled echo sequences...
June 1, 2017: Cartilage
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