David Millrine, Ana Cardus Figueras, Javier Uceda Fernandez, Robert Andrews, Barbara Szomolay, Benjamin C Cossins, Christopher M Rice, Jasmine Li, Victoria J Tyrrell, Louise McLeod, Peter Holmans, Valerie B O'Donnell, Philip R Taylor, Stephen J Turner, Brendan J Jenkins, Gareth W Jones, Nicholas Topley, Nigel M Williams, Simon A Jones
Cytokines that signal via STAT1 and STAT3 transcription factors instruct decisions affecting tissue homeostasis, antimicrobial host defense, and inflammation-induced tissue injury. To understand the coordination of these activities, we applied RNA sequencing, chromatin immunoprecipitation sequencing, and assay for transposase-accessible chromatin with high-throughput sequencing to identify the transcriptional output of STAT1 and STAT3 in peritoneal tissues from mice during acute resolving inflammation and inflammation primed to drive fibrosis...
June 5, 2023: Journal of Immunology